Edn1 (endothelin 1) - Rat Genome Database

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Pathways
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Gene: Edn1 (endothelin 1) Ictidomys tridecemlineatus
Analyze
Symbol: Edn1
Name: endothelin 1
RGD ID: 12718861
Description: ENCODES a protein that exhibits endothelin A receptor binding (ortholog); endothelin B receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); artery smooth muscle contraction (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; inflammatory response pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN basal part of cell (ortholog); extracellular space (ortholog); rough endoplasmic reticulum lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endothelin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936534885,287 - 891,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aortic atherosclerosis  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
Hyperalgesia  (ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypogonadism  (ISO)
Hypotension  (ISO)
impotence  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
overactive bladder syndrome  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
Urinary Retention  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
artery smooth muscle contraction  (IEA,ISO)
axon extension  (IEA)
axon guidance  (IEA)
axonogenesis involved in innervation  (IEA)
blood vessel morphogenesis  (IEA,ISO)
body fluid secretion  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
calcium-mediated signaling  (IEA)
canonical Wnt signaling pathway  (IEA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
cartilage development  (IEA,ISO)
cell surface receptor signaling pathway  (IEA)
cell-cell signaling  (IEA)
cellular response to calcium ion  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to human chorionic gonadotropin stimulus  (IEA)
cellular response to hydrogen peroxide  (IEA)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to luteinizing hormone stimulus  (IEA)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to organic substance  (IEA)
cellular response to peptide hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cellular response to xenobiotic stimulus  (ISO)
dorsal/ventral pattern formation  (IEA,ISO)
embryonic heart tube development  (IEA)
endothelin receptor signaling pathway  (IEA)
endothelin receptor signaling pathway involved in heart process  (IEA)
epithelial fluid transport  (ISO)
ERK1 and ERK2 cascade  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
gene expression  (IEA)
glomerular endothelium development  (IEA)
glomerular filtration  (IEA)
heart development  (IEA,ISO)
heart process  (IEA)
histamine secretion  (ISO)
in utero embryonic development  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA)
intracellular signal transduction  (ISO)
MAPK cascade  (IEA)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA)
membrane depolarization  (ISO)
middle ear morphogenesis  (IEA,ISO)
mitochondrion organization  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (IEA)
negative regulation of protein metabolic process  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neural crest cell development  (IEA,ISO)
neural crest cell differentiation  (IEA)
neural crest cell fate commitment  (IEA)
neuron projection development  (IEA)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (IEA)
noradrenergic neuron differentiation  (IEA)
peptide hormone secretion  (IEA)
pharyngeal arch artery morphogenesis  (IEA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
podocyte differentiation  (IEA)
positive regulation of artery morphogenesis  (IEA)
positive regulation of calcium-mediated signaling  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell size  (IEA)
positive regulation of chemokine-mediated signaling pathway  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of heart rate  (IEA)
positive regulation of hormone secretion  (IEA)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein localization to nucleus  (IEA)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of sarcomere organization  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of urine volume  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostaglandin biosynthetic process  (IEA)
protein kinase A signaling  (IEA)
protein kinase C deactivation  (IEA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of pH  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IEA)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (IEA)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (IEA)
response to dexamethasone  (ISO)
response to hypoxia  (IEA,ISO)
response to leptin  (ISO)
response to lipopolysaccharide  (ISO)
response to muscle stretch  (ISO)
response to nicotine  (ISO)
response to ozone  (ISO)
response to prostaglandin F  (ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic excitation  (IEA,ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA)
skeletal system development  (IEA,ISO)
smooth muscle contraction  (IEA,ISO)
superoxide anion generation  (ISO)
sympathetic neuron axon guidance  (IEA)
thyroid gland development  (IEA)
transcription by RNA polymerase II  (IEA)
vasoconstriction  (IEA,ISO)
vein smooth muscle contraction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936534885,287 - 891,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38612,230,516 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36Build 36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBICelera
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
T2T-CHM13v2.0612,098,871 - 12,165,580 (+)NCBIT2T-CHM13v2.0
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)EnsemblGRCm39 Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBIMGSCv36mm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81722,660,799 - 22,666,687 (-)NCBIGRCr8
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1722,330,779 - 22,336,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,934,458 - 23,940,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01722,266,095 - 22,271,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p12NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2526,853,626 - 26,951,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1622,843,513 - 22,941,706 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3511,907,494 - 11,914,179 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBIUU_Cfam_GSD_1.0
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604412,341,006 - 12,348,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475613,842,164 - 13,849,029 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005327471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000000549   ⟹   ENSSTOP00000000496
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936534885,287 - 891,772 (-)Ensembl
RefSeq Acc Id: XM_005327471   ⟹   XP_005327528
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBI
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005327528 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000496.2
GenBank Protein KAG3288678 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005327528   ⟸   XM_005327471
- UniProtKB: I3LWV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000000496   ⟸   ENSSTOT00000000549
Protein Domains
Endothelin-like toxin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000551 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000549.3 UniProtKB/TrEMBL
InterPro Endothelin UniProtKB/TrEMBL
  Endothelin_toxin_CS UniProtKB/TrEMBL
  Endothln-like_toxin UniProtKB/TrEMBL
NCBI Gene Edn1 ENTREZGENE
PANTHER ENDOTHELIN-1 UniProtKB/TrEMBL
  PTHR13874 UniProtKB/TrEMBL
Pfam Endothelin UniProtKB/TrEMBL
PRINTS ENDOTHELIN UniProtKB/TrEMBL
PROSITE ENDOTHELIN UniProtKB/TrEMBL
SMART END UniProtKB/TrEMBL
UniProt I3LWV9 ENTREZGENE, UniProtKB/TrEMBL