RGD Reference Report - Tissue-specific modulation of endothelin receptors in a rat model of hypertension. - Rat Genome Database

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Tissue-specific modulation of endothelin receptors in a rat model of hypertension.

Authors: Telemaque-Potts, S  Kuc, RE  Yanagisawa, M  Davenport, AP 
Citation: Telemaque-Potts S, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S122-3.
RGD ID: 8661804
Pubmed: PMID:11078355   (View Abstract at PubMed)

Adenovirus gene transfer of endothelin-1 (ET-1) in rats causes a transient elevation of plasma ET-1 levels, leading to systemic hypertension. Our aim was to evaluate modulation of both ET receptor subtypes in this experimental model. Recombinant adenovirus encoding either the human preproendothelin-1 (Ad.CMV.ET-1) or beta-galactosidase (Ad.CMV.beta-gal) as control was injected systemically into rats. Elevated plasma ET-1 levels and systemic blood pressure were confirmed 96 h after viral administration. Competition binding studies were carried out using tissues from liver, heart, kidney and brain to measure affinities and receptor densities. In the liver, both ET receptor densities were significantly reduced in the Ad.CMV.ET-1 group. In the heart, only the endothelin-A- (ET(A)) receptor density was significantly reduced. In the kidney and brain, the density of the ET receptors did not differ from the control group. In all tissues studied, there was no change in affinities between the two groups. The tissue-specific modulation of ET receptors and the fine regulation of ET(A)-receptors in the heart support the suggested role of the ET system in the development of cardiovascular diseases.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EDN1Humanhypertension  IMP human gene in a rat modelRGD 
Edn1Rathypertension  ISOEDN1 (Homo sapiens)human gene in a rat modelRGD 
Edn1Mousehypertension  ISOEDN1 (Homo sapiens)human gene in a rat modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)

Genes (Mus musculus)
Edn1  (endothelin 1)

Genes (Homo sapiens)
EDN1  (endothelin 1)


Additional Information