Arunc2 QTL Report (Rattus norvegicus) - Rat Genome Database
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QTL Registration

QTL: Arunc2 (Aerobic running capacity QTL 2) Rattus norvegicus

Symbol: Arunc2
Name: Aerobic running capacity QTL 2
RGD ID: 1298527
Also known as: Arc2
Trait: exercise endurance trait   (VT:0002332)    
Measurement Type: maximum distance run on treadmill   (CMO:0001406)    
LOD Score: 2.9
P Value: Not Available
Variance: Not Available
Inheritance Type: dominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01673,219,638 - 80,115,794RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01672,850,762 - 79,690,408RGDRnor5.0
RGSC_v3.41673,394,189 - 79,850,195RGDRGSC3.4
RGSC_v3.11673,394,454 - 79,850,460RGD
Cross Type: Not Available
Strains Crossed: COP/OlaHsd DA/OlaHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Acsl1 is a candidate Gene for Arunc2
Irs2 is a candidate Gene for Arunc2
Pdlim3 is a candidate Gene for Arunc2
Ppif is a candidate Gene for Arunc2
Tm2d2 is a candidate Gene for Arunc2

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain
COP/OlaHsd  (IEA)
DA/OlaHsd  (IEA)

References

References - curated
1. Lee SJ, etal., Physiol Genomics 2005 Jul 20;.
2. Ways JA, etal., Genomics 2002 Jul;80(1):13-20.
Related QTLs

Related QTL Description Reference
Arunc3 interacts with RGD:619535


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
619943Defb1defensin beta 1167529438575309127Rat
619944Defb4defensin beta 4167563459875637789Rat
3699Slc20a2solute carrier family 20 member 2167431828774408030Rat
3342Platplasminogen activator, tissue type167409826374122897Rat
3363PolbDNA polymerase beta167423700174260272Rat
621577Vdac3voltage-dependent anion channel 3167429246674308910Rat
631437Myom2myomesin 2167958713679672871Rat
621861Angpt2angiopoietin 2167596648076016147Rat
628905Spag11asperm associated antigen 11A167566643975668180Rat
727857Np4defensin NP-4 precursor167547854875481146Rat
620224Dlgap2DLG associated protein 2167987223880596977Rat
621074Sfrp1secreted frizzled-related protein 1167337200773410777Rat
621375Ikbkbinhibitor of nuclear factor kappa B kinase subunit beta167417723374230809Rat
1304852Defa24defensin alpha 24167534508675346122Rat
70969Ap3m2adaptor related protein complex 3 subunit mu 2167407584274091230Rat
727951Defa5defensin alpha 5167533805075340401Rat
2180Atp7bATPase copper transporting beta167486551674944935Rat
1307419Nek3NIMA-related kinase 3167478137174806567Rat
1304892Kat6alysine acetyltransferase 6A167394266974020750Rat
1305103Csmd1CUB and Sushi multiple domains 1167715282378850222Rat
1305825Tpte2transmembrane phosphoinositide 3-phosphatase and tensin homolog 2167455285974662194Rat
1306405Agpat51-acylglycerol-3-phosphate O-acyltransferase 5167581283775855996Rat
1306998Thsd1thrombospondin type 1 domain containing 1167468062174712368Rat
1307397Gins4GINS complex subunit 4167358441273596808Rat
1309754Vps36vacuolar protein sorting 36 homolog167471964274743921Rat
1559811Ccdc70coiled-coil domain containing 70167495889774963925Rat
1559883Defb13defensin beta 13167502713175028977Rat
1311631Ckap2cytoskeleton associated protein 2167475265574779184Rat
1311488Slc25a15solute carrier family 25 member 15167450531874554523Rat
1309620Ank1ankyrin 1167368142273912605Rat
1307668Mrps31mitochondrial ribosomal protein S31167446787474504834Rat
1562293Defa6defensin alpha 6167540078175401655Rat
1564879Defb12defensin beta 12167511800275120417Rat
1561378Defb14defensin beta 14167564752375650913Rat
1561398Defal1defensin alpha-like 1167536692575367985Rat
1566065Defa8defensin alpha 8167542867575429568Rat
1560642Mcph1microcephalin 1167590408776110624Rat
1561801Defb38defensin beta 38167505857275061804Rat
1563712Defb40defensin beta 40167570234775705489Rat
1565043Arhgef10Rho guanine nucleotide exchange factor 10167972562979817065Rat
1562959Defb33defensin beta 33167557868175585475Rat
1564032Defb11defensin beta 11167514620075156555Rat
1563172Dkk4dickkopf WNT signaling pathway inhibitor 4167426055174264142Rat
1560790Defb37defensin beta 37167508317375094963Rat
1560529Defa7defensin alpha 7167541478675415555Rat
1563576Kbtbd11kelch repeat and BTB domain containing 11167969639579716129Rat
1564725Alg11ALG11, alpha-1,2-mannosyltransferase167485400774866096Rat
1563061Defb15defensin beta 15167510529075107931Rat
1563816Defb39defensin beta 39167504251675046320Rat
1359335Xkr5XK related 5167574478675762694Rat
1310520Gpat4glycerol-3-phosphate acyltransferase 4167361594973649769Rat
1563138Defb9defensin beta 9167517630775179090Rat
1587186Defa11defensin alpha 11167551742175519605Rat
1587187Defa10defensin alpha 10167549823675499012Rat
1583286LOC685012similar to heterogeneous nuclear ribonucleoprotein A3167347096773471996Rat
1359725Golga7golgin A7167356417273579389Rat
1565394Defb52defensin beta 52167557201475574546Rat
1564555Defa9defensin alpha 9167546571075466604Rat
1563282Defb50defensin beta 50167524970475262002Rat
1564782Defb51defensin beta 51167555485275558974Rat
1566125Defb2defensin beta 2167522746875241303Rat
1562518Defb10defensin beta 10167519817875208230Rat
1563630Defb5defensin beta 5167559732375599483Rat
1590228LOC685740hypothetical protein LOC685740167505343075054032Rat
1590848LOC364636similar to myc induced nuclear antigen167955734179559145Rat
1589653RatNP-3bdefensin RatNP-3 precursor167552834875530511Rat
1359518Cln8CLN8, transmembrane ER and ERGIC protein167982832179838212Rat
1593817Nek5NIMA-related kinase 5167480951374851895Rat
1597780Nkx6-3NK6 homeobox 3167366526973670482Rat
2318111Fam90a1family with sequence similarity 90, member A1167500103375016173Rat
2318364Smim19small integral membrane protein 19167440808574422070Rat
2323116Map1lc3b2microtubule-associated protein 1 light chain 3 beta 2167586414475874567Rat
2323322LOC100359819hypothetical protein LOC100359819167545851175459338Rat
2323473LOC100359767hypothetical LOC100359767167538729675389923Rat
2324475Spag11blsperm associated antigen 11b-like167514523475148750Rat
6485037LOC100912990beta-defensin 12-like167510994675110960Rat
6498623LOC100910418tissue-type plasminogen activator-like167374576773763198Rat
7524089LOC102551219uncharacterized LOC102551219167981672979817535Rat
7505881LOC102550761uncharacterized LOC102550761167886310178915311Rat
7513826LOC102547381uncharacterized LOC102547381167972116979725984Rat
7516097LOC102551088uncharacterized LOC102551088167439235974393752Rat
7539166LOC102555020glyceraldehyde-3-phosphate dehydrogenase-like167372410673725109Rat
7665195LOC102556951uncharacterized LOC102556951167407137274075115Rat
7666555LOC102551183uncharacterized LOC102551183167498592974987186Rat
7561455LOC102551149uncharacterized LOC102551149167970645079711937Rat
7550023LOC102557538uncharacterized LOC102557538167973254179741119Rat
7690544LOC102550986serine/arginine repetitive matrix protein 1-like167429028674293169Rat
7712656LOC102555283alpha-defensin 24-like167542226675422380Rat
7713472LOC102549912uncharacterized LOC102549912167439075074392384Rat
7700141LOC102550919uncharacterized LOC102550919167944907179480307Rat
7709651LOC102551089uncharacterized LOC102551089167958959279591704Rat
7711557LOC102550098activated RNA polymerase II transcriptional coactivator p15-like167465065474651244Rat
9076410LOC103693993uncharacterized LOC103693993167385153073855207Rat
9241721LOC103693996uncharacterized LOC103693996167576942675800150Rat
9377306LOC103693995uncharacterized LOC103693995167407819574080929Rat
9335848LOC103693994uncharacterized LOC103693994167397971773980664Rat
9436659LOC103690227uncharacterized LOC103690227167953062479540622Rat
9438733LOC103693992uncharacterized LOC103693992167387468973880778Rat
11367158LOC108348424uncharacterized LOC108348424167670815776772854Rat
11448278LOC108348292glyceraldehyde-3-phosphate dehydrogenase pseudogene167414431174145318Rat
11368550LOC108348426uncharacterized LOC108348426167713011477138640Rat
11452962LOC108348423uncharacterized LOC108348423167613789676143472Rat
11426526LOC108348420uncharacterized LOC108348420167363432673636348Rat
11378360LOC108353108alpha-defensin 9-like167539429175394630Rat
11403925LOC108353087cyclin-dependent kinase 4 pseudogene167814812978149108Rat
11405023LOC108353085uncharacterized LOC108353085167494423274945964Rat
11405117LOC108348421uncharacterized LOC108348421167418105074182023Rat
11498719LOC108348427heterogeneous nuclear ribonucleoprotein A3 pseudogene167961865279621247Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
35553D16Rat16172167611188776112058Ratregion
37786D16Rat25141167567636275676500Ratregion
36608D16Rat48150168011564180115794Ratregion
34959D16Rat14162167559497375595106Ratregion
35158D16Rat13157167817205078172206Ratregion
39822D16Rat94227167846002078460246Ratregion
40632D16Rat57228167362709473627313Ratregion
39288D16Rat37214167583877575839000Ratregion
42016D16Arb272167622616776226242Ratregion
41324D16Rat55166167666762876667805Ratregion
42412D16Rat130232167891207678912307Ratregion
40796D16Rat56221167379647973796715Ratregion
60130D16Got77298167481516574815462Ratregion
60131D16Got81111167754241577542522Ratregion
45384D16Got76112167423309174233202Ratregion
45385D16Got75200167530432075304516Ratregion
45386D16Got92167167417354674173712Ratregion
45388D16Got78185167678183476782018Ratregion
45389D16Got79228167717343277173659Ratregion
45390D16Got8093167687620776876299Ratregion
45390D16Got8093167648061776480709Ratregion
45391D16Got82213167874608578746297Ratregion
45395D16Got93175167960564979605797Ratregion
45397D16Got90124167934302079343142Ratregion
625825D16Got74204167423309074233293Ratregion
66391D16Mco6364167417348674173858Ratregion
1628156D16Wox27182167547949275479673Ratregion
1628354D16Got119129167617239476172522Ratregion
1639032D16Cebr2283167531496275315244Ratregion
1635835D16Ulb1174167617754176177714Ratregion
1637695D16Wox28200167552931775529516Ratregion
5038832RH127358207167430867174308877Ratregion
5033913RH140593200167582548475825682Ratregion
5033913RH140593200167571471375714911Ratregion
5026022RH130609180167440036874400547Ratregion
5026052RH130718198167426198474262181Ratregion
5031422AU048376248167610638876106635Ratregion
5034189RH141704200167367471973674918Ratregion
5029333RH144398122167365032373650444Ratregion
5032685RH134919189167759707277597260Ratregion
5027355AU041707101167364961873649718Ratregion
5030073BE098027158167958897179589128Ratregion
5032917RH136959152167581308975813240Ratregion
5033175RH137859166167482078374820948Ratregion
5033213RH137999204167746038177460584Ratregion
5033363RH138560209167485151174851719Ratregion
5025532RH128687217167431838674318602Ratregion
5030887BF399189131167601846476018594Ratregion
5051849RH94694190167494387874944067Ratregion
5055883RH144058228167590093475901161Ratregion
5056097RH144181232167844316778443398Ratregion
5058748BF387021181167581397875814163Ratregion
5059870BE103463155167477869074778844Ratregion
5059166BE102937206167714898777149192Ratregion
5053641RH142766173167581371375813885Ratregion
5053393RH142622191167611021276110402Ratregion
5043434RH130023184167471932574719508Ratregion
5045330RH131116185167972576179725945Ratregion
5041830RH129083180167581147675811655Ratregion
5048704RH133057197167409288574093081Ratregion
5045560RH131248203167423015874230360Ratregion
5047772RH132520194167958721379587406Ratregion
5047176RH132177185167407152174071705Ratregion
5039446RH127710219167982843279828650Ratregion
5041924RH129137199167601591876016113Ratregion
5048500RH132939217167365184273652060Ratregion
5042276RH129341193167364952173649713Ratregion
5042310RH129360185167601589976016080Ratregion
5042238RH129319181167485610574856285Ratregion
7191237Sfrp1779167337433973375117Ratregion
5040288RH128197215167409840474098618Ratregion
5043692RH130172182167455307474553255Ratregion
5072252RH136741123167973974679739868Ratregion
5076984RH139492211167580925175809461Ratregion
5075874RH138847158167454197674542134Ratregion
5075874RH138847158167451618674516344Ratregion
5074970RH138324137168008745880087594Ratregion
5076136RH139000127167359029173590417Ratregion
5075614RH138696135167422765174227785Ratregion
5079600RH141094181167337344973373629Ratregion
5077790RH139961187167423055874230744Ratregion
5077584RH139840213167442180174422013Ratregion
5079856RH141243202167337215873372359Ratregion
5080018RH141335182167359652973596710Ratregion
5080026RH141340194167409459374094786Ratregion
5078138RH140165205167480625274806456Ratregion
5078416RH140329135167580925175809385Ratregion
5079090RH140730227167394412773944353Ratregion
5070772RH134696188167576229975762486Ratregion
5080234RH141462198167471747874717675Ratregion
5073358RH137390175167434548074345654Ratregion
5073536RH137493190167337439473374593Ratregion
5070650RH134625214167455426474554477Ratregion
5071596RH135173210167337609573376304Ratregion
5071812RH135299204167485773174857934Ratregion
5072042RH135431184167337377973373972Ratregion
5074330RH137954140167409797974098118Ratregion
5071910RH135355193167471729574717487Ratregion
5065054BF405594173167782516277825334Ratregion
5067016AU048015155167688753576887689Ratregion
5067016AU048015155167681796076818114Ratregion
5067422AU047758118167404440774044524Ratregion
5070105RH94475173167409858874098760Ratregion
5069198AU046655270167790920177909464Ratregion
5069198AU046655270167790920177909422Ratregion
5065268BE121319155167585679575856950Ratregion
5062226BE106374150167715668877156837Ratregion
5060980BF389634175167448598074486154Ratregion
5061994BE112434180167455429874554477Ratregion
5060640BE098786160167449881974498978Ratregion
5064258BE120928163167412312774123289Ratregion
5064258BE120928163167374536273745524Ratregion
5064812BF405139250167595642775956676Ratregion
5082449BE119431162167590326375903424Ratregion
5087644PMC96815P1140167529449275294631Ratregion
5087648PMC96815P3175167552839275528566Ratregion
5087652PMC96815P5123167529451275294634Ratregion
5089263AU049052249167707947477079722Ratregion
5089567AU049232225167710455477104778Ratregion
5087646PMC96815P2178167563461575634792Ratregion
5087650PMC96815P4123167547860375478725Ratregion
5085461AW533825158167977414479774301Ratregion
5080782RH141778186167596782575968010Ratregion
5082911BF390395152167575978875759939Ratregion
5083137BF390838158167418823374188390Ratregion
5081677BE117978186167337001373370198Ratregion
5083591BI276346158167378857473788731Ratregion
5507705UniSTS:252200167519314675193758Ratregion
5505044Myst3249167402018874020436Ratregion
5505046Myst3156167394392473944079Ratregion
5505372Atp7b858167490617174907028Ratregion
5505768UniSTS:492990859167564768075648538Ratregion
5502928Sfrp1781167337433973375119Ratregion
5502817VDAC3177167430205974303682Ratregion
Position Markers

Flank 1: (D16Rat42)
Rat AssemblyChrPosition (strand)Source
Celera1665,511,878 - 65,512,027UniSTS
RH 3.4 Map16640.0RGD
RH 3.4 Map16640.0UniSTS
RH 2.0 Map16768.4RGD
SHRSP x BN Map1633.9399RGD
Peak: (D16Rat55)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01676,667,628 - 76,667,805NCBI
Rnor_5.01676,270,497 - 76,270,674UniSTS
RGSC_v3.41676,622,103 - 76,622,281RGD
RGSC_v3.41676,622,104 - 76,622,281UniSTS
RGSC_v3.11676,622,369 - 76,622,546RGD
Celera1669,610,546 - 69,610,723UniSTS
RH 3.4 Map16702.2UniSTS
RH 3.4 Map16702.2RGD
RH 2.0 Map16815.0RGD
SHRSP x BN Map1638.59RGD
Flank 2: (D16Rat48)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01680,115,641 - 80,115,794NCBI
Rnor_5.01679,690,255 - 79,690,408UniSTS
RGSC_v3.41679,850,041 - 79,850,195RGD
RGSC_v3.41679,850,042 - 79,850,195UniSTS
RGSC_v3.11679,850,307 - 79,850,460RGD
Celera1672,845,336 - 72,845,489UniSTS
Cytogenetic Map16q12.5UniSTS
RH 3.4 Map16730.4RGD
RH 3.4 Map16730.4UniSTS
SHRSP x BN Map1645.5099UniSTS
SHRSP x BN Map1645.5099RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162834031573340315Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)167321963880115794Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Arunc2


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Arunc2  Aerobic running capacity QTL 2  Arc2    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_cand_genes candidate genes RGD1306769, Pdlim3, Ppif detect differential expression in in the left ventricles of high aerobic capacity vs. low aerobic capacity strains; candidate genes Irs2, Acsl1 are members of biological networks containing differentially expressed genes 1547852
qtl_general only male rats were used in this study 619535
qtl_general a significant interaction was found with Arc3; rats homozygous for DA allele at both marker loci had 42% higher running distances than those homozygous for COP allele 619535