Mki67 (marker of proliferation Ki-67) - Rat Genome Database

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Gene: Mki67 (marker of proliferation Ki-67) Rattus norvegicus
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Symbol: Mki67
Name: marker of proliferation Ki-67
RGD ID: 1305476
Description: Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of several diseases, including alcohol use disorder; colon cancer; mucositis; type 2 diabetes mellitus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67); INTERACTS WITH (+)-taxifolin; (-)-cotinine; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antigen identified by monoclonal antibody Ki-67; antigen KI-67; LOC291234; proliferation marker protein Ki-67
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Mki67-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81199,926,150 - 199,952,847 (-)NCBIGRCr8
mRatBN7.21190,496,319 - 190,522,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1190,496,319 - 190,522,762 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1198,852,141 - 198,878,981 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01206,011,398 - 206,037,482 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01198,684,856 - 198,710,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01207,993,895 - 208,020,454 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1207,993,895 - 208,020,454 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01214,925,922 - 214,952,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41195,310,027 - 195,336,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11195,460,292 - 195,486,216 (-)NCBI
Celera1188,211,009 - 188,236,363 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-cotinine  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyltryptophan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2':5',2''-terthiophene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-nitropropane  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-nitropropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
ABT-737  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
aminoguanidine  (ISO)
amoxicillin  (ISO)
anastrozole  (ISO)
aniline  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
atrazine  (ISO)
auramine O  (EXP)
azathioprine  (ISO)
azithromycin  (ISO)
benzene  (ISO)
benzidine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
Berberrubine  (ISO)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
betulin  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brexpiprazole  (ISO)
bromoethene  (EXP)
bucladesine  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
Carbadox  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carteolol  (ISO)
catechol  (EXP)
cefaloridine  (EXP)
celecoxib  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclohexanols  (EXP)
Cyclopamine  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
diisononyl phthalate  (ISO)
Dimefox  (ISO)
dimethylarsinic acid  (EXP)
diosmin  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (EXP)
embelin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
ethanol  (EXP,ISO)
Ethylenethiourea  (EXP)
exemestane  (ISO)
fenbendazole  (EXP)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fenthion  (ISO)
flavokawain B  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
glucose  (ISO)
glycine betaine  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
harmaline  (ISO)
Heliotrine  (EXP)
hexadecanoic acid  (ISO)
Hexamethonium  (EXP)
hydrazine  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
icariside II  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP)
iodoacetic acid  (ISO)
irinotecan  (ISO)
isoflavones  (EXP)
isoliquiritigenin  (ISO)
isopimaric acid  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
letrozole  (ISO)
Leucomalachite green  (EXP)
levonorgestrel  (ISO)
lignan  (ISO)
linezolid  (EXP)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
lucanthone  (ISO)
lupeol  (ISO)
LY294002  (ISO)
lycopene  (EXP)
maneb  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-Nitrosodiethanolamine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosomethylethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitrosobis(2-oxopropyl)amine  (EXP)
Nitrosoheptamethyleneimine  (EXP)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
Octicizer  (ISO)
olaparib  (ISO)
omacetaxine mepesuccinate  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
oxfendazole  (EXP)
ozone  (ISO)
palbociclib  (ISO)
para-Cresidine  (EXP)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pectolinarigenin  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
PhIP  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
propiconazole  (ISO)
propofol  (ISO)
propranolol  (ISO)
Pseudolaric acid B  (ISO)
Ptaquiloside  (ISO)
quartz  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
remdesivir  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
rucaparib  (ISO)
ruthenium atom  (EXP)
SB 431542  (ISO)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sophoraflavanone B  (EXP)
succimer  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theobromine  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
tolbutamide  (EXP)
topotecan  (EXP)
trabectedin  (EXP)
trametinib  (ISO)
tremolite asbestos  (ISO)
triamcinolone acetonide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
triphenylstannane  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vemurafenib  (ISO)
verteporfin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. Adams LS, etal., J Nutr. 2011 Oct;141(10):1805-12. Epub 2011 Aug 31.
2. Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt. Amin MM and Azim ZA, Indian J Pathol Microbiol. 2012 Jan-Mar;55(1):56-60.
3. Hippocampal neurovascular and hypothalamic-pituitary-adrenal axis alterations in spontaneously type 2 diabetic GK rats. Beauquis J, etal., Exp Neurol. 2010 Mar;222(1):125-34. Epub 2010 Jan 4.
4. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Broyl A, etal., Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21.
5. Clinical and pathological differences between human immunodeficiency virus-positive and human immunodeficiency virus-negative patients with plasmablastic lymphoma. Castillo JJ, etal., Leuk Lymphoma. 2010 Nov;51(11):2047-53. Epub 2010 Oct 4.
6. MicroRNA-432 functions as a tumor suppressor gene through targeting E2F3 and AXL in lung adenocarcinoma. Chen L, etal., Oncotarget. 2016 Apr 12;7(15):20041-53. doi: 10.18632/oncotarget.7884.
7. Antitumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity. Chen L, etal., PLoS One. 2011;6(9):e24407. Epub 2011 Sep 9.
8. Magnetic enhancement of cell retention, engraftment and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion. Cheng K, etal., Cell Transplant. 2012 Mar 8.
9. DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway. Cui X, etal., Cell Death Dis. 2019 Sep 20;10(10):701. doi: 10.1038/s41419-019-1943-0.
10. Perfusion MRI for monitoring the effect of sorafenib on experimental prostate carcinoma: a validation study. Cyran CC, etal., AJR Am J Roentgenol. 2012 Feb;198(2):384-91.
11. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. Dougherty U, etal., BMC Complement Altern Med. 2011 Nov 9;11:111.
12. Evolutionary conservation in various mammalian species of the human proliferation-associated epitope recognized by the Ki-67 monoclonal antibody. Falini B, etal., J Histochem Cytochem. 1989 Oct;37(10):1471-8.
13. MiR-193a-3p is an Important Tumour Suppressor in Lung Cancer and Directly Targets KRAS. Fan Q, etal., Cell Physiol Biochem. 2017;44(4):1311-1324. doi: 10.1159/000485491. Epub 2017 Nov 29.
14. Utility of Ki67 immunostaining in the grading of pineal parenchymal tumours: a multicentre study. Fevre-Montange M, etal., Neuropathol Appl Neurobiol. 2012 Feb;38(1):87-94. doi: 10.1111/j.1365-2990.2011.01202.x.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. Gemetzi C, etal., Eur J Haematol. 2012 Mar;88(3):210-23. doi: 10.1111/j.1600-0609.2011.01722.x. Epub 2011 Nov 24.
17. Ki-67 expression during rat liver regeneration after partial hepatectomy. Gerlach C, etal., Hepatology. 1997 Sep;26(3):573-8.
18. Evaluation of biocompatibility and anti-glioma efficacy of doxorubicin and irinotecan drug-eluting bead suspensions in alginate. Glage S, etal., Clin Transl Oncol. 2012 Jan;14(1):50-9.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Activation and expansion of CD8(+) T effector cells in patients with chronic graft-versus-host disease. Grogan BM, etal., Biol Blood Marrow Transplant. 2011 Aug;17(8):1121-32. Epub 2011 Mar 24.
21. 1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model. Halder SK, etal., Biol Reprod. 2012 Apr 19;86(4):116. Print 2012 Apr.
22. Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance. Jiang Z, etal., Bioengineered. 2022 Jan;13(1):810-823. doi: 10.1080/21655979.2021.2012952.
23. Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). Karamitopoulou E, etal., Pathology. 2010 Apr;42(3):229-34.
24. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
25. Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents. Leitao RF, etal., BMC Gastroenterol. 2011 Aug 16;11:90.
26. Longitudinal analysis of the human T cell response during acute hantavirus infection. Lindgren T, etal., J Virol. 2011 Oct;85(19):10252-60. Epub 2011 Jul 27.
27. Hyaluronan mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell transplantation. Lionetti V, etal., J Biol Chem. 2010 Mar 26;285(13):9949-61. doi: 10.1074/jbc.M109.087254. Epub 2010 Jan 22.
28. Proliferative potential and apoptosis in rat glioma cell lines after hyperthermia. Liu RY, etal., Neurol Med Chir (Tokyo). 1998 Apr;38(4):196-201; discussion 201-2.
29. Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus. Marashi SM, etal., J Allergy Clin Immunol. 2011 Jun;127(6):1385-93.e4. Epub 2011 May 4.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Changes in the ER, PgR, HER2, p53 and Ki-67 biological markers between primary and recurrent breast cancer: discordance rates and prognosis. Nishimura R, etal., World J Surg Oncol. 2011 Oct 17;9:131.
32. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Olave I, etal., Genes Dev. 2002 Oct 1;16(19):2509-17.
33. Inhibition of bladder tumour growth by sirolimus in an experimental carcinogenesis model. Parada B, etal., BJU Int. 2010 Mar 29.
34. Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders. Piconi S, etal., Blood. 2011 Sep 22;118(12):3263-72. Epub 2011 May 16.
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Comprehensive gene review and curation RGD comprehensive gene curation
38. Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma. Rijken AM, etal., Ann Surg Oncol. 1998 Dec;5(8):699-705.
39. Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease. Rutella S, etal., Am J Gastroenterol. 2011 Apr;106(4):762-70. Epub 2011 Mar 1.
40. Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome. Shie JH and Kuo HC, BJU Int. 2011 Jul;108(2 Pt 2):E136-41. doi: 10.1111/j.1464-410X.2010.09911.x. Epub 2010 Dec 16.
41. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
42. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Silva-Peña D, etal., Addict Biol. 2019 Sep;24(5):1019-1033. doi: 10.1111/adb.12668. Epub 2018 Sep 12.
43. Up-regulation of Cks1 and Skp2 with TNFalpha/NF-kappaB signaling in chronic progressive nephropathy. Suzuki S, etal., Genes Cells. 2011 Nov;16(11):1110-20. doi: 10.1111/j.1365-2443.2011.01553.x.
44. The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. Tsai NM, etal., J Neurochem. 2006 Nov;99(4):1251-62. Epub 2006 Sep 20.
45. Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Wang SJ, etal., Cancer Lett. 2010 Feb 3.
46. The p53/miR-193a/EGFR feedback loop function as a driving force for non-small cell lung carcinoma tumorigenesis. Wang W, etal., Ther Adv Med Oncol. 2019 May 23;11:1758835919850665. doi: 10.1177/1758835919850665. eCollection 2019.
47. [Result of p53, ki-67 protein expression in cholangiocarcinoma with in situ hybridization and immunohistochemistry methods] Wang X, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Feb;22(1):57-60.
48. Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. Weise C, etal., Pediatr Allergy Immunol. 2011 Aug;22(5):497-504. doi: 10.1111/j.1399-3038.2010.01133.x. Epub 2011 Feb 7.
49. [Study on clinicopathologic features and metastasizing potential of solid pseudopapillary tumor of pancreas.] Yang B, etal., Zhonghua Bing Li Xue Za Zhi. 2010 Jan;39(1):25-30.
50. Increased Expression of VEGF, COX-2, and Ki-67 in Barrett's Esophagus: Does the Length Matter? Zampeli E, etal., Dig Dis Sci. 2012 May;57(5):1190-6. Epub 2011 Dec 7.
51. Changes in the expression of telomere maintenance genes might play a role in the pathogenesis of systemic lupus erythematosus. Zhou JG, etal., Lupus. 2011 Jul;20(8):820-8.
Additional References at PubMed
PMID:11731231   PMID:12355204   PMID:12972605   PMID:15237214   PMID:15632090   PMID:16314515   PMID:17257418   PMID:17577209   PMID:18604197   PMID:19303854   PMID:19409883   PMID:19806804  
PMID:19946888   PMID:20857180   PMID:21388619   PMID:21464233   PMID:22378020   PMID:22658674   PMID:22954396   PMID:22959929   PMID:22984613   PMID:23107969   PMID:23284756   PMID:23786676  
PMID:24191021   PMID:24582971   PMID:25433207   PMID:25446530   PMID:26949251   PMID:27362226   PMID:28285967   PMID:29748930   PMID:35057663  


Genomics

Comparative Map Data
Mki67
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81199,926,150 - 199,952,847 (-)NCBIGRCr8
mRatBN7.21190,496,319 - 190,522,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1190,496,319 - 190,522,762 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1198,852,141 - 198,878,981 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01206,011,398 - 206,037,482 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01198,684,856 - 198,710,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01207,993,895 - 208,020,454 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1207,993,895 - 208,020,454 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01214,925,922 - 214,952,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41195,310,027 - 195,336,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11195,460,292 - 195,486,216 (-)NCBI
Celera1188,211,009 - 188,236,363 (-)NCBICelera
Cytogenetic Map1q41NCBI
MKI67
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810128,096,659 - 128,126,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10128,096,659 - 128,126,423 (-)EnsemblGRCh38hg38GRCh38
GRCh3710129,894,923 - 129,924,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610129,784,913 - 129,814,645 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410129,784,912 - 129,814,458NCBI
Celera10123,566,399 - 123,595,953 (-)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10123,469,633 - 123,499,187 (-)NCBIHuRef
CHM1_110130,177,330 - 130,206,878 (-)NCBICHM1_1
T2T-CHM13v2.010128,995,212 - 129,024,955 (-)NCBIT2T-CHM13v2.0
Mki67
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397135,291,513 - 135,318,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7135,291,513 - 135,318,090 (-)EnsemblGRCm39 Ensembl
GRCm387135,689,784 - 135,716,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7135,689,784 - 135,716,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv377142,881,471 - 142,908,062 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367135,528,127 - 135,554,760 (-)NCBIMGSCv36mm8
Celera7135,512,892 - 135,539,280 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map781.32NCBI
Mki67
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554775,847,288 - 5,875,970 (-)NCBIChiLan1.0ChiLan1.0
MKI67
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28139,974,907 - 140,004,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110139,980,261 - 140,010,069 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010124,684,336 - 124,714,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110128,933,508 - 128,963,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10128,936,037 - 128,962,555 (-)Ensemblpanpan1.1panPan2
MKI67
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12836,920,679 - 36,939,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2836,913,023 - 36,939,486 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2836,965,380 - 36,994,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02837,541,611 - 37,570,825 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12837,031,991 - 37,050,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02837,016,504 - 37,045,697 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02837,271,417 - 37,300,625 (-)NCBIUU_Cfam_GSD_1.0
Mki67
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072139,973,938 - 9,999,971 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648615,561,327 - 15,587,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKI67
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114137,266,622 - 137,296,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214149,170,365 - 149,198,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MKI67
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19120,697,183 - 120,727,039 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9120,698,834 - 120,726,866 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604882,086,680 - 82,116,196 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mki67
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473718,935,686 - 18,963,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mki67
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000038176
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

Markers in Region
RH141402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21190,508,058 - 190,508,253 (+)MAPPERmRatBN7.2
Rnor_6.01208,005,751 - 208,005,945NCBIRnor6.0
Rnor_5.01214,937,778 - 214,937,972UniSTSRnor5.0
RGSC_v3.41195,321,767 - 195,321,961UniSTSRGSC3.4
Celera1188,221,660 - 188,221,854UniSTS
RH 3.4 Map11432.0UniSTS
Cytogenetic Map1q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 37 27 19 27 1 1 49 22 39 7 1
Low 16 18 12 12 7 9 23 13 2 4 7
Below cutoff 2 2 2 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000038176   ⟹   ENSRNOP00000038727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1190,496,319 - 190,522,762 (-)Ensembl
Rnor_6.0 Ensembl1207,993,895 - 208,020,454 (-)Ensembl
RefSeq Acc Id: NM_001271366   ⟹   NP_001258295
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81199,926,150 - 199,952,593 (-)NCBI
mRatBN7.21190,496,319 - 190,522,762 (-)NCBI
Rnor_6.01207,993,895 - 208,020,454 (-)NCBI
Rnor_5.01214,925,922 - 214,952,481 (-)NCBI
Celera1188,211,009 - 188,236,363 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230453   ⟹   XP_006230515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81199,926,155 - 199,952,847 (-)NCBI
mRatBN7.21190,496,324 - 190,522,983 (-)NCBI
Rnor_6.01207,993,900 - 208,020,449 (-)NCBI
Rnor_5.01214,925,922 - 214,952,481 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258295 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230515 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11799 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038727
  ENSRNOP00000038727.6
RefSeq Acc Id: NP_001258295   ⟸   NM_001271366
- UniProtKB: D4A0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230515   ⟸   XM_006230453
- Peptide Label: isoform X1
- UniProtKB: D4A0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038727   ⟸   ENSRNOT00000038176
Protein Domains
FHA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690495
Promoter ID:EPDNEW_R1020
Type:initiation region
Name:Mki67_1
Description:marker of proliferation Ki-67
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01208,020,499 - 208,020,559EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305476 AgrOrtholog
BioCyc Gene G2FUF-57145 BioCyc
Ensembl Genes ENSRNOG00000028137 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038176.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/TrEMBL
InterPro FHA_dom UniProtKB/TrEMBL
  K167R UniProtKB/TrEMBL
  PP1-bd UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
NCBI Gene 291234 ENTREZGENE
PANTHER ANTIGEN KI-67-LIKE PROTEIN UniProtKB/TrEMBL
  PROLIFERATION MARKER PROTEIN KI-67 UniProtKB/TrEMBL
Pfam FHA UniProtKB/TrEMBL
  K167R UniProtKB/TrEMBL
  PP1_bind UniProtKB/TrEMBL
PhenoGen Mki67 PhenoGen
PROSITE FHA_DOMAIN UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028137 RatGTEx
SMART FHA UniProtKB/TrEMBL
  K167R UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
UniProt D4A0Y6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Mki67  marker of proliferation Ki-67  Mki67  antigen identified by monoclonal antibody Ki-67  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mki67  antigen identified by monoclonal antibody Ki-67   Mki67_predicted  antigen identified by monoclonal antibody Ki-67 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mki67_predicted  antigen identified by monoclonal antibody Ki-67 (predicted)      Symbol and Name status set to approved 70820 APPROVED