Arunc2 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Arunc2 (Aerobic running capacity QTL 2) Rattus norvegicus

Symbol: Arunc2
Name: Aerobic running capacity QTL 2
RGD ID: 1298527
Also known as: Arc2
Trait: exercise endurance trait   (VT:0002332)    
Measurement Type: maximum distance run on treadmill   (CMO:0001406)    
LOD Score: 2.9
P Value: Not Available
Variance: Not Available
Inheritance Type: dominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,532,716 - 75,029,966RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01673,219,638 - 80,115,794RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01672,850,762 - 79,690,408RGDRnor5.0
RGSC_v3.41673,394,189 - 79,850,195RGDRGSC3.4
RGSC_v3.11673,394,454 - 79,850,460RGD
Cross Type: Not Available
Strains Crossed: COP/OlaHsd DA/OlaHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Acsl1 is a candidate Gene for Arunc2
Irs2 is a candidate Gene for Arunc2
Pdlim3 is a candidate Gene for Arunc2
Ppif is a candidate Gene for Arunc2
Tm2d2 is a candidate Gene for Arunc2

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain
COP/OlaHsd  (IEA)
DA/OlaHsd  (IEA)

References

References - curated
1. Lee SJ, etal., Physiol Genomics 2005 Jul 20;.
2. Ways JA, etal., Genomics 2002 Jul;80(1):13-20.
Related QTLs

Related QTL Description Reference
Arunc3 interacts with RGD:619535


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
619943Defb1defensin beta 1167029886270313604Rat
619944Defb4defensin beta 4167065047270653665Rat
3699Slc20a2solute carrier family 20 member 2166946085069551418Rat
3342Platplasminogen activator, tissue type166924058269265177Rat
3363PolbDNA polymerase beta166937943869402710Rat
621577Vdac3voltage-dependent anion channel 3166943498269451473Rat
631437Myom2myomesin 2167452014874592658Rat
621861Angpt2angiopoietin 2167108836471138805Rat
628905Spag11asperm associated antigen 11A167068232670684067Rat
727857Np4defensin NP-4 precursor167049460770497261Rat
620224Dlgap2DLG associated protein 2167478677175496402Rat
621074Sfrp1secreted frizzled-related protein 1166857576368613905Rat
621375Ikbkbinhibitor of nuclear factor kappa B kinase subunit beta166931948769373251Rat
1304852Defa24defensin alpha 24167034955070350582Rat
70969Ap3m2adaptor related protein complex 3 subunit mu 2166921752669237372Rat
727951Defa5defensin alpha 5167034253070344836Rat
2180Atp7bATPase copper transporting beta166995228670024404Rat
1307419Nek3NIMA-related kinase 3166986702069892477Rat
1304892Kat6alysine acetyltransferase 6A166908491469165923Rat
1305103Csmd1CUB and Sushi multiple domains 1167221818973818380Rat
1305825Tpte2transmembrane phosphoinositide 3-phosphatase and tensin homolog 2166965887469756571Rat
1306405Agpat51-acylglycerol-3-phosphate O-acyltransferase 5167093948070985761Rat
1306998Thsd1thrombospondin type 1 domain containing 1166977140869804844Rat
1307397Gins4GINS complex subunit 4166878757268799938Rat
1309754Vps36vacuolar protein sorting 36 homolog166981040469834789Rat
1559811Ccdc70coiled-coil domain containing 70167003730970042401Rat
1559883Defb13defensin beta 13167012962570131473Rat
1311631Ckap2cytoskeleton associated protein 2166983966869864852Rat
1311488Slc25a15solute carrier family 25 member 15166963158169654869Rat
1309620Ank1ankyrin 1166887629469054812Rat
1307668Mrps31mitochondrial ribosomal protein S31166960134969621609Rat
1562293Defa6defensin alpha 6167040526870406142Rat
1564879Defb12defensin beta 12167072572270728143Rat
1561378Defb14defensin beta 14167066344370668473Rat
1561398Defal1defensin alpha-like 1167037151870372353Rat
1566065Defa8defensin alpha 8167043316670434059Rat
1560642Mcph1microcephalin 1167102185571224067Rat
1561801Defb38defensin beta 38167075640970759641Rat
1563712Defb40defensin beta 40167082452270827449Rat
1565043Arhgef10Rho guanine nucleotide exchange factor 10167464714774738784Rat
1562959Defb33defensin beta 33167059476270601625Rat
1564032Defb11defensin beta 11167015614770163029Rat
1563172Dkk4dickkopf WNT signaling pathway inhibitor 4166940298969406580Rat
1560790Defb37defensin beta 37167078361570796698Rat
1560529Defa7defensin alpha 7167041927770420046Rat
1563576Kbtbd11kelch repeat and BTB domain containing 11167461829174638010Rat
1564725Alg11ALG11, alpha-1,2-mannosyltransferase166994054069951617Rat
1563061Defb15defensin beta 15167014119370143834Rat
1563816Defb39defensin beta 39167074034770744157Rat
1359335Xkr5XK related 5167087498370892972Rat
1310520Gpat4glycerol-3-phosphate acyltransferase 4166881903168852903Rat
1563138Defb9defensin beta 9167018077170183554Rat
1587186Defa11defensin alpha 11167053343670535646Rat
1587187Defa10defensin alpha 10167051424870515024Rat
1583286LOC685012similar to heterogeneous nuclear ribonucleoprotein A3166867405568675087Rat
1359725Golga7golgin A7166876725968782536Rat
1565394Defb52defensin beta 52167058815070590626Rat
1564555Defa9defensin alpha 9167048181370482803Rat
1563282Defb50defensin beta 50167025418570266484Rat
1564782Defb51defensin beta 51167057092970575052Rat
1566125Defb2defensin beta 2167023194570245784Rat
1562518Defb10defensin beta 10167020265570212707Rat
1563630Defb5defensin beta 5167061320070615360Rat
1590228LOC685740hypothetical protein LOC685740167075135670751842Rat
1590848LOC364636similar to myc induced nuclear antigen167449032074492124Rat
1589653RatNP-3bdefensin RatNP-3 precursor167054436470546533Rat
1359518Cln8CLN8, transmembrane ER and ERGIC protein167474966274759553Rat
1593817Nek5NIMA-related kinase 5166989541469938668Rat
1597780Nkx6-3NK6 homeobox 3166886840468873617Rat
2318111Fam90a1family with sequence similarity 90, member A1167009843970106147Rat
2318364Smim19small integral membrane protein 19166955147069565450Rat
2323116Map1lc3b2microtubule-associated protein 1 light chain 3 beta 2167099389370994586Rat
2324475Spag11blsperm associated antigen 11b-like167069781070700336Rat
2324120LOC100362738M2 pyruvate kinase-like167083857270840735Rat
7505881LOC102550761uncharacterized LOC102550761167382990973858522Rat
7561455LOC102551149uncharacterized LOC102551149167463231574633836Rat
7550023LOC102557538uncharacterized LOC102557538167465350174661465Rat
7690544LOC102550986serine/arginine repetitive matrix protein 1-like166943284969435732Rat
7700141LOC102550919uncharacterized LOC102550919167437920774473037Rat
7709651LOC102551089uncharacterized LOC102551089167452259474524791Rat
7711557LOC102550098activated RNA polymerase II transcriptional coactivator p15-like166974132869742039Rat
11367158LOC108348424uncharacterized LOC108348424167182176171886903Rat
11448278LOC108348292glyceraldehyde-3-phosphate dehydrogenase pseudogene166928587169287728Rat
11368550LOC108348426uncharacterized LOC108348426167219418872203386Rat
11378360LOC108353108alpha-defensin 9-like167039877870398984Rat
11403925LOC108353087cyclin-dependent kinase 4 pseudogene167316304673164202Rat
13207460Lnc-hclncRNA derived from hepatocytes166965345869654867Rat
41355023LOC120097377beta-defensin 12167013621870138645Rat
41379300LOC120097441neutrophil antibiotic peptide NP-2-like167045492270455803Rat
41323020LOC120097554uncharacterized LOC120097554167423054774233919Rat
41277817LOC120097613small nucleolar RNA SNORA17167442447974424603Rat
41324475NEWGENE_40934091transfer RNA alanine (anticodon AGC)166975226369752335Rat
41325543LOC120097529uncharacterized LOC120097529166918849069205200Rat
41142380LOC120097578putative protein FAM90A8P167011089370118229Rat
41145025LOC120097608small nucleolar RNA SNORA17167287036472870488Rat
41360519LOC120097635U4 spliceosomal RNA166866421968664351Rat
41120881LOC120097609small nucleolar RNA SNORA17166873431868734454Rat
41149989LOC120097399dynein assembly factor 3, axonemal homolog166916336069217498Rat
41096911LOC120097401putative protein FAM90A8P167004560670056398Rat
41154183LOC120097543uncharacterized LOC120097543167142305271462255Rat
41343898LOC120097552uncharacterized LOC120097552167413797874140817Rat
41368796LOC120093117sperm-associated antigen 11-like167015206170154406Rat
41124527LOC120097516beta-defensin 15167072020070723134Rat
41288370LOC120097528uncharacterized LOC120097528166916615169202680Rat
41289242LOC120097536neutrophil antibiotic peptide NP-2-like167039178170392695Rat
41291833LOC120097623small nucleolar RNA SNORA17167152906871529192Rat
41070910LOC120097611small nucleolar RNA SNORA17167129810471298230Rat
41071646LOC120097402putative protein FAM90A7P167006043570069633Rat
41128358LOC120097525uncharacterized LOC120097525166894646768948885Rat
41402600LOC120097400uncharacterized LOC120097400166953261469536391Rat
41320303LOC120097550uncharacterized LOC120097550167400308674012880Rat
41377630LOC120097500putative protein FAM90A8P167008610570093757Rat
40975440LOC120097509putative protein FAM90A8P167007398670081411Rat
40999196LOC120097551uncharacterized LOC120097551167407246474076678Rat
40984573LOC120097621small nucleolar RNA SNORA17167121221771212319Rat
40944475LOC120097555uncharacterized LOC120097555167447306574477583Rat
41312663LOC120097532uncharacterized LOC120097532166962174669627990Rat
41312810LOC120097527uncharacterized LOC120097527166913914269162178Rat
41080127LOC120097408uncharacterized LOC120097408167274265772769166Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
35553D16Rat16172167122567271225844Ratregion
37786D16Rat25141167069224870692389Ratregion
36608D16Rat48150167502981075029966Ratregion
34959D16Rat14162167061084970610983Ratregion
35158D16Rat13157167318714173187298Ratregion
39822D16Rat94227167346533973465568Ratregion
40632D16Rat57228166883022368830445Ratregion
39288D16Rat37214167096851970968745Ratregion
42016D16Arb272167134074471340820Ratregion
41324D16Rat55166167178125271781430Ratregion
42412D16Rat130232167385525473855486Ratregion
40796D16Rat56221166893799268938229Ratregion
60130D16Got77298166990171669902014Ratregion
60131D16Got81111167260593272606040Ratregion
45384D16Got76112166937553369375645Ratregion
45385D16Got75200167030879670308993Ratregion
45386D16Got92167166931586769316034Ratregion
45388D16Got78185167189549571895680Ratregion
45389D16Got79228167223940072239628Ratregion
45390D16Got8093167194913771949230Ratregion
45391D16Got82213167371555973715772Ratregion
45397D16Got90124167427663774276760Ratregion
625825D16Got74204166937553269375736Ratregion
66391D16Mco6364166931580769316180Ratregion
1628156D16Wox27182167049555070495732Ratregion
1628354D16Got119129167128617571286304Ratregion
1639032D16Cebr2283167031943870319723Ratregion
1635835D16Ulb1174167129132271291496Ratregion
1637695D16Wox28200167054533870545538Ratregion
5038832RH127358207166945123369451440Ratregion
5033913RH140593200167095522570955424Ratregion
5026022RH130609180166954375969543939Ratregion
5026052RH130718198166940442169404619Ratregion
5034189RH141704200166887786968878069Ratregion
5029333RH144398122166885345668853578Ratregion
5032685RH134919189167265748472657673Ratregion
5027355AU041707101166885275168852852Ratregion
5030073BE098027158167452197574522133Ratregion
5032917RH136959152167094322270943374Ratregion
5033175RH137859166166990734269907508Ratregion
5033213RH137999204167253232272532526Ratregion
5033363RH138560209166993828069938489Ratregion
5025532RH128687217166946094869461165Ratregion
5030887BF399189131167114112171141252Ratregion
5051849RH94694190167002257870022768Ratregion
5055883RH144058228167102219571022423Ratregion
5056097RH144181232167461634074616572Ratregion
5058748BF387021181167094411170944297Ratregion
5059870BE103463155166986435569864510Ratregion
5059166BE102937206167221492672215132Ratregion
5053641RH142766173167094384670944019Ratregion
5053393RH142622191167122399771224188Ratregion
5043434RH130023184166981008669810270Ratregion
5045330RH131116185167464728074647465Ratregion
5041830RH129083180167094180970941989Ratregion
5048704RH133057197166923520169235398Ratregion
5045560RH131248203166937259969372802Ratregion
5047772RH132520194167452021774520411Ratregion
5047176RH132177185166921384269214027Ratregion
5039446RH127710219167474977274749991Ratregion
5041924RH129137199167113857271138771Ratregion
5048500RH132939217166885497568855194Ratregion
5042276RH129341193166885265468852847Ratregion
5042310RH129360185167113855371138738Ratregion
5042238RH129319181166994287469943055Ratregion
7191237Sfrp1779166857809468578873Ratregion
5040288RH128197215166924072269240937Ratregion
5043692RH130172182166965341969653601Ratregion
5072252RH136741123167466128174661404Ratregion
5076984RH139492211167093958470939795Ratregion
5075874RH138847158166964232169642480Ratregion
5074970RH138324137167500174375001880Ratregion
5076136RH139000127166879342268793549Ratregion
5075614RH138696135166937009269370227Ratregion
5079600RH141094181166857720468577385Ratregion
5077790RH139961187166937299969373186Ratregion
5077584RH139840213166956518869565401Ratregion
5079856RH141243202166857591368576115Ratregion
5080018RH141335182166879965868799840Ratregion
5080026RH141340194166923690969237103Ratregion
5078138RH140165205166989216169892366Ratregion
5078416RH140329135167093958470939719Ratregion
5079090RH140730227166908637169086598Ratregion
5070772RH134696188167089257470892762Ratregion
5080234RH141462198166980823969808437Ratregion
5073358RH137390175166948987869490053Ratregion
5073536RH137493190166857814968578349Ratregion
5070650RH134625214166965460969654823Ratregion
5071596RH135173210166857985468580064Ratregion
5071812RH135299204166994450069944704Ratregion
5072042RH135431184166857753468577728Ratregion
5074330RH137954140166924029769240437Ratregion
5071910RH135355193166980805669808249Ratregion
5065054BF405594173167284768272847855Ratregion
5067016AU048015155167196049271960647Ratregion
5067422AU047758118166918729769187417Ratregion
5070105RH94475173166924090669241079Ratregion
5069198AU046655270167293176972932033Ratregion
5069198AU046655270167293176972931991Ratregion
5065268BE121319155167098653970986695Ratregion
5062226BE106374150167222265272222802Ratregion
5060980BF389634175166961103269611207Ratregion
5061994BE112434180166965464369654823Ratregion
5060640BE098786160166962387369624033Ratregion
5064258BE120928163166926544569265608Ratregion
5064258BE120928163166926544569265608Ratregion
5064812BF405139250167107831071078560Ratregion
5082449BE119431162167102452471024686Ratregion
5087644PMC96815P1140167029896870299108Ratregion
5087652PMC96815P5123167029898870299111Ratregion
5089263AU049052249167214440572144654Ratregion
5089567AU049232225167216927572169500Ratregion
5087646PMC96815P2178167065048870650666Ratregion
5087650PMC96815P4123167049466170494784Ratregion
5085461AW533825158167469568574695843Ratregion
5080782RH141778186167108970871089894Ratregion
5082911BF390395152167089006370890215Ratregion
5083137BF390838158166933056169330719Ratregion
5081677BE117978186166857376868573954Ratregion
5083591BI276346158166893008768930245Ratregion
5507705UniSTS:252200167019762270198235Ratregion
5505044Myst3249166916304369163292Ratregion
5505046Myst3156166908616869086324Ratregion
5505372Atp7b858166998711469987972Ratregion
5505768UniSTS:492990859167066355570664414Ratregion
5502928Sfrp1781166857809468578875Ratregion
5502817VDAC3177166944462169446245Ratregion
Position Markers

Flank 1: (D16Rat42)
Rat AssemblyChrPosition (strand)Source
Celera1665,511,878 - 65,512,027UniSTS
RH 3.4 Map16640.0RGD
RH 3.4 Map16640.0UniSTS
RH 2.0 Map16768.4RGD
SHRSP x BN Map1633.9399RGD
Peak: (D16Rat55)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21671,781,252 - 71,781,430 (+)MAPPER
Rnor_6.01676,667,628 - 76,667,805NCBI
Rnor_5.01676,270,497 - 76,270,674UniSTS
RGSC_v3.41676,622,104 - 76,622,281UniSTS
RGSC_v3.41676,622,103 - 76,622,281RGD
RGSC_v3.11676,622,369 - 76,622,546RGD
Celera1669,610,546 - 69,610,723UniSTS
RH 3.4 Map16702.2RGD
RH 3.4 Map16702.2UniSTS
RH 2.0 Map16815.0RGD
SHRSP x BN Map1638.59RGD
Flank 2: (D16Rat48)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21675,029,810 - 75,029,966 (+)MAPPER
Rnor_6.01680,115,641 - 80,115,794NCBI
Rnor_5.01679,690,255 - 79,690,408UniSTS
RGSC_v3.41679,850,041 - 79,850,195RGD
RGSC_v3.41679,850,042 - 79,850,195UniSTS
RGSC_v3.11679,850,307 - 79,850,460RGD
Celera1672,845,336 - 72,845,489UniSTS
RH 3.4 Map16730.4UniSTS
RH 3.4 Map16730.4RGD
SHRSP x BN Map1645.5099UniSTS
SHRSP x BN Map1645.5099RGD
Cytogenetic Map16q12.5UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Arunc2


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Arunc2  Aerobic running capacity QTL 2  Arc2    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_cand_genes candidate genes RGD1306769, Pdlim3, Ppif detect differential expression in in the left ventricles of high aerobic capacity vs. low aerobic capacity strains; candidate genes Irs2, Acsl1 are members of biological networks containing differentially expressed genes 1547852
qtl_general only male rats were used in this study 619535
qtl_general a significant interaction was found with Arc3; rats homozygous for DA allele at both marker loci had 42% higher running distances than those homozygous for COP allele 619535