Hsd3b2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2) - Rat Genome Database

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Gene: Hsd3b2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2) Rattus norvegicus
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Symbol: Hsd3b2
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
RGD ID: 67377
Description: Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity and steroid delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum; intercellular bridge; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 17alpha-ethynylestradiol; 2,4-Dihydroxybenzophenone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3 beta-hydroxysteroid dehydrogenase 6; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3-beta-HSD IV; Hsd3b1; Hsd3b2l1; Hsd3b6; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; hydroxysteroid dehydrogenase-6 delta<5>-3-beta; hydroxysteroid dehydrogenase-6, delta<5>-3-beta; LOC108348086; MGC109236
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,784,614 - 188,812,535 (-)NCBIGRCr8
mRatBN7.22186,095,897 - 186,105,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,095,897 - 186,101,852 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,745,518 - 193,754,936 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,547,554 - 191,557,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,378,092 - 186,387,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,712,895 - 200,722,429 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2202,341,422 - 202,350,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02221,794,088 - 221,803,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,337,342 - 193,346,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,571,952 - 178,581,409 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenol  (ISO)
2,4-Dihydroxybenzophenone  (EXP)
2,6-dibromophenol  (ISO)
2-bromophenol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-nitro-m-cresol  (ISO)
8-Br-cAMP  (ISO)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (EXP)
alternariol  (ISO)
apigenin  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
carbamazepine  (ISO)
chlorohydrocarbon  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
cypermethrin  (EXP,ISO)
daidzein  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
fenitrothion  (EXP)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
hexachlorophene  (EXP)
imidacloprid  (EXP)
ketoconazole  (ISO)
lamotrigine  (ISO)
levetiracetam  (ISO)
mercury dichloride  (EXP)
metyrapone  (ISO)
Mitotane  (ISO)
mycotoxin  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
niclosamide  (ISO)
octreotide  (EXP)
oxybenzone  (EXP)
pasireotide  (EXP)
perflubron  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
sodium arsenite  (EXP)
topiramate  (ISO)
torcetrapib  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zearalenone  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin. Couet J, etal., J Invest Dermatol. 1994 Jul;103(1):60-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury. Hashimoto N, etal., Neurosci Lett 2003 Apr 3;340(1):45-8.
5. Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells. Izumi S and Mitani F, Acta Histochem. 2005;107(4):269-77. Epub 2005 Sep 1.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
8. Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. Lachance Y, etal., J Biol Chem 1990 Nov 25;265(33):20469-75.
9. Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Murrell JR, etal., Circulation. 2005 Aug 30;112(9):1301-8. Epub 2005 Aug 22.
10. Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary. Nampoothiri LP and Gupta S, J Biochem Mol Toxicol. 2008 Sep;22(5):337-44.
11. Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Naville D, etal., Mol Endocrinol 1991 Aug;5(8):1090-100.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Rosmond R, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):629-32.
21. Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin. Simard J, etal., J Biol Chem 1993 Sep 15;268(26):19659-68.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. Viollet B, etal., J Biol Chem 1996 Jan 19;271(3):1405-15.
24. Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. Zhao HF, etal., J Biol Chem 1991 Jan 5;266(1):583-93.
Additional References at PubMed
PMID:1944309   PMID:12477932   PMID:15489334   PMID:17257522   PMID:19071209  


Genomics

Comparative Map Data
Hsd3b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,784,614 - 188,812,535 (-)NCBIGRCr8
mRatBN7.22186,095,897 - 186,105,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,095,897 - 186,101,852 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,745,518 - 193,754,936 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,547,554 - 191,557,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,378,092 - 186,387,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,712,895 - 200,722,429 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2202,341,422 - 202,350,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02221,794,088 - 221,803,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,337,342 - 193,346,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,571,952 - 178,581,409 (-)NCBICelera
Cytogenetic Map2q34NCBI
HSD3B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,414,931 - 119,423,034 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,414,931 - 119,423,035 (+)EnsemblGRCh38hg38GRCh38
GRCh371119,957,554 - 119,965,657 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,759,296 - 119,767,174 (+)NCBINCBI36Build 36hg18NCBI36
Build 341119,669,814 - 119,677,693NCBI
Celera1118,188,369 - 118,196,423 (+)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,816,103 - 117,824,157 (+)NCBIHuRef
CHM1_11120,073,104 - 120,081,190 (+)NCBICHM1_1
T2T-CHM13v2.01119,428,182 - 119,436,213 (+)NCBIT2T-CHM13v2.0
Hsd3b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543522,414,605 - 22,421,682 (+)NCBIChiLan1.0ChiLan1.0
HSD3B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21112,031,114 - 112,039,643 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,634,957 - 111,643,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0183,130,065 - 83,156,996 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,128,493 - 118,153,124 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,128,493 - 118,153,124 (-)Ensemblpanpan1.1panPan2
HSD3B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,552,945 - 56,561,062 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,552,945 - 56,561,062 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,201,670 - 56,209,794 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01757,425,539 - 57,433,679 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,425,539 - 57,433,679 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,461,835 - 56,469,954 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,493,794 - 56,501,741 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,083,743 - 57,091,866 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Hsd3b2
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:68
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000026306, ENSRNOT00000056172, ENSRNOT00000068511
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat

Markers in Region
RH128688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,169,892 - 186,170,042 (+)MAPPERmRatBN7.2
Rnor_6.02200,756,587 - 200,756,736NCBIRnor6.0
Rnor_5.02220,223,694 - 220,223,843UniSTSRnor5.0
RGSC_v3.42193,500,945 - 193,501,094UniSTSRGSC3.4
Celera2178,651,862 - 178,652,011UniSTS
RH 3.4 Map21261.2UniSTS
Cytogenetic Map2q34UniSTS
RH131337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,095,922 - 186,096,079 (+)MAPPERmRatBN7.2
Rnor_6.02202,341,443 - 202,341,599NCBIRnor6.0
Rnor_6.02200,712,921 - 200,713,077NCBIRnor6.0
Rnor_5.02221,794,114 - 221,794,270UniSTSRnor5.0
Rnor_5.02220,180,003 - 220,180,159UniSTSRnor5.0
RGSC_v3.42193,337,368 - 193,337,524UniSTSRGSC3.4
Celera2178,571,978 - 178,572,134UniSTS
RH 3.4 Map21263.4UniSTS
Cytogenetic Map2q34UniSTS
RH139877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,139,789 - 186,139,977 (+)MAPPERmRatBN7.2
mRatBN7.22186,171,600 - 186,171,788 (+)MAPPERmRatBN7.2
Rnor_6.02200,758,285 - 200,758,472NCBIRnor6.0
Rnor_5.02220,225,287 - 220,225,474UniSTSRnor5.0
RGSC_v3.42193,502,653 - 193,502,840UniSTSRGSC3.4
Celera2178,653,570 - 178,653,757UniSTS
Celera2178,615,849 - 178,616,036UniSTS
RH 3.4 Map21261.2UniSTS
Cytogenetic Map2q34UniSTS
HSD3B  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,096,288 - 186,096,462 (+)MAPPERmRatBN7.2
Rnor_6.02202,341,809 - 202,341,982NCBIRnor6.0
Rnor_6.02200,713,287 - 200,713,460NCBIRnor6.0
Rnor_5.02220,180,369 - 220,180,542UniSTSRnor5.0
Rnor_5.02221,794,480 - 221,794,653UniSTSRnor5.0
RGSC_v3.42193,337,734 - 193,337,907UniSTSRGSC3.4
Celera2178,572,344 - 178,572,517UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 8 14
Below cutoff 1 2 15 14 1 14 11 9 9 2

Sequence


RefSeq Acc Id: ENSRNOT00000026306   ⟹   ENSRNOP00000026306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,095,897 - 186,101,852 (-)Ensembl
Rnor_6.0 Ensembl2202,341,422 - 202,350,929 (-)Ensembl
RefSeq Acc Id: NM_017265   ⟹   NP_058961
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,794,069 (-)NCBI
mRatBN7.22186,095,897 - 186,105,354 (-)NCBI
Rnor_6.02200,712,895 - 200,722,429 (-)NCBI
Rnor_5.02221,794,088 - 221,803,545 (-)NCBI
RGSC_v3.42193,337,342 - 193,346,799 (-)RGD
Celera2178,571,952 - 178,581,409 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281672   ⟹   XP_063137742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,534 (-)NCBI
RefSeq Acc Id: XM_063281673   ⟹   XP_063137743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,142 (-)NCBI
RefSeq Acc Id: XM_063281674   ⟹   XP_063137744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,534 (-)NCBI
RefSeq Acc Id: XM_063281675   ⟹   XP_063137745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,803,394 (-)NCBI
RefSeq Acc Id: XM_063281676   ⟹   XP_063137746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,535 (-)NCBI
RefSeq Acc Id: XM_063281677   ⟹   XP_063137747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,534 (-)NCBI
RefSeq Acc Id: XM_063281678   ⟹   XP_063137748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,535 (-)NCBI
RefSeq Acc Id: NP_058961   ⟸   NM_017265
- UniProtKB: Q5FVK0 (UniProtKB/Swiss-Prot),   Q62878 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026306   ⟸   ENSRNOT00000026306
RefSeq Acc Id: XP_063137748   ⟸   XM_063281678
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137746   ⟸   XM_063281676
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137747   ⟸   XM_063281677
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137744   ⟸   XM_063281674
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137742   ⟸   XM_063281672
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137743   ⟸   XM_063281673
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137745   ⟸   XM_063281675
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   F1LNS3 (UniProtKB/TrEMBL),   A6K3E0 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62878-F1-model_v2 AlphaFold Q62878 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67377 AgrOrtholog
BioCyc Gene G2FUF-51909 BioCyc
Ensembl Genes ENSRNOG00000019441 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000042884 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026306 ENTREZGENE
  ENSRNOT00000026306.6 UniProtKB/Swiss-Prot
  ENSRNOT00000056172 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7309637 IMAGE-MGC_LOAD
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109236 IMAGE-MGC_LOAD
NCBI Gene 29632 ENTREZGENE
PANTHER BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPIMERASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3Beta_HSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd3b2 PhenoGen
RatGTEx ENSRNOG00000019441 RatGTEx
  ENSRNOG00000042884 RatGTEx
Superfamily-SCOP NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC219828
UniProt 3BHS4_RAT UniProtKB/Swiss-Prot
  A6K3E0 ENTREZGENE, UniProtKB/TrEMBL
  F1LNS3 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVK0 ENTREZGENE
  Q62878 ENTREZGENE
UniProt Secondary Q5FVK0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  LOC108348086  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4  Data merged from RGD:11496463 737654 PROVISIONAL
2016-08-02 LOC108348086  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-08-18 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Hsd3b2l1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Name and Symbol changed 629549 APPROVED
2015-08-18 Hsd3b2l1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Symbol changed 629549 APPROVED
2010-11-02 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b6  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-18 Hsd3b6  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1      Name updated 70584 APPROVED
2001-10-23 Hsd3b1  hydroxysteroid dehydrogenase-6, delta<5>-3-beta      Name updated 68916 PENDING

RGD Curation Notes
Note Type Note Reference
gene_function contains both 3 beta-hydroxysteroid dehydrogenase and delta 5-delta 4-isomerase activities 632870
gene_protein 42-kDa protein 632870