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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNAPMID:18796159 PMID:21215274
Acsl1affects expressionISOAcsl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ACSL1 mRNAPMID:21570461
Acsl1decreases expressionISOACSL1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNAPMID:20106945 PMID:21632981 PMID:26238291
Acsl1decreases expressionISOAcsl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNAPMID:19770486 PMID:22539624 PMID:28238261
Acsl1increases expressionISOAcsl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ACSL1 mRNAPMID:17035482
Acsl1multiple interactionsISOACSL1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ACSL1 gene]PMID:28681081
Acsl1multiple interactionsISOAcsl1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ACSL1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]PMID:16054899 PMID:17942748
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