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Gene: Pde10a (phosphodiesterase 10A) Mus musculus
Symbol: Pde10a
Name: phosphodiesterase 10A
Description: Exhibits 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in regulation of cAMP-mediated signaling and regulation of protein kinase A signaling. Predicted to localize to membrane and perikaryon. Is expressed in alimentary system; cardiovascular system; nervous system; and sensory organ. Orthologous to human PDE10A (phosphodiesterase 10A); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase; PDE10A2 brain-specific isoform
Homo sapiens (human) : PDE10A (phosphodiesterase 10A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pde10a (phosphodiesterase 10A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde10a (phosphodiesterase 10A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE10A (phosphodiesterase 10A)
Canis lupus familiaris (dog) : PDE10A (phosphodiesterase 10A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde10a (phosphodiesterase 10A)
Sus scrofa (pig) : PDE10A (phosphodiesterase 10A)
Chlorocebus sabaeus (African green monkey) : PDE10A (phosphodiesterase 10A)
Heterocephalus glaber (naked mole-rat) : Pde10a (phosphodiesterase 10A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl178,525,372 - 8,986,648 (+)EnsemblGRCm38mm10GRCm38
GRCm38178,525,187 - 8,986,648 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37178,994,610 - 9,179,513 (+)NCBIGRCm37mm9NCBIm37
MGSCv36178,639,919 - 8,824,822 (+)NCBImm8
Celera178,848,994 - 9,030,858 (+)NCBICelera
Cytogenetic Map17A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pde10a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68650
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.