Pde10a (phosphodiesterase 10A) - Rat Genome Database

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Gene: Pde10a (phosphodiesterase 10A) Ictidomys tridecemlineatus
Analyze
Symbol: Pde10a
Name: phosphodiesterase 10A
RGD ID: 12461691
Description: ENCODES a protein that exhibits cAMP binding (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN negative regulation of cAMP-mediated signaling (ortholog); negative regulation of cGMP-mediated signaling (ortholog); regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); Infantile-Onset Limb and Orofacial Dyskinesia (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,143,922 - 148,659,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648915,400,629 - 15,671,600 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648915,401,248 - 15,671,594 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pde10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,143,922 - 148,659,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648915,400,629 - 15,671,600 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648915,401,248 - 15,671,594 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386165,327,289 - 165,988,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6165,327,287 - 165,988,117 (-)EnsemblGRCh38hg38GRCh38
GRCh376165,740,778 - 166,076,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366165,664,519 - 165,995,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 346165,714,945 - 166,045,996NCBI
Celera6166,478,886 - 166,814,271 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6163,202,267 - 163,537,621 (-)NCBIHuRef
CHM1_16166,003,719 - 166,338,432 (-)NCBICHM1_1
T2T-CHM13v2.06166,693,362 - 167,356,384 (-)NCBIT2T-CHM13v2.0
Pde10a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,742,719 - 9,205,480 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,744,204 - 9,205,480 (+)EnsemblGRCm39 Ensembl
GRCm38178,525,187 - 8,986,648 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,525,372 - 8,986,648 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,994,610 - 9,179,513 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36178,639,919 - 8,824,822 (+)NCBIMGSCv36mm8
Celera178,848,994 - 9,030,858 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.96NCBI
Pde10a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,313,343 - 54,765,668 (-)NCBIGRCr8
mRatBN7.2151,765,743 - 52,218,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl151,770,132 - 52,216,563 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,476,016 - 52,919,928 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0158,463,473 - 58,911,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,551,592 - 52,995,519 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,360,296 - 52,544,448 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,360,296 - 52,544,450 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,617,430 - 53,800,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,392,900 - 46,589,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,395,844 - 46,592,020 (-)NCBI
Celera147,539,418 - 47,723,290 (-)NCBICelera
Cytogenetic Map1q12NCBI
Pde10a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543916,114,530 - 16,365,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543916,114,530 - 16,370,648 (+)NCBIChiLan1.0ChiLan1.0
PDE10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25185,514,841 - 186,181,000 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16183,411,044 - 184,076,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06163,274,252 - 163,612,749 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16168,259,978 - 168,596,401 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6168,265,707 - 168,645,231 (-)Ensemblpanpan1.1panPan2
PDE10A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1153,457,781 - 54,049,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl153,462,979 - 53,801,966 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha154,243,884 - 54,542,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0153,634,410 - 54,231,358 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl153,639,079 - 53,984,940 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1153,531,754 - 53,830,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0153,379,457 - 53,678,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,012,303 - 54,310,827 (-)NCBIUU_Cfam_GSD_1.0
PDE10A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,829,411 - 3,392,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113,120,418 - 3,394,236 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214,618,673 - 4,742,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11393,012,027 - 93,684,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1393,020,696 - 93,344,369 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604064,833,189 - 65,491,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde10a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478513,497,495 - 13,880,345 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478513,208,518 - 13,885,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000001954   ⟹   ENSSTOP00000001742
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648915,401,398 - 15,671,600 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000030405   ⟹   ENSSTOP00000032236
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648915,401,398 - 15,556,463 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000037497   ⟹   ENSSTOP00000025384
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648915,401,398 - 15,555,880 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000040928   ⟹   ENSSTOP00000025429
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648915,400,629 - 15,555,454 (-)Ensembl
RefSeq Acc Id: XM_013356933   ⟹   XP_013212387
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,419,601 (-)NCBI
SpeTri2.0NW_00493648915,401,248 - 15,671,594 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040283542   ⟹   XP_040139476
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,657,998 (-)NCBI
RefSeq Acc Id: XM_040283543   ⟹   XP_040139477
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,924 - 148,659,124 (-)NCBI
RefSeq Acc Id: XM_040283544   ⟹   XP_040139478
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,419,607 (-)NCBI
RefSeq Acc Id: XM_040283545   ⟹   XP_040139479
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,370,133 (-)NCBI
RefSeq Acc Id: XM_040283546   ⟹   XP_040139480
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,657,996 (-)NCBI
RefSeq Acc Id: XM_040283547   ⟹   XP_040139481
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,324,084 (-)NCBI
RefSeq Acc Id: XM_040283548   ⟹   XP_040139482
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,412,876 (-)NCBI
RefSeq Acc Id: XM_040283550   ⟹   XP_040139484
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,152,277 - 148,658,000 (-)NCBI
RefSeq Acc Id: XM_040283551   ⟹   XP_040139485
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,924 - 148,659,124 (-)NCBI
RefSeq Acc Id: XM_040283552   ⟹   XP_040139486
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,370,132 (-)NCBI
RefSeq Acc Id: XM_040283553   ⟹   XP_040139487
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,275,712 (-)NCBI
RefSeq Acc Id: XM_040283554   ⟹   XP_040139488
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,143,922 - 148,303,457 (-)NCBI
RefSeq Acc Id: XP_013212387   ⟸   XM_013356933
- Peptide Label: isoform X6
- UniProtKB: I3LZH9 (UniProtKB/TrEMBL),   A0A287CVY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139476   ⟸   XM_040283542
- Peptide Label: isoform X1
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139480   ⟸   XM_040283546
- Peptide Label: isoform X3
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139478   ⟸   XM_040283544
- Peptide Label: isoform X2
- UniProtKB: A0A287DF97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139482   ⟸   XM_040283548
- Peptide Label: isoform X5
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139479   ⟸   XM_040283545
- Peptide Label: isoform X2
- UniProtKB: A0A287DF97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139486   ⟸   XM_040283552
- Peptide Label: isoform X9
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139481   ⟸   XM_040283547
- Peptide Label: isoform X4
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139488   ⟸   XM_040283554
- Peptide Label: isoform X10
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139487   ⟸   XM_040283553
- Peptide Label: isoform X10
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139485   ⟸   XM_040283551
- Peptide Label: isoform X8
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139477   ⟸   XM_040283543
- Peptide Label: isoform X2
- UniProtKB: A0A287DF97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139484   ⟸   XM_040283550
- Peptide Label: isoform X7
- UniProtKB: A0A287CVY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000001742   ⟸   ENSSTOT00000001954
RefSeq Acc Id: ENSSTOP00000025384   ⟸   ENSSTOT00000037497
RefSeq Acc Id: ENSSTOP00000032236   ⟸   ENSSTOT00000030405
RefSeq Acc Id: ENSSTOP00000025429   ⟸   ENSSTOT00000040928
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001947 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001954.3 UniProtKB/TrEMBL
  ENSSTOT00000030405.1 UniProtKB/TrEMBL
  ENSSTOT00000037497.1 UniProtKB/TrEMBL
  ENSSTOT00000040928.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene Pde10a ENTREZGENE
PANTHER CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam GAF UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
Superfamily-SCOP GAF domain-like UniProtKB/TrEMBL
  HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A287CVT7_ICTTR UniProtKB/TrEMBL
  A0A287CVY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A287DF97 ENTREZGENE, UniProtKB/TrEMBL
  I3LZH9 ENTREZGENE, UniProtKB/TrEMBL