RGD Reference Report - Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary. - Rat Genome Database

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Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary.

Authors: Nampoothiri, LP  Gupta, S 
Citation: Nampoothiri LP and Gupta S, J Biochem Mol Toxicol. 2008 Sep;22(5):337-44.
RGD ID: 4890965
Pubmed: PMID:18972398   (View Abstract at PubMed)
DOI: DOI:10.1002/jbt.20246   (Journal Full-text)

Adult virgin 4-day cycling synchronized Charles foster females were treated subcutaneously (0.05 mg/kg body wt/day) with sodium acetate (control), lead acetate or cadmium acetate alone, or both during gestational period, with pretreatment of 5 days prior to mating. There were no alterations in reproductive performance in all metal-treated groups. Implantation enzymes, cathepsin-D and alkaline phosphatase, activity were altered, but no change in the reproductive performance was observed. The key steroidogenic enzymes of ovary and placenta (3beta-HSD and 17beta-HSD), along with gonadal steroids, were affected the most in cadmium and combined treated animals whereas lead-treated animals showed a minimum change compared to the control group. Maximum displacement of zinc bound to metallothionein was more in cadmium and combined treated rats when compared to other metal-treated groups. Biomolecules such as glycogen, protein, RNA, DNA, and protein content were affected in all metal-treated groups, whereas cadmium-treated animals showed greater effect. General parameters of toxicity such as alkaline phosphatase, serum glutamate pyruvate transaminase, and creatinine were altered but were within the normal range. Biochemical effects are correlated with metals accumulated in blood, reproductive tissue such as placenta and ovary.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to cadmium ion  IEP 4890965; 4890965 RGD 
response to lead ion  IEP 4890965; 4890965 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hsd3b1  (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)
Hsd3b2  (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)


Additional Information