Me1 (malic enzyme 1) - Rat Genome Database
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Gene: Me1 (malic enzyme 1) Rattus norvegicus
Analyze
Symbol: Me1
Name: malic enzyme 1
RGD ID: 3074
Description: Exhibits NADP binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in response to hormone. Localizes to cytosol and mitochondrion. Orthologous to human ME1 (malic enzyme 1); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytosolic malic enzyme 1; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Malic enzyme 1 soluble; malic enzyme 1, NADP(+)-dependent, cytosolic; Malic enzyme 1, soluble; MOD1; NADP-dependent malic enzyme; NADP-ME
Orthologs:
Homo sapiens (human) : ME1 (malic enzyme 1)  HGNC  Alliance
Mus musculus (house mouse) : Me1 (malic enzyme 1, NADP(+)-dependent, cytosolic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Me1 (malic enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ME1 (malic enzyme 1)
Canis lupus familiaris (dog) : ME1 (malic enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Me1 (malic enzyme 1)
Sus scrofa (pig) : ME1 (malic enzyme 1)
Chlorocebus sabaeus (African green monkey) : ME1 (malic enzyme 1)
Heterocephalus glaber (naked mole-rat) : Me1 (malic enzyme 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0894,256,830 - 94,368,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl894,256,839 - 94,368,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0893,769,078 - 93,863,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4891,839,845 - 91,955,917 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1891,860,614 - 91,975,372 (-)NCBI
Celera887,151,761 - 87,246,579 (-)NCBICelera
Cytogenetic Map8q31NCBI
RH 3.4 Map8999.69RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-cinnamyl alcohol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
Actein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Bandrowski's base  (ISO)
benazepril  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzoic acid  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
daidzein  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
equol  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
felbamate  (EXP)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
fipronil  (EXP)
fluoranthene  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gedunin  (ISO)
genistein  (ISO)
glafenine  (EXP)
glutathione  (EXP)
hexadecanoic acid  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (EXP)
ifosfamide  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
L-ethionine  (EXP)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nelfinavir  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP,ISO)
omeprazole  (EXP)
oxfendazole  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
propan-2-ol  (ISO)
pyrazinecarboxamide  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
saquinavir  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
stavudine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
trans-isoeugenol  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA)
mitochondrion  (IBA,IDA)

References

Additional References at PubMed
PMID:2699453   PMID:3211151   PMID:4385090   PMID:6838491   PMID:7667285   PMID:18614015   PMID:18755687   PMID:18802677   PMID:19293334   PMID:22871113   PMID:23334421  


Genomics

Comparative Map Data
Me1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0894,256,830 - 94,368,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl894,256,839 - 94,368,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0893,769,078 - 93,863,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4891,839,845 - 91,955,917 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1891,860,614 - 91,975,372 (-)NCBI
Celera887,151,761 - 87,246,579 (-)NCBICelera
Cytogenetic Map8q31NCBI
RH 3.4 Map8999.69RGD
ME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl683,210,402 - 83,431,051 (-)EnsemblGRCh38hg38GRCh38
GRCh38683,210,402 - 83,431,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37683,920,108 - 84,140,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36683,976,827 - 84,197,498 (-)NCBINCBI36hg18NCBI36
Build 34683,977,975 - 84,197,499NCBI
Celera684,353,414 - 84,574,177 (-)NCBI
Cytogenetic Map6q14.2NCBI
HuRef681,148,328 - 81,370,879 (-)NCBIHuRef
CHM1_1684,017,801 - 84,238,482 (-)NCBICHM1_1
Me1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39986,463,416 - 86,577,967 (-)NCBI
GRCm38986,581,363 - 86,695,914 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl986,581,371 - 86,695,953 (-)EnsemblGRCm38mm10GRCm38
MGSCv37986,474,970 - 86,589,947 (-)NCBIGRCm37mm9NCBIm37
MGSCv36987,524,432 - 87,639,643 (-)NCBImm8
MGSCv36986,378,094 - 86,492,941 (-)NCBImm8
Celera983,658,088 - 83,772,920 (-)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map946.58NCBI
Me1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541110,938,944 - 11,065,085 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541110,938,580 - 11,084,171 (-)NCBIChiLan1.0ChiLan1.0
ME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1684,382,732 - 84,595,701 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl684,382,732 - 84,595,701 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0681,107,569 - 81,320,050 (-)NCBIMhudiblu_PPA_v0panPan3
ME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1243,624,945 - 43,828,775 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11243,623,413 - 43,793,590 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Me1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365107,425,983 - 7,571,090 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,794,964 - 82,991,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,799,878 - 82,989,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2193,051,393 - 93,241,425 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p12NCBI
ME1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl137,887,984 - 8,112,533 (-)Ensembl
ChlSab1.1137,889,211 - 8,112,793 (-)NCBI
Me1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479911,166,398 - 11,382,662 (+)NCBI

Position Markers
RH129138  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0894,256,960 - 94,257,148NCBIRnor6.0
Rnor_5.0893,769,199 - 93,769,387UniSTSRnor5.0
RGSC_v3.4891,839,966 - 91,840,154UniSTSRGSC3.4
Celera887,151,882 - 87,152,070UniSTS
Cytogenetic Map8q31UniSTS
AU048158  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0894,347,354 - 94,347,489NCBIRnor6.0
Rnor_5.0893,858,715 - 93,858,850UniSTSRnor5.0
Celera887,241,607 - 87,241,743UniSTS
Cytogenetic Map8q31UniSTS
ME1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0894,322,488 - 94,322,642NCBIRnor6.0
Rnor_5.0893,834,727 - 93,834,881UniSTSRnor5.0
RGSC_v3.4891,905,747 - 91,905,901UniSTSRGSC3.4
Celera887,217,631 - 87,217,785UniSTS
Cytogenetic Map8q31UniSTS
RH130391  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0894,257,888 - 94,258,083NCBIRnor6.0
Rnor_5.0893,770,127 - 93,770,322UniSTSRnor5.0
RGSC_v3.4891,840,894 - 91,841,089UniSTSRGSC3.4
Celera887,152,810 - 87,153,005UniSTS
Cytogenetic Map8q31UniSTS
RH 3.4 Map8998.59UniSTS
RH94870  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0894,258,061 - 94,258,323NCBIRnor6.0
Rnor_5.0893,770,300 - 93,770,562UniSTSRnor5.0
RGSC_v3.4891,841,067 - 91,841,329UniSTSRGSC3.4
Celera887,152,983 - 87,153,245UniSTS
Cytogenetic Map8q31UniSTS
RH 3.4 Map8999.69UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)855659105100659105Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)858230766106394378Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)858425510106526740Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)859234112108068306Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)872849686117849686Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)874917593121080545Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)876103982127182642Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)878805083123805083Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)878805083123805083Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)878805083123805083Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)878805083123805083Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)880697934125697934Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:127
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000013244
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 28 13 7 13 8 11 60 35 40 10 8
Low 10 29 28 12 28 14 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07070970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07070971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07070972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01056045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01056046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01056047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB613492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB810743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO395247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO560778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H34871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013244   ⟹   ENSRNOP00000013244
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl894,256,839 - 94,352,246 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078977   ⟹   ENSRNOP00000071968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl894,258,198 - 94,368,834 (-)Ensembl
RefSeq Acc Id: NM_012600   ⟹   NP_036732
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0894,256,839 - 94,368,834 (-)NCBI
Rnor_5.0893,769,078 - 93,863,611 (-)NCBI
RGSC_v3.4891,839,845 - 91,955,917 (-)RGD
Celera887,151,761 - 87,246,579 (-)RGD
Sequence:
RefSeq Acc Id: XM_008766439   ⟹   XP_008764661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0894,256,830 - 94,368,686 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036732 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764661 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41563 (Get FASTA)   NCBI Sequence Viewer  
  AAA41564 (Get FASTA)   NCBI Sequence Viewer  
  EDL77625 (Get FASTA)   NCBI Sequence Viewer  
  P13697 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036732   ⟸   NM_012600
- Sequence:
RefSeq Acc Id: XP_008764661   ⟸   XM_008766439
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000013244   ⟸   ENSRNOT00000013244
RefSeq Acc Id: ENSRNOP00000071968   ⟸   ENSRNOT00000078977
Protein Domains
malic   Malic_M

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696161
Promoter ID:EPDNEW_R6686
Type:initiation region
Name:Me1_1
Description:malic enzyme 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0894,368,867 - 94,368,927EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 91937838 91937839 T G snv SS/JrHsdMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3074 AgrOrtholog
Ensembl Genes ENSRNOG00000009715 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013244 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071968 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013244 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000078977 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Malic_enzyme_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malic_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malic_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malic_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malic_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24552 ENTREZGENE
Pfam malic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malic_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Me1 PhenoGen
PIRSF PIRSF000106 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MALOXRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MALIC_ENZYMES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART malic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malic_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217846
UniGene Rn.3519 ENTREZGENE
UniProt A0A0G2K1S6_RAT UniProtKB/TrEMBL
  F1LQQ1_RAT UniProtKB/TrEMBL
  MAOX_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Me1  malic enzyme 1  Me1  malic enzyme 1, NADP(+)-dependent, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Me1  malic enzyme 1, NADP(+)-dependent, cytosolic  Me1  malic enzyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Me1  malic enzyme 1    Malic enzyme 1, soluble  Name updated 625702 APPROVED
2002-06-10 Me1  Malic enzyme 1, soluble      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology putative NADP-binding site is similar to the fatty acid synthetase enoyl reductase NADP-binding domain 633307