Pde10a (phosphodiesterase 10A) - Rat Genome Database

Name: Pde10a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pde10a (phosphodiesterase 10A) Rattus norvegicus

Analyze

Symbol:

Pde10a

Name:

phosphodiesterase 10A

RGD ID:

68434

Description:

Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in membrane and perikaryon. Orthologous to human PDE10A (phosphodiesterase 10A); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; Pde10a3; testis-specific phosphodiesterase PDE10A2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE10A (phosphodiesterase 10A)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Pde10a (phosphodiesterase 10A)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PDE10A (phosphodiesterase 10A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Mus musculus (house mouse):	Pde10a (phosphodiesterase 10A)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	pde-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	51,765,743 - 52,218,086 (-)	NCBI
Rnor_6.0 Ensembl	1	52,360,296 - 52,544,450 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	52,360,296 - 52,544,448 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	53,617,430 - 53,800,479 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	46,392,900 - 46,589,076 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	46,395,844 - 46,592,020 (-)	NCBI
Celera	1	47,539,418 - 47,723,290 (-)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain Injuries, Traumatic (IEP)

Developmental Disabilities (ISO)

Infantile-Onset Limb and Orofacial Dyskinesia (ISO)

Striatal Degeneration, Autosomal Dominant 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3',5'-cyclic AMP (ISO)

3',5'-cyclic GMP (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

5-(hydroxymethyl)cytosine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

belinostat (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butanal (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

clothianidin (ISO)

clozapine (EXP,ISO)

cocaine (ISO)

dextran sulfate (ISO)

diazinon (EXP)

dipyridamole (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

flavonoids (EXP)

folic acid (ISO)

graphite (EXP)

haloperidol (EXP)

L-methionine (ISO)

mercury dibromide (ISO)

morphine (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel sulfate (ISO)

nicotine (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (ISO)

pentanal (ISO)

phencyclidine (ISO)

phenylmercury acetate (ISO)

PhIP (EXP)

rotenone (EXP)

SB 431542 (ISO)

T-2 toxin (EXP)

testosterone (EXP)

testosterone enanthate (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cAMP catabolic process (IEA)

cGMP catabolic process (IEA)

negative regulation of cAMP-mediated signaling (IDA)

negative regulation of cGMP-mediated signaling (IBA,IDA)

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

regulation of protein kinase A signaling (ISO)

signal transduction (IBA,IEA)

Cellular Component

cytoplasm (IEA)

membrane (IDA)

neuronal cell body (IDA)

perikaryon (IDA)

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity (IEA)

3',5'-cyclic-GMP phosphodiesterase activity (IEA)

3',5'-cyclic-nucleotide phosphodiesterase activity (IBA,IEA,ISO)

cAMP binding (ISO)

cGMP binding (IEA)

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (IBA,ISO,ISS)

cyclic-nucleotide phosphodiesterase activity (IDA)

metal ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

protein kinase A (PKA) signaling pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated


1.	Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2.	Fujishige K, etal., Eur J Biochem 1999 Dec;266(3):1118-27.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	GOA data from the GO Consortium
5.	KEGG
6.	Kotera J, etal., J Biol Chem. 2004 Feb 6;279(6):4366-75. Epub 2003 Nov 6.
7.	Kruse LS, etal., Brain Res. 2009 Jul 24;1281:25-34. Epub 2009 May 13.
8.	Matthiesen K and Nielsen J, Biochem J. 2009 Oct 12;423(3):401-9. doi: 10.1042/BJ20090982.
9.	MGD data from the GO Consortium
10.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	Pipeline to import KEGG annotations from KEGG into RGD
12.	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	RGD automated data pipeline
14.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	RGD automated import pipeline for gene-chemical interactions
16.	Seeger TF, etal., Brain Res. 2003 Sep 26;985(2):113-26.
17.	Song H, etal., J Proteome Res. 2018 Feb 2;17(2):858-869. doi: 10.1021/acs.jproteome.7b00618. Epub 2017 Dec 27.
18.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19.	Xie Z, etal., Neuroscience. 2006 May 12;139(2):597-607. Epub 2006 Feb 17.

Additional References at PubMed

PMID:10359840	PMID:14752115	PMID:18923023	PMID:19056933	PMID:19103603	PMID:21194525	PMID:21494592	PMID:21515371	PMID:21777010	PMID:22142545	PMID:26256420	PMID:27058446
PMID:30053369

Genomics

Comparative Map Data

Pde10a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	51,765,743 - 52,218,086 (-)	NCBI
Rnor_6.0 Ensembl	1	52,360,296 - 52,544,450 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	52,360,296 - 52,544,448 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	53,617,430 - 53,800,479 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	46,392,900 - 46,589,076 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	46,395,844 - 46,592,020 (-)	NCBI
Celera	1	47,539,418 - 47,723,290 (-)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

PDE10A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	165,327,287 - 165,988,078 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	165,327,287 - 165,988,115 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	165,740,778 - 166,076,729 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	165,664,519 - 165,995,574 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	165,714,945 - 166,045,996	NCBI
Celera	6	166,478,886 - 166,814,271 (-)	NCBI
Cytogenetic Map	6	q27	NCBI
HuRef	6	163,202,267 - 163,537,621 (-)	NCBI		HuRef
CHM1_1	6	166,003,719 - 166,338,432 (-)	NCBI		CHM1_1

Pde10a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	8,742,719 - 9,205,480 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	17	8,744,204 - 9,205,480 (+)	Ensembl
GRCm38	17	8,525,187 - 8,986,648 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	8,525,372 - 8,986,648 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	8,994,610 - 9,179,513 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	8,639,919 - 8,824,822 (+)	NCBI			mm8
Celera	17	8,848,994 - 9,030,858 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI

Pde10a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	16,114,530 - 16,365,146 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	16,114,530 - 16,370,648 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDE10A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	168,259,978 - 168,596,401 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	168,265,707 - 168,645,231 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	163,274,252 - 163,612,749 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

PDE10A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	53,457,781 - 54,049,735 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	53,462,979 - 53,801,966 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	54,243,884 - 54,542,326 (-)	NCBI
ROS_Cfam_1.0	1	53,634,410 - 54,231,358 (-)	NCBI
UMICH_Zoey_3.1	1	53,531,754 - 53,830,179 (-)	NCBI
UNSW_CanFamBas_1.0	1	53,379,457 - 53,678,753 (-)	NCBI
UU_Cfam_GSD_1.0	1	54,012,303 - 54,310,827 (-)	NCBI

Pde10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	148,143,922 - 148,659,124 (-)	NCBI
SpeTri2.0	NW_004936489	15,401,248 - 15,671,594 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE10A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	3,120,223 - 3,392,651 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	3,120,418 - 3,394,236 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	4,618,673 - 4,742,489 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE10A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	93,012,027 - 93,684,349 (-)	NCBI
ChlSab1.1 Ensembl	13	93,020,696 - 93,344,369 (-)	Ensembl
Vero_WHO_p1.0	NW_023666040	64,833,189 - 65,491,475 (-)	NCBI

Pde10a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624785	13,208,518 - 13,885,261 (+)	NCBI

Position Markers

D17Mit247

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	51,776,532 - 51,776,645 (+)	MAPPER
Rnor_6.0	1	52,366,636 - 52,366,748	NCBI	Rnor6.0
Rnor_5.0	1	53,623,770 - 53,623,882	UniSTS	Rnor5.0
RGSC_v3.4	1	46,399,301 - 46,399,413	UniSTS	RGSC3.4
Celera	1	47,545,819 - 47,545,931	UniSTS
Cytogenetic Map	1	q11	UniSTS

BE121313

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	51,943,640 - 51,943,799 (+)	MAPPER
Rnor_6.0	1	52,534,475 - 52,534,633	NCBI	Rnor6.0
Rnor_5.0	1	53,790,506 - 53,790,664	UniSTS	Rnor5.0
RGSC_v3.4	1	46,579,103 - 46,579,261	UniSTS	RGSC3.4
Celera	1	47,713,317 - 47,713,475	UniSTS
RH 3.4 Map	1	607.2	UniSTS
Cytogenetic Map	1	q11	UniSTS

BE097292

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	51,964,411 - 51,964,566 (+)	MAPPER
Rnor_6.0	1	52,554,878 - 52,555,032	NCBI	Rnor6.0
Rnor_5.0	1	53,810,943 - 53,811,097	UniSTS	Rnor5.0
RGSC_v3.4	1	46,600,046 - 46,600,200	UniSTS	RGSC3.4
Celera	1	47,733,835 - 47,733,989	UniSTS
RH 3.4 Map	1	606.7	UniSTS
Cytogenetic Map	1	q11	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	64407321	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	254393	86904217	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5655769	122614963	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	5655772	85706974	Rat
1300167	Hrtrt2	Heart rate QTL 2	4.35		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	11314489	75844121	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	1	11314489	83657083	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11314489	83657083	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11314489	83657083	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11314489	83657083	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11314489	83657083	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11314489	83657083	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11314489	83657083	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	12493439	57493439	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	13629251	58629251	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20341560	58000154	Rat
724520	Bp145	Blood pressure QTL 145	2.1	0.0024	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	21079305	66079305	Rat
1357400	Bw62	Body weight QTL62	4.05		inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	1	23406428	68406428	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	23406428	108057505	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	24297799	78748000	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	25951907	130917265	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	31489454	79689689	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	34449112	79449112	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	34449112	79449112	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34993530	173445086	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	35377508	94364229	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	35377692	217372257	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	35854167	80854167	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	35854167	80854167	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	35854167	80854167	Rat
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	36033165	79689689	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	36033165	79689689	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	41907249	86907249	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43579208	126240667	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43579208	126240667	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43579208	126240667	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43579208	126240667	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43579208	126240667	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	1	43579208	126240667	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43579208	126240667	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	46113461	79689689	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	49147799	156446783	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	49547328	83657083	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49578577	94578577	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49578577	169852184	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49578693	217054291	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	50522714	57861469	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	50522714	94225616	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	182
Count of miRNA genes:	91
Interacting mature miRNAs:	110
Transcripts:	ENSRNOT00000043474, ENSRNOT00000067142
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			5						64		8
Low	2	38	16	7	17	7	8	10	10	35	33	9	8
Below cutoff	1	5	32	30	2	30		1				2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001388509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001388510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001388511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB027155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB027156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY462091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY462092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY462093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY462094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY462095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000043474 ⟹ ENSRNOP00000042134

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	52,360,296 - 52,544,450 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000067142 ⟹ ENSRNOP00000060834

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	52,361,038 - 52,495,582 (-)	Ensembl

RefSeq Acc Id:

NM_001388509 ⟹ NP_001375438

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,138 - 52,218,086 (-)	NCBI

RefSeq Acc Id:

NM_001388510 ⟹ NP_001375439

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,138 - 52,218,086 (-)	NCBI

RefSeq Acc Id:

NM_001388511 ⟹ NP_001375440

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,138 - 52,218,086 (-)	NCBI

RefSeq Acc Id:

NM_022236 ⟹ NP_071572

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,138 - 51,953,614 (-)	NCBI
Rnor_6.0	1	52,360,296 - 52,544,448 (-)	NCBI
Rnor_5.0	1	53,617,430 - 53,800,479 (-)	NCBI
RGSC_v3.4	1	46,392,900 - 46,589,076 (-)	RGD
Celera	1	47,539,418 - 47,723,290 (-)	RGD

Sequence:

show sequence

GAATTCGGCACGAGGCAGCGGCGGGCGGCGGCGGCTCTTCCTTTCGCCTGCGATCCAAGGCTTG
CTGCTCCCAGCCCGCTCCGGGCCCCGGCCACCTCCACCGCCGCGGCTCCCCTTACACCCGGGCG
CACACCGCGCGGACTCCTTGGGTTTTCCGGGTGCCGGCGGGGGCTGCCCTGGCCTCGGCCCCGG
CTCTGCGGCCGGTGGCCGAACTCCGTGGCGGCCCCGAGGCACCGCCCTCCCCCTTGCCACTGCC
TGGCCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCCTCTAACAATGCGAGTTGCTTCCGAA
GGCTGACCGAGTGTTTCCTCAGCCCCAGTTTGACGGATGAAAAGGTGAAGGCCTATCTTTCCCT
CCATCCCCAGGTATTAGACGAGTTTGTTTCTGAAAGTGTTAGTGCGGAGACTGTGGAGAAGTGG
CTGAAGAGGAAAAACAACAAAGCAGAAGATGAACCATCTCCTAAGGAAGTCAGCAGGTACCAGG
ACACGAACATGCAGGGAGTCGTGTACGAGCTGAACAGCTACATAGAGCAGCGCCTGGACACCGG
CGGGGACAACCACCTGCTCCTGTACGAGCTAAGCAGTATCATCAGGATAGCCACAAAAGCCGAC
GGATTTGCACTGTACTTCCTTGGAGAGTGCAATAATAGTCTGTGTGTCTTCACACCACCCGGAA
TGAAGGAAGGTCAACCCCGTCTCATCCCCGCAGGGCCCATCACCCAGGGCACCACCATCTCTGC
CTATGTGGCCAAGTCTAGGAAGACCCTGCTGGTAGAGGACATCCTTGGGGATGAGCGATTTCCC
AGAGGCACTGGTCTGGAGTCAGGAACCCGAATCCAGTCTGTCCTTTGCTTGCCTATTGTCACTG
CCATTGGAGACTTGATTGGCATCCTTGAACTGTACAGGCACTGGGGCAAAGAGGCCTTCTGCCT
CAGCCATCAGGAGGTTGCAACCGCCAATCTCGCTTGGGCTTCCGTAGCAATACACCAGGTGCAG
GTGTGCAGAGGTCTCGCCAAGCAGACCGAACTGAATGACTTCCTGCTCGATGTATCAAAGACAT
ACTTTGATAACATAGTCGCCATAGACTCTCTACTTGAACACATCATGATATATGCAAAAAATCT
AGTGAACGCCGACCGCTGCGCGCTCTTCCAGGTGGACCACAAGAACAAGGAGCTGTACTCGGAC
CTGTTTGACATTGGGGAGGAGAAGGAGGGGAAGCCCGTCTTCAAGAAGACCAAGGAGATCAGAT
TTTCCATTGAGAAAGGGATTGCTGGTCAAGTGGCAAGAACGGGAGAAGTCCTGAACATTCCTGA
TGCCTACGCAGACCCGCGCTTTAACAGGGAGGTGGACCTGTACACAGGCTATACCACGCGGAAC
ATTCTGTGTATGCCCATAGTGAGCCGCGGCAGCGTGATCGGTGTGGTGCAAATGGTTAACAAGA
TCAGCGGCAGCGCCTTCTCCAAGACGGATGAGAACAACTTCAAGATGTTTGCTGTCTTCTGCGC
TCTGGCCCTGCACTGCGCTAACATGTACCACAGGATCCGCCACTCAGAGTGCATCTACAGGGTT
ACCATGGAGAAGCTGTCTTACCACAGCATCTGCACCTCTGAGGAATGGCAAGGCCTCATGCACT
TCAACTTGCCAGCACGCATCTGCCGGGACATCGAGCTATTCCACTTTGACATTGGTCCTTTCGA
GAACATGTGGCCTGGGATCTTTGTCTACATGATCCATCGGTCTTGTGGGACATCCTGTTTTGAA
CTTGAAAAATTGTGCCGTTTTATCATGTCTGTGAAGAAGAACTATAGGCGGGTTCCTTACCACA
ACTGGAAGCATGCAGTCACGGTGGCGCACTGCATGTACGCCATACTTCAAAACAACAATGGCCT
CTTCACAGACCTTGAGCGCAAAGGCCTGCTAATTGCCTGTCTGTGCCATGACCTGGACCACAGG
GGCTTCAGTAACAGCTACCTGCAGAAATTCGACCACCCCCTGGCTGCGTTGTACTCCACCTCCA
CCATGGAGCAACACCACTTCTCCCAGACGGTGTCCATCCTCCAGCTGGAAGGACACAACATCTT
CTCCACCCTGAGCTCCAGCGAGTACGAGCAGGTGCTGGAGATCATCCGCAAAGCCATCATCGCC
ACTGACCTCGCACTGTACTTTGGGAACAGGAAGCAGTTGGAGGAGATGTACCAGACAGGGTCGC
TGAACCTCCACAACCAGTCCCATCGAGACCGCGTCATCGGCTTGATGATGACTGCCTGCGATCT
TTGCTCTGTGACGAAACTATGGCCAGTTACAAAATTGACAGCAAATGATATATATGCAGAGTTC
TGGGCTGAGGGGGATGAGATGAAGAAGTTGGGGATACAGCCCATCCCTATGATGGACAGAGACA
AGCGAGATGAAGTCCCTCAAGGACAGCTTGGATTCTACAATGCTGTGGCCATCCCCTGCTATAC
CACCCTGACGCAGATCCTCCCACCCACAGAGCCTCTGCTGAAGGCCTGCAGGGATAACCTCAAT
CAGTGGGAGAAGGTAATTCGAGGGGAAGAGACAGCAATGTGGATTTCAGGCCCAGCAACTAGCA
AAAGCACATCTGAGAAGCCGACCAGGAAGGTCGATGACTGATCCTGAGGTGATGTCTGCCTAGC
AACTGACTCAACCTGCTTCTGTGACTTCGTTCTTTTTATTTTTATTTTTTTAACGGGGTGAAAA
CCTCTCTCAGAAGGTACCGTCGCATATCCATGTGAAGCAGATGACTCCCTGCGCACACCTCGGA
CCGTGAGCAACCCGGGCTCCACCGTGTTCAGACGTCGGCTATTCCATGGCTCCGCCTGACCCCC
GAATGCCATTTGCTACCAGGCCAGAACTGCGCTGGCTGGAGGGGGCAGAGACGACAGGAGGGGT
TCTTACCTGCATCCTTCCATGAGGGTGTGGTTCTGTGTTTCATCTCTAACAGAGATGCTACTGC
TTGGTGGCGTTTGTTAGAAATGGGACACATGCCCCTGTCGTGAAGTTTACATGTGACCTTCTTG
TAGGTAACTTGAGTTCGTAGCCTGGGACCCCTGTAATGAAGGTTACAGTCCACAGGTGATAGAG
AAATTCAAGCTGTAAGTTACAGGTGCACTACAAGTGTGTTCATTCAGTTTACCTGGGGGCATGG
AGGTGAGTCAGCTCCACGAGGAAGGAAGCATACCTCTGCCCTCATCAAGGGGACACAGGGTACA
TCCCAGGCATCAGAGAACTGCAGCTCACCTCAAACCATGTCAAAGAATTAAAACACACCCCCAT
CCCCTCACTGTAGCCTTTGGCAACTTCGCCAAACCCTTCACACAAAGAAAATAAAAGTAAGGCG
TATAAATTTCCTCCAGCAAGCCTCGTGCCGAATTC

hide sequence

RefSeq Acc Id:

XM_039089147 ⟹ XP_038945075

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,999,679 (-)	NCBI

RefSeq Acc Id:

XM_039089154 ⟹ XP_038945082

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,999,690 (-)	NCBI

RefSeq Acc Id:

XM_039089156 ⟹ XP_038945084

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,765,743 - 51,954,190 (-)	NCBI

RefSeq Acc Id:

XM_039089160 ⟹ XP_038945088

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 52,216,507 (-)	NCBI

RefSeq Acc Id:

XM_039089171 ⟹ XP_038945099

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 52,216,507 (-)	NCBI

RefSeq Acc Id:

XM_039089177 ⟹ XP_038945105

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,904,826 (-)	NCBI

RefSeq Acc Id:

XM_039089181 ⟹ XP_038945109

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,904,826 (-)	NCBI

RefSeq Acc Id:

XM_039089184 ⟹ XP_038945112

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,906,531 (-)	NCBI

RefSeq Acc Id:

XM_039089188 ⟹ XP_038945116

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,868,011 (-)	NCBI

RefSeq Acc Id:

XM_039089191 ⟹ XP_038945119

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,770,107 - 51,825,465 (-)	NCBI

RefSeq Acc Id:

XR_005491608

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	51,800,923 - 51,999,679 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001375438	(Get FASTA)	NCBI Sequence Viewer
	NP_001375439	(Get FASTA)	NCBI Sequence Viewer
	NP_001375440	(Get FASTA)	NCBI Sequence Viewer
	NP_071572	(Get FASTA)	NCBI Sequence Viewer
	XP_038945075	(Get FASTA)	NCBI Sequence Viewer
	XP_038945082	(Get FASTA)	NCBI Sequence Viewer
	XP_038945084	(Get FASTA)	NCBI Sequence Viewer
	XP_038945088	(Get FASTA)	NCBI Sequence Viewer
	XP_038945099	(Get FASTA)	NCBI Sequence Viewer
	XP_038945105	(Get FASTA)	NCBI Sequence Viewer
	XP_038945109	(Get FASTA)	NCBI Sequence Viewer
	XP_038945112	(Get FASTA)	NCBI Sequence Viewer
	XP_038945116	(Get FASTA)	NCBI Sequence Viewer
	XP_038945119	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS21243	(Get FASTA)	NCBI Sequence Viewer
	AAS21244	(Get FASTA)	NCBI Sequence Viewer
	AAS21245	(Get FASTA)	NCBI Sequence Viewer
	AAS21246	(Get FASTA)	NCBI Sequence Viewer
	AAS21247	(Get FASTA)	NCBI Sequence Viewer
	BAA88996	(Get FASTA)	NCBI Sequence Viewer
	BAA88997	(Get FASTA)	NCBI Sequence Viewer
	EDL83102	(Get FASTA)	NCBI Sequence Viewer
	EDL83103	(Get FASTA)	NCBI Sequence Viewer
	EDL83104	(Get FASTA)	NCBI Sequence Viewer
	EDL83105	(Get FASTA)	NCBI Sequence Viewer
	EDL83106	(Get FASTA)	NCBI Sequence Viewer
	Q9QYJ6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_071572 ⟸ NM_022236
- Peptide Label:	isoform 1
- UniProtKB:	Q9QYJ6 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKA EDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLG ECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESG TRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQ TELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEK EGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS RGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYH SICTSEEWQGLMHFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFI MSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQ KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFG NRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMK KLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRG EETAMWISGPATSKSTSEKPTRKVDD hide sequence

RefSeq Acc Id:

ENSRNOP00000042134 ⟸ ENSRNOT00000043474

RefSeq Acc Id:

ENSRNOP00000060834 ⟸ ENSRNOT00000067142

RefSeq Acc Id:	XP_038945084 ⟸ XM_039089156
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945099 ⟸ XM_039089171
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038945088 ⟸ XM_039089160
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945082 ⟸ XM_039089154
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945075 ⟸ XM_039089147
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945112 ⟸ XM_039089184
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038945105 ⟸ XM_039089177
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038945109 ⟸ XM_039089181
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038945116 ⟸ XM_039089188
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038945119 ⟸ XM_039089191
- Peptide Label:	isoform X6

RefSeq Acc Id:	NP_001375440 ⟸ NM_001388511
- Peptide Label:	isoform 3

RefSeq Acc Id:	NP_001375438 ⟸ NM_001388509
- Peptide Label:	isoform 2

RefSeq Acc Id:	NP_001375439 ⟸ NM_001388510
- Peptide Label:	isoform 2

Protein Domains

PDEase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68434	AgrOrtholog
Ensembl Genes	ENSRNOG00000011310	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000042134	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000060834	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000043474	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000067142	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1300.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.450.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GAF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GAF-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HD/PDEase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_catalytic_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_catalytic_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:63885	UniProtKB/Swiss-Prot
NCBI Gene	63885	ENTREZGENE
Pfam	GAF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pde10a	PhenoGen
PRINTS	PDIESTERASE1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PDEASE_I_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEASE_I_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	GAF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HDc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC206846
UniProt	F1LX13_RAT	UniProtKB/TrEMBL
	PDE10_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q6S9E6	UniProtKB/Swiss-Prot
	Q6S9E7	UniProtKB/Swiss-Prot
	Q6S9E8	UniProtKB/Swiss-Prot
	Q6S9E9	UniProtKB/Swiss-Prot
	Q9QYJ5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Pde10a	phosphodiesterase 10A			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)