EDN1 (endothelin 1) - Rat Genome Database

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Gene: EDN1 (endothelin 1) Canis lupus familiaris
Analyze
Symbol: EDN1
Name: endothelin 1
RGD ID: 12377803
Description: ENCODES a protein that exhibits endothelin A receptor binding (ortholog); endothelin B receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); artery smooth muscle contraction (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; inflammatory response pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN basal part of cell (ortholog); extracellular space (ortholog); rough endoplasmic reticulum lumen (ortholog); INTERACTS WITH fenfluramine; lead(II) chloride; serotonin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelin-1; ET-1; gene for endothelin; PPET1; preproendothelin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBI
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBI
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBI
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBI
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Diseases  (ISO)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
Hyperalgesia  (ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypogonadism  (ISO)
Hypotension  (ISO)
impotence  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
Overactive Urinary Bladder  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
artery smooth muscle contraction  (IEA,ISO)
axon extension  (IEA)
axonogenesis involved in innervation  (IEA)
blood vessel morphogenesis  (ISO)
body fluid secretion  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
calcium-mediated signaling  (IEA)
canonical Wnt signaling pathway  (IEA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
cartilage development  (IEA,ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell signaling  (ISO)
cellular calcium ion homeostasis  (IBA)
cellular response to calcium ion  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to human chorionic gonadotropin stimulus  (IEA)
cellular response to hydrogen peroxide  (IEA)
cellular response to hypoxia  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to luteinizing hormone stimulus  (IEA)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to organic substance  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
dorsal/ventral pattern formation  (IEA,ISO)
embryonic heart tube development  (IEA)
endothelin receptor signaling pathway  (ISS)
endothelin receptor signaling pathway involved in heart process  (IEA)
epithelial fluid transport  (ISO)
ERK1 and ERK2 cascade  (IEA)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (ISO)
heart development  (ISO)
histamine secretion  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA)
in utero embryonic development  (IEA,ISO)
inositol phosphate-mediated signaling  (IEA)
intracellular signal transduction  (ISO)
MAPK cascade  (ISO)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA)
membrane depolarization  (ISO)
middle ear morphogenesis  (IEA,ISO)
mitochondrion organization  (IEA)
multicellular organism aging  (IEA,ISO)
negative regulation of cellular protein metabolic process  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neural crest cell development  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (IEA)
neuron projection development  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (IEA)
noradrenergic neuron differentiation  (IEA)
peptide hormone secretion  (IEA)
pharyngeal arch artery morphogenesis  (IEA)
phosphatidylinositol 3-kinase signaling  (IEA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cation channel activity  (IEA)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell size  (IEA)
positive regulation of chemokine-mediated signaling pathway  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of heart rate  (IEA)
positive regulation of hormone secretion  (IEA)
positive regulation of JUN kinase activity  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of prostaglandin-endoperoxide synthase activity  (IBA)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of sarcomere organization  (IEA)
positive regulation of signaling receptor activity  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of urine volume  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostaglandin biosynthetic process  (IEA)
protein kinase A signaling  (IEA)
protein kinase C deactivation  (IEA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
protein phosphorylation  (IEA)
regulation of blood pressure  (ISO)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of pH  (IEA,ISO)
regulation of sensory perception of pain  (ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (IEA)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (IEA)
response to dexamethasone  (ISO)
response to hypoxia  (IEA,ISO)
response to leptin  (ISO)
response to lipopolysaccharide  (ISO)
response to muscle stretch  (ISO)
response to nicotine  (ISO)
response to ozone  (ISO)
response to prostaglandin F  (ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic excitation  (IEA,ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA)
sensory perception of pain  (ISO)
skeletal system development  (ISO)
superoxide anion generation  (ISO)
sympathetic neuron axon guidance  (IEA)
thyroid gland development  (IEA)
transcription by RNA polymerase II  (IEA)
vasoconstriction  (ISO)
vein smooth muscle contraction  (IBA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2657658   PMID:15838277   PMID:15838278   PMID:15838286   PMID:15838288   PMID:15838324   PMID:16327228   PMID:16627363   PMID:16951040   PMID:17338155   PMID:17993509   PMID:18788466  
PMID:19585255   PMID:20207425   PMID:20210880   PMID:20497708   PMID:24447631   PMID:24496516   PMID:25816929   PMID:25920760   PMID:26426813  


Genomics

Comparative Map Data
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBI
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBI
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBI
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBI
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBI
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)Ensembl
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0panPan3
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBI
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604412,341,006 - 12,348,096 (+)NCBIVero_WHO_p1.0
Edn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 3
Low 5 3 12 4 5 4 3 4 7 5 3
Below cutoff 2 10 2 1 2 2 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015551   ⟹   ENSCAFP00000014389
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)Ensembl
RefSeq Acc Id: NM_001002956   ⟹   NP_001002956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13511,808,892 - 11,815,383 (+)NCBI
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBI
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBI
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBI
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBI
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002956 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK01932 (Get FASTA)   NCBI Sequence Viewer  
  BAD02920 (Get FASTA)   NCBI Sequence Viewer  
  P13206 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002956   ⟸   NM_001002956
- Peptide Label: precursor
- UniProtKB: P13206 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014389   ⟸   ENSCAFT00000015551

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
35 11812260 11812261 T C snv Wolf (WO001_895), Saluki (SL006)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009794 Ensembl
NCBI Gene EDN1 ENTREZGENE
UniProt P13206 ENTREZGENE
VGNC ID VGNC:40199 ENTREZGENE