Timp1 (TIMP metallopeptidase inhibitor 1) - Rat Genome Database

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Pathways
Gene: Timp1 (TIMP metallopeptidase inhibitor 1) Rattus norvegicus
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Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
RGD ID: 621675
Description: Enables protease binding activity. Involved in several processes, including cartilage development; negative regulation of apoptotic process; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of cholestasis; gastric ulcer; heart disease (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1); PARTICIPATES IN interleukin-6 signaling pathway; INTERACTS WITH (R)-carnitine; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metalloproteinase inhibitor 1; Timp; TIMP-1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Animal Disease Models  (ISO)
aortic valve insufficiency  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
cholangitis  (ISO)
cholestasis  (IEP)
chronic obstructive pulmonary disease  (IEP)
congenital disorder of glycosylation type IIm  (ISO)
congestive heart failure  (IEP)
COVID-19  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (IDA)
diabetes mellitus  (ISO)
Down syndrome  (ISO)
Emphysema  (IEP)
endometrial carcinoma  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
Female Urogenital Diseases  (ISO)
gastric ulcer  (IEP)
genetic disease  (ISO)
heart disease  (IEP,ISO)
heart valve disease  (ISO)
Hemorrhagic Shock  (IEP)
hyperhomocysteinemia  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP,ISO)
IgA glomerulonephritis  (ISO)
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (IEP)
Kawasaki disease  (ISO)
Lymphatic Metastasis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
neurodegeneration with brain iron accumulation 5  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pre-eclampsia  (ISO)
preretinal fibrosis  (ISO)
pulmonary fibrosis  (IEP,ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Stroke  (IEP)
syndromic X-linked intellectual disability Lubs type  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
vascular disease  (IEP,ISO)
Wilson disease  (ISO)
Wounds and Injuries  (IEP)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)
X-linked severe congenital neutropenia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allyl alcohol  (EXP)
Allylamine  (EXP)
AM-251  (ISO)
aminoguanidine  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphotericin B methyl ester  (ISO)
ampicillin  (ISO)
anandamide  (ISO)
andrographolide  (ISO)
anethole  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (EXP)
Arecaidine  (ISO)
arecoline  (ISO)
Arg-Gly-Asp  (ISO)
argatroban  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
astragaloside IV  (EXP)
ATP  (ISO)
Aurothioglucose  (ISO)
Azaspiracid  (EXP)
azathioprine  (ISO)
azetidine  (ISO)
bacitracin  (EXP)
beclomethasone  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
betulin  (EXP)
betulinic acid  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
budesonide  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbendazim  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP)
carvone  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin E  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanuric acid  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cystamine  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diltiazem  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP,ISO)
dizocilpine maleate  (EXP)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
edaravone  (EXP)
elemental selenium  (EXP,ISO)
erastin  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
fasudil  (ISO)
fenhexamid  (ISO)
fenofibrate  (ISO)
fenoldopam  (EXP)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fucoidan  (ISO)
furan  (EXP)
gadodiamide hydrate  (EXP,ISO)
gallic acid  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
Gly-His-Lys  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
herbimycin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (EXP)
icariin  (EXP)
ilomastat  (EXP)
imiquimod  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isocyanuric acid  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
juglone  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (EXP)
lithocholic acid  (ISO)
lornoxicam  (EXP)
losartan  (EXP)
LY294002  (ISO)
Meclizine  (ISO)
megestrol  (ISO)
melamine  (EXP)
mercury dichloride  (EXP)
metaproterenol  (EXP)
methamphetamine  (EXP)
Methanandamide  (ISO)
methapyrilene  (EXP)
Methazolamide  (ISO)
methimazole  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mifepristone  (EXP)
milrinone  (EXP)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
Muraglitazar  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
natamycin  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nobiletin  (EXP)
NS-398  (ISO)
nystatin  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP)
oleanolic acid  (ISO)
oleic acid  (ISO)
orciprenaline  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (ISO)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphatidylcholine  (EXP)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prednisolone  (EXP)
progesterone  (ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinidine  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
razoxane  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rotenone  (ISO)
SB 203580  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
solasodine  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetramethylpyrazine  (EXP)
tetraphene  (ISO)
thalidomide  (EXP)
theophylline  (EXP)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomatidine  (ISO)
topotecan  (EXP)
tranexamic acid  (ISO)
trans-anethole  (ISO)
trans-rhaponticin  (EXP)
tremolite asbestos  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
ursolic acid  (EXP,ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
verapamil  (EXP,ISO)
vildagliptin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP,ISO)
XL147  (ISO)
Yessotoxin  (EXP)
zinc protoporphyrin  (EXP,ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment. Avolio C, etal., Mult Scler. 2005 Aug;11(4):441-6.
3. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon beta. Boz C, etal., Clin Neurol Neurosurg. 2006 Feb;108(2):124-8.
4. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
5. ANG II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo. Castoldi G, etal., Am J Physiol Heart Circ Physiol 2003 Feb;284(2):H635-43.
6. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Chua PK, etal., Clin Diagn Lab Immunol. 2003 Mar;10(2):308-14.
7. Localization of preovulatory expression of plasminogen activator inhibitor type-1 and tissue inhibitor of metalloproteinase type-1 mRNAs in the rat ovary. Chun SY, etal., Biol Reprod. 1992 Aug;47(2):245-53.
8. Glomerular Protein Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 Are Lower in Diabetic Subjects. Cornish TC, etal., J Histochem Cytochem. 2009 Jun 8.
9. Cellular localization of tissue inhibitors of metalloproteinases in the rat ovary throughout pseudopregnancy. Curry TE Jr and Wheeler SE, Biol Reprod 2002 Dec;67(6):1943-51.
10. Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. Dagues N, etal., Toxicol Sci. 2007 Nov;100(1):238-47. Epub 2007 Jun 14.
11. Metallothionein-1 messenger RNA transcription in steroid-secreting cells of the rat ovary during the periovulatory period. Espey LL, etal., Biol Reprod 2003 May;68(5):1895-902.
12. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
13. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes.] Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents. Glowinska-Olszewska B and Urban M, Metabolism. 2007 Jun;56(6):799-805.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent. Gouyer V, etal., Cancer. 2005 Apr 15;103(8):1676-84.
18. [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma] Guo W, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Oct;37(10):604-7.
19. Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Handy JA, etal., Biochem J. 2011 Dec 15;440(3):385-95. doi: 10.1042/BJ20102148.
20. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Heymans S, etal., Circulation. 2005 Aug 23;112(8):1136-44. Epub 2005 Aug 15.
21. Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
22. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
23. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
24. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Iredale JP, etal., Hepatology. 1996 Jul;24(1):176-84.
25. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Iulita MF, etal., Brain. 2014 Mar;137(Pt 3):860-72. doi: 10.1093/brain/awt372. Epub 2014 Feb 11.
26. Differential regulation of tissue inhibitor of metalloproteinase mRNA expression in response to intracranial injury. Jaworski DM Glia. 2000 Apr;30(2):199-208.
27. TIMP-1 transgenic mice recover from diabetes induced by multiple low-dose streptozotocin. Jiang H, etal., Diabetes. 2007 Jan;56(1):49-56.
28. Mechanism of Yiqi Huayu Bushen Recipe in treating cervical syndrome with kidney deficiency in rats Jiang JC, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Dec;6(12):1280-5. doi: 10.3736/jcim200812114.
29. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
30. Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Kallakury BV, etal., Clin Cancer Res. 2001 Oct;7(10):3113-9.
31. Increased levels of serum tissue inhibitor of metalloproteinase-1 but not metalloproteinase-3 in atopic dermatitis. Katoh N, etal., Clin Exp Immunol. 2002 Feb;127(2):283-8.
32. Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain. Koyama Y, etal., Neuroscience. 2007 Jul 13;147(3):620-30. Epub 2007 Jun 6.
33. Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. Krex D, etal., Stroke. 2003 Dec;34(12):2817-21. Epub 2003 Nov 6.
34. Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes. Lee SW, etal., Diabetes Res Clin Pract. 2005 Aug;69(2):175-9.
35. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
36. The role of matrix metalloproteinases in extracellular matrix remodelling in chronic obstructive pulmonary disease rat models Li H, etal., Zhonghua Nei Ke Za Zhi 2002 Jun;41(6):393-8.
37. Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. Li YY, etal., Cardiovasc Res. 1999 Apr;42(1):162-72.
38. Inhibition of apoptosis in rat mesangial cells by tissue inhibitor of metalloproteinase-1. Lin H, etal., Kidney Int. 2002 Jul;62(1):60-9.
39. Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer. Lipton A, etal., Cancer. 2007 May 15;109(10):1933-9.
40. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Lorenzl S, etal., J Neurol Sci. 2003 Mar 15;207(1-2):71-6.
41. Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in differential diagnosis between low malignant potential (LMP) and malignant ovarian tumours. Maatta M, etal., Anticancer Res. 2007 Jul-Aug;27(4C):2753-8.
42. Inhibition of matrix metalloproteinase on hepatic transforming growth factor beta1 and caspase-3 activation in hemorrhage. Maitra SR, etal., Acad Emerg Med. 2005 Sep;12(9):797-803. doi: 10.1197/j.aem.2005.04.017.
43. Increased levels of tissue inhibitor of metalloproteinase-1 in human hepatocellular carcinoma. Matsumoto E, etal., Liver Int. 2004 Aug;24(4):379-83.
44. MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation. Mercer PF, etal., Respir Res. 2005 Dec 22;6:151.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. Epigenetic regulation of aortic remodeling in hyperhomocysteinemia. Narayanan N, etal., FASEB J. 2014 Aug;28(8):3411-22. doi: 10.1096/fj.14-250183. Epub 2014 Apr 16.
47. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. Ogata T, etal., J Vasc Surg. 2005 Jun;41(6):1036-42.
49. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Parsons CJ, etal., Hepatology. 2004 Nov;40(5):1106-15.
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. Identification of neutrophil activation markers as novel surrogate markers of CF lung disease. Rath T, etal., PLoS One. 2014 Dec 29;9(12):e115847. doi: 10.1371/journal.pone.0115847. eCollection 2014.
52. MMP9 overexpression is associated with good surgical outcome in children with UPJO: Preliminary results. Reis ST, etal., BMC Urol. 2016 Jul 23;16(1):44. doi: 10.1186/s12894-016-0162-6.
53. GOA pipeline RGD automated data pipeline
54. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
55. Tissue inhibitor of matrix metalloproteinase-1 is prognostic in head and neck squamous cell carcinoma: comparison of the circulating and tissue immunoreactive protein. Ruokolainen H, etal., Clin Cancer Res. 2005 May 1;11(9):3257-64.
56. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
57. Tumor tissue levels of tissue inhibitor of metalloproteinase-1 as a prognostic marker in primary breast cancer. Schrohl AS, etal., Clin Cancer Res. 2004 Apr 1;10(7):2289-98.
58. Primary tumor levels of tissue inhibitor of metalloproteinases-1 are predictive of resistance to chemotherapy in patients with metastatic breast cancer. Schrohl AS, etal., Clin Cancer Res. 2006 Dec 1;12(23):7054-8. Epub 2006 Nov 17.
59. Concentrations of TIMP1 mRNA splice variants and TIMP-1 protein are differentially associated with prognosis in primary breast cancer. Sieuwerts AM, etal., Clin Chem. 2007 Jul;53(7):1280-8. Epub 2007 May 3.
60. The interplay of collagen IV, tumor necrosis factor-alpha, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis. Siu MK, etal., Endocrinology 2003 Jan;144(1):371-87.
61. Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
62. Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia. Suryadevara R, etal., Glia. 2003 Oct;44(1):47-56.
63. Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. Taghavi S, etal., Am J Transplant. 2005 Jun;5(6):1548-52.
64. Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats. Takahashi I, etal., J Mol Histol. 2005 Jun;36(5):355-66. Epub 2005 Oct 6.
65. Tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9 levels in patients with hypertension Relationship to tissue Doppler indices of diastolic relaxation. Tayebjee MH, etal., Am J Hypertens. 2004 Sep;17(9):770-4.
66. Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension. Tayebjee MH, etal., Am J Hypertens. 2005 Mar;18(3):325-9.
67. Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. Thibert KA, etal., PLoS One. 2012;7(11):e50430. doi: 10.1371/journal.pone.0050430. Epub 2012 Nov 21.
68. Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy. von Moers A, etal., Acta Neuropathol (Berl). 2005 Mar;109(3):285-93. Epub 2004 Dec 23.
69. Effect of Liuweibuqi capsule, a Chinese patent medicine, on the JAK1/STAT3 pathway and MMP9/TIMP1 in a chronic obstructive pulmonary disease rat model. Wang C, etal., J Tradit Chin Med. 2015 Feb;35(1):54-62.
70. Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression following focal stroke. Wang X, etal., Stroke. 1998 Feb;29(2):516-20.
71. Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 as biomarkers of ulcerative colitis activity. Wiercinska-Drapalo A, etal., World J Gastroenterol. 2003 Dec;9(12):2843-5.
72. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Wollmer MA, etal., Psychiatr Genet. 2002 Sep;12(3):155-60.
73. Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer. Wu ZS, etal., Int J Cancer. 2008 May 1;122(9):2050-6.
74. Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice. Yang Y, etal., Aging (Albany NY). 2019 Nov 22;11(22):10016-10030. doi: 10.18632/aging.102388. Epub 2019 Nov 22.
75. Expression of gelatinases A and B, and TIMPs 1 and 2 during corneal wound healing. Ye HQ and Azar DT, Invest Ophthalmol Vis Sci. 1998 May;39(6):913-21.
76. [Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia]. Zhang H, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Aug;41(8):509-13.
77. Zhonghua xin xue guan bing za zhi ZHANG N, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Dec;36(12):1115-9.
78. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
79. Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Zhao YG, etal., Mol Reprod Dev 2002 Jun;62(2):149-58.
80. [Changes of matrix metalloproteinase 2,9 and tissue inhibitor of metalloproteinase 1, 2, 3 expression level in aged rat lung.] Zhao ZJ, etal., Beijing Da Xue Xue Bao. 2008 Feb 18;40(1):101-104.
81. [Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats] Zheng LY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:72-6.
82. Inhibitory effects of alkaline extract of Citrus reticulata on pulmonary fibrosis. Zhou XM, etal., J Ethnopharmacol. 2013 Mar 7;146(1):372-8. doi: 10.1016/j.jep.2013.01.006. Epub 2013 Jan 11.
83. Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats. Zhou Y, etal., Transl Res. 2012 Jun;159(6):464-72. doi: 10.1016/j.trsl.2011.09.007. Epub 2011 Oct 24.
Additional References at PubMed
PMID:1309971   PMID:3839290   PMID:3903517   PMID:7777858   PMID:7926820   PMID:8559663   PMID:9573338   PMID:11860503   PMID:12477932   PMID:12631082   PMID:12714508   PMID:12826691  
PMID:12882763   PMID:12950084   PMID:14695775   PMID:15051730   PMID:15052653   PMID:15300910   PMID:15451430   PMID:15609084   PMID:15793858   PMID:15968723   PMID:16183640   PMID:16191269  
PMID:16488444   PMID:16707552   PMID:16718785   PMID:16762003   PMID:16917503   PMID:16931573   PMID:17033093   PMID:17210139   PMID:17485851   PMID:18000599   PMID:18095594   PMID:18279587  
PMID:18390195   PMID:18471418   PMID:18509851   PMID:18636553   PMID:18675881   PMID:18678246   PMID:18807189   PMID:19184368   PMID:19235898   PMID:19272247   PMID:19330523   PMID:19462901  
PMID:19467832   PMID:19497125   PMID:19537852   PMID:19917734   PMID:20226641   PMID:20388475   PMID:20854798   PMID:20939987   PMID:21180139   PMID:21319376   PMID:21356369   PMID:21468558  
PMID:21535944   PMID:21782897   PMID:21895415   PMID:22092673   PMID:22218048   PMID:22427646   PMID:22449799   PMID:23100531   PMID:23142791   PMID:23207149   PMID:23376485   PMID:23456624  
PMID:23493620   PMID:23500774   PMID:23533145   PMID:23819982   PMID:23886643   PMID:23974514   PMID:24006456   PMID:24322055   PMID:24471921   PMID:24560960   PMID:25028660   PMID:25575598  
PMID:25697011   PMID:25867313   PMID:26087281   PMID:26252163   PMID:26258010   PMID:26277580   PMID:27320964   PMID:27322513   PMID:27323108   PMID:27339256   PMID:28220578   PMID:28259914  
PMID:28506758   PMID:29158549   PMID:29302675   PMID:30121936   PMID:31099017   PMID:31200003   PMID:32122211   PMID:32194232   PMID:32570968   PMID:33355364  


Genomics

Comparative Map Data
Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,405 - 20,740,976 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X49,212,076 - 49,216,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,345,832 - 13,350,248 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
LOC103231892
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,759,412 - 44,763,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,760,531 - 44,765,571 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656624,012 - 27,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978121,803 - 124,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timp1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000013745
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat

Markers in Region
AA957593  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,605,811 - 57,606,019 (+)MAPPERmRatBN7.2
Rnor_6.0456,283,244 - 56,283,451NCBIRnor6.0
Rnor_5.0456,030,613 - 56,030,820UniSTSRnor5.0
RGSC_v3.4455,873,680 - 55,873,887UniSTSRGSC3.4
Celera452,717,188 - 52,717,395UniSTS
RH 3.4 Map4307.2UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 37 35 26 12 26 2 2 58 28 39 11 2
Low 6 22 15 7 15 6 9 16 7 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF411319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000013745   ⟹   ENSRNOP00000013745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)Ensembl
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)Ensembl
RefSeq Acc Id: NM_053819   ⟹   NP_446271
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,984 - 1,217,582 (-)NCBI
Rnor_6.0X1,364,786 - 1,369,384 (-)NCBI
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBI
RGSC_v3.4X12,542,496 - 12,547,094 (-)RGD
CeleraX1,780,586 - 1,785,184 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256608   ⟹   XP_006256670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBI
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBI
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099406   ⟹   XP_038955334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,969 - 1,217,669 (-)NCBI
RefSeq Acc Id: XM_039099407   ⟹   XP_038955335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,212,969 - 1,217,655 (-)NCBI
RefSeq Acc Id: NP_446271   ⟸   NM_053819
- Peptide Label: precursor
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256670   ⟸   XM_006256608
- Peptide Label: isoform X1
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013745   ⟸   ENSRNOT00000013745
RefSeq Acc Id: XP_038955334   ⟸   XM_039099406
- Peptide Label: isoform X1
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955335   ⟸   XM_039099407
- Peptide Label: isoform X1
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30120-F1-model_v2 AlphaFold P30120 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621675 AgrOrtholog
BioCyc Gene G2FUF-3199 BioCyc
Ensembl Genes ENSRNOG00000010208 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000013745 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013745 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930800 IMAGE-MGC_LOAD
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116510 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124582 IMAGE-MGC_LOAD
NCBI Gene 116510 ENTREZGENE
PANTHER METALLOPROTEASE INHIBITOR UniProtKB/TrEMBL
  METALLOPROTEINASE INHIBITOR 1 UniProtKB/TrEMBL
  PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF20 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timp1 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JZR1 ENTREZGENE, UniProtKB/TrEMBL
  P30120 ENTREZGENE
  P70533 ENTREZGENE
  Q53YM7 ENTREZGENE
  TIMP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P70533 UniProtKB/Swiss-Prot
  Q53YM7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Timp1  TIMP metallopeptidase inhibitor 1  Timp1  tissue inhibitor of metalloproteinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Timp1  tissue inhibitor of metalloproteinase 1  Timp1  tissue inhibitor of metallopeptidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-06-29   tissue inhibitor of metallopeptidase 1  Timp1  tissue inhibitor of metalloproteinase 1  Name updated 1299863 APPROVED
2004-09-10 Timp1  tissue inhibitor of metalloproteinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Timp1  tissue inhibitor of metalloproteinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression increases in response to angiotensin II 730067