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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfoxaflor
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Accession:CHEBI:133305 term browser browse the term
Definition:A mixture of the four diastereoisomers arising from the two tetrahedral stereocentres of [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide (the sulfur atom and the carbon attached to position 3 of the pyridine ring). [Both E- and Z-isomers involving the S=N double bond and the cyano group exist, but they interconvert rapidly at r.t.]. A nicotinic acetylcholine receptor agonist in insects, sulfoxaflor is used as an insecticide, particularly for the control of aphids.
Synonyms:exact_synonym: [(Xi)-methyl(oxo){(1Xi)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide
 related_synonym: Formula=C10H10F3N3OS;   GF 2032;   GF 2372;   Isoclast;   N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-lambda(4)-sulfanylidene]cyanamide;   Transform;   [methyl(oxo){1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-lambda(6)-sulfanylidene]cyanamide;   sulfoxaflore
 xref: CAS:946578-00-3
 xref_mesh: MESH:C560328
 xref: PMID:23112103;   PMID:23203347;   PMID:24420841;   PMID:24832550;   PMID:24832551;   PMID:24832552;   PMID:24832553;   PMID:25149228;   PMID:25168114;   PMID:26470367;   PMID:26706115;   PMID:26732903;   PMID:26968095;   PMID:26992075;   PMID:27367042;   PMID:27535848;   Pesticides:sulfoxaflor;   Reaxys:12447570


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sulfoxaflor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:94,286,550...94,294,968
Ensembl chr 9:94,286,550...94,294,968
JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:94,302,218...94,308,591 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP
ISO
sulfoxaflor results in increased expression of CYP2B1 mRNA
sulfoxaflor results in increased expression of CYP2B10 mRNA
NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]
CTD PMID:23607986 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP sulfoxaflor results in increased expression of CYP3A23-3A1 mRNA CTD PMID:23607986 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases response to substance
ISO NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I2 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases response to substance
ISO NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I3 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

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  CHEBI ontology 19787
    role 19734
      application 19393
        agrochemical 14436
          sulfoxaflor 8
Path 2
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  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteromonocyclic compound 16445
                                    pyridines 8381
                                      [methyl(oxido)\{1-[6-(trifluoromethyl)pyridin-3-yl]ethyl\}-lambda(6)-sulfanylidene]cyanamide 8
                                        (RC,RS)-sulfoxaflor 8
                                          sulfoxaflor 8
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