Nlrp3 (NLR family, pyrin domain containing 3) - Rat Genome Database

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Gene: Nlrp3 (NLR family, pyrin domain containing 3) Rattus norvegicus
Analyze
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
RGD ID: 1308314
Description: Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in leukocyte migration involved in inflammatory response; response to ethanol; and response to organic cyclic compound. Predicted to be located in Golgi membrane and nucleus. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in cytoplasm. Biomarker of alcoholic hepatitis. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH (+)-taxifolin; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cias1; cold autoinflammatory syndrome 1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 homolog (human); cold autoinflammatory syndrome 1 protein homolog; cryopyrin; LOC287362; mast cell maturation-associated-inducible protein 1; NACHT, LRR and PYD domains-containing protein 3; PYRIN-containing APAF1-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nlrp3em2Mcwi   Nlrp3em1Mcwi  
Genetic Models: SS-Nlrp3em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,326,770 - 44,353,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,328,566 - 44,352,811 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,023,259 - 49,047,629 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01048,513,616 - 48,537,987 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01044,017,231 - 44,041,597 (+)NCBIRnor_WKY
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP)
2,5-hexanedione  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allicin  (ISO)
allopurinol  (EXP,ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amitriptyline  (ISO)
amphetamine  (EXP)
amphibole asbestos  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asbestos  (ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP)
ATP  (ISO)
atropine  (ISO)
aurantio-obtusin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
baicalin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP)
Bergenin  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
CCCP  (ISO)
celastrol  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethyldithiocarbamic acid  (ISO)
dihydroartemisinin  (EXP)
dimethyldithiocarbamate  (ISO)
diosmetin  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ergosterol  (EXP)
eriodictyol  (ISO)
Erionite  (ISO)
ethanol  (EXP,ISO)
flutamide  (ISO)
fluvastatin  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP,ISO)
furosemide  (EXP)
Fusaric acid  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glycidol  (EXP)
glyphosate  (EXP)
guggulsterone  (EXP)
hexadecanoic acid  (EXP,ISO)
HU-308  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
icariin  (ISO)
iohexol  (EXP)
isoflurane  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
lysophosphatidylcholine  (ISO)
magnesium dihydroxide  (ISO)
maneb  (ISO)
mangiferin  (ISO)
mebendazole  (ISO)
memantine  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (ISO)
myrtenol  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nigericin  (ISO)
NMN zwitterion  (EXP,ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
Palbinone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
patulin  (ISO)
pentanal  (ISO)
permethrin  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
procyanidin B2  (EXP)
propanal  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salidroside  (EXP,ISO)
SB 203580  (EXP,ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tungsten carbide  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
acute inflammatory response  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to peptidoglycan  (ISO)
cellular response to virus  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (ISO)
detection of biotic stimulus  (ISO,ISS)
inflammatory response  (IBA,IEA,ISO,ISS)
innate immune response  (IEA)
leukocyte migration involved in inflammatory response  (IEP)
negative regulation of acute inflammatory response  (IBA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (IBA,ISO)
NLRP3 inflammasome complex assembly  (ISO,ISS)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of interleukin-1 beta production  (ISO,ISS)
positive regulation of interleukin-13 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-5 production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of T-helper 17 cell differentiation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type 2 immune response  (ISO)
protein homooligomerization  (ISO,ISS)
regulation of inflammatory response  (IBA,ISO)
response to ethanol  (IEP)
response to organic cyclic compound  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
2. Immunological and inflammatory functions of the interleukin-1 family. Dinarello CA Annu Rev Immunol. 2009;27:519-50.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Hoffman HM, etal., Nat Genet. 2001 Nov;29(3):301-5.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
12. Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow. Wakabayashi T, etal., Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2576-2589. doi: 10.1161/ATVBAHA.118.311648.
13. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
14. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
Additional References at PubMed
PMID:12093792   PMID:12483741   PMID:14662828   PMID:15030775   PMID:15817483   PMID:16531551   PMID:17008311   PMID:17164409   PMID:17178985   PMID:19158675   PMID:22002608   PMID:22297845  
PMID:22753929   PMID:23089744   PMID:23229815   PMID:23580606   PMID:23582325   PMID:23892989   PMID:23986436   PMID:23997220   PMID:24630722   PMID:24859041   PMID:25024200   PMID:25136835  
PMID:25152022   PMID:25281528   PMID:25338942   PMID:25388914   PMID:25516224   PMID:25568124   PMID:25602171   PMID:25651569   PMID:25967877   PMID:26025362   PMID:26098997   PMID:26133299  
PMID:26438340   PMID:26514727   PMID:26576075   PMID:26728324   PMID:26754474   PMID:26770647   PMID:26866373   PMID:26881256   PMID:26996110   PMID:27247388   PMID:27345365   PMID:27367537  
PMID:27374331   PMID:27509875   PMID:27543123   PMID:27843532   PMID:27872860   PMID:27973457   PMID:28000751   PMID:28038382   PMID:28189055   PMID:28189971   PMID:28215032   PMID:28247334  
PMID:28374152   PMID:28420787   PMID:28428961   PMID:28525945   PMID:28592436   PMID:28655515   PMID:28714351   PMID:28782714   PMID:28798291   PMID:28847925   PMID:28851669   PMID:28936769  
PMID:28961497   PMID:28981106   PMID:29069583   PMID:29096724   PMID:29129820   PMID:29258866   PMID:29303910   PMID:29304864   PMID:29305119   PMID:29522854   PMID:29802529   PMID:29842860  
PMID:29884910   PMID:29890246   PMID:29901140   PMID:30144105   PMID:30153825   PMID:30161099   PMID:30232232   PMID:30259999   PMID:30626731   PMID:30628668   PMID:30700851   PMID:30942391  
PMID:31017263   PMID:31037898   PMID:31056470   PMID:31058793   PMID:31059678   PMID:31118021   PMID:31173172   PMID:31199706   PMID:31266422   PMID:31541678   PMID:31573048   PMID:31652453  
PMID:31657084   PMID:31747940   PMID:31763668   PMID:31869244   PMID:31975410   PMID:32126269   PMID:32323758   PMID:32439949   PMID:32461137   PMID:32485293   PMID:32596762   PMID:32607760  
PMID:32626997   PMID:32686873   PMID:32721950   PMID:32729005   PMID:32860822   PMID:32870491   PMID:32950473   PMID:32952148   PMID:32980492   PMID:32991876   PMID:33012731   PMID:33022900  
PMID:33040786   PMID:33135192   PMID:33155218   PMID:33187650   PMID:33236152   PMID:33385377   PMID:33398367   PMID:33415876   PMID:33470533   PMID:33608866   PMID:33626373   PMID:33641439  
PMID:33648977   PMID:33655332   PMID:33677218   PMID:33713981   PMID:33777317   PMID:33814530   PMID:33862118   PMID:33928044   PMID:33930202   PMID:33933884   PMID:33975327   PMID:33977303  
PMID:34396759   PMID:34398134   PMID:34414459   PMID:34414461   PMID:34422094   PMID:34423720   PMID:34432650   PMID:34472725   PMID:34481142   PMID:34492249   PMID:34517258   PMID:34599154  
PMID:34638670   PMID:34676022   PMID:34687223   PMID:34743016   PMID:34830465   PMID:34890588   PMID:34899720   PMID:34933200   PMID:35033112   PMID:35042119   PMID:35046893   PMID:35089581  
PMID:35104732   PMID:35263214   PMID:35301664   PMID:35401582   PMID:35585627   PMID:35605331   PMID:35678979   PMID:35729645   PMID:35775127   PMID:35932799   PMID:35953459   PMID:35962723  
PMID:36085346   PMID:36114434   PMID:36238641  


Genomics

Comparative Map Data
Nlrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,326,770 - 44,353,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,328,566 - 44,352,811 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,023,259 - 49,047,629 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01048,513,616 - 48,537,987 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01044,017,231 - 44,041,597 (+)NCBIRnor_WKY
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBICelera
Cytogenetic Map10q22NCBI
NLRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,416,077 - 247,448,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1247,416,156 - 247,449,108 (+)EnsemblGRCh38hg38GRCh38
GRCh371247,579,475 - 247,612,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,646,098 - 245,679,033 (+)NCBINCBI36Build 36hg18NCBI36
Build 341243,907,391 - 243,938,445NCBI
Celera1220,878,780 - 220,911,159 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBIHuRef
CHM1_11248,851,104 - 248,884,745 (+)NCBICHM1_1
T2T-CHM13v2.01246,852,663 - 246,885,459 (+)NCBIT2T-CHM13v2.0
Nlrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,432,395 - 59,457,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,432,394 - 59,457,782 (+)EnsemblGRCm39 Ensembl
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBIMGSCv36mm8
MGSCv361159,358,881 - 59,383,151 (+)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
Nlrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581597,667 - 617,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955581597,952 - 616,903 (+)NCBIChiLan1.0ChiLan1.0
NLRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11228,505,147 - 228,537,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1228,505,147 - 228,537,216 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01223,052,307 - 223,084,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NLRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.18251,776 - 313,290 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl8253,407 - 313,059 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha8277,639 - 339,097 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.08299,639 - 361,123 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl8301,633 - 360,913 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.18242,540 - 300,444 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.08204,531 - 262,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.08337,026 - 389,302 (+)NCBIUU_Cfam_GSD_1.0
Nlrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721388,366,531 - 88,390,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864709,709 - 731,718 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936864709,693 - 732,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl256,892,243 - 56,977,228 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1256,892,241 - 56,977,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2257,789,084 - 57,873,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12584,431,436 - 84,463,387 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2584,434,527 - 84,463,249 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605586,817,681 - 86,848,042 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlrp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937564,191 - 584,470 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlrp3
170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:89
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000004280
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat


Genetic Models
This gene Nlrp3 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 1
Low 3 31 57 41 8 41 8 8 70 35 30 10 8
Below cutoff 12 3 4 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004280   ⟹   ENSRNOP00000004280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,328,566 - 44,352,811 (+)Ensembl
Rnor_6.0 Ensembl1045,893,018 - 45,917,287 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086710   ⟹   ENSRNOP00000072545
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,328,805 - 44,352,811 (+)Ensembl
Rnor_6.0 Ensembl1045,893,106 - 45,918,254 (+)Ensembl
RefSeq Acc Id: NM_001191642   ⟹   NP_001178571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,566 - 44,352,811 (+)NCBI
Rnor_6.01045,893,018 - 45,917,287 (+)NCBI
Rnor_5.01045,648,191 - 45,674,617 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246453   ⟹   XP_006246515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,326,770 - 44,353,814 (+)NCBI
Rnor_6.01045,891,057 - 45,918,290 (+)NCBI
Rnor_5.01045,648,191 - 45,674,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246455   ⟹   XP_006246517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,392 - 44,353,814 (+)NCBI
Rnor_6.01045,892,902 - 45,918,290 (+)NCBI
Rnor_5.01045,648,191 - 45,674,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246457   ⟹   XP_006246519
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,392 - 44,352,214 (+)NCBI
Rnor_6.01045,892,902 - 45,916,633 (+)NCBI
Rnor_5.01045,648,191 - 45,674,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085394   ⟹   XP_038941322
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,327,853 - 44,353,814 (+)NCBI
RefSeq Acc Id: XM_039085395   ⟹   XP_038941323
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,327,853 - 44,353,814 (+)NCBI
RefSeq Acc Id: XM_039085396   ⟹   XP_038941324
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,392 - 44,353,814 (+)NCBI
RefSeq Acc Id: XM_039085397   ⟹   XP_038941325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,392 - 44,341,163 (+)NCBI
RefSeq Acc Id: XR_005489721
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,392 - 44,351,539 (+)NCBI
RefSeq Acc Id: XR_005489722
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,328,392 - 44,353,814 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001178571   ⟸   NM_001191642
- UniProtKB: D4A523 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246515   ⟸   XM_006246453
- Peptide Label: isoform X1
- UniProtKB: D4A523 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246519   ⟸   XM_006246457
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006246517   ⟸   XM_006246455
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000004280   ⟸   ENSRNOT00000004280
RefSeq Acc Id: ENSRNOP00000072545   ⟸   ENSRNOT00000086710
RefSeq Acc Id: XP_038941322   ⟸   XM_039085394
- Peptide Label: isoform X1
- UniProtKB: D4A523 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941323   ⟸   XM_039085395
- Peptide Label: isoform X1
- UniProtKB: D4A523 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941324   ⟸   XM_039085396
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K391 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941325   ⟸   XM_039085397
- Peptide Label: isoform X5
Protein Domains
NACHT   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A523-F1-model_v2 AlphaFold D4A523 1-1035 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308314 AgrOrtholog
BioCyc Gene G2FUF-24888 BioCyc
Ensembl Genes ENSRNOG00000003170 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004280 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072545 ENTREZGENE
  ENSRNOP00000072545.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004280 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086710 ENTREZGENE
  ENSRNOT00000086710.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DAPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT-assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287362 UniProtKB/Swiss-Prot
NCBI Gene 287362 ENTREZGENE
Pfam FISNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nlrp3 PhenoGen
PROSITE DAPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FISNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K391 ENTREZGENE, UniProtKB/TrEMBL
  D4A523 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Nlrp3  NLR family, pyrin domain containing 3   Nlrp3_predicted  NLR family, pyrin domain containing 3 (predicted)  'predicted' is removed 2292626 APPROVED
2007-03-28 Nlrp3_predicted  NLR family, pyrin domain containing 3 (predicted)  Cias1_predicted  cold autoinflammatory syndrome 1 homolog (human) (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-30 Cias1_predicted  cold autoinflammatory syndrome 1 homolog (human) (predicted)    cold autoinflammatory syndrome 1 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Cias1_predicted  cold autoinflammatory syndrome 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED