RGD Reference Report - Structure and regulation of rat long-chain acyl-CoA synthetase. - Rat Genome Database

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Structure and regulation of rat long-chain acyl-CoA synthetase.

Authors: Suzuki, H  Kawarabayasi, Y  Kondo, J  Abe, T  Nishikawa, K  Kimura, S  Hashimoto, T  Yamamoto, T 
Citation: Suzuki H, etal., J Biol Chem 1990 May 25;265(15):8681-5.
RGD ID: 70279
Pubmed: PMID:2341402   (View Abstract at PubMed)

Complementary DNAs encoding rat long-chain acyl-CoA synthetase have been isolated. The cDNAs were identified using synthetic oligonucleotide probes based on partial amino acid sequences of lysyl endopeptidase peptides of the purified enzyme. Rat long-chain acyl-CoA synthetase is predicted to contain 699 amino acid residues and to have a calculated molecular weight of 78,177. Significant sequence similarity was found between parts of long-chain acyl-CoA synthetase and firefly luciferase. Based on the similarity of the reaction mechanisms of the two enzymes, we propose a function for the similar region. The long-chain acyl-CoA synthetase mRNA is expressed in liver, heart, and epididymal adipose tissues and, to a much lesser extent, in brain, small intestine, and lung. The level of long-chain acyl-CoA synthetase mRNA is increased 7-8-fold in rat liver by feeding a diet high in carbohydrate or fat, consistent with the physiological significance of the enzyme in fatty acid metabolism.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acetate-CoA ligase activity  TAS 70279 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acsl1  (acyl-CoA synthetase long-chain family member 1)

Objects referenced in this article
Gene ACSL1 acyl-CoA synthetase long chain family member 1 Homo sapiens

Additional Information