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Gene: EDN1 (endothelin 1) Homo sapiens
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Symbol: EDN1
Name: endothelin 1
Description: Exhibits signaling receptor binding activity. Involved in several processes, including intracellular signal transduction; regulation of macromolecule biosynthetic process; and vascular smooth muscle contraction. Localizes to the cytoplasm and extracellular space. Implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARCND3; endothelin-1; ET1; HDLCQ7; PPET1; preproendothelin-1; QME
Orthologs:
Mus musculus (house mouse) : Edn1 (endothelin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Edn1 (endothelin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn1 (endothelin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN1 (endothelin 1)
Canis lupus familiaris (dog) : EDN1 (endothelin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn1 (endothelin 1)
Sus scrofa (pig) : EDN1 (endothelin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,529 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EDN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730848
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.