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Gene: Acsl6 (acyl-CoA synthetase long-chain family member 6) Rattus norvegicus
Symbol: Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Description: Exhibits arachidonate-CoA ligase activity; long-chain fatty acid-CoA ligase activity; and protein homodimerization activity. Involved in several processes, including generation of neurons; organophosphate biosynthetic process; and positive regulation of long-chain fatty acid import across plasma membrane. Localizes to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: arachidonate--CoA ligase; Facl6; fatty acid Coenzyme A ligase, long chain 6; LACS 6; Lacsl; long-chain acyl-CoA synthetase 6; long-chain acyl-CoA synthetase-like; long-chain-fatty-acid--CoA ligase 6; long-chain-fatty-acid--CoA ligase, brain isozyme
Homo sapiens (human) : ACSL6 (acyl-CoA synthetase long chain family member 6)  HGNC  Alliance
Mus musculus (house mouse) : Acsl6 (acyl-CoA synthetase long-chain family member 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl6 (acyl-CoA synthetase long chain family member 6)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL6 (acyl-CoA synthetase long chain family member 6)
Canis lupus familiaris (dog) : ACSL6 (acyl-CoA synthetase long chain family member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl6 (acyl-CoA synthetase long chain family member 6)
Sus scrofa (pig) : ACSL6 (acyl-CoA synthetase long chain family member 6)
Chlorocebus sabaeus (African green monkey) : ACSL6 (acyl-CoA synthetase long chain family member 6)
Heterocephalus glaber (naked mole-rat) : Acsl6 (acyl-CoA synthetase long chain family member 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01039,654,771 - 39,717,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,655,455 - 39,719,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,430,561 - 39,491,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,729,805 - 39,778,106 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,743,427 - 39,791,726 (+)NCBI
Celera1037,792,002 - 37,839,268 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Acsl6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69403
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.