EDN1 (endothelin 1) - Rat Genome Database

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Gene: EDN1 (endothelin 1) Homo sapiens
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Symbol: EDN1
Name: endothelin 1
RGD ID: 730848
HGNC Page HGNC
Description: Enables signaling receptor binding activity. Involved in several processes, including intracellular signal transduction; regulation of macromolecule biosynthetic process; and vascular associated smooth muscle contraction. Located in cytoplasm and extracellular space. Implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); glaucoma (multiple); lung disease (multiple); and retinal disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARCND3; endothelin-1; ET1; HDLCQ7; PPET1; preproendothelin-1; QME
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Acute Lung Injury  (EXP)
adult respiratory distress syndrome  (EXP,IEP,ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (IEP)
anterolateral myocardial infarction  (IEP)
aspiration pneumonia  (ISO)
asthma  (EXP,IAGP,IEP)
atherosclerosis  (ISO)
atrial fibrillation  (EXP,IEP)
Auriculocondylar Syndrome  (EXP)
Auriculocondylar Syndrome 3  (IAGP)
autosomal dominant polycystic kidney disease  (IEP)
Behcet's disease  (IEP)
Bradycardia  (EXP)
brain ischemia  (ISO)
bronchiolitis obliterans  (IMP)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Arrhythmias  (EXP)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (EXP)
Cardiovascular Abnormalities  (EXP)
cardiovascular system disease  (EXP)
cartilage disease  (EXP)
cerebrovascular disease  (EXP)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (IAGP,IEP)
chronic rhinitis  (IEP)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (EXP)
congestive heart failure  (EXP,IDA,IEP,ISO)
coronary artery disease  (IAGP,IEP,ISO)
coronary stenosis  (IDA)
Craniofacial Abnormalities  (EXP,ISO)
cystic fibrosis  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IAGP,IEP,ISO)
Diaphragmatic Hernia  (EXP)
dilated cardiomyopathy  (IEP)
Dyspnea  (IEP)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (IEP)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP)
focal segmental glomerulosclerosis  (EXP)
Gastrointestinal Diseases  (EXP)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (EXP)
Hyperalgesia  (EXP,ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (EXP)
Hyperoxia  (ISO)
hypertension  (EXP,IAGP,IEP,IMP,ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (EXP)
hypogonadism  (ISO)
Hypotension  (EXP,ISO)
impotence  (EXP,ISO)
Inflammation  (EXP)
intermediate coronary syndrome  (IEP)
kidney disease  (EXP)
kidney failure  (EXP,ISO)
Left Ventricular Hypertrophy  (EXP,ISO)
Lewy body dementia  (EXP)
liver cirrhosis  (ISO)
low tension glaucoma  (IEP)
major depressive disorder  (EXP)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (EXP)
multiple sclerosis  (IEP)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (EXP)
neovascular glaucoma  (IEP)
neovascular inflammatory vitreoretinopathy  (IEP)
nephritis  (ISO)
nephrosis  (EXP,ISO)
obesity  (IAGP)
obstructive sleep apnea  (IAGP,IEP,ISO)
optic nerve disease  (IDA)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (EXP)
ovarian carcinoma  (IEP)
Overactive Urinary Bladder  (EXP)
Pain  (EXP)
Parkinson's disease  (EXP)
peptic ulcer disease  (EXP)
pneumonia  (IEP)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (EXP)
Pregnancy-Induced Hypertension  (IAGP)
Premature Birth  (EXP)
Presbycusis  (IAGP)
primary open angle glaucoma  (IEP)
pulmonary embolism  (ISO)
pulmonary fibrosis  (EXP,IEP,ISO)
pulmonary hypertension  (EXP,IEP,ISO)
Question Mark Ears, Isolated  (IAGP)
renal artery disease  (ISO)
Reperfusion Injury  (EXP,ISO)
retinal degeneration  (ISO)
retinal detachment  (IEP)
retinitis pigmentosa  (IEP)
rheumatoid arthritis  (IDA)
Sepsis  (ISO)
Slow Coronary Flow  (IEP)
Stroke  (EXP)
Subarachnoid Hemorrhage  (EXP)
systemic scleroderma  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (EXP,IEP,ISO)
uremia  (ISO)
ureteral obstruction  (EXP,ISO)
Urinary Retention  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-NITROINDAZOLE  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrolein  (EXP)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
aminoguanidine  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
ampicillin  (EXP)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (EXP)
atenolol  (EXP)
atorvastatin calcium  (EXP)
atrasentan  (ISO)
atropine  (EXP)
belinostat  (EXP)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-carotene  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
caesium chloride  (EXP)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (ISO)
capsaicin  (EXP)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carvedilol  (EXP,ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
chetomin  (EXP)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
cicaprost  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cytarabine  (EXP,ISO)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
dapsone  (ISO)
daunorubicin  (ISO)
Deoxycorticosterone acetate  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dydrogesterone  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
elemental carbon  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
furan  (ISO)
geldanamycin  (EXP)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glycidol  (ISO)
glycoursodeoxycholic acid  (EXP)
GW 4064  (ISO)
heparin  (EXP,ISO)
hexadecanoic acid  (EXP)
histamine  (EXP)
homocysteine  (EXP)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
ICI 118551  (EXP)
indometacin  (EXP,ISO)
iodixanol  (ISO)
iopromide  (ISO)
irbesartan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (EXP)
isoprenaline  (ISO)
isoquinoline-1,5-diol  (ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (EXP)
ivermectin  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-mimosine  (EXP,ISO)
lamivudine  (EXP)
leflunomide  (ISO)
leukotriene C4  (EXP)
levamisole  (EXP)
linalool  (EXP)
linoleic acid  (EXP)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
manganese(II) chloride  (ISO)
Meglumine sodium amidotrizoate  (ISO)
melphalan  (EXP)
menadione  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (EXP)
methyl beta-cyclodextrin  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
metoprolol  (ISO)
Mibefradil  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
montelukast  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nebivolol  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nisoldipine  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (ISO)
Nutlin-3  (EXP)
ochratoxin A  (EXP)
octadecanoic acid  (EXP)
oleic acid  (EXP)
Olmesartan medoxomil  (ISO)
olodaterol  (EXP)
orotic acid  (ISO)
oroxylin A  (ISO)
ouabain  (EXP,ISO)
Oxotremorine  (EXP)
ozone  (EXP,ISO)
panobinostat  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
paricalcitol  (ISO)
PD123319  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (EXP)
PhIP  (ISO)
phosgene  (ISO)
phosphoramide mustard  (ISO)
phosphoramidon  (ISO)
picrotoxin  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium chromate  (EXP)
pravastatin  (EXP,ISO)
prazosin  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP,ISO)
prostaglandin E2  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
Ro 31-8220  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
S-methyl-L-thiocitrulline  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (EXP)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
steviol  (EXP)
stevioside  (EXP)
stilbene-4,4'-diol  (EXP)
streptozocin  (EXP,ISO)
Sucralfate  (ISO)
sulfur dioxide  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
telmisartan  (ISO)
temozolomide  (EXP)
tenofovir disoproxil fumarate  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracosanoic acid  (EXP)
tetraphene  (ISO)
theophylline  (EXP)
thioacetamide  (ISO)
thymidine  (EXP)
tiotropium bromide  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trans-caffeic acid  (ISO)
trans-stilbene-4,4'-diol  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (EXP)
verapamil  (EXP)
vinclozolin  (ISO)
water  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (EXP)
zidovudine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
artery smooth muscle contraction  (IDA,ISO,TAS)
axon extension  (ISO)
axonogenesis involved in innervation  (ISO)
blood vessel morphogenesis  (ISO)
body fluid secretion  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (ISO)
calcium-mediated signaling  (IDA)
canonical Wnt signaling pathway  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cartilage development  (IEA,ISO)
cell surface receptor signaling pathway  (IDA)
cell-cell signaling  (IDA)
cellular calcium ion homeostasis  (IBA)
cellular response to calcium ion  (IEA,ISO)
cellular response to fatty acid  (IEA,ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to human chorionic gonadotropin stimulus  (ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to interferon-gamma  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to mineralocorticoid stimulus  (IEA,ISO)
cellular response to organic substance  (ISO)
cellular response to peptide hormone stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
dorsal/ventral pattern formation  (IEA,ISO)
embryonic heart tube development  (ISO)
endothelin receptor signaling pathway  (IMP)
endothelin receptor signaling pathway involved in heart process  (ISO)
epithelial fluid transport  (IEA,ISO)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor signaling pathway  (IDA)
gene expression  (ISO)
heart development  (IEA,ISO)
histamine secretion  (IEA,ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
in utero embryonic development  (IEA,ISO)
inositol phosphate-mediated signaling  (IDA)
intracellular signal transduction  (ISO)
leukocyte activation  (TAS)
MAPK cascade  (ISO)
maternal process involved in parturition  (IEA,ISO)
meiotic cell cycle process involved in oocyte maturation  (ISO)
membrane depolarization  (IEA,ISO)
middle ear morphogenesis  (IEA,ISO)
mitochondrion organization  (ISO)
multicellular organism aging  (IEA,ISO)
negative regulation of blood coagulation  (TAS)
negative regulation of cellular protein metabolic process  (IDA)
negative regulation of gene expression  (IEA)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (IDA)
negative regulation of smooth muscle cell apoptotic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neural crest cell development  (IEA,ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (ISO)
neuron projection development  (ISO)
neutrophil chemotaxis  (IDA)
nitric oxide transport  (IDA)
noradrenergic neuron differentiation  (ISO)
peptide hormone secretion  (IDA)
pharyngeal arch artery morphogenesis  (ISO)
phosphatidylinositol 3-kinase signaling  (IDA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of cell growth involved in cardiac muscle cell development  (IDA,IGI)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell size  (IDA)
positive regulation of chemokine-mediated signaling pathway  (IDA)
positive regulation of cytosolic calcium ion concentration  (IDA,ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of endothelial cell migration  (TAS)
positive regulation of heart rate  (IDA)
positive regulation of hormone secretion  (IDA)
positive regulation of JUN kinase activity  (IDA)
positive regulation of MAP kinase activity  (IDA)
positive regulation of mitotic nuclear division  (IDA)
positive regulation of neutrophil chemotaxis  (IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of nitric oxide biosynthetic process  (TAS)
positive regulation of odontogenesis  (IEA,ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
positive regulation of prostaglandin-endoperoxide synthase activity  (IBA,IMP)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of sarcomere organization  (IMP)
positive regulation of signaling receptor activity  (IDA)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of urine volume  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
prostaglandin biosynthetic process  (IDA)
protein kinase C deactivation  (IDA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of blood pressure  (ISO)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of pH  (IEA,ISO)
regulation of sensory perception of pain  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA,IDA)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (ISO)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to activity  (IEA,ISO)
response to amino acid  (IEA,ISO)
response to amphetamine  (ISO)
response to dexamethasone  (IEA,ISO)
response to hypoxia  (ISO)
response to leptin  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
response to nicotine  (IEA,ISO)
response to ozone  (IEA,ISO)
response to prostaglandin F  (IEA,ISO)
response to salt  (IEA,ISO)
response to testosterone  (IEA,ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic excitation  (IEA,ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (ISO)
sensory perception of pain  (IEA,ISO)
skeletal system development  (ISO)
superoxide anion generation  (IEA,ISO)
sympathetic neuron axon guidance  (ISO)
thyroid gland development  (ISO)
transcription by RNA polymerase II  (ISO)
vasoconstriction  (IDA,ISO)
vein smooth muscle contraction  (IBA,IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

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Additional References at PubMed
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PMID:21701423   PMID:21712053   PMID:21730058   PMID:21741393   PMID:21767690   PMID:21773759   PMID:21777246   PMID:21786569   PMID:21801587   PMID:21813388   PMID:21826669   PMID:21851036  
PMID:21873635   PMID:21896842   PMID:21908890   PMID:21932697   PMID:21952518   PMID:21959927   PMID:22006997   PMID:22045428   PMID:22082020   PMID:22113444   PMID:22165675   PMID:22175913  
PMID:22232246   PMID:22265324   PMID:22299030   PMID:22321643   PMID:22330820   PMID:22341591   PMID:22377253   PMID:22412088   PMID:22415226   PMID:22483689   PMID:22483692   PMID:22503784  
PMID:22504006   PMID:22520393   PMID:22525370   PMID:22527528   PMID:22545467   PMID:22552325   PMID:22553998   PMID:22569256   PMID:22580289   PMID:22666926   PMID:22675930   PMID:22727793  
PMID:22759779   PMID:22770822   PMID:22796455   PMID:22856221   PMID:22856224   PMID:22869459   PMID:22907118   PMID:22960172   PMID:22965194   PMID:22971991   PMID:22994522   PMID:22997346  
PMID:23002189   PMID:23018104   PMID:23103494   PMID:23142694   PMID:23163519   PMID:23168014   PMID:23208497   PMID:23227981   PMID:23233754   PMID:23255664   PMID:23273644   PMID:23290569  
PMID:23329136   PMID:23344160   PMID:23372172   PMID:23381795   PMID:23384184   PMID:23401650   PMID:23436272   PMID:23436727   PMID:23444087   PMID:23457411   PMID:23465236   PMID:23523690  
PMID:23530911   PMID:23565184   PMID:23597562   PMID:23643051   PMID:23654314   PMID:23683481   PMID:23713736   PMID:23720837   PMID:23793138   PMID:23815989   PMID:23828677   PMID:23832707  
PMID:23863409   PMID:23884378   PMID:23887640   PMID:23902937   PMID:23942766   PMID:23985981   PMID:23987825   PMID:24015303   PMID:24035903   PMID:24056654   PMID:24069190   PMID:24071933  
PMID:24088748   PMID:24088894   PMID:24111610   PMID:24117217   PMID:24123836   PMID:24140435   PMID:24151613   PMID:24156724   PMID:24184161   PMID:24196534   PMID:24268655   PMID:24275556  
PMID:24328421   PMID:24332749   PMID:24333656   PMID:24373848   PMID:24376792   PMID:24423482   PMID:24463938   PMID:24473118   PMID:24482377   PMID:24529882   PMID:24530737   PMID:24530772  
PMID:24550382   PMID:24607779   PMID:24628039   PMID:24633486   PMID:24647318   PMID:24727057   PMID:24735956   PMID:24736615   PMID:24747133   PMID:24756349   PMID:24769306   PMID:24815860  
PMID:24852947   PMID:24853905   PMID:24856242   PMID:24877885   PMID:24878772   PMID:24885051   PMID:24969188   PMID:24978044   PMID:25016214   PMID:25042451   PMID:25045892   PMID:25048859  
PMID:25051669   PMID:25095655   PMID:25099217   PMID:25137915   PMID:25138825   PMID:25158193   PMID:25159325   PMID:25194819   PMID:25195814   PMID:25203431   PMID:25230302   PMID:25237831  
PMID:25245046   PMID:25268585   PMID:25284689   PMID:25345870   PMID:25389292   PMID:25394359   PMID:25398294   PMID:25399435   PMID:25403488   PMID:25460732   PMID:25486928   PMID:25541019  
PMID:25556429   PMID:25572612   PMID:25584774   PMID:25595970   PMID:25617859   PMID:25623906   PMID:25627007   PMID:25681034   PMID:25739168   PMID:25741585   PMID:25753689   PMID:25801761  
PMID:25814673   PMID:25820093   PMID:25823218   PMID:25864450   PMID:25870197   PMID:25892606   PMID:25902111   PMID:25903653   PMID:25946671   PMID:25990837   PMID:25994955   PMID:26035976  
PMID:26071554   PMID:26074317   PMID:26089601   PMID:26098770   PMID:26108089   PMID:26121692   PMID:26138305   PMID:26141182   PMID:26142066   PMID:26144293   PMID:26190179   PMID:26322793  
PMID:26322806   PMID:26352058   PMID:26460070   PMID:26482255   PMID:26501871   PMID:26554436   PMID:26565974   PMID:26573599   PMID:26573609   PMID:26599223   PMID:26617785   PMID:26638464  
PMID:26641207   PMID:26710051   PMID:26752193   PMID:26763086   PMID:26823880   PMID:26846374   PMID:26917562   PMID:26923419   PMID:26952167   PMID:26972958   PMID:27102411   PMID:27105310  
PMID:27106952   PMID:27155341   PMID:27267037   PMID:27300270   PMID:27335279   PMID:27372047   PMID:27425626   PMID:27450023   PMID:27465439   PMID:27481876   PMID:27485004   PMID:27534881  
PMID:27612006   PMID:27682654   PMID:27761928   PMID:27765761   PMID:27777505   PMID:27788598   PMID:27810862   PMID:27846260   PMID:27876299   PMID:27881399   PMID:27885846   PMID:27892645  
PMID:27899487   PMID:27906839   PMID:27939477   PMID:27941335   PMID:28025386   PMID:28030574   PMID:28092772   PMID:28095606   PMID:28153500   PMID:28211916   PMID:28222015   PMID:28284500  
PMID:28320472   PMID:28323184   PMID:28398455   PMID:28542386   PMID:28548215   PMID:28548598   PMID:28587741   PMID:28606962   PMID:28634054   PMID:28692114   PMID:28726796   PMID:28753427  
PMID:28781261   PMID:28831601   PMID:28882114   PMID:28886122   PMID:28901422   PMID:28904960   PMID:28937251   PMID:28942357   PMID:28977804   PMID:29025769   PMID:29044995   PMID:29101349  
PMID:29212952   PMID:29302812   PMID:29351334   PMID:29439204   PMID:29441862   PMID:29444773   PMID:29529394   PMID:29562761   PMID:29630085   PMID:29654172   PMID:29674204   PMID:29806659  
PMID:29845193   PMID:29849817   PMID:29913121   PMID:29996135   PMID:30022320   PMID:30229506   PMID:30271160   PMID:30279475   PMID:30351652   PMID:30359461   PMID:30392707   PMID:30411193  
PMID:30530965   PMID:30537754   PMID:30605125   PMID:30621952   PMID:30685994   PMID:30737857   PMID:30771901   PMID:30828008   PMID:30921293   PMID:30987836   PMID:31055534   PMID:31106465  
PMID:31111864   PMID:31117937   PMID:31293143   PMID:31425950   PMID:31476318   PMID:31514181   PMID:31566901   PMID:31583031   PMID:31608892   PMID:31672620   PMID:31972008   PMID:31981468  
PMID:32119570   PMID:32141526   PMID:32151622   PMID:32168316   PMID:32246794   PMID:32251485   PMID:32268070   PMID:32315546   PMID:32343134   PMID:32386379   PMID:32496159   PMID:32499477  
PMID:32538758   PMID:32567294   PMID:32589590   PMID:32615041   PMID:32703408   PMID:32731692   PMID:32747363   PMID:32879758   PMID:33221345   PMID:33275248   PMID:33340492   PMID:33445111  
PMID:33539452   PMID:33985491   PMID:34011397  


Genomics

Comparative Map Data
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)Ensembl
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0panPan3
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBI
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBI
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBI
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBI
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBI
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBI
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBI
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)Ensembl
Vero_WHO_p1.0NW_02366604412,341,006 - 12,348,096 (+)NCBI
Edn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBI

Position Markers
WI-7563  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37612,296,377 - 12,296,713UniSTSGRCh37
Build 36612,404,363 - 12,404,699RGDNCBI36
Celera613,524,434 - 13,524,770RGD
Cytogenetic Map6p24.1UniSTS
HuRef612,228,002 - 12,228,338UniSTS
GeneMap99-GB4 RH Map647.73UniSTS
Whitehead-YAC Contig Map6 UniSTS
A006R11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37612,295,685 - 12,295,810UniSTSGRCh37
Build 36612,403,671 - 12,403,796RGDNCBI36
Celera613,523,742 - 13,523,867RGD
Cytogenetic Map6p24.1UniSTS
HuRef612,227,310 - 12,227,435UniSTS
GeneMap99-GB4 RH Map647.73UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR1-1hsa-miR-1Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22963810
MIR1-1hsa-miR-1OncomiRDBexternal_infoNANA22963810
MIR199A1hsa-miR-199a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19783678
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19783678

Predicted Target Of
Summary Value
Count of predictions:493
Count of miRNA genes:393
Interacting mature miRNAs:436
Transcripts:ENST00000379375
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 1598 956 185 140 673 42 2921 795 1564 194 611 873 113 1