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Gene: Me1 (malic enzyme 1) Rattus norvegicus
Symbol: Me1
Name: malic enzyme 1
Description: Exhibits NADP binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in response to hormone. Localizes to the cytosol and mitochondrion. Orthologous to human ME1 (malic enzyme 1); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytosolic malic enzyme 1; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Malic enzyme 1 soluble; malic enzyme 1, NADP(+)-dependent, cytosolic; Malic enzyme 1, soluble; MOD1; NADP-dependent malic enzyme; NADP-ME
Homo sapiens (human) : ME1 (malic enzyme 1)  HGNC  Alliance
Mus musculus (house mouse) : Me1 (malic enzyme 1, NADP(+)-dependent, cytosolic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Me1 (malic enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ME1 (malic enzyme 1)
Canis lupus familiaris (dog) : ME1 (malic enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Me1 (malic enzyme 1)
Sus scrofa (pig) : ME1 (malic enzyme 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0894,256,830 - 94,368,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl894,256,839 - 94,368,834 (-)Ensembl
Rnor_5.0893,769,078 - 93,863,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4891,839,845 - 91,955,917 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1891,860,614 - 91,975,372 (-)NCBI
Celera887,151,761 - 87,246,579 (-)NCBICelera
Cytogenetic Map8q31NCBI
RH 3.4 Map8999.69RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Me1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3074
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.