RGD Reference Report - Plasma cytokines and portopulmonary hypertension in patients with cirrhosis waiting for orthotopic liver transplantation. - Rat Genome Database

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Plasma cytokines and portopulmonary hypertension in patients with cirrhosis waiting for orthotopic liver transplantation.

Authors: Pellicelli, AM  Barbaro, G  Puoti, C  Guarascio, P  Lusi, EA  Bellis, L  D'Ambrosio, C  Villani, R  Vennarecci, G  Liotta, G  Ettore, G  Andreoli, A 
Citation: Pellicelli AM, etal., Angiology. 2010 Nov;61(8):802-6. Epub 2010 May 24.
RGD ID: 4144882
Pubmed: PMID:20498147   (View Abstract at PubMed)
DOI: DOI:10.1177/0003319710369101   (Journal Full-text)

Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1beta, and TNF-alpha were measured in patients with pulmonary systolic arterial pressure (PAPs) >30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs >30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC and patients with cirrhosis. Endothelin 1 and IL-6 could be implicated in the pathogenesis of PPHTN. On the basis of these results, ET-1 receptor antagonists or anti-IL-6 could have a rationale in the treatment of PPHTN.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary hypertension  IEP 4144882Hypertension more ...RGD 
pulmonary hypertension  ISOEDN1 (Homo sapiens)4144882; 4144882Hypertension more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)

Genes (Mus musculus)
Edn1  (endothelin 1)

Genes (Homo sapiens)
EDN1  (endothelin 1)


Additional Information