Acsl1 (acyl-CoA synthetase long-chain family member 1) - Rat Genome Database

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Gene: Acsl1 (acyl-CoA synthetase long-chain family member 1) Rattus norvegicus
Analyze
Symbol: Acsl1
Name: acyl-CoA synthetase long-chain family member 1
RGD ID: 2015
Description: Enables arachidonate-CoA ligase activity; oleoyl-CoA ligase activity; and phytanate-CoA ligase activity. Involved in several processes, including fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in bounding membrane of organelle; endoplasmic reticulum; and plasma membrane. Biomarker of obesity. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine palmitoyltransferase I deficiency pathway; carnitine-acylcarnitine translocase deficiency; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acas; ACS; Acyl CoA synthetase long chain; Acyl CoA synthetase, long chain; arachidonate--CoA ligase; COAA; Facl2; fatty acid Coenzyme A ligase, long chain 2; LACS 1; long-chain acyl-CoA synthetase 1; long-chain-fatty-acid--CoA ligase 1; long-chain-fatty-acid--CoA ligase, liver isozyme; phytanate--CoA ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Arunc2 Arunc1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21645,755,246 - 45,821,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,755,254 - 45,821,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,154,126 - 51,196,774 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01654,521,461 - 54,565,831 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01649,793,500 - 49,836,154 (-)NCBIRnor_WKY
Rnor_6.01648,937,456 - 49,003,898 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,937,456 - 49,003,246 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,653,023 - 48,719,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,036,892 - 49,081,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,036,966 - 49,081,491 (-)NCBI
Celera1643,758,263 - 43,802,634 (-)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-nitroquinoline N-oxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
choline  (ISO)
chromium atom  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entacapone  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (EXP)
fenvalerate  (EXP)
flutamide  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 7647  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
ifosfamide  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
nefazodone  (EXP,ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry. Distler AM, etal., Biochim Biophys Acta. 2007 May;1774(5):628-36. Epub 2007 Mar 28.
2. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Durgan DJ, etal., Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2480-97. Epub 2006 Jan 20.
3. Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Ellis JM, etal., Cell Metab. 2010 Jul 7;12(1):53-64. doi: 10.1016/j.cmet.2010.05.012.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance. Gertow K, etal., Eur J Clin Nutr. 2006 Dec;60(12):1406-13. Epub 2006 Jun 21.
6. Effect of a hypolipidemic drug, Di (2-ethylhexyl) phthalate, on mRNA-expression associated fatty acid and acetate metabolism in rat tissues. Itsuki-Yoneda A, etal., Biosci Biotechnol Biochem. 2007 Feb;71(2):414-20. Epub 2007 Feb 7.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. Kim JH, etal., J Biol Chem 2001 Jul 6;276(27):24667-73.
10. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
11. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Lewin TM, etal., Arch Biochem Biophys. 2002 Aug 15;404(2):263-70.
12. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. Lewin TM, etal., J Biol Chem 2001 Jul 6;276(27):24674-9.
13. Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes. Li LO, etal., J Biol Chem. 2006 Dec 1;281(48):37246-55. Epub 2006 Oct 6.
14. Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target. Martin G, etal., J Biol Chem. 2000 Apr 28;275(17):12612-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Inhibitory effect of D-penicillamine on the fibrosis caused by bleomycin treatment in rat carrageein granuloma. Otsuka K, etal., Chem Pharm Bull (Tokyo) 1977 Jun;25(6):1220-4.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats. Ryu MH, etal., Nutrition. 2005 Apr;21(4):537-42.
23. Protein mediated fatty acid uptake: synergy between CD36/FAT-facilitated transport and acyl-CoA synthetase-driven metabolism. Schneider H, etal., Arch Biochem Biophys. 2014 Mar 15;546:8-18. doi: 10.1016/j.abb.2014.01.025. Epub 2014 Feb 4.
24. Thioesterification of 2-arylpropionic acids by recombinant acyl-coenzyme A synthetases (ACS1 and ACS2). Sevoz C, etal., Drug Metab Dispos. 2000 Apr;28(4):398-402.
25. Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa). Shimomura I, etal., Biochim Biophys Acta. 1992 Mar 4;1124(2):112-8.
26. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. Steinberg SJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):615-21.
27. The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase. Steinberg SJ, etal., J Biol Chem. 2000 May 26;275(21):15605-8. doi: 10.1074/jbc.C000015200.
28. Structure and regulation of rat long-chain acyl-CoA synthetase. Suzuki H, etal., J Biol Chem 1990 May 25;265(15):8681-5.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases. Tong F, etal., Arch Biochem Biophys. 2006 Mar 1;447(1):46-52. Epub 2006 Jan 23.
31. Diurnal variation of the adenylyl cyclase type 1 in the rat pineal gland. Tzavara ET, etal., Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11208-12.
32. Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Wang YL, etal., Obes Res. 2004 Nov;12(11):1781-8.
33. Phytanic acid activation in rat liver peroxisomes is catalyzed by long-chain acyl-CoA synthetase. Watkins PA, etal., J Lipid Res. 1996 Nov;37(11):2288-95.
34. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
35. Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. Zhan T, etal., PLoS One. 2012;7(9):e45087. doi: 10.1371/journal.pone.0045087. Epub 2012 Sep 14.
Additional References at PubMed
PMID:8973631   PMID:14622223   PMID:14651853   PMID:15051725   PMID:15093965   PMID:18614015   PMID:19946888   PMID:20667975   PMID:21242590   PMID:22022213   PMID:24095834   PMID:24269233  
PMID:26136511   PMID:26316108   PMID:27136724   PMID:33437196  


Genomics

Comparative Map Data
Acsl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21645,755,246 - 45,821,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,755,254 - 45,821,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,154,126 - 51,196,774 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01654,521,461 - 54,565,831 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01649,793,500 - 49,836,154 (-)NCBIRnor_WKY
Rnor_6.01648,937,456 - 49,003,898 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,937,456 - 49,003,246 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,653,023 - 48,719,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,036,892 - 49,081,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,036,966 - 49,081,491 (-)NCBI
Celera1643,758,263 - 43,802,634 (-)NCBICelera
Cytogenetic Map16q11NCBI
ACSL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,755,595 - 184,826,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4184,755,595 - 184,826,818 (-)EnsemblGRCh38hg38GRCh38
GRCh374185,676,749 - 185,747,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,913,743 - 185,984,209 (-)NCBINCBI36Build 36hg18NCBI36
Build 344186,051,898 - 186,122,364NCBI
Celera4183,005,275 - 183,075,742 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,430,075 - 181,478,058 (-)NCBIHuRef
CHM1_14185,652,944 - 185,723,638 (-)NCBICHM1_1
T2T-CHM13v2.04188,099,036 - 188,169,396 (-)NCBIT2T-CHM13v2.0
Acsl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39846,924,074 - 46,989,088 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl846,924,074 - 46,989,088 (+)EnsemblGRCm39 Ensembl
GRCm38846,471,037 - 46,536,051 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,471,037 - 46,536,051 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,556,396 - 47,621,404 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36847,969,859 - 48,034,867 (+)NCBIMGSCv36mm8
Celera849,153,706 - 49,218,586 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
Acsl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540324,190,674 - 24,236,780 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540324,190,674 - 24,235,354 (+)NCBIChiLan1.0ChiLan1.0
ACSL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14189,145,403 - 189,216,458 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,145,403 - 189,198,646 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04176,920,811 - 176,991,495 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACSL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,735,675 - 45,806,235 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,735,703 - 45,804,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1646,229,060 - 46,299,523 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01647,951,751 - 48,022,201 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1647,951,663 - 48,216,959 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11645,918,792 - 45,989,322 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,531,804 - 46,602,185 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,664,118 - 46,734,659 (+)NCBIUU_Cfam_GSD_1.0
Acsl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,625,129 - 33,684,355 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365544,425,495 - 4,484,887 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365544,425,518 - 4,484,853 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,866,857 - 45,963,729 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,866,858 - 45,936,327 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,526,606 - 52,595,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,712,633 - 130,783,360 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,712,308 - 130,763,756 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,965,130 - 111,036,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476915,503,757 - 15,584,777 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476915,503,757 - 15,584,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acsl1
331 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:146
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000014235
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
AW533279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,755,774 - 45,755,985 (+)MAPPERmRatBN7.2
Rnor_6.01648,937,985 - 48,938,195NCBIRnor6.0
Rnor_5.01648,653,552 - 48,653,762UniSTSRnor5.0
RGSC_v3.41649,037,421 - 49,037,631UniSTSRGSC3.4
Celera1643,758,792 - 43,759,002UniSTS
RH 3.4 Map16448.6UniSTS
Cytogenetic Map16q11UniSTS
RH128996  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,755,331 - 45,755,551 (+)MAPPERmRatBN7.2
Rnor_6.01648,937,542 - 48,937,761NCBIRnor6.0
Rnor_5.01648,653,109 - 48,653,328UniSTSRnor5.0
RGSC_v3.41649,036,978 - 49,037,197UniSTSRGSC3.4
Celera1643,758,349 - 43,758,568UniSTS
Cytogenetic Map16q11UniSTS
RH141505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,769,235 - 45,769,442 (+)MAPPERmRatBN7.2
Rnor_6.01648,951,447 - 48,951,653NCBIRnor6.0
Rnor_5.01648,666,988 - 48,667,194UniSTSRnor5.0
RGSC_v3.41649,050,883 - 49,051,089UniSTSRGSC3.4
Celera1643,772,153 - 43,772,359UniSTS
RH 3.4 Map16448.9UniSTS
Cytogenetic Map16q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5 5 5
Medium 3 43 52 36 19 36 8 11 62 35 33 11 8
Low 12 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014235   ⟹   ENSRNOP00000014235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1645,755,254 - 45,821,541 (-)Ensembl
Rnor_6.0 Ensembl1648,937,456 - 48,981,980 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089501   ⟹   ENSRNOP00000072677
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1645,755,254 - 45,821,541 (-)Ensembl
Rnor_6.0 Ensembl1648,938,935 - 49,003,246 (-)Ensembl
RefSeq Acc Id: NM_012820   ⟹   NP_036952
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,246 - 45,799,770 (-)NCBI
Rnor_6.01648,937,456 - 48,981,980 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
RGSC_v3.41649,036,892 - 49,081,416 (-)RGD
Celera1643,758,263 - 43,802,634 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253122   ⟹   XP_006253184
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,254 - 45,821,217 (-)NCBI
Rnor_6.01648,937,464 - 49,003,551 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253123   ⟹   XP_006253185
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,250 - 45,821,541 (-)NCBI
Rnor_6.01648,937,464 - 49,003,898 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253124   ⟹   XP_006253186
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,254 - 45,801,543 (-)NCBI
Rnor_6.01648,937,464 - 48,983,717 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253125   ⟹   XP_006253187
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,254 - 45,814,554 (-)NCBI
Rnor_6.01648,937,464 - 48,996,935 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253126   ⟹   XP_006253188
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,254 - 45,804,405 (-)NCBI
Rnor_6.01648,937,464 - 48,986,597 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253127   ⟹   XP_006253189
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,254 - 45,801,588 (-)NCBI
Rnor_6.01648,937,464 - 48,983,798 (-)NCBI
Rnor_5.01648,653,023 - 48,719,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094200   ⟹   XP_038950128
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,429 - 45,821,492 (-)NCBI
RefSeq Acc Id: XM_039094201   ⟹   XP_038950129
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,250 - 45,821,536 (-)NCBI
RefSeq Acc Id: XM_039094202   ⟹   XP_038950130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21645,755,254 - 45,821,224 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036952   ⟸   NM_012820
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253185   ⟸   XM_006253123
- Peptide Label: isoform X1
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253184   ⟸   XM_006253122
- Peptide Label: isoform X1
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253187   ⟸   XM_006253125
- Peptide Label: isoform X1
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253188   ⟸   XM_006253126
- Peptide Label: isoform X1
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253189   ⟸   XM_006253127
- Peptide Label: isoform X1
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253186   ⟸   XM_006253124
- Peptide Label: isoform X1
- UniProtKB: P18163 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072677   ⟸   ENSRNOT00000089501
RefSeq Acc Id: ENSRNOP00000014235   ⟸   ENSRNOT00000014235
RefSeq Acc Id: XP_038950129   ⟸   XM_039094201
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950130   ⟸   XM_039094202
- Peptide Label: isoform X4
- UniProtKB: A0A8L2R6L8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950128   ⟸   XM_039094200
- Peptide Label: isoform X2
Protein Domains
AMP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18163-F1-model_v2 AlphaFold P18163 1-699 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700097
Promoter ID:EPDNEW_R10621
Type:multiple initiation site
Name:Acsl1_1
Description:acyl-CoA synthetase long-chain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10622  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01648,982,003 - 48,982,063EPDNEW
RGD ID:13700105
Promoter ID:EPDNEW_R10622
Type:initiation region
Name:Acsl1_2
Description:acyl-CoA synthetase long-chain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10621  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01649,003,236 - 49,003,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2015 AgrOrtholog
BioCyc Gene G2FUF-11357 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
Ensembl Genes ENSRNOG00000010633 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014235 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072677 ENTREZGENE
  ENSRNOP00000072677.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014235 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089501 ENTREZGENE
  ENSRNOT00000089501.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LC-FACS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25288 UniProtKB/Swiss-Prot
NCBI Gene 25288 ENTREZGENE
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsl1 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217023
UniProt A0A8L2R6L8 ENTREZGENE, UniProtKB/TrEMBL
  ACSL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl1  acyl-CoA synthetase long-chain family member 1  Facl2  fatty acid Coenzyme A ligase, long chain 2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Facl2  fatty acid Coenzyme A ligase, long chain 2      Symbol and Name status set to approved 70586 APPROVED
2001-12-12 Facl2  fatty acid Coenzyme A ligase, long chain 2      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA increases in response to high carbohydrate or high fat diets 70279
gene_expression mRNA expressed in liver, heart and epididymal adipose tissues; smaller amount found in brain, small intestine and lung 70279
gene_function catalyzes the ligation of long chain fatty acids with coenzyme A to produce long chain acyl-CoAs 70279
gene_process plays a key role in lipid synthesis and in fatty acid degradation 70279
gene_process involved in energy use via b-oxidation and the synthesis of triacylglycerol, phospholipids, cholesterol esters, and sphingomyelin 68670
gene_product member of the luciferase superfamily 70279
gene_protein predicted 699 amino acids and 78 kDa 70279
gene_transcript 3.8 kbp mRNA 70279