RGD Reference Report - Plasma endothelin-1 levels in Behcet's disease. - Rat Genome Database

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Plasma endothelin-1 levels in Behcet's disease.

Authors: Uslu, T  Erem, C  Tosun, M  Deger, O 
Citation: Uslu T, etal., Clin Rheumatol. 1997 Jan;16(1):59-61.
RGD ID: 8661801
Pubmed: PMID:9132327   (View Abstract at PubMed)

Plasma concentrations of endothelin-1 (ET-1), a vasoconstrictor peptide released from vascular endothelial and synovial cells, were measured by radioimmunoassay in 27 patients with Behcet's disease (BD) and 18 healthy controls. The plasma ET-1 concentrations were found to be significantly increased in patients with BD (121.15 +/- 11.6 fmol/dl) compared with the healthy subjects (89.37 +/- 8.03 fmol/dl p < 0.05). The elevation of ET-1 did not correlate with the disease duration, gender, ocular or articular involvement. Whether the elevated ET-1 level is a direct result of its increased synthesis from injured vascular endothelial cells or whether its presence in high concentrations may be responsible, together with other factors for both vascular and articular complications in patients with BD is uncertain.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
EDN1HumanBehcet's disease  IEP protein:increased expression:plasma (human)RGD 
Edn1RatBehcet's disease  ISORGD:730848protein:increased expression:plasma (human)RGD 
Edn1MouseBehcet's disease  ISORGD:730848protein:increased expression:plasma (human)RGD 


Genes (Rattus norvegicus)
Edn1  (endothelin 1)

Genes (Mus musculus)
Edn1  (endothelin 1)

Genes (Homo sapiens)
EDN1  (endothelin 1)