Edn1 (endothelin 1) - Rat Genome Database

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Gene: Edn1 (endothelin 1) Mus musculus
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Symbol: Edn1
Name: endothelin 1
RGD ID: 10499
MGI Page MGI
Description: Enables endothelin A receptor binding activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; animal organ development; and branching involved in blood vessel morphogenesis. Located in extracellular space. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; gut; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endothelin-1; ET-1; PPET1; preproendothelin; preproendothelin-1; preproET
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (IDA)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (IEP)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (IMP,ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Diseases  (ISO)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
Hypercapnia  (IMP,ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypogonadism  (ISO)
Hypotension  (IMP,ISO)
impotence  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (IDA)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
Overactive Urinary Bladder  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (IEP,IMP)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-Hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-NITROINDAZOLE  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (ISO)
atropine  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (EXP)
bezafibrate  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bosentan  (ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caesium chloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (ISO)
capsaicin  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carvedilol  (ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
chetomin  (ISO)
chlordecone  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
chrysin  (ISO)
cicaprost  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (EXP,ISO)
D-glucose  (ISO)
dantrolene  (ISO)
dapsone  (EXP)
daunorubicin  (ISO)
Deoxycorticosterone acetate  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental carbon  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glyburide  (ISO)
glycidol  (ISO)
glycoursodeoxycholic acid  (ISO)
GW 4064  (ISO)
heparin  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
ICI 118551  (ISO)
indometacin  (ISO)
iodixanol  (ISO)
iopromide  (ISO)
irbesartan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoprenaline  (ISO)
isoquinoline-1,5-diol  (ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (ISO)
ivermectin  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-mimosine  (ISO)
lamivudine  (ISO)
leflunomide  (EXP)
leukotriene C4  (ISO)
levamisole  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
losartan  (ISO)
LY294002  (ISO)
Magnolol  (ISO)
manganese(II) chloride  (ISO)
Meglumine sodium amidotrizoate  (ISO)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methyl beta-cyclodextrin  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
Mibefradil  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
montelukast  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid-adenine dinucleotide phosphate  (EXP)
nifedipine  (ISO)
nimesulide  (ISO)
nisoldipine  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (EXP)
nitroglycerin  (ISO)
nitroprusside  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (ISO)
olodaterol  (ISO)
orotic acid  (ISO)
oroxylin A  (ISO)
ouabain  (ISO)
Oxotremorine  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
PD123319  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phosgene  (ISO)
phosphoramide mustard  (ISO)
phosphoramidon  (ISO)
picrotoxin  (ISO)
potassium atom  (EXP)
potassium chloride  (ISO)
potassium chromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
prostaglandin E2  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Ro 31-8220  (ISO)
rolipram  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-methyl-L-thiocitrulline  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (ISO)
Sucralfate  (ISO)
sulfur dioxide  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracosanoic acid  (ISO)
tetraphene  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
thymidine  (ISO)
tiotropium bromide  (ISO)
Tiron  (EXP)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trans-caffeic acid  (EXP)
trans-stilbene-4,4'-diol  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
water  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IDA,IGI)
artery smooth muscle contraction  (ISO)
axon extension  (IDA)
axonogenesis involved in innervation  (IMP)
blood vessel morphogenesis  (IMP)
body fluid secretion  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
calcium ion transmembrane transport  (IDA)
calcium-mediated signaling  (ISO)
canonical Wnt signaling pathway  (IDA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IDA)
cartilage development  (IMP)
cell surface receptor signaling pathway  (ISO)
cell-cell signaling  (ISO)
cellular calcium ion homeostasis  (IBA,IDA,ISO)
cellular response to calcium ion  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to human chorionic gonadotropin stimulus  (IDA)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to luteinizing hormone stimulus  (IDA)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to organic substance  (IDA,IMP,ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
dorsal/ventral pattern formation  (IMP)
embryonic heart tube development  (IMP)
endothelin receptor signaling pathway  (ISO)
endothelin receptor signaling pathway involved in heart process  (IDA)
epithelial fluid transport  (ISO)
ERK1 and ERK2 cascade  (IDA)
G protein-coupled receptor signaling pathway  (ISO,TAS)
gene expression  (IDA,IMP)
heart development  (IMP)
histamine secretion  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IDA)
in utero embryonic development  (IMP)
inositol phosphate-mediated signaling  (ISO)
intracellular signal transduction  (ISO)
MAPK cascade  (IDA,IMP)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (IDA)
membrane depolarization  (ISO)
middle ear morphogenesis  (IMP)
mitochondrion organization  (IDA)
multicellular organism aging  (IDA,ISO)
negative regulation of cellular protein metabolic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell development  (IMP)
neural crest cell differentiation  (IMP)
neural crest cell fate commitment  (IMP)
neuron projection development  (IDA)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (ISO)
noradrenergic neuron differentiation  (IMP)
peptide hormone secretion  (ISO)
pharyngeal arch artery morphogenesis  (IMP)
phosphatidylinositol 3-kinase signaling  (ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine-mediated signaling pathway  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IDA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of hormone secretion  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of prostaglandin-endoperoxide synthase activity  (IBA,ISO)
positive regulation of renal sodium excretion  (IMP)
positive regulation of sarcomere organization  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urine volume  (IGI,IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostaglandin biosynthetic process  (ISO)
protein kinase A signaling  (ISO)
protein kinase C deactivation  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IDA)
protein phosphorylation  (IDA)
regulation of blood pressure  (IMP,ISO)
regulation of glucose transmembrane transport  (IDA)
regulation of pH  (IDA)
regulation of sensory perception of pain  (ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA,ISO)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (IDA)
respiratory gaseous exchange by respiratory system  (IMP)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (IMP)
response to dexamethasone  (ISO)
response to hypoxia  (IMP,ISO)
response to leptin  (ISO)
response to lipopolysaccharide  (ISO)
response to muscle stretch  (ISO)
response to nicotine  (ISO)
response to ozone  (ISO)
response to prostaglandin F  (ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic excitation  (IMP)
semaphorin-plexin signaling pathway involved in axon guidance  (IMP)
sensory perception of pain  (ISO)
signal transduction  (IBA)
skeletal system development  (IMP)
superoxide anion generation  (ISO)
sympathetic neuron axon guidance  (IMP)
thyroid gland development  (IMP)
transcription by RNA polymerase II  (IDA)
vasoconstriction  (ISO)
vein smooth muscle contraction  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta morphology  (IAGP)
abnormal blood gas level  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal carotid artery morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal sympathetic nervous system physiology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
absent hyoid bone  (IAGP)
absent outer ear  (IAGP)
absent right subclavian artery  (IAGP)
absent submandibular gland  (IAGP)
aorta tubular hypoplasia  (IAGP)
cleft chin  (IAGP)
cleft palate  (IAGP)
decreased circulating antidiuretic hormone level  (IAGP)
decreased circulating sodium level  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine sodium level  (IAGP)
dilated heart right ventricle  (IAGP)
double outlet right ventricle  (IAGP)
hypercapnia  (IAGP)
hypertension  (IAGP)
hypoxia  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased urine osmolality  (IAGP)
interrupted aorta  (IAGP)
mandible hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oliguria  (IAGP)
overriding aortic valve  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
salt-sensitive hypertension  (IAGP)
small second pharyngeal arch  (IAGP)
ventricular septal defect  (IAGP)
References

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Additional References at PubMed
PMID:2542249   PMID:2768235   PMID:7615798   PMID:7883980   PMID:7904485   PMID:8002984   PMID:8010105   PMID:8238383   PMID:8563573   PMID:8575440   PMID:8587354   PMID:8680799  
PMID:8688455   PMID:8824799   PMID:8978712   PMID:9012511   PMID:9153073   PMID:9405477   PMID:9449664   PMID:9476873   PMID:9495516   PMID:9649553   PMID:9671575   PMID:9767170  
PMID:9826706   PMID:9834185   PMID:10194519   PMID:10221345   PMID:10349636   PMID:10354604   PMID:10405217   PMID:10479458   PMID:10512195   PMID:10570734   PMID:10597135   PMID:10601039  
PMID:10601144   PMID:10626068   PMID:10708518   PMID:10938240   PMID:10976045   PMID:11042159   PMID:11076861   PMID:11180952   PMID:11217851   PMID:11259380   PMID:11409899   PMID:11413164  
PMID:11546805   PMID:12193061   PMID:12193078   PMID:12193100   PMID:12372435   PMID:12397601   PMID:12413905   PMID:12441350   PMID:12466851   PMID:12477932   PMID:12648486   PMID:12773307  
PMID:12907686   PMID:12943527   PMID:12950721   PMID:14623826   PMID:14651962   PMID:14764893   PMID:14966371   PMID:14969349   PMID:14976138   PMID:15067320   PMID:15110048   PMID:15115660  
PMID:15126361   PMID:15239958   PMID:15314687   PMID:15327783   PMID:15489334   PMID:15543132   PMID:15567344   PMID:15610731   PMID:15632412   PMID:15645445   PMID:15784596   PMID:15838304  
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PMID:18310504   PMID:18391099   PMID:18391571   PMID:18401410   PMID:18475147   PMID:18515326   PMID:18516095   PMID:18516098   PMID:18524861   PMID:18621079   PMID:18635823   PMID:18756537  
PMID:18772340   PMID:19017795   PMID:19033447   PMID:19049669   PMID:19074677   PMID:19106220   PMID:19111534   PMID:19111553   PMID:19150882   PMID:19162127   PMID:19164391   PMID:19179430  
PMID:19193724   PMID:19202458   PMID:19230825   PMID:19370413   PMID:19520754   PMID:19707218   PMID:19969036   PMID:20042899   PMID:20195637   PMID:20234380   PMID:20333701   PMID:20497976  
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PMID:21267068   PMID:21448844   PMID:21482739   PMID:21525433   PMID:21677750   PMID:21705674   PMID:21801589   PMID:21873635   PMID:21918182   PMID:21926268   PMID:22053184   PMID:22209709  
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PMID:22570335   PMID:22689747   PMID:22820168   PMID:22846580   PMID:22902530   PMID:22937132   PMID:23077601   PMID:23078398   PMID:23112163   PMID:23279852   PMID:23293787   PMID:23313614  
PMID:23389444   PMID:23462468   PMID:23596057   PMID:23670300   PMID:23676500   PMID:23698114   PMID:23933587   PMID:24117726   PMID:24129228   PMID:24261709   PMID:24355292   PMID:24371298  
PMID:24412382   PMID:24412386   PMID:24412387   PMID:24424064   PMID:24491691   PMID:24507193   PMID:24523936   PMID:24530289   PMID:24586188   PMID:24632479   PMID:24632840   PMID:24700498  
PMID:24722437   PMID:24853267   PMID:24875861   PMID:24927936   PMID:25010841   PMID:25012164   PMID:25181417   PMID:25190801   PMID:25267836   PMID:25399435   PMID:25572710   PMID:25584774  
PMID:25587122   PMID:25725491   PMID:25753689   PMID:25848038   PMID:25889273   PMID:25899174   PMID:25903653   PMID:26098770   PMID:26104290   PMID:26268928   PMID:26275708   PMID:26342031  
PMID:26378152   PMID:26400543   PMID:26416771   PMID:26417040   PMID:26506449   PMID:26531127   PMID:26546722   PMID:26743624   PMID:26775567   PMID:26883974   PMID:27026367   PMID:27031954  
PMID:27062279   PMID:27102411   PMID:27280426   PMID:27381259   PMID:27465439   PMID:27553900   PMID:27612006   PMID:27694478   PMID:27832660   PMID:27870582   PMID:27899487   PMID:28025386  
PMID:28030574   PMID:28120456   PMID:28164238   PMID:28234994   PMID:28455376   PMID:28515175   PMID:28539637   PMID:28769044   PMID:29031500   PMID:29089036   PMID:29101349   PMID:29251627  
PMID:29438518   PMID:29453306   PMID:29745253   PMID:29870994   PMID:29996135   PMID:30735130   PMID:30737857   PMID:30926169   PMID:30990108   PMID:31025223   PMID:31112136   PMID:31219639  
PMID:31228092   PMID:31272714   PMID:31273050   PMID:31657718   PMID:31733648   PMID:31752395   PMID:31843983   PMID:31923844   PMID:32200679   PMID:32437627   PMID:32572011   PMID:32755450  
PMID:32946788   PMID:33443158  


Genomics

Comparative Map Data
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)Ensembl
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0panPan3
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBI
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBI
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBI
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBI
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBI
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBI
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604412,341,006 - 12,348,096 (+)NCBIVero_WHO_p1.0
Edn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D43775  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,307,177 - 42,307,295UniSTSGRCm38
MGSCv371342,402,546 - 42,402,664UniSTSGRCm37
Celera1343,385,846 - 43,385,964UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
Whitehead/MRC_RH13445.44UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371342,403,080 - 42,403,247UniSTSGRCm37
Celera1343,386,380 - 43,386,547UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
cM Map1326.0UniSTS
cM Map1326.0UniSTS
U35233  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,307,045 - 42,307,205UniSTSGRCm38
MGSCv371342,402,414 - 42,402,574UniSTSGRCm37
Celera1343,385,714 - 43,385,874UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
Whitehead_YAC13 UniSTS
D13Mit138  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,300,805 - 42,300,948UniSTSGRCm38
MGSCv371342,396,174 - 42,396,317UniSTSGRCm37
Celera1343,379,474 - 43,379,617UniSTS
Cytogenetic Map13A4UniSTS
cM Map1324.0UniSTS
Whitehead Genetic1314.2UniSTS
Whitehead_YAC13 UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381342,307,711 - 42,307,878UniSTSGRCm38
MGSCv371342,403,080 - 42,403,247UniSTSGRCm37
Celera1343,386,380 - 43,386,547UniSTS
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS
Edn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS
cM Map1326.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13390000075900000Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13436402652947604Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131699396044765084Mouse
1301880Hypt_mhypertension (mouse)Not determined131797280951972941Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131887692552877067Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131940000053400000Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132029344259673791Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20293442112761890Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132043134255572704Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132043134272237070Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132056296354563080Mouse
1558844Lith15_mlithogenic gene 15 (mouse)Not determined132176326255763430Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2568305359683053Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132776499361765084Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132805696662057068Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132806390362064039Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132806390362064039Mouse
10755517Chol15_mcholesterol 15 (mouse)133081599164815991Mouse
10755533Chol18_mcholesterol 18 (mouse)133081599164815991Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133097563464975634Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133119126065191260Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133476790768768045Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133587692596102654Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133594749469947604Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133594749469947604Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133599078469990868Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133857254572572704Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133948143673481584Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133948143673481584Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133948143673481584Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134044044074440440Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134134122875341344Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:295
Interacting mature miRNAs:342
Transcripts:ENSMUST00000021796
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB081657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY618506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ135809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D70842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU095329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S66650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021796   ⟹   ENSMUSP00000021796
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)Ensembl
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)Ensembl
RefSeq Acc Id: NM_010104   ⟹   NP_034234
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391342,454,952 - 42,461,466 (+)NCBI
GRCm381342,301,476 - 42,307,990 (+)NCBI
MGSCv371342,396,639 - 42,403,358 (+)RGD
Celera1343,379,939 - 43,386,658 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034234   ⟸   NM_010104
- Peptide Label: preproprotein
- UniProtKB: P22387 (UniProtKB/Swiss-Prot),   Q544E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021796   ⟸   ENSMUST00000021796
Protein Domains
END

Promoters
RGD ID:8680186
Promoter ID:EPDNEW_M18124
Type:multiple initiation site
Name:Edn1_1
Description:Mus musculus endothelin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381342,301,619 - 42,301,679EPDNEW
RGD ID:6823832
Promoter ID:MM_KWN:13915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_010104_EDN1,   UC007QFL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361342,395,991 - 42,397,067 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95283 AgrOrtholog
Ensembl Genes ENSMUSG00000021367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000021796 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021796 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothelin_toxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothln-like_toxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13614 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95283 ENTREZGENE
NCBI Gene 13614 ENTREZGENE
PANTHER PTHR13874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Edn1 PhenoGen
PRINTS ENDOTHELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ENDOTHELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART END UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EDN1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544E0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70203 UniProtKB/Swiss-Prot
  P97338 UniProtKB/Swiss-Prot