Grik2 (glutamate ionotropic receptor kainate type subunit 2) - Rat Genome Database

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Gene: Grik2 (glutamate ionotropic receptor kainate type subunit 2) Rattus norvegicus
Analyze
Symbol: Grik2
Name: glutamate ionotropic receptor kainate type subunit 2
RGD ID: 2733
Description: Enables several functions, including PDZ domain binding activity; enzyme binding activity; and kainate selective glutamate receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of neuron apoptotic process; and regulation of JNK cascade. Located in several cellular components, including dendrite cytoplasm; perikaryon; and terminal bouton. Part of ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive intellectual developmental disorder 6. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GluK2; gluR-6; GluR6; glutamate receptor 6; glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22052,135,325 - 52,833,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2052,133,851 - 52,838,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2053,835,165 - 54,527,304 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02053,484,886 - 54,177,017 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02054,176,501 - 54,864,656 (-)NCBIRnor_WKY
Rnor_6.02053,791,428 - 54,517,691 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2053,789,760 - 54,517,709 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02055,397,877 - 56,122,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42053,231,473 - 53,713,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12053,258,695 - 53,741,826 (-)NCBI
Celera2047,307,163 - 47,987,148 (+)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Chaudhry C, etal., Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12329-34. doi: 10.1073/pnas.0904175106. Epub 2009 Jul 15.
2. Domain organization and function in GluK2 subtype kainate receptors. Das U, etal., Proc Natl Acad Sci U S A. 2010 May 4;107(18):8463-8. doi: 10.1073/pnas.1000838107. Epub 2010 Apr 19.
3. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Egebjerg J, etal., Nature 1991 Jun 27;351(6329):745-8.
4. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Garcia EP, etal., Neuron. 1998 Oct;21(4):727-39.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression. Guo W, etal., Eur J Pharmacol 2002 Oct 11;452(3):309-18.
8. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
9. Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury. Jiang HX, etal., J Neurosci Res. 2007 Oct;85(13):2960-70.
10. Localization and function of pre- and postsynaptic kainate receptors in the rat globus pallidus. Jin XT, etal., Eur J Neurosci. 2006 Jan;23(2):374-86.
11. Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Konopacki FA, etal., Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19772-7. doi: 10.1073/pnas.1111575108. Epub 2011 Nov 16.
12. The N-terminal domain of GluR6-subtype glutamate receptor ion channels. Kumar J, etal., Nat Struct Mol Biol. 2009 Jun;16(6):631-8. doi: 10.1038/nsmb.1613. Epub 2009 May 24.
13. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
14. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
15. Evidence for the GluR6 gene associated with younger onset age of Huntington's disease. MacDonald ME, etal., Neurology 1999 Oct 12;53(6):1330-2.
16. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Martin S, etal., Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7.
17. Structural mechanism of glutamate receptor activation and desensitization. Meyerson JR, etal., Nature. 2014 Oct 16;514(7522):328-34. doi: 10.1038/nature13603. Epub 2014 Aug 3.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
22. GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors. Paternain AV, etal., J Neurosci. 2000 Jan 1;20(1):196-205.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. Salinas GD, etal., J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.
28. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. Savinainen A, etal., J Biol Chem. 2001 Apr 6;276(14):11382-6. Epub 2001 Jan 10.
29. Pursuit auditory tracking of dichotically presented tonal amplitudes. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
30. Conformational restriction blocks glutamate receptor desensitization. Weston MC, etal., Nat Struct Mol Biol. 2006 Dec;13(12):1120-7. Epub 2006 Nov 19.
31. SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation. Zhu QJ, etal., FEBS Lett. 2012 May 7;586(9):1259-64. doi: 10.1016/j.febslet.2012.03.048. Epub 2012 Mar 31.
Additional References at PubMed
PMID:1310861   PMID:1322826   PMID:7681676   PMID:9141074   PMID:9490692   PMID:9580260   PMID:9880586   PMID:10479699   PMID:10704492   PMID:11069933   PMID:11144357   PMID:11182092  
PMID:11744724   PMID:11985817   PMID:12151522   PMID:12223554   PMID:12947409   PMID:12954862   PMID:14724198   PMID:15014126   PMID:15458844   PMID:15483117   PMID:15509753   PMID:15513934  
PMID:15537878   PMID:15539395   PMID:15632090   PMID:15673679   PMID:15677325   PMID:15796762   PMID:15928066   PMID:16219388   PMID:16267825   PMID:16354929   PMID:16439423   PMID:17005866  
PMID:17174564   PMID:17428973   PMID:17620617   PMID:18172894   PMID:18307989   PMID:18562501   PMID:18680160   PMID:19180187   PMID:19449206   PMID:19561126   PMID:19784088   PMID:20848775  
PMID:21148565   PMID:21557511   PMID:21734292   PMID:22114280   PMID:22345355   PMID:22445759   PMID:22509486   PMID:22522402   PMID:22813734   PMID:23400781   PMID:23530186   PMID:23720540  
PMID:23861400   PMID:23949220   PMID:23955023   PMID:23975096   PMID:24895134   PMID:25201974   PMID:25316086   PMID:26282342   PMID:27580033   PMID:28100490   PMID:28180184   PMID:28636947  
PMID:29193067   PMID:30421168   PMID:30559217   PMID:31628192   PMID:33537798   PMID:33724189  


Genomics

Comparative Map Data
Grik2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22052,135,325 - 52,833,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2052,133,851 - 52,838,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2053,835,165 - 54,527,304 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02053,484,886 - 54,177,017 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02054,176,501 - 54,864,656 (-)NCBIRnor_WKY
Rnor_6.02053,791,428 - 54,517,691 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2053,789,760 - 54,517,709 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02055,397,877 - 56,122,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42053,231,473 - 53,713,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12053,258,695 - 53,741,826 (-)NCBI
Celera2047,307,163 - 47,987,148 (+)NCBICelera
Cytogenetic Map20q13NCBI
GRIK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386101,393,708 - 102,070,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6100,962,701 - 102,081,622 (+)EnsemblGRCh38hg38GRCh38
GRCh376101,841,584 - 102,517,958 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366101,953,675 - 102,623,474 (+)NCBINCBI36Build 36hg18NCBI36
Build 346101,953,674 - 102,623,474NCBI
Celera6102,490,982 - 103,163,448 (+)NCBICelera
Cytogenetic Map6q16.3NCBI
HuRef699,289,230 - 99,962,155 (+)NCBIHuRef
CHM1_16102,108,429 - 102,780,216 (+)NCBICHM1_1
T2T-CHM13v2.06102,567,466 - 103,245,122 (+)NCBIT2T-CHM13v2.0
Grik2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391048,969,776 - 49,666,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1048,970,929 - 49,664,862 (-)EnsemblGRCm39 Ensembl
GRCm381049,093,680 - 49,790,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1049,094,833 - 49,788,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371048,819,269 - 49,508,560 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361048,789,404 - 49,471,824 (-)NCBIMGSCv36mm8
Celera1049,961,395 - 50,650,295 (-)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1024.87NCBI
Grik2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541127,103,470 - 27,801,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541127,096,214 - 27,759,503 (+)NCBIChiLan1.0ChiLan1.0
GRIK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16103,106,776 - 103,784,640 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6103,334,707 - 103,783,092 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0698,720,430 - 99,903,582 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRIK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11258,932,754 - 59,991,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1259,355,017 - 59,990,408 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1258,685,896 - 59,760,448 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01259,766,364 - 60,827,294 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1260,189,211 - 60,826,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11259,112,703 - 60,183,136 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01258,954,426 - 60,016,937 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01259,195,178 - 60,257,015 (+)NCBIUU_Cfam_GSD_1.0
Grik2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494694,301,120 - 94,944,470 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366512,762,380 - 3,401,808 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366512,756,559 - 3,401,806 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl168,057,538 - 68,679,256 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1168,052,086 - 68,680,448 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2177,317,681 - 77,555,955 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11371,855,960 - 72,545,376 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1371,855,794 - 72,325,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604044,140,787 - 44,845,039 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248102,733,118 - 3,401,909 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248102,731,573 - 3,407,186 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grik2
5030 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000037559
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
D20Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22052,631,053 - 52,631,303 (+)MAPPERmRatBN7.2
Rnor_6.02054,294,088 - 54,294,337NCBIRnor6.0
Rnor_5.02055,896,923 - 55,897,172UniSTSRnor5.0
RGSC_v3.42053,738,803 - 53,739,053RGDRGSC3.4
RGSC_v3.42053,738,804 - 53,739,053UniSTSRGSC3.4
RGSC_v3.12053,767,501 - 53,767,750RGD
Celera2047,501,945 - 47,502,194UniSTS
RH 3.4 Map20562.35RGD
RH 3.4 Map20562.35UniSTS
Cytogenetic Map20q13UniSTS
BF394244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22052,771,477 - 52,771,687 (+)MAPPERmRatBN7.2
Rnor_6.02054,457,376 - 54,457,585NCBIRnor6.0
Rnor_5.02056,059,981 - 56,060,190UniSTSRnor5.0
RGSC_v3.42053,886,466 - 53,886,675UniSTSRGSC3.4
Celera2047,368,495 - 47,368,704UniSTS
Cytogenetic Map20q13UniSTS
AU046653  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22052,830,638 - 52,830,774 (+)MAPPERmRatBN7.2
Rnor_6.02054,515,269 - 54,515,404NCBIRnor6.0
Rnor_5.02056,119,893 - 56,120,028UniSTSRnor5.0
RGSC_v3.42052,447,060 - 52,447,195UniSTSRGSC3.4
Celera2047,309,450 - 47,309,585UniSTS
Cytogenetic Map20q13UniSTS
RH134654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22052,133,991 - 52,134,174 (+)MAPPERmRatBN7.2
Rnor_6.02053,790,095 - 53,790,277NCBIRnor6.0
Rnor_5.02055,396,544 - 55,396,726UniSTSRnor5.0
RGSC_v3.42053,230,140 - 53,230,322UniSTSRGSC3.4
Celera2047,988,299 - 47,988,481UniSTS
RH 3.4 Map20557.94UniSTS
Cytogenetic Map20q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 5 4
Low 10 16 12 6 6 6 30 30 8 6
Below cutoff 3 33 18 18 7 18 2 4 7 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037559   ⟹   ENSRNOP00000033070
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,133,851 - 52,607,007 (-)Ensembl
Rnor_6.0 Ensembl2053,789,760 - 54,269,525 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076234   ⟹   ENSRNOP00000068172
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,133,851 - 52,838,375 (-)Ensembl
Rnor_6.0 Ensembl2053,789,954 - 54,517,709 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076805
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,135,527 - 52,606,868 (-)Ensembl
Rnor_6.0 Ensembl2053,789,954 - 54,517,709 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097789   ⟹   ENSRNOP00000082305
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,147,995 - 52,606,868 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112090   ⟹   ENSRNOP00000081018
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,135,239 - 52,838,375 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118241   ⟹   ENSRNOP00000080218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2052,135,239 - 52,838,375 (-)Ensembl
RefSeq Acc Id: NM_019309   ⟹   NP_062182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22052,135,325 - 52,833,061 (-)NCBI
Rnor_6.02053,791,428 - 54,517,691 (-)NCBI
Rnor_5.02055,397,877 - 56,122,315 (-)NCBI
RGSC_v3.42053,231,473 - 53,713,131 (-)RGD
Celera2047,307,163 - 47,987,148 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA77647 (Get FASTA)   NCBI Sequence Viewer  
  CAA77778 (Get FASTA)   NCBI Sequence Viewer  
  EDL99658 (Get FASTA)   NCBI Sequence Viewer  
  EDL99659 (Get FASTA)   NCBI Sequence Viewer  
  P42260 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062182   ⟸   NM_019309
- Peptide Label: precursor
- UniProtKB: P42260 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033070   ⟸   ENSRNOT00000037559
RefSeq Acc Id: ENSRNOP00000068172   ⟸   ENSRNOT00000076234
RefSeq Acc Id: ENSRNOP00000082305   ⟸   ENSRNOT00000097789
RefSeq Acc Id: ENSRNOP00000080218   ⟸   ENSRNOT00000118241
RefSeq Acc Id: ENSRNOP00000081018   ⟸   ENSRNOT00000112090
Protein Domains
Lig_chan-Glu_bd   PBPe

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42260-F1-model_v2 AlphaFold P42260 1-908 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2733 AgrOrtholog
BioCyc Gene G2FUF-3235 BioCyc
Ensembl Genes ENSRNOG00000000368 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033070.6 UniProtKB/TrEMBL
  ENSRNOP00000068172 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000080218.1 UniProtKB/TrEMBL
  ENSRNOP00000081018.1 UniProtKB/TrEMBL
  ENSRNOP00000081220.1 UniProtKB/TrEMBL
  ENSRNOP00000082305.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037559.6 UniProtKB/TrEMBL
  ENSRNOT00000076234 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000076805.2 UniProtKB/TrEMBL
  ENSRNOT00000097789.1 UniProtKB/TrEMBL
  ENSRNOT00000112090.1 UniProtKB/TrEMBL
  ENSRNOT00000118241.1 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54257 UniProtKB/Swiss-Prot
NCBI Gene 54257 ENTREZGENE
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grik2 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZP88_RAT UniProtKB/TrEMBL
  A0A8I5ZS08_RAT UniProtKB/TrEMBL
  A0A8I5ZU84_RAT UniProtKB/TrEMBL
  A0A8I6G7P1_RAT UniProtKB/TrEMBL
  F1M855_RAT UniProtKB/TrEMBL
  GRIK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik2  glutamate ionotropic receptor kainate type subunit 2  Grik2  glutamate receptor, ionotropic, kainate 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grik2  glutamate receptor, ionotropic, kainate 2      Name updated 70584 APPROVED