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Gene: Mki67 (marker of proliferation Ki-67) Rattus norvegicus
Symbol: Mki67
Name: marker of proliferation Ki-67
Description: Predicted to have protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; cell population proliferation; and hyaluronan metabolic process. Localizes to the nucleus. Used to study leiomyoma; malignant glioma; and prostate carcinoma. Biomarker of kidney disease; mucositis; type 2 diabetes mellitus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67); INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: antigen identified by monoclonal antibody Ki-67; antigen KI-67; LOC291234
Homo sapiens (human) : MKI67 (marker of proliferation Ki-67)  HGNC  Alliance
Mus musculus (house mouse) : Mki67 (antigen identified by monoclonal antibody Ki 67)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mki67 (marker of proliferation Ki-67)
Pan paniscus (bonobo/pygmy chimpanzee) : MKI67 (marker of proliferation Ki-67)
Canis lupus familiaris (dog) : MKI67 (marker of proliferation Ki-67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mki67 (marker of proliferation Ki-67)
Sus scrofa (pig) : MKI67 (marker of proliferation Ki-67)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01207,993,895 - 208,020,454 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01214,925,922 - 214,952,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41195,310,027 - 195,336,224 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11195,460,292 - 195,486,216 (-)NCBI
Celera1188,211,009 - 188,236,363 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mki67
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305476
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.