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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl1affects expressionEXP 6480464CTDbisphenol A affects the expression of ACSL1 mRNAPMID:30903817
Acsl1increases expressionEXP 6480464CTDbisphenol A results in increased expression of ACSL1 mRNA; bisphenol A results in increased expression of ACSL1 proteinPMID:25181051 PMID:30816183 PMID:32145629 PMID:32528016 PMID:34947998
Acsl1affects methylationISOAcsl1 (Mus musculus)6480464CTDbisphenol A affects the methylation of ACSL1 promoterPMID:27334623
Acsl1decreases expressionISOACSL1 (Homo sapiens)6480464CTDbisphenol A analog results in decreased expression of ACSL1 mRNAPMID:32763284
Acsl1increases expressionISOACSL1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of ACSL1 proteinPMID:34186270
Acsl1increases methylationISOACSL1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of ACSL1 genePMID:31601247
Acsl1multiple interactionsISOACSL1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of ACSL1 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACSL1 mRNAPMID:28628672 PMID:31601247
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