Adtrp (androgen-dependent TFPI-regulating protein)

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Gene: Adtrp (androgen-dependent TFPI-regulating protein) Rattus norvegicus

Analyze

Symbol:

Adtrp

Name:

androgen-dependent TFPI-regulating protein

RGD ID:

1305679

Description:

Predicted to enable hydrolase activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of secretion by cell; and positive regulation of macromolecule metabolic process. Predicted to be located in caveola and cell surface. Predicted to be active in endomembrane system. Orthologous to human ADTRP (androgen dependent TFPI regulating protein); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Aa2-020; androgen-dependent TPF1-regulating protein; FAHFA hydrolase ADTRP; fatty acid esters of hydroxy fatty acids hydrolase ADTRP; hypothetical protein LOC361228; liver regeneration-related protein LRRG140; LOC361228; RGD1305679; similar to 9530008L14Rik protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADTRP (androgen dependent TFPI regulating protein)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Adtrp (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adtrp (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADTRP (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADTRP (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adtrp (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADTRP (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADTRP (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adtrp (androgen dependent TFPI regulating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AIG1 (androgen induced 1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	ADTRP (androgen dependent TFPI regulating protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adtrp (androgen dependent TFPI regulating protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C37E2.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11601	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG3625	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6149	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YHR140W	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	C37E2.10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	22,930,012 - 22,993,834 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	22,930,740 - 22,993,826 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	22,782,697 - 22,868,861 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	24,386,378 - 24,472,529 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	22,717,160 - 22,803,208 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	22,619,913 - 22,688,296 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	22,619,891 - 22,688,307 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	24,597,532 - 24,662,658 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	28,815,650 - 28,879,571 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	28,818,490 - 28,882,411 (+)	NCBI
Celera	17	22,604,529 - 22,667,496 (+)	NCBI		Celera
Cytogenetic Map	17	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

coronary artery disease (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-nicotine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4,5,3',4',5'-Hexachlorobiphenyl (EXP)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

9-hydroxyoctadecanoic acid (ISO)

acetamide (EXP)

amiodarone (EXP)

atrazine (EXP)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

clofibrate (EXP,ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

endosulfan (EXP)

flutamide (EXP)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

glafenine (EXP)

GW 4064 (ISO)

hydroquinone (ISO)

isotretinoin (ISO)

L-ethionine (EXP)

lead diacetate (ISO)

lipopolysaccharide (ISO)

mercury dichloride (EXP)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

nicotine (ISO)

nitrofen (EXP)

omeprazole (EXP)

p-toluidine (EXP)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP)

propanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium fluoride (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichloroethene (EXP)

troglitazone (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration involved in sprouting angiogenesis (ISO)

cellular response to oxidised low-density lipoprotein particle stimulus (ISO)

cellular response to steroid hormone stimulus (ISO)

long-chain fatty acid catabolic process (ISO)

negative regulation of blood coagulation (ISO)

negative regulation of extracellular matrix constituent secretion (ISO)

negative regulation of leukocyte cell-cell adhesion (ISO)

negative regulation of leukocyte migration (ISO)

negative regulation of lymphocyte migration (ISO)

negative regulation of protein secretion (ISO)

positive regulation of gene expression (ISO)

positive regulation of protein phosphorylation (ISO)

protein kinase B signaling (ISO)

Cellular Component

caveola (ISO)

cell surface (ISO)

endomembrane system (IBA)

membrane (IEA,ISO)

Molecular Function

hydrolase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:21868574	PMID:27018888	PMID:28341552

Genomics

Comparative Map Data

Adtrp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	22,930,012 - 22,993,834 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	22,930,740 - 22,993,826 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	22,782,697 - 22,868,861 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	24,386,378 - 24,472,529 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	22,717,160 - 22,803,208 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	22,619,913 - 22,688,296 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	22,619,891 - 22,688,307 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	24,597,532 - 24,662,658 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	28,815,650 - 28,879,571 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	28,818,490 - 28,882,411 (+)	NCBI
Celera	17	22,604,529 - 22,667,496 (+)	NCBI		Celera
Cytogenetic Map	17	p13	NCBI

ADTRP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	11,713,523 - 11,778,803 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	11,712,054 - 11,807,046 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	11,713,756 - 11,779,036 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	11,821,895 - 11,887,052 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	11,821,894 - 11,887,052	NCBI
Celera	6	12,941,888 - 13,007,296 (-)	NCBI		Celera
Cytogenetic Map	6	p24.1	NCBI
HuRef	6	11,645,931 - 11,711,306 (-)	NCBI		HuRef
CHM1_1	6	11,716,021 - 11,781,371 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	11,581,768 - 11,647,014 (-)	NCBI		T2T-CHM13v2.0

Adtrp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	41,916,621 - 42,001,092 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	41,916,624 - 42,001,160 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	41,763,145 - 41,847,616 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	41,763,148 - 41,847,684 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	41,858,517 - 41,942,985 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	41,774,122 - 41,858,462 (-)	NCBI		MGSCv36	mm8
Celera	13	42,843,698 - 42,926,413 (-)	NCBI		Celera
Cytogenetic Map	13	A4	NCBI

Adtrp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	2,742,169 - 2,809,790 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	2,721,171 - 2,823,368 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADTRP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	11,829,782 - 11,895,656 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	11,829,782 - 11,895,656 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	11,550,584 - 11,648,755 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ADTRP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	11,300,186 - 11,362,893 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	11,300,887 - 11,362,101 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	11,251,953 - 11,314,604 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	11,405,929 - 11,467,996 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	11,406,525 - 11,468,000 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	11,235,206 - 11,297,780 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	11,284,005 - 11,346,710 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	12,608,632 - 12,671,260 (-)	NCBI		UU_Cfam_GSD_1.0

Adtrp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	13,063,146 - 13,119,309 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936534	1,332,625 - 1,389,572 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936534	1,332,682 - 1,389,242 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADTRP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	8,243,371 - 8,313,648 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	8,242,770 - 8,313,684 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	8,566,929 - 8,644,961 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADTRP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	60,371,412 - 60,436,988 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	60,368,546 - 60,438,864 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	11,738,513 - 11,805,652 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adtrp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	14,290,028 - 14,354,284 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	14,289,144 - 14,354,999 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Adtrp
326 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	53
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000019478, ENSRNOT00000060403
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9201365	23653323	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9201365	23653323	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9201365	23653323	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15330613	23017269	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat

Markers in Region

D17Got205

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	22,939,104 - 22,939,206 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	22,628,984 - 22,629,085	NCBI	Rnor6.0
Rnor_5.0	17	24,606,609 - 24,606,710	UniSTS	Rnor5.0
RGSC_v3.4	17	28,824,015 - 28,824,116	UniSTS	RGSC3.4
Celera	17	22,612,894 - 22,612,995	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		38	37	1	37				17	8	5
Low		22	19	4	18	4	8	8	56	18	33	6	8
Below cutoff		21						3	16

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001395610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY325171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000019478 ⟹ ENSRNOP00000019478

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	22,930,853 - 22,950,114 (+)	Ensembl
Rnor_6.0 Ensembl	17	22,620,721 - 22,639,988 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000060403 ⟹ ENSRNOP00000057148

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	22,930,755 - 22,993,826 (+)	Ensembl
Rnor_6.0 Ensembl	17	22,619,891 - 22,688,307 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115307 ⟹ ENSRNOP00000076653

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	22,930,740 - 22,993,826 (+)	Ensembl

RefSeq Acc Id:

NM_001014144 ⟹ NP_001014166

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	22,930,740 - 22,993,827 (+)	NCBI
Rnor_6.0	17	22,620,619 - 22,688,296 (+)	NCBI
Rnor_5.0	17	24,597,532 - 24,662,658 (+)	NCBI
RGSC_v3.4	17	28,815,650 - 28,879,571 (+)	RGD
Celera	17	22,604,529 - 22,667,496 (+)	RGD

Sequence:

show sequence

GCAGCTCCGGTGTGAACAGAGTGCAGCTGTGACTCCCAGGACCGAGTGAGAGCAGAGCAGGTAC
ACCGCCACCACCTTCGTCGTCGTCGTCATCGTTCTGATCCACGGAAACCATGACGAAAACAACT
ACTTGCTTGTATCACTTCGTTGTTTTGAACTGGTACATTTTCCTCAATTATTACATCCCACAGA
TTGGAAAGGATGAGGAGAAACTAAAGGAATTCCATGACGGTGGACGGTCCAAGTACTTGACACT
CCTGAATCTGCTCTTGCAGGCCGTTTTCTTTGGGGTCGCCTGCCTGGATGATGTGCTAAAAAGA
GTCATCGGAAGGAAAGACATCAAGTTCATCACCTACTTCAGAGATCTGCTTTTTACTACGCTGG
CTTTTCCTTTATCCACATTTGTATTCTTGGTATTCTGGTCCCTCTTCCACTACGACCGGAGCCT
CGTTTACCCCAAGGGCTTGGATGATTTCTTTCCAGCATGGGTTAATCACGCAATGCATACCTCC
ATATTTCCCTTTTCCCTGGCTGAAACCGTTCTCAGACCACACAACTATCCATCGAAGAAGCTAG
GACTCAGCTTGCTGGGTGCCTGTAATTTTGCCTACATTATCAGGATCCTTTGGCGCTACGTTCA
GACCGGAAACTGGGTGTACCCCGTGTTTGCCTCCCTCAGCCCGCTGGGTATTATTCTCTTCTTC
TCAGCCAGTTACATCCTGAGTGCCAGCCTCTACCTGTTTGGAGAGAAGATCAATCACTGGAAAT
GGGGTGCCACAGTGAAGCCACGGATGAAGAAGAATTGACTACACACTGTTTTCCAAGAAACATG
GAAGAAGAAACTTAAGAACTGGTCCAATTTCTATTATTCTCCTTCTTCTTATTTCTTTTTGGAC
CAGGGTGGAATTGCTTGGGGAGATAAAAAGGATGGAGAATGTTGCATAGTTTTAATAAAGAGCA
TGAAGGGAGCTTGGCTTGGGATCTCCTGGTTTTCTAAAAGACTGACCAATAATTCTTCACATGT
CAGAATCTGTTATGTTTGTCTGACCTCCATGGGAGATTTTGTTTCTGGCTAAAATAAAGGCTAA
ATAAGCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006253833 ⟹ XP_006253895

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	22,930,013 - 22,993,834 (+)	NCBI
Rnor_6.0	17	22,619,913 - 22,688,296 (+)	NCBI
Rnor_5.0	17	24,597,532 - 24,662,658 (+)	NCBI

Sequence:

show sequence

CCCCTTCTGCACAGGTGGAGGTAGGGACCTGTCCTTTTCTCTCCCAATCCAATTATGTCTTGTA
CTCCCCAGCGCAGTACAGAGGCCCTTGCTACCCCTGACATATACCCACGACCAACCATGTCTAC
ACTCAGCTCCGGTGTGAACAGAGTGCAGCTGTGACTCCCAGGACCGAGTGAGAGCAGAGCAGGT
ACACCGCCACCACCTTCGTCGTCGTCGTCATCGTTCTGATCCACGGAAACCATGACGAAAACAA
CTACTTGCTTGTATCACTTCGTTGTTTTGAACTGGTACATTTTCCTCAATTATTACATCCCACA
GATTGGAAAGGATGAGGAGAAACTAAAGGAATTCCATGACGGTGGACGGTCCAAGTACTTGACA
CTCCTGAATCTGCTCTTGCAGGCCGTTTTCTTTGGGGTCGCCTGCCTGGATGATGTGCTAAAAA
GAGTCATCGGAAGGAAAGACATCAAGTTCATCACCTACTTCAGAGATCTGCTTTTTACTACGCT
GGCTTTTCCTTTATCCACATTTGTATTCTTGGTATTCTGGTCCCTCTTCCACTACGACCGGAGC
CTCGTTTACCCCAAGGGCTTGGATGATTTCTTTCCAGCATGGGTTAATCACGCAATGCATACCT
CCATATTTCCCTTTTCCCTGGCTGAAACCGTTCTCAGACCACACAACTATCCATCGAAGAAGCT
AGGACTCAGCTTGCTGGGTGCCTGTAATTTTGCCTACATTATCAGGATCCTTTGGCGCTACGTT
CAGACCGGAAACTGGGTGTACCCCGTGTTTGCCTCCCTCAGCCCGCTGGGTATTATTCTCTTCT
TCTCAGCCAGTTACATCCTGAGTGCCAGCCTCTACCTGTTTGGAGAGAAGATCAATCACTGGAA
ATGGGGTGCCACAGTGAAGCCACGGATGAAGAAGAATTGACTACACACTGTTTTCCAAGAAACA
TGGAAGAAGAAACTTAAGAACTGGTCCAATTTCTATTATTCTCCTTCTTCTTATTTCTTTTTGG
ACCAGGGTGGAATTGCTTGGGGAGATAAAAAGGATGGAGAATGTTGCATAGTTTTAATAAAGAG
CATGAAGGGAGCTTGGCTTGGGATCTCCTGGTTTTCTAAAAGACTGACCAATAATTCTTCACAT
GTCAGAATCTGTTATGTTTGTCTGACCTCCATGGGAGATTTTGTTTCTGGCTAAAATAAAGGCT
AAATAAGCTTA

hide sequence

RefSeq Acc Id:

XM_039095874 ⟹ XP_038951802

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	22,930,013 - 22,993,834 (+)	NCBI

RefSeq Acc Id:

XR_005495297

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	22,930,012 - 22,979,569 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014166	(Get FASTA)	NCBI Sequence Viewer
	NP_001382539	(Get FASTA)	NCBI Sequence Viewer
	XP_006253895	(Get FASTA)	NCBI Sequence Viewer
	XP_038951802	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88287	(Get FASTA)	NCBI Sequence Viewer
	AAP92572	(Get FASTA)	NCBI Sequence Viewer
	EDL98209	(Get FASTA)	NCBI Sequence Viewer
	Q5M828	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001014166 ⟸ NM_001014144

- UniProtKB:

Q7TP74 (UniProtKB/Swiss-Prot), Q5M828 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MTKTTTCLYHFVVLNWYIFLNYYIPQIGKDEEKLKEFHDGGRSKYLTLLNLLLQAVFFGVACLD
DVLKRVIGRKDIKFITYFRDLLFTTLAFPLSTFVFLVFWSLFHYDRSLVYPKGLDDFFPAWVNH
AMHTSIFPFSLAETVLRPHNYPSKKLGLSLLGACNFAYIIRILWRYVQTGNWVYPVFASLSPLG
IILFFSASYILSASLYLFGEKINHWKWGATVKPRMKKN

hide sequence

RefSeq Acc Id:	XP_006253895 ⟸ XM_006253833
- Peptide Label:	isoform X1
- UniProtKB:	Q5M828 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MTKTTTCLYHFVVLNWYIFLNYYIPQIGKDEEKLKEFHDGGRSKYLTLLNLLLQAVFFGVACLD DVLKRVIGRKDIKFITYFRDLLFTTLAFPLSTFVFLVFWSLFHYDRSLVYPKGLDDFFPAWVNH AMHTSIFPFSLAETVLRPHNYPSKKLGLSLLGACNFAYIIRILWRYVQTGNWVYPVFASLSPLG IILFFSASYILSASLYLFGEKINHWKWGATVKPRMKKN hide sequence

RefSeq Acc Id:

ENSRNOP00000057148 ⟸ ENSRNOT00000060403

RefSeq Acc Id:

ENSRNOP00000019478 ⟸ ENSRNOT00000019478

RefSeq Acc Id:	XP_038951802 ⟸ XM_039095874
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000076653 ⟸ ENSRNOT00000115307

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5M828-F1-model_v2	AlphaFold	Q5M828	1-230	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700381

Promoter ID:

EPDNEW_R10904

Type:

initiation region

Name:

Adtrp_2

Description:

androgen-dependent TFPI-regulating protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R10905

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	22,619,899 - 22,619,959	EPDNEW

RGD ID:

13700392

Promoter ID:

EPDNEW_R10905

Type:

initiation region

Name:

Adtrp_1

Description:

androgen-dependent TFPI-regulating protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R10904

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	22,620,641 - 22,620,701	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305679	AgrOrtholog
BioCyc Gene	G2FUF-9767	BioCyc
Ensembl Genes	ENSRNOG00000014481	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019478.4	UniProtKB/Swiss-Prot
	ENSRNOP00000057148.3	UniProtKB/TrEMBL
	ENSRNOP00000076653	ENTREZGENE
	ENSRNOP00000076653.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000019478.7	UniProtKB/Swiss-Prot
	ENSRNOT00000060403.5	UniProtKB/TrEMBL
	ENSRNOT00000115307	ENTREZGENE
	ENSRNOT00000115307.1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7321485	IMAGE-MGC_LOAD
InterPro	Far-17a_AIG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:361228	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109474	IMAGE-MGC_LOAD
NCBI Gene	361228	ENTREZGENE
PANTHER	ANDROGEN-DEPENDENT TFPI-REGULATING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10989	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Far-17a_AIG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Adtrp	PhenoGen
UniProt	A0A0H2UI01_RAT	UniProtKB/TrEMBL
	ADTRP_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q7TP74	ENTREZGENE
UniProt Secondary	Q7TP74	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-10	Adtrp	androgen-dependent TFPI-regulating protein	RGD1305679	similar to 9530008L14Rik protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1305679	similar to 9530008L14Rik protein	RGD1305679_predicted	similar to 9530008L14Rik protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305679_predicted	similar to 9530008L14Rik protein (predicted)	LOC361228_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC361228_predicted	similar to 9530008L14Rik protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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