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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67decreases expressionISOMKI67 (Homo sapiens)6480464CTDCurcumin results in decreased expression of MKI67 proteinPMID:18226269 PMID:19372569
Mki67multiple interactionsISOMki67 (Mus musculus)6480464CTD[Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 proteinPMID:17440100
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