Timp1 (TIMP metallopeptidase inhibitor 1) - Rat Genome Database

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Gene: Timp1 (TIMP metallopeptidase inhibitor 1) Rattus norvegicus
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Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
RGD ID: 621675
Description: Enables protease binding activity. Involved in several processes, including cartilage development; response to peptide hormone; and wound healing. Located in basement membrane. Used to study degenerative disc disease. Biomarker of cholestasis; gastric ulcer; heart disease (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1); PARTICIPATES IN interleukin-6 signaling pathway; INTERACTS WITH (R)-carnitine; (S)-colchicine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: metalloproteinase inhibitor 1; Timp; TIMP-1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBI
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Animal Disease Models  (ISO)
aortic valve insufficiency  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
cholangitis  (ISO)
cholestasis  (IEP)
chronic obstructive pulmonary disease  (IEP)
congestive heart failure  (IEP)
COVID-19  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (IDA)
diabetes mellitus  (ISO)
Down syndrome  (ISO)
Emphysema  (IEP)
endometrial carcinoma  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
Female Urogenital Diseases  (ISO)
gastric ulcer  (IEP)
heart disease  (IEP,ISO)
heart valve disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP,ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (IEP)
Kawasaki disease  (ISO)
Lymphatic Metastasis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pre-eclampsia  (ISO)
preretinal fibrosis  (ISO)
pulmonary fibrosis  (IEP,ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Stroke  (IEP)
syndromic X-linked intellectual disability Lubs type  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
vascular disease  (IEP,ISO)
Wilson disease  (ISO)
Wounds and Injuries  (IEP)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allyl alcohol  (EXP)
AM-251  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphotericin B methyl ester  (ISO)
ampicillin  (ISO)
anandamide  (ISO)
andrographolide  (ISO)
anethole  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (EXP)
Arecaidine  (ISO)
arecoline  (ISO)
Arg-Gly-Asp  (ISO)
argatroban  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
ATP  (ISO)
Aurothioglucose  (ISO)
Azaspiracid  (EXP)
azathioprine  (ISO)
azetidine  (ISO)
bacitracin  (EXP)
beclomethasone  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
betulin  (EXP)
betulinic acid  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
budesonide  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbendazim  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP)
cefaloridine  (EXP)
celastrol  (EXP)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin E  (EXP,ISO)
curcumin  (EXP,ISO)
cyanuric acid  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cystamine  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
Deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diltiazem  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP,ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
edaravone  (EXP)
elemental selenium  (EXP,ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
fasudil hydrochloride  (ISO)
fenhexamid  (ISO)
fenofibrate  (ISO)
fenoldopam  (EXP)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fucoidan  (ISO)
furan  (EXP)
gadodiamide hydrate  (EXP,ISO)
gallic acid  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
Gly-His-Lys  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
herbimycin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (EXP)
ilomastat  (EXP)
imiquimod  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isocyanuric acid  (EXP)
isoprenaline  (EXP,ISO)
juglone  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP)
lithocholic acid  (ISO)
lornoxicam  (EXP)
losartan  (EXP)
LY294002  (ISO)
Meclizine  (ISO)
megestrol  (ISO)
melamine  (EXP)
mercury dichloride  (EXP)
metaproterenol  (EXP)
methamphetamine  (EXP)
Methanandamide  (ISO)
methapyrilene  (EXP)
Methazolamide  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mifepristone  (EXP)
milrinone  (EXP)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
Natamycin  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nimodipine  (EXP)
NS-398  (ISO)
nystatin  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP)
oleanolic acid  (ISO)
oleic acid  (ISO)
orciprenaline  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorooctanoic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphatidylcholine  (EXP)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prednisolone  (EXP)
progesterone  (ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinidine  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
razoxane  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rotenone  (ISO)
SB 203580  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
solasodine  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetramethylpyrazine  (EXP)
tetraphene  (ISO)
thalidomide  (EXP)
theophylline  (EXP)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomatidine  (ISO)
topotecan  (EXP)
tranexamic acid  (ISO)
trans-anethole  (ISO)
trans-rhaponticin  (EXP)
tremolite asbestos  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
ursolic acid  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
verapamil  (EXP,ISO)
vildagliptin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP,ISO)
XL147  (ISO)
Yessotoxin  (EXP)
zinc protoporphyrin  (EXP,ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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2. Avolio C, etal., Mult Scler. 2005 Aug;11(4):441-6.
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16. GOA data from the GO Consortium
17. Gouyer V, etal., Cancer. 2005 Apr 15;103(8):1676-84.
18. Guo W, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Oct;37(10):604-7.
19. Handy JA, etal., Biochem J. 2011 Dec 15;440(3):385-95. doi: 10.1042/BJ20102148.
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21. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
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25. Iulita MF, etal., Brain. 2014 Mar;137(Pt 3):860-72. doi: 10.1093/brain/awt372. Epub 2014 Feb 11.
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27. Jiang H, etal., Diabetes. 2007 Jan;56(1):49-56.
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44. MGD data from the GO Consortium
45. Narayanan N, etal., FASEB J. 2014 Aug;28(8):3411-22. doi: 10.1096/fj.14-250183. Epub 2014 Apr 16.
46. NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. Ogata T, etal., J Vasc Surg. 2005 Jun;41(6):1036-42.
48. Parsons CJ, etal., Hepatology. 2004 Nov;40(5):1106-15.
49. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
50. Rath T, etal., PLoS One. 2014 Dec 29;9(12):e115847. doi: 10.1371/journal.pone.0115847. eCollection 2014.
51. Reis ST, etal., BMC Urol. 2016 Jul 23;16(1):44. doi: 10.1186/s12894-016-0162-6.
52. RGD automated data pipeline
53. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1309971   PMID:3839290   PMID:3903517   PMID:7777858   PMID:7926820   PMID:8559663   PMID:9573338   PMID:11860503   PMID:12477932   PMID:12631082   PMID:12714508   PMID:12826691  
PMID:12882763   PMID:12950084   PMID:14695775   PMID:15051730   PMID:15052653   PMID:15300910   PMID:15451430   PMID:15609084   PMID:15793858   PMID:15968723   PMID:16183640   PMID:16191269  
PMID:16488444   PMID:16707552   PMID:16718785   PMID:16762003   PMID:16917503   PMID:16931573   PMID:17033093   PMID:17210139   PMID:17485851   PMID:18000599   PMID:18095594   PMID:18279587  
PMID:18390195   PMID:18471418   PMID:18509851   PMID:18636553   PMID:18675881   PMID:18678246   PMID:18807189   PMID:19184368   PMID:19235898   PMID:19272247   PMID:19330523   PMID:19462901  
PMID:19467832   PMID:19497125   PMID:19537852   PMID:19917734   PMID:20226641   PMID:20388475   PMID:20854798   PMID:20939987   PMID:21180139   PMID:21319376   PMID:21356369   PMID:21468558  
PMID:21535944   PMID:21782897   PMID:21895415   PMID:22092673   PMID:22218048   PMID:22427646   PMID:22449799   PMID:23100531   PMID:23142791   PMID:23207149   PMID:23376485   PMID:23456624  
PMID:23493620   PMID:23500774   PMID:23533145   PMID:23819982   PMID:23886643   PMID:23974514   PMID:24006456   PMID:24322055   PMID:24471921   PMID:24560960   PMID:25028660   PMID:25575598  
PMID:25697011   PMID:25867313   PMID:26087281   PMID:26252163   PMID:26258010   PMID:26277580   PMID:27320964   PMID:27322513   PMID:27323108   PMID:27339256   PMID:28220578   PMID:28259914  
PMID:28506758   PMID:29158549   PMID:29302675   PMID:30121936   PMID:31099017   PMID:31200003   PMID:32122211   PMID:32194232   PMID:32570968   PMID:33355364  


Genomics

Comparative Map Data
Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBI
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh38X47,582,408 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,405 - 20,740,976 (+)NCBIGRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBImm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0panPan3
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBI
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBI
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBI
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBI
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBI
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBI
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
LOC103231892
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,759,412 - 44,763,243 (+)NCBI
ChlSab1.1 EnsemblX44,760,531 - 44,765,571 (+)Ensembl
Vero_WHO_p1.0NW_02366656624,012 - 27,843 (-)NCBI
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBI

Position Markers
AA957593  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,605,811 - 57,606,019 (+)MAPPER
Rnor_6.0456,283,244 - 56,283,451NCBIRnor6.0
Rnor_5.0456,030,613 - 56,030,820UniSTSRnor5.0
RGSC_v3.4455,873,680 - 55,873,887UniSTSRGSC3.4
Celera452,717,188 - 52,717,395UniSTS
RH 3.4 Map4307.2UniSTS
Cytogenetic MapXq12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000013745
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 37 35 26 12 26 2 2 58 28 39 11 2
Low 6 22 15 7 15 6 9 16 7 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF411319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013745   ⟹   ENSRNOP00000013745
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)Ensembl
RefSeq Acc Id: NM_053819   ⟹   NP_446271
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,984 - 1,217,582 (-)NCBI
Rnor_6.0X1,364,786 - 1,369,384 (-)NCBI
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBI
RGSC_v3.4X12,542,496 - 12,547,094 (-)RGD
CeleraX1,780,586 - 1,785,184 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256608   ⟹   XP_006256670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBI
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBI
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099406   ⟹   XP_038955334
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,969 - 1,217,669 (-)NCBI
RefSeq Acc Id: XM_039099407   ⟹   XP_038955335
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,969 - 1,217,655 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446271   ⟸   NM_053819
- Peptide Label: precursor
- UniProtKB: P30120 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256670   ⟸   XM_006256608
- Peptide Label: isoform X1
- UniProtKB: P30120 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013745   ⟸   ENSRNOT00000013745
RefSeq Acc Id: XP_038955334   ⟸   XM_039099406
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955335   ⟸   XM_039099407
- Peptide Label: isoform X1
Protein Domains
NTR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701691
Promoter ID:EPDNEW_R12215
Type:multiple initiation site
Name:Timp1_1
Description:TIMP metallopeptidase inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,369,397 - 1,369,457EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621675 AgrOrtholog
Ensembl Genes ENSRNOG00000010208 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000013745 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013745 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930800 IMAGE-MGC_LOAD
InterPro Netrin_domain UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
  TIMP1 UniProtKB/Swiss-Prot
  TIMP_C UniProtKB/Swiss-Prot
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report rno:116510 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124582 IMAGE-MGC_LOAD
NCBI Gene 116510 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF20 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot
PhenoGen Timp1 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
SMART NTR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
UniProt P30120 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P70533 UniProtKB/Swiss-Prot
  Q53YM7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Timp1  TIMP metallopeptidase inhibitor 1  Timp1  tissue inhibitor of metalloproteinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Timp1  tissue inhibitor of metalloproteinase 1  Timp1  tissue inhibitor of metallopeptidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-06-29   tissue inhibitor of metallopeptidase 1  Timp1  tissue inhibitor of metalloproteinase 1  Name updated 1299863 APPROVED
2004-09-10 Timp1  tissue inhibitor of metalloproteinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Timp1  tissue inhibitor of metalloproteinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression increases in response to angiotensin II 730067