Gene: Grik2 (glutamate ionotropic receptor kainate type subunit 2) Rattus norvegicus
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Symbol:
Grik2
Name:
glutamate ionotropic receptor kainate type subunit 2
Description:
Exhibits several functions, including PDZ domain binding activity; enzyme binding activity; and kainate selective glutamate receptor activity. Involved in several processes, including negative regulation of glutamatergic synaptic transmission; positive regulation of neuron apoptotic process; and regulation of JNK cascade. Localizes to several cellular components, including the dendrite cytoplasm; ionotropic glutamate receptor complex; and perikaryon. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive non-syndromic intellectual disability. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
GluK2; gluR-6; GluR6; glutamate receptor 6; glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GRIK2 (glutamate ionotropic receptor kainate type subunit 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Grik2 (glutamate receptor, ionotropic, kainate 2 (beta 2)) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Grik2 (glutamate ionotropic receptor kainate type subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GRIK2 (glutamate ionotropic receptor kainate type subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GRIK2 (glutamate ionotropic receptor kainate type subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Grik2 (glutamate ionotropic receptor kainate type subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GRIK2 (glutamate ionotropic receptor kainate type subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
GRIK2 (glutamate ionotropic receptor kainate type subunit 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Grik2 (glutamate receptor, ionotropic, kainate 2 (beta 2))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG11155
Alliance
DIOPT (Hieranoid, OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
glr-5
Alliance
DIOPT (Hieranoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
KaiR1D
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER)
Drosophila melanogaster (fruit fly):
Grik
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
clumsy
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
GluRIIA
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
GluRIIB
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
GluRIIC
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
GluRIID
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
GluRIIE
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 53,791,428 - 54,517,691 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 53,789,760 - 54,517,709 (-) Ensembl Rnor_5.0 20 55,397,877 - 56,122,315 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 53,231,473 - 53,713,131 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 53,258,695 - 53,741,826 (-) NCBI Celera 20 47,307,163 - 47,987,148 (+) NCBI Celera Cytogenetic Map 20 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
head and neck squamous cell carcinoma ISO RGD:733691 8554872 ClinVar Annotator: match by term: Lip and oral cavity carcinoma ClinVar PMID:26614431 intellectual disability ISO RGD:733691 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:25741868 Mental Retardation, Autosomal Recessive 6 ISO RGD:733691 8554872 ClinVar Annotator: match by OMIM:611092 ClinVar PMID:25039795 Mental Retardation, Autosomal Recessive 6 ISO RGD:733691 8554872 ClinVar Annotator: match by null ClinVar PMID:17847003
Imported Annotations - CTD
autistic disorder ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11920157 , PMID:20442744 bipolar disorder ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18332879 Breast Neoplasms ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Colonic Neoplasms ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Esophageal Neoplasms ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 glioblastoma multiforme ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Liver Neoplasms ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 lung non-small cell carcinoma ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Lymphatic Metastasis ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Ovarian Neoplasms ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 schizophrenia ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18923069 sexual disorder ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19295509 substance-related disorder ISO RGD:733691 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20098672 Imported Annotations - MGI
autosomal recessive non-syndromic intellectual disability ISS RGD:733691 13592920 OMIM:249500 more ... MouseDO Imported Annotations - OMIM
Mental Retardation, Autosomal Recessive 6 ISO RGD:733691 7240710 OMIM
(+)-pilocarpine multiple interactions EXP 6480464 [Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA CTD PMID:16819974 (S)-nicotine increases expression ISO RGD:736517 6480464 Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile affects response to substance ISO RGD:733691 6480464 GRIK2 polymorphism affects the susceptibility to Citalopram CTD PMID:19295509 17beta-estradiol affects expression ISO RGD:733691 6480464 Estradiol affects the expression of GRIK2 mRNA CTD PMID:22574217 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GRIK2 mRNA CTD PMID:26496021 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of GRIK2 mRNA CTD PMID:11752688 , PMID:23871856 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:736517 6480464 tetrabromobisphenol A results in decreased expression of GRIK2 mRNA CTD PMID:25172293 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of GRIK2 mRNA CTD PMID:24780913 aflatoxin B1 decreases methylation ISO RGD:733691 6480464 Aflatoxin B1 results in decreased methylation of GRIK2 gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:733691 6480464 Tretinoin results in increased expression of GRIK2 mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GRIK2 mRNA CTD PMID:16483693 androgen antagonist multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 antirheumatic drug decreases expression ISO RGD:733691 6480464 Antirheumatic Agents results in decreased expression of GRIK2 mRNA CTD PMID:24449571 benzoates multiple interactions ISO RGD:733691 6480464 Benzoates analog binds to and results in decreased activity of GRIK2 protein CTD PMID:14667236 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:733691 6480464 Diethylhexyl Phthalate results in decreased expression of GRIK2 mRNA CTD PMID:31163220 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIK2 mRNA more ... CTD PMID:25607892 , PMID:26496021 bisphenol A decreases expression ISO RGD:733691 6480464 bisphenol A results in decreased expression of GRIK2 mRNA CTD PMID:27685785 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GRIK2 mRNA CTD PMID:25181051 bisphenol F decreases expression ISO RGD:736517 6480464 bisphenol F results in decreased expression of GRIK2 mRNA CTD PMID:30951980 butanal decreases expression ISO RGD:733691 6480464 butyraldehyde results in decreased expression of GRIK2 mRNA CTD PMID:26079696 carbamazepine decreases expression ISO RGD:736517 6480464 Carbamazepine results in decreased expression of GRIK2 mRNA, Carbamazepine results in decreased expression of GRIK2 protein CTD PMID:19596362 celecoxib multiple interactions ISO RGD:736517 6480464 [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA CTD PMID:21589914 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of GRIK2 mRNA CTD PMID:18668222 , PMID:19440498 citalopram affects response to substance ISO RGD:733691 6480464 GRIK2 polymorphism affects the susceptibility to Citalopram CTD PMID:19295509 clozapine increases expression EXP 6480464 Clozapine results in increased expression of GRIK2 mRNA CTD PMID:18923069 cocaine affects expression EXP 6480464 Cocaine affects the expression of GRIK2 protein CTD PMID:15140200 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 diazinon affects expression EXP 6480464 Diazinon affects the expression of GRIK2 mRNA CTD PMID:19440498 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 doxorubicin decreases expression ISO RGD:733691 6480464 Doxorubicin results in decreased expression of GRIK2 mRNA CTD PMID:29803840 enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIK2 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK2 mRNA CTD PMID:25607892 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 ethanol increases expression EXP 6480464 Ethanol results in increased expression of GRIK2 protein CTD PMID:12045474 ethanol increases expression ISO RGD:736517 6480464 Ethanol results in increased expression of GRIK2 mRNA CTD PMID:30319688 fluoxetine multiple interactions ISO RGD:736517 6480464 ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA] more ... CTD PMID:21320410 fluoxetine increases expression ISO RGD:736517 6480464 Fluoxetine results in increased expression of GRIK2 mRNA, Fluoxetine results in increased expression of GRIK2 protein CTD PMID:21320410 haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of GRIK2 mRNA CTD PMID:18923069 kainic acid increases expression ISO RGD:736517 6480464 Kainic Acid results in increased expression of GRIK2 mRNA CTD PMID:17997037 , PMID:29208536 kainic acid multiple interactions ISO RGD:736517 6480464 [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA CTD PMID:21589914 lead diacetate increases expression ISO RGD:736517 6480464 lead acetate results in increased expression of GRIK2 mRNA CTD PMID:24260418 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 lithium atom decreases expression ISO RGD:736517 6480464 Lithium results in decreased expression of GRIK2 mRNA, Lithium results in decreased expression of GRIK2 protein CTD PMID:19596362 lithium atom multiple interactions EXP 6480464 [Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA CTD PMID:16819974 lithium hydride decreases expression ISO RGD:736517 6480464 Lithium results in decreased expression of GRIK2 mRNA, Lithium results in decreased expression of GRIK2 protein CTD PMID:19596362 lithium hydride multiple interactions EXP 6480464 [Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA CTD PMID:16819974 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GRIK2 mRNA CTD PMID:20360939 nickel atom decreases expression ISO RGD:733691 6480464 Nickel results in decreased expression of GRIK2 mRNA CTD PMID:24768652 , PMID:25583101 nicotine increases expression ISO RGD:736517 6480464 Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 paracetamol multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 pentanal decreases expression ISO RGD:733691 6480464 pentanal results in decreased expression of GRIK2 mRNA CTD PMID:26079696 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GRIK2 mRNA CTD PMID:20360939 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 silicon dioxide decreases expression ISO RGD:733691 6480464 Silicon Dioxide analog results in decreased expression of GRIK2 mRNA CTD PMID:25895662 thimerosal increases expression ISO RGD:733691 6480464 Thimerosal results in increased expression of GRIK2 mRNA CTD PMID:27188386 trichostatin A increases expression ISO RGD:733691 6480464 trichostatin A results in increased expression of GRIK2 mRNA CTD PMID:24935251 triclosan decreases expression ISO RGD:733691 6480464 Triclosan results in decreased expression of GRIK2 mRNA CTD PMID:30510588 valproic acid decreases expression ISO RGD:736517 6480464 Valproic Acid results in decreased expression of GRIK2 mRNA, Valproic Acid results in decreased expression of GRIK2 protein CTD PMID:19596362 valproic acid increases expression ISO RGD:733691 6480464 Valproic Acid results in increased expression of GRIK2 mRNA CTD PMID:23179753 , PMID:25192806 vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of GRIK2 mRNA CTD PMID:19015723 zinc atom increases expression ISO RGD:733691 6480464 Zinc results in increased expression of GRIK2 mRNA CTD PMID:16870260 zinc dichloride increases expression ISO RGD:733691 6480464 zinc chloride results in increased expression of GRIK2 mRNA CTD PMID:16870260 zinc(0) increases expression ISO RGD:733691 6480464 Zinc results in increased expression of GRIK2 mRNA CTD PMID:16870260
Biological Process behavioral fear response ISO RGD:736517 1624291 MGI:MGI:1857979 (MGI:MGI:3577154 , PMID:15673679) RGD MGI:MGI:3577154 , PMID:15673679 behavioral fear response IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular calcium ion homeostasis ISO RGD:736517 1624291 MGI:MGI:1857979 (MGI:MGI:3611088 , PMID:16219388) RGD MGI:MGI:3611088 , PMID:16219388 cellular calcium ion homeostasis IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemical synaptic transmission IMP 69852 RGD chemical synaptic transmission ISO RGD:736517 1624291 MGI:MGI:1857979 more ... RGD MGI:MGI:3688795 , PMID:15928066 excitatory postsynaptic potential ISO RGD:736517 1624291 MGI:MGI:107164 more ... RGD MGI:MGI:3575241 more ... excitatory postsynaptic potential IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 inhibitory postsynaptic potential ISO RGD:736517 1624291 MGI:MGI:1857979 more ... RGD MGI:MGI:1327732 more ... inhibitory postsynaptic potential IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 intracellular protein transport ISO RGD:736517 1624291 (MGI:MGI:3574145, PMID:15014126) RGD MGI:MGI:3574145 , PMID:15014126 ion transmembrane transport IEA GO:0005216 1600115 GO_REF:0000108 GOC GO_REF:0000108 ion transmembrane transport IEA GO:0015276 1600115 GO_REF:0000108 GOC GO_REF:0000108 ionotropic glutamate receptor signaling pathway IEA GO:0004970 1600115 GO_REF:0000108 GOC GO_REF:0000108 ionotropic glutamate receptor signaling pathway IEA GO:0015277 1600115 GO_REF:0000108 GOC GO_REF:0000108 modulation of chemical synaptic transmission ISO RGD:733691 1624291 (PMID:15537878) RGD PMID:15537878 modulation of chemical synaptic transmission IBA PANTHER:PTN001826301 , UniProtKB:Q13002 13792537 PMID:21873635 GO_Central modulation of chemical synaptic transmission IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central negative regulation of neuron apoptotic process ISO RGD:736517 1624291 MGI:MGI:95819 (MGI:MGI:1344923 , PMID:10479699) RGD MGI:MGI:1344923 , PMID:10479699 negative regulation of neuron apoptotic process IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of synaptic transmission, glutamatergic ISO RGD:736517 1624291 MGI:MGI:95814 (MGI:MGI:3575241 , PMID:11985817) RGD MGI:MGI:3575241 , PMID:11985817 negative regulation of synaptic transmission, glutamatergic IDA 8554693 PMID:16420445 UniProt neuron apoptotic process IMP 8554109 PMID:11152698 UniProt neuronal action potential ISO RGD:736517 1624291 MGI:MGI:1857979 (MGI:MGI:3622010 , PMID:15539395) RGD MGI:MGI:3622010 , PMID:15539395 neuronal action potential IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of neuron apoptotic process IMP 2316528 RGD positive regulation of synaptic transmission ISO RGD:733691 1624291 (PMID:15537878) RGD PMID:15537878 positive regulation of synaptic transmission IEA UniProtKB:Q13002 , ensembl:ENSP000003970261600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor clustering IDA 8554157 PMID:9808460 UniProt regulation of JNK cascade IMP 8554109 PMID:11152698 UniProt regulation of long-term neuronal synaptic plasticity ISO RGD:736517 1624291 MGI:MGI:1857979 (MGI:MGI:3040774 more ... RGD MGI:MGI:3040774 more ... regulation of long-term neuronal synaptic plasticity IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of membrane potential ISO RGD:736517 1624291 MGI:MGI:1857979 more ... RGD MGI:MGI:1197809 more ... regulation of presynaptic membrane potential IEA GO:0099507 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of short-term neuronal synaptic plasticity ISO RGD:736517 1624291 MGI:MGI:1857979 (MGI:MGI:3050715 , PMID:11182092) RGD MGI:MGI:3050715 , PMID:11182092 regulation of short-term neuronal synaptic plasticity IEA UniProtKB:Q13002 , ensembl:ENSP000003970261600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of short-term neuronal synaptic plasticity IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of short-term neuronal synaptic plasticity ISO RGD:733691 1624291 (PMID:15537878) RGD PMID:15537878 synaptic transmission, glutamatergic ISO RGD:736517 1624291 MGI:MGI:1857979 (MGI:MGI:1202247 more ... RGD MGI:MGI:1202247 more ... synaptic transmission, glutamatergic IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central synaptic transmission, glutamatergic IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central Cellular Component axon IDA 1642495 RGD cell IEA GO:0006874 1600115 GO_REF:0000108 GOC GO_REF:0000108 cell junction IEA UniProtKB-KW:KW-0965 1600115 GO_REF:0000038 UniProt GO_REF:0000038 cell junction IEA UniProtKB-KW:KW-0965 1600115 GO_REF:0000037 UniProt GO_REF:0000037 dendrite IDA 1642473 ; 1642482 RGD dendrite IDA 8554157 PMID:9808460 UniProt dendrite cytoplasm IDA 1642495 RGD glutamatergic synapse IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse ISO RGD:736517 1624291 (MGI:MGI:3844269, PMID:17620617) RGD MGI:MGI:3844269 , PMID:17620617 hippocampal mossy fiber to CA3 synapse ISO RGD:736517 1624291 (MGI:MGI:1202247 more ... RGD MGI:MGI:1202247 more ... hippocampal mossy fiber to CA3 synapse IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 integral component of plasma membrane IDA 8554157 PMID:9808460 UniProt ionotropic glutamate receptor complex IDA 8553571 PMID:10627597 UniProt kainate selective glutamate receptor complex ISO RGD:736517 1624291 UniProtKB:Q60934 more ... RGD MGI:MGI:2674165 more ... kainate selective glutamate receptor complex IBA MGI:MGI:95814 more ... 13792537 PMID:21873635 GO_Central membrane ISO RGD:736517 1624291 (MGI:MGI:2674165 more ... RGD MGI:MGI:2674165 more ... neuronal cell body ISO RGD:736517 1624291 (MGI:MGI:87588, PMID:9141074) RGD MGI:MGI:87588 , PMID:9141074 perikaryon IDA 1642495 RGD plasma membrane IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central plasma membrane IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central postsynaptic density ISO RGD:736517 1624291 (MGI:MGI:5139965, PMID:21734292) RGD MGI:MGI:5139965 , PMID:21734292 postsynaptic density membrane IBA MGI:MGI:95808 more ... 13792537 PMID:21873635 GO_Central postsynaptic density membrane IBA MGI:MGI:95808 more ... 13792537 PMID:21873635 GO_Central postsynaptic membrane ISO RGD:736517 1624291 (MGI:MGI:3615737, PMID:14724198) RGD MGI:MGI:3615737 , PMID:14724198 postsynaptic membrane IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central postsynaptic membrane IBA MGI:MGI:1933206 more ... 13792537 PMID:21873635 GO_Central postsynaptic membrane IEA UniProtKB-SubCell:SL-0219 1600115 GO_REF:0000040 UniProt GO_REF:0000040 presynaptic membrane ISO RGD:736517 1624291 (MGI:MGI:3575241 more ... RGD MGI:MGI:3575241 more ... presynaptic membrane IBA MGI:MGI:95814 more ... 13792537 PMID:21873635 GO_Central synapse IDA 1642482 RGD synapse ISO RGD:736517 1624291 (MGI:MGI:5139965, PMID:21734292) RGD MGI:MGI:5139965 , PMID:21734292 terminal bouton IDA 1642495 RGD Molecular Function extracellularly glutamate-gated ion channel activity ISO RGD:733691 1624291 (PMID:28180184) RGD PMID:28180184 extracellularly glutamate-gated ion channel activity ISS UniProtKB:Q13002 1600115 GO_REF:0000024 UniProt GO_REF:0000024 glutamate receptor activity IDA 8553571 PMID:10627597 UniProt glutamate receptor activity IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central glutamate receptor activity IBA FB:FBgn0004620 more ... 13792537 PMID:21873635 GO_Central identical protein binding IDA 69852 RGD identical protein binding IPI UniProtKB:P42260 13432242 PMID:25119039 IntAct identical protein binding IPI UniProtKB:P42260 13432256 PMID:20404149 IntAct identical protein binding IPI UniProtKB:P42260 13432236 PMID:19617541 IntAct identical protein binding IPI UniProtKB:P42260 13432328 PMID:19465914 IntAct identical protein binding IPI UniProtKB:P42260 13432262 PMID:17115050 IntAct identical protein binding IPI RGD:2733 69852 homodimerization RGD ionotropic glutamate receptor activity TAS 69852 RGD ionotropic glutamate receptor activity IEA InterPro:IPR019594 1600115 GO_REF:0000002 InterPro GO_REF:0000002 ionotropic glutamate receptor activity ISO RGD:736517 1624291 (MGI:MGI:3690189, PMID:16354929) RGD MGI:MGI:3690189 , PMID:16354929 kainate selective glutamate receptor activity IDA 69852 RGD kainate selective glutamate receptor activity IBA MGI:MGI:95814 more ... 13792537 PMID:21873635 GO_Central kainate selective glutamate receptor activity ISO RGD:736517 1624291 MGI:MGI:1857979 more ... RGD MGI:MGI:1202247 more ... kainate selective glutamate receptor activity ISO RGD:733691 1624291 (PMID:15537878) RGD PMID:15537878 ligand-gated ion channel activity IBA FB:FBgn0004619 more ... 13792537 PMID:21873635 GO_Central ligand-gated ion channel activity involved in regulation of presynaptic membrane potential IEA UniProtKB:P39087 , ensembl:ENSMUSP000001519211600115 GO_REF:0000107 Ensembl GO_REF:0000107 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential ISO RGD:736517 1624291 (MGI:MGI:3844269, PMID:17620617) RGD MGI:MGI:3844269 , PMID:17620617 PDZ domain binding IPI UniProtKB:P31016 8553546 PMID:1127911 UniProt PDZ domain binding IPI UniProtKB:P31016 8554157 PMID:9808460 UniProt PDZ domain binding IPI UniProtKB:Q62696 8553546 PMID:1127911 UniProt protein binding IPI UniProtKB:Q8K430 8553595 PMID:17062563 UniProt protein binding IPI UniProtKB:Q5I0H3 13432300 PMID:22089239 IntAct protein binding IPI UniProtKB:Q5I0H3 8554830 PMID:22483987 IntAct protein binding IPI UniProtKB:Q5I0H3 1642482 PMID:17486098 IntAct protein binding IPI UniProtKB:P63281 1642482 PMID:17486098 IntAct protein binding IPI UniProtKB:O70260 1642482 PMID:17486098 IntAct protein binding IPI UniProtKB:Q66HA1 8554830 PMID:22483987 IntAct protein binding ISO RGD:736517 1624291 UniProtKB:P21279 more ... RGD MGI:MGI:2674165 more ... protein binding IPI UniProtKB:P31016 8554157 PMID:9808460 UniProt signaling receptor activity IBA FB:FBgn0004619 more ... 13792537 PMID:21873635 GO_Central transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ISO RGD:736517 1624291 (MGI:MGI:1202247 more ... RGD MGI:MGI:1202247 more ... transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA MGI:MGI:1933206 more ... 13792537 PMID:21873635 GO_Central transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA MGI:MGI:95815 , PANTHER:PTN001826301 13792537 PMID:21873635 GO_Central ubiquitin conjugating enzyme binding IPI RGD:3926 1642482 RGD ubiquitin protein ligase binding IPI RGD:708413 1642482 RGD
Gene-Chemical Interaction Annotations
