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Gene: MKI67 (marker of proliferation Ki-67) Homo sapiens
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Symbol: MKI67
Name: marker of proliferation Ki-67
Description: Exhibits protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Localizes to the nuclear body and nucleolus. Colocalizes with the condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; diffuse large B-cell lymphoma; endocrine gland cancer (multiple); interstitial cystitis; and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen identified by monoclonal antibody Ki-67; antigen KI-67; antigen Ki67; KIA; MIB-; MIB-1; PPP1R105; proliferation marker protein Ki-67; proliferation-related Ki-67 antigen
Orthologs:
Mus musculus (house mouse) : Mki67 (antigen identified by monoclonal antibody Ki 67)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mki67 (marker of proliferation Ki-67)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mki67 (marker of proliferation Ki-67)
Pan paniscus (bonobo/pygmy chimpanzee) : MKI67 (marker of proliferation Ki-67)
Canis lupus familiaris (dog) : MKI67 (marker of proliferation Ki-67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mki67 (marker of proliferation Ki-67)
Sus scrofa (pig) : MKI67 (marker of proliferation Ki-67)
Chlorocebus sabaeus (African green monkey) : MKI67 (marker of proliferation Ki-67)
Heterocephalus glaber (naked mole-rat) : Mki67 (marker of proliferation Ki-67)
more info ...
Related Pseudogenes: MKI67P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10128,096,659 - 128,126,423 (-)Ensembl
GRCh3810128,096,659 - 128,126,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710129,894,923 - 129,924,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610129,784,913 - 129,814,645 (-)NCBINCBI36hg18NCBI36
Build 3410129,784,912 - 129,814,458NCBI
Celera10123,566,399 - 123,595,953 (-)NCBI
Cytogenetic Map10q26.2NCBI
HuRef10123,469,633 - 123,499,187 (-)NCBIHuRef
CHM1_110130,177,330 - 130,206,878 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MKI67
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313525
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.