Gene: Mki67 (marker of proliferation Ki-67) Rattus norvegicus
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Symbol: Mki67
Name: marker of proliferation Ki-67
Description: ENCODES a protein that exhibits protein C-terminus binding (ortholog); INVOLVED IN animal organ regeneration; cell population proliferation; cellular response to heat; ASSOCIATED WITH kidney disease; leiomyoma; malignant glioma; FOUND IN nucleus; chromosome, centromeric region (ortholog); condensed chromosome (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine
AGR Description: Predicted to have protein C-terminus binding activity; involved in several processes, including DNA metabolic process, animal organ regeneration, and cell population proliferation; localizes to the nucleus; used to study leiomyoma, malignant glioma, and prostate carcinoma; biomarker of kidney disease, mucositis, type 2 diabetes mellitus, and urinary bladder cancer; orthologous to human MKI67 (marker of proliferation Ki-67).
Merged Description: Predicted to have protein C-terminus binding activity; involved in several processes, including DNA metabolic process, animal organ regeneration, and cell population proliferation; localizes to the nucleus; used to study leiomyoma, malignant glioma, and prostate carcinoma; biomarker of kidney disease, mucositis, type 2 diabetes mellitus, and urinary bladder cancer; orthologous to human MKI67 (marker of proliferation Ki-67); INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: antigen identified by monoclonal antibody Ki-67; antigen KI-67; LOC291234
Orthologs:
Homo sapiens (human) : MKI67 (marker of proliferation Ki-67)  HGNC  Alliance
Mus musculus (house mouse) : Mki67 (antigen identified by monoclonal antibody Ki 67)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mki67 (marker of proliferation Ki-67)
Pan paniscus (bonobo/pygmy chimpanzee) : MKI67 (marker of proliferation Ki-67)
Canis lupus familiaris (dog) : MKI67 (marker of proliferation Ki-67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mki67 (marker of proliferation Ki-67)
Sus scrofa (pig) : MKI67 (marker of proliferation Ki-67)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01207,993,895 - 208,020,454 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01214,925,922 - 214,952,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41195,310,027 - 195,336,224 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11195,460,292 - 195,486,216 (-)NCBI
Celera1188,211,009 - 188,236,363 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mki67
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305476
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.