RGD Reference Report - Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa). - Rat Genome Database

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Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa).

Authors: Shimomura, I  Tokunaga, K  Jiao, S  Funahashi, T  Keno, Y  Kobatake, T  Kotani, K  Suzuki, H  Yamamoto, T  Tarui, S 
Citation: Shimomura I, etal., Biochim Biophys Acta. 1992 Mar 4;1124(2):112-8.
RGD ID: 1625737
Pubmed: PMID:1543733   (View Abstract at PubMed)

To clarify the role of acyl-CoA synthetase in development of obesity, the mRNA levels and activities were studied in Zucker fatty rats (fa/fa). In Zucker fatty rats compared with their lean littermates, marked enhancement of ACS were observed in adipose tissues. Obese/lean rats ratio of ACS activity and mRNA in abdominal subcutaneous fat (3.3- and 3.9-fold, respectively) were greater than in mesenteric fat (2.0- and 2.2-fold). The enhancement of ACS activity and mRNA in the liver of fatty rats (1.2- and 1.8-fold) were less than those in the adipose tissues. There were no enhancement of ACS activities and mRNA levels in heart tissue of the obese rats. LPL mRNA levels were also enhanced in adipose tissue of fatty rats and obese/lean ratio of LPL mRNA was also higher in abdominal subcutaneous fat than mesenteric fat (6.2- vs 3.1-fold). The larger obese/lean rats ratio of LPL and ACS parameters in abdominal subcutaneous fat than mesenteric fat may be related to the observation that the increase of subcutaneous fat weight was larger than that of mesenteric fat weight in fatty rats (21.1- vs 4.9-fold). Integrated enhancement of LPL and ACS gene expression in adipose tissue may play an important role in the development of obesity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  ISOAcsl1 (Rattus norvegicus)1625737; 1625737mRNA more ...RGD 
obesity  IEP 1625737mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acsl1  (acyl-CoA synthetase long-chain family member 1)

Genes (Mus musculus)
Acsl1  (acyl-CoA synthetase long-chain family member 1)

Genes (Homo sapiens)
ACSL1  (acyl-CoA synthetase long chain family member 1)


Additional Information