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GENE - TERM ANNOTATION REPORT

RGD ID: 12718861
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: DOID:9007102
Term: Myocardial Ischemia
Definition: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Definition Source(s): MESH:D017202
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1 ISOEDN1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:10462014 PMID:11707688 PMID:16306806
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