EDN1 (endothelin 1) - Rat Genome Database

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Gene: EDN1 (endothelin 1) Homo sapiens
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Symbol: EDN1
Name: endothelin 1
RGD ID: 730848
HGNC Page HGNC:3176
Description: Enables signaling receptor binding activity. Involved in several processes, including intracellular signal transduction; regulation of macromolecule biosynthetic process; and vascular associated smooth muscle contraction. Located in cytoplasm and extracellular space. Implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); glaucoma (multiple); lung disease (multiple); and retinal disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ARCND3; endothelin-1; ET1; HDLCQ7; PPET1; preproendothelin-1; QME
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38612,256,484 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36Build 36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBICelera
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
T2T-CHM13v2.0612,158,745 - 12,165,580 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Acute Lung Injury  (EXP)
adult respiratory distress syndrome  (EXP,IEP,ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (IEP)
anterolateral myocardial infarction  (IEP)
aspiration pneumonia  (ISO)
asthma  (EXP,IAGP,IEP)
atherosclerosis  (ISO)
atrial fibrillation  (EXP,IEP)
Auriculocondylar Syndrome  (EXP)
Auriculocondylar Syndrome 3  (IAGP)
autosomal dominant polycystic kidney disease  (IEP)
Behcet's disease  (IEP)
Bradycardia  (EXP)
brain ischemia  (ISO)
bronchiolitis obliterans  (IMP)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Arrhythmias  (EXP)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (EXP)
Cardiovascular Abnormalities  (EXP)
cardiovascular system disease  (EXP)
cartilage disease  (EXP)
cerebrovascular disease  (EXP)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (IAGP,IEP)
chronic rhinitis  (IEP)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (EXP)
congestive heart failure  (EXP,IDA,IEP,ISO)
coronary artery disease  (IAGP,IEP,ISO)
coronary stenosis  (IDA)
Craniofacial Abnormalities  (EXP,ISO)
cystic fibrosis  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IAGP,IEP,ISO)
Diaphragmatic Hernia  (EXP)
dilated cardiomyopathy  (IEP)
Dyspnea  (IEP)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (IEP)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP)
focal segmental glomerulosclerosis  (EXP)
gastrointestinal system disease  (EXP)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (EXP)
Hyperalgesia  (EXP,ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (EXP)
Hyperoxia  (ISO)
hypertension  (EXP,IAGP,IEP,IMP,ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (EXP)
hypogonadism  (ISO)
Hypotension  (EXP,ISO)
impotence  (EXP,ISO)
Inflammation  (EXP)
intermediate coronary syndrome  (IEP)
kidney disease  (EXP)
kidney failure  (EXP,ISO)
Left Ventricular Hypertrophy  (EXP,ISO)
Lewy body dementia  (EXP)
liver cirrhosis  (ISO)
low tension glaucoma  (IEP)
major depressive disorder  (EXP)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (EXP)
multiple sclerosis  (IEP)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (EXP)
neovascular glaucoma  (IEP)
neovascular inflammatory vitreoretinopathy  (IEP)
nephritis  (ISO)
nephrosis  (EXP,ISO)
nephrotic syndrome  (EXP)
obesity  (IAGP)
obstructive sleep apnea  (IAGP,IEP,ISO)
optic nerve disease  (IDA)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (EXP)
ovarian carcinoma  (IEP)
Overactive Urinary Bladder  (EXP)
Pain  (EXP)
Parkinson's disease  (EXP)
peptic ulcer disease  (EXP)
pneumonia  (IEP)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (EXP)
Pregnancy-Induced Hypertension  (IAGP)
Premature Birth  (EXP)
Presbycusis  (IAGP)
primary open angle glaucoma  (IEP)
pulmonary embolism  (ISO)
pulmonary fibrosis  (EXP,IEP,ISO)
pulmonary hypertension  (EXP,IEP,ISO)
Question Mark Ears, Isolated  (IAGP)
renal artery disease  (ISO)
Reperfusion Injury  (EXP,ISO)
retinal degeneration  (ISO)
retinal detachment  (IEP)
retinitis pigmentosa  (IEP)
rheumatoid arthritis  (IDA)
Sepsis  (ISO)
Slow Coronary Flow  (IEP)
Stroke  (EXP)
Subarachnoid Hemorrhage  (EXP)
systemic scleroderma  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (EXP,IEP,ISO)
uremia  (ISO)
ureteral obstruction  (EXP,ISO)
Urinary Retention  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-NITROINDAZOLE  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrolein  (EXP)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
agmatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
aminoguanidine  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
ampicillin  (EXP)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (EXP)
atenolol  (EXP)
atorvastatin calcium  (EXP)
atrasentan  (ISO)
atropine  (EXP)
belinostat  (EXP)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-carotene  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
caesium chloride  (EXP)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (ISO)
capsaicin  (EXP)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carvedilol  (EXP,ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
chetomin  (EXP)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
cicaprost  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cytarabine  (EXP,ISO)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
dapsone  (ISO)
daunorubicin  (ISO)
Deoxycorticosterone acetate  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dydrogesterone  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
elemental carbon  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
furan  (ISO)
geldanamycin  (EXP)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glycidol  (ISO)
glycoursodeoxycholic acid  (EXP)
GW 4064  (ISO)
heparin  (EXP,ISO)
hexadecanoic acid  (EXP)
histamine  (EXP)
homocysteine  (EXP)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
ICI 118551  (EXP)
indometacin  (EXP,ISO)
iodixanol  (ISO)
iopromide  (ISO)
irbesartan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (EXP)
isoprenaline  (ISO)
isoquinoline-1,5-diol  (ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (EXP)
ivermectin  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-mimosine  (EXP,ISO)
lamivudine  (EXP)
leflunomide  (ISO)
leukotriene C4  (EXP)
levamisole  (EXP)
linalool  (EXP)
linoleic acid  (EXP)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP)
losartan  (EXP,ISO)
LY294002  (ISO)
Magnolol  (ISO)
manganese(II) chloride  (ISO)
Meglumine sodium amidotrizoate  (ISO)
melphalan  (EXP)
menadione  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (EXP)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
metoprolol  (ISO)
Mibefradil  (ISO)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
montelukast  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nebivolol  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nisoldipine  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (ISO)
Nutlin-3  (EXP)
ochratoxin A  (EXP)
octadecanoic acid  (EXP)
oleic acid  (EXP)
Olmesartan medoxomil  (ISO)
olodaterol  (EXP)
orotic acid  (ISO)
oroxylin A  (ISO)
ouabain  (EXP,ISO)
Oxotremorine  (EXP)
ozone  (EXP,ISO)
panobinostat  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
paricalcitol  (ISO)
PD123319  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (EXP)
PhIP  (ISO)
phosgene  (ISO)
phosphoramide mustard  (ISO)
phosphoramidon  (ISO)
picrotoxin  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium chromate  (EXP)
pravastatin  (EXP,ISO)
prazosin  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP,ISO)
prostaglandin E2  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
Ro 31-8220  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
S-methyl-L-thiocitrulline  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (EXP)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
steviol  (EXP)
stevioside  (EXP)
stilbene-4,4'-diol  (EXP)
streptozocin  (EXP,ISO)
Sucralfate  (ISO)
sulfur dioxide  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
telmisartan  (ISO)
temozolomide  (EXP)
tenofovir disoproxil fumarate  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracosanoic acid  (EXP)
tetraphene  (ISO)
theophylline  (EXP)
thioacetamide  (ISO)
thymidine  (EXP)
tiotropium bromide  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trans-caffeic acid  (ISO)
trans-stilbene-4,4'-diol  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (EXP)
verapamil  (EXP)
vinclozolin  (ISO)
water  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (EXP)
zidovudine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
artery smooth muscle contraction  (IDA,IEA,ISO,TAS)
axon extension  (IEA)
axonogenesis involved in innervation  (IEA)
blood vessel diameter maintenance  (IEA)
blood vessel morphogenesis  (IEA,ISO)
body fluid secretion  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
calcium-mediated signaling  (IDA)
canonical Wnt signaling pathway  (IEA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
cartilage development  (IEA,ISO)
cell surface receptor signaling pathway  (IDA)
cell-cell signaling  (IDA)
cellular calcium ion homeostasis  (IBA,IDA,IEA)
cellular response to calcium ion  (IEA,ISO)
cellular response to fatty acid  (IEA,ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to human chorionic gonadotropin stimulus  (IEA)
cellular response to hydrogen peroxide  (IDA)
cellular response to hypoxia  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to luteinizing hormone stimulus  (IEA)
cellular response to mineralocorticoid stimulus  (IEA,ISO)
cellular response to organic substance  (IDA,IEA)
cellular response to peptide hormone stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to type II interferon  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
dorsal/ventral pattern formation  (IEA,ISO)
embryonic heart tube development  (IEA)
endothelin receptor signaling pathway  (IMP)
endothelin receptor signaling pathway involved in heart process  (IEA)
epithelial fluid transport  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA)
G protein-coupled receptor signaling pathway  (IDA)
gene expression  (IEA)
heart development  (IEA,ISO)
histamine secretion  (IEA,ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA)
in utero embryonic development  (IEA,ISO)
inositol phosphate-mediated signaling  (IDA)
intracellular signal transduction  (IEA,ISO)
leukocyte activation  (TAS)
MAPK cascade  (IEA)
maternal process involved in parturition  (IEA,ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA)
membrane depolarization  (IEA,ISO)
middle ear morphogenesis  (IEA,ISO)
mitochondrion organization  (IEA)
multicellular organism aging  (IEA,ISO)
negative regulation of blood coagulation  (TAS)
negative regulation of gene expression  (IEA)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (IDA)
negative regulation of protein metabolic process  (IDA)
negative regulation of smooth muscle cell apoptotic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neural crest cell development  (IEA,ISO)
neural crest cell differentiation  (IEA)
neural crest cell fate commitment  (IEA)
neuron projection development  (IEA)
neutrophil chemotaxis  (IDA)
nitric oxide transport  (IDA)
noradrenergic neuron differentiation  (IEA)
peptide hormone secretion  (IDA)
pharyngeal arch artery morphogenesis  (IEA)
phosphatidylinositol 3-kinase signaling  (IDA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of cation channel activity  (IDA)
positive regulation of cell growth involved in cardiac muscle cell development  (IDA,IGI)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA,IEA,ISO)
positive regulation of cell size  (IDA)
positive regulation of chemokine-mediated signaling pathway  (IDA)
positive regulation of cytosolic calcium ion concentration  (IDA,IEA,ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of endothelial cell migration  (TAS)
positive regulation of heart rate  (IDA)
positive regulation of hormone secretion  (IDA)
positive regulation of JUN kinase activity  (IDA)
positive regulation of MAP kinase activity  (IDA)
positive regulation of mitotic nuclear division  (IDA)
positive regulation of neutrophil chemotaxis  (IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of nitric oxide biosynthetic process  (TAS)
positive regulation of odontogenesis  (IEA,ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
positive regulation of prostaglandin-endoperoxide synthase activity  (IBA,IMP)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of sarcomere organization  (IMP)
positive regulation of signaling receptor activity  (IDA)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of urine volume  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
prostaglandin biosynthetic process  (IDA)
protein kinase A signaling  (IDA)
protein kinase C deactivation  (IDA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
protein phosphorylation  (IEA)
regulation of biological quality  (IEA)
regulation of blood pressure  (IEA,ISO)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of pH  (IEA,ISO)
regulation of sensory perception of pain  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA,IDA)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (IEA)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to activity  (IEA,ISO)
response to amino acid  (IEA,ISO)
response to amphetamine  (IEA)
response to dexamethasone  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to leptin  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
response to nicotine  (IEA,ISO)
response to ozone  (IEA,ISO)
response to prostaglandin F  (IEA,ISO)
response to salt  (IEA,ISO)
response to testosterone  (IEA,ISO)
response to transforming growth factor beta  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic excitation  (IEA,ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA)
sensory perception of pain  (IEA,ISO)
skeletal system development  (IEA,ISO)
smooth muscle contraction  (IEA,ISO)
superoxide anion generation  (IEA,ISO)
sympathetic neuron axon guidance  (IEA)
thyroid gland development  (IEA)
transcription by RNA polymerase II  (IEA)
vasoconstriction  (IDA,IEA,ISO)
vein smooth muscle contraction  (IBA,IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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85. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
86. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
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111. Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
112. Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats. Wu Y, etal., Can J Physiol Pharmacol. 2010 Jun;88(6):607-15. doi: 10.1139/Y10-033.
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