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Gene: Nlrp3 (NLR family, pyrin domain containing 3) Rattus norvegicus
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Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Description: Predicted to have identical protein binding activity; sequence-specific DNA binding activity; and transcription factor binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of transcription, DNA-templated; and response to bacterium. Predicted to localize to the Golgi membrane; NLRP3 inflammasome complex; and nucleus. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; acetic acid; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cias1; cold autoinflammatory syndrome 1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 homolog (human); cold autoinflammatory syndrome 1 protein homolog; cryopyrin; LOC287362; mast cell maturation-associated-inducible protein 1; NACHT, LRR and PYD domains-containing protein 3; PYRIN-containing APAF1-like protein 1
Orthologs:
Homo sapiens (human) : NLRP3 (NLR family pyrin domain containing 3)  HGNC  Alliance
Mus musculus (house mouse) : Nlrp3 (NLR family, pyrin domain containing 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrp3 (NLR family pyrin domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP3 (NLR family pyrin domain containing 3)
Canis lupus familiaris (dog) : NLRP3 (NLR family pyrin domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp3 (NLR family pyrin domain containing 3)
Sus scrofa (pig) : NLRP3 (NLR family pyrin domain containing 3)
more info ...
Allele / Splice: Nlrp3em2Mcwi   Nlrp3em1Mcwi  
Genetic Models: SS-Nlrp3em1Mcwi SS-Nlrp3em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)Ensembl
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Nlrp3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308314
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.