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Gene: Nlrp3 (NLR family, pyrin domain containing 3) Rattus norvegicus
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
RGD ID: 1308314
Description: Predicted to have identical protein binding activity; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in leukocyte migration involved in inflammatory response; response to ethanol; and response to organic cyclic compound. Predicted to localize to Golgi membrane; NLRP3 inflammasome complex; and nucleus. Biomarker of alcoholic hepatitis. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2,5-hexanedione; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
Also known as: Cias1; cold autoinflammatory syndrome 1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 homolog (human); cold autoinflammatory syndrome 1 protein homolog; cryopyrin; LOC287362; mast cell maturation-associated-inducible protein 1; NACHT, LRR and PYD domains-containing protein 3; PYRIN-containing APAF1-like protein 1
Homo sapiens (human) : NLRP3 (NLR family pyrin domain containing 3)  HGNC  Alliance
Mus musculus (house mouse) : Nlrp3 (NLR family, pyrin domain containing 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrp3 (NLR family pyrin domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP3 (NLR family pyrin domain containing 3)
Canis lupus familiaris (dog) : NLRP3 (NLR family pyrin domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp3 (NLR family pyrin domain containing 3)
Sus scrofa (pig) : NLRP3 (NLR family pyrin domain containing 3)
Chlorocebus sabaeus (African green monkey) : NLRP3 (NLR family pyrin domain containing 3)
Heterocephalus glaber (naked mole-rat) : Nlrp3 (NLR family pyrin domain containing 3)
more info ...
Allele / Splice: Nlrp3em2Mcwi   Nlrp3em1Mcwi  
Genetic Models: SS-Nlrp3em1Mcwi SS-Nlrp3em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Nlrp3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308314
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.