GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Edn1 | decreases activity | EXP | | 6480464 | CTD | bosentan results in decreased activity of EDN1 protein | PMID:10961375 | Edn1 | decreases expression | EXP | | 6480464 | CTD | bosentan results in decreased expression of EDN1 protein | PMID:16431896 | Edn1 | multiple interactions | EXP | | 6480464 | CTD | 3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDN1 protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]; bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA] | PMID:10474778 PMID:11093786 PMID:20967148 | Edn1 | decreases activity | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | bosentan results in decreased activity of EDN1 protein | PMID:22796455 | Edn1 | multiple interactions | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]; bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]; EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA] | PMID:20392896 PMID:22483689 PMID:22796455 | | ||||||||||||||||||||||
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