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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:131518
Term: N,N-bis(2-hydroxypropyl)nitrosamine
Definition: A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.
Chemical ID: MESH:C012457
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67multiple interactionsEXP 6480464CTD[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein, [Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein, Copper deficiency inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein], Copper inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein], Indomethacin inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein], nimesulide inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein]

PMID:19497425, PMID:22387750
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.