Nxph2 (neurexophilin 2) - Rat Genome Database

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Gene: Nxph2 (neurexophilin 2) Rattus norvegicus
Analyze
Symbol: Nxph2
Name: neurexophilin 2
RGD ID: 1598138
Description: Orthologous to human NXPH2 (neurexophilin 2); INTERACTS WITH bisphenol A; 2,2',5,5'-tetrachlorobiphenyl (ortholog); acrylamide (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC679932; neurexophilin-2; similar to neurexophilin 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8326,373,858 - 26,392,392 (+)NCBIGRCr8
mRatBN7.235,986,175 - 5,988,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl35,756,621 - 5,987,008 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0367,027 - 309,536 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3307,204 - 307,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03287,673 - 305,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.431,389,458 - 1,425,644 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3588,303 - 827,274 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Nxph2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8326,373,858 - 26,392,392 (+)NCBIGRCr8
mRatBN7.235,986,175 - 5,988,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl35,756,621 - 5,987,008 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0367,027 - 309,536 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3307,204 - 307,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03287,673 - 305,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.431,389,458 - 1,425,644 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3588,303 - 827,274 (+)NCBICelera
Cytogenetic Map3p13NCBI
NXPH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382138,669,157 - 138,780,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2138,669,157 - 138,780,390 (-)EnsemblGRCh38hg38GRCh38
GRCh372139,426,727 - 139,537,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362139,144,921 - 139,254,281 (-)NCBINCBI36Build 36hg18NCBI36
Build 342139,262,182 - 139,371,543NCBI
Celera2133,138,346 - 133,249,419 (-)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2131,418,025 - 131,528,441 (-)NCBIHuRef
CHM1_12139,431,333 - 139,542,431 (-)NCBICHM1_1
T2T-CHM13v2.02139,114,820 - 139,226,050 (-)NCBIT2T-CHM13v2.0
Nxph2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,211,258 - 23,291,998 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,211,258 - 23,291,985 (+)EnsemblGRCm39 Ensembl
GRCm38223,321,246 - 23,401,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl223,321,246 - 23,401,973 (+)EnsemblGRCm38mm10GRCm38
MGSCv37223,176,766 - 23,257,493 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,143,255 - 23,223,982 (+)NCBIMGSCv36mm8
Celera223,053,318 - 23,134,200 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.28NCBI
Nxph2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554405,699,352 - 5,700,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554405,697,702 - 5,700,095 (-)NCBIChiLan1.0ChiLan1.0
NXPH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21336,145,494 - 36,262,803 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B36,160,460 - 36,272,428 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B21,071,974 - 21,184,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B142,743,932 - 142,855,893 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B142,745,699 - 142,751,017 (-)Ensemblpanpan1.1panPan2
NXPH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11941,316,391 - 41,321,165 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1941,318,149 - 41,318,904 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1941,569,643 - 41,679,428 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01942,753,113 - 42,862,679 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1942,753,798 - 42,862,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11941,414,481 - 41,524,828 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01941,563,886 - 41,673,853 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01942,789,176 - 42,899,197 (-)NCBIUU_Cfam_GSD_1.0
Nxph2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303104,108,224 - 104,215,767 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646937,402,858 - 37,509,500 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646937,402,071 - 37,509,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NXPH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1512,953,195 - 13,073,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11512,953,062 - 13,073,208 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21515,096,481 - 15,217,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NXPH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11024,032,797 - 24,145,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1024,032,902 - 24,145,130 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040175,201,804 - 175,314,359 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nxph2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473238,433,156 - 38,560,534 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473238,433,202 - 38,560,449 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nxph2
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000062080
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 18 89 12 13 11 1 11 43 19 89 6 35 2

Sequence


Ensembl Acc Id: ENSRNOT00000062080   ⟹   ENSRNOP00000058783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl35,756,621 - 5,987,008 (+)Ensembl
Rnor_6.0 Ensembl3307,204 - 307,980 (+)Ensembl
RefSeq Acc Id: XM_008761617   ⟹   XP_008759839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,373,858 - 26,392,392 (+)NCBI
mRatBN7.235,986,175 - 5,988,525 (+)NCBI
Rnor_6.0367,027 - 309,536 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008759839 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93677 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058783.4
RefSeq Acc Id: XP_008759839   ⟸   XM_008761617
- Sequence:
Ensembl Acc Id: ENSRNOP00000058783   ⟸   ENSRNOT00000062080

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWT9-F1-model_v2 AlphaFold F1LWT9 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598138 AgrOrtholog
BioCyc Gene G2FUF-50534 BioCyc
Ensembl Genes ENSRNOG00000040333 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000062080.4 UniProtKB/TrEMBL
InterPro Nxph UniProtKB/TrEMBL
  NXPH/NXPE UniProtKB/TrEMBL
KEGG Report rno:679932 UniProtKB/TrEMBL
NCBI Gene 679932 ENTREZGENE
PANTHER NEUREXOPHILIN-2 UniProtKB/TrEMBL
  PTHR17103 UniProtKB/TrEMBL
Pfam Neurexophilin UniProtKB/TrEMBL
PhenoGen Nxph2 PhenoGen
PIRSF Neurexophilin UniProtKB/TrEMBL
RatGTEx ENSRNOG00000040333 RatGTEx
UniProt A6JSW9_RAT UniProtKB/TrEMBL
  F1LWT9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Nxph2  neurexophilin 2  LOC679932  similar to neurexophilin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679932  similar to neurexophilin 2  LOC687026  similar to neurexophilin 2  Data merged from RGD:1590142 1643240 APPROVED
2006-11-20 LOC679932  similar to neurexophilin 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC687026  similar to neurexophilin 2      Symbol and Name status set to provisional 70820 PROVISIONAL