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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1multiple interactionsEXP 6480464CTDHeparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]PMID:1443220
Edn1decreases expressionISOEDN1 (Homo sapiens)6480464CTDHeparin results in decreased expression of EDN1 mRNAPMID:7509996 PMID:8408661
Edn1decreases secretionISOEDN1 (Homo sapiens)6480464CTDHeparin results in decreased secretion of EDN1 proteinPMID:7509996 PMID:8408661
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDHeparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]PMID:7509996 PMID:8408661
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