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Gene: Edn1 (endothelin 1) Mus musculus
Symbol: Edn1
Name: endothelin 1
RGD ID: 10499
Description: Exhibits endothelin A receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; animal organ development; and branching involved in blood vessel morphogenesis. Localizes to extracellular space. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; gut; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endothelin-1; ET-1; PPET1; preproendothelin; preproendothelin-1; preproET
Homo sapiens (human) : EDN1 (endothelin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Edn1 (endothelin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn1 (endothelin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN1 (endothelin 1)
Canis lupus familiaris (dog) : EDN1 (endothelin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn1 (endothelin 1)
Sus scrofa (pig) : EDN1 (endothelin 1)
Chlorocebus sabaeus (African green monkey) : EDN1 (endothelin 1)
Heterocephalus glaber (naked mole-rat) : Edn1 (endothelin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391342,454,952 - 42,461,466 (+)NCBI
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Edn1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10499
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.