Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) - Rat Genome Database

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Gene: Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) Rattus norvegicus
Symbol: Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
RGD ID: 1308676
Description: Enables several functions, including NAD binding activity; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and steroid delta-isomerase activity. Involved in several processes, including cellular response to hormone stimulus; gonad development; and steroid biosynthetic process. Located in mitochondrial crista. Biomarker of several diseases, including hyperprolactinemia; hypertension; polycystic ovary syndrome; sciatic neuropathy; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (+)-taxifolin; (-)-citrinin; (E)-thiamethoxam.
Type: protein-coding
Previously known as: 3 beta-hydroxysteroid dehydrogenase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3betaHSD; delta-5-3-ketosteroid isomerase; dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; LOC360348; MGC105549; steroid Delta-isomerase
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22186,169,864 - 186,175,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,825,866 - 193,831,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,621,665 - 191,627,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,458,432 - 186,464,495 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.42193,500,916 - 193,507,633 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,651,833 - 178,657,861 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-citrinin  (EXP)
(E)-thiamethoxam  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trichlorophenol  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bosentan  (ISO)
bucladesine  (EXP)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlormequat chloride  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
Chorionic gonadotropin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
coumarin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
dibenzothiophene  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dimethomorph  (EXP)
dipentyl phthalate  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenarimol  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
glucose  (ISO)
glutathione  (EXP)
glycidol  (ISO)
glycine  (ISO)
glycitein  (EXP)
glycitin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
icariin  (ISO)
inulin  (ISO)
iodoacetic acid  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
linuron  (EXP)
lycopene  (EXP)
menadione  (ISO)
mestranol  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
Octicizer  (ISO)
octreotide  (ISO)
Oxine-copper  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pasireotide  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sertraline  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulfasalazine  (EXP)
sulindac sulfide  (ISO)
terbutylazine  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiamethoxam  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
triadimefon  (ISO)
tributylstannane  (EXP,ISO)
triclosan  (ISO)
triflumizole  (ISO)
trilostane  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
uranium atom  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
XAV939  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEP)
biphenyl metabolic process  (IEP)
C21-steroid hormone metabolic process  (IBA,IDA)
cellular response to antibiotic  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to luteinizing hormone stimulus  (IEP)
cellular response to mercury ion  (IEP)
cellular response to methylmercury  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
dibenzo-p-dioxin metabolic process  (IEP)
diterpenoid metabolic process  (IEP)
female gonad development  (IEP)
granulocyte differentiation  (IEP)
hippocampus development  (IBA,IEP)
insecticide metabolic process  (IEP)
Leydig cell differentiation  (IEP)
male gonad development  (IEP)
maternal process involved in female pregnancy  (IEP)
organic acid metabolic process  (IEP)
phenol-containing compound metabolic process  (IEP)
phosphatidylcholine metabolic process  (IEP)
progesterone biosynthetic process  (IDA)
response to activity  (IEP)
response to alkaloid  (IEP)
response to arsenic-containing substance  (IEP)
response to cadmium ion  (IEP)
response to calcium ion  (IEP)
response to corticosterone  (IBA,IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to fungicide  (IEP)
response to herbicide  (IEP)
response to L-ascorbic acid  (IEP)
response to lead ion  (IEP)
response to metal ion  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
steroid biosynthetic process  (IBA,IEA)
steroid metabolic process  (IDA)
testosterone biosynthetic process  (IEP)
toluene metabolic process  (IEP)


References - curated
# Reference Title Reference Citation
1. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Adamsson A, etal., Int J Androl. 2009 Oct;32(5):575-85. Epub 2008 Jul 9.
2. Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis. Brokken LJ, etal., Endocrinology. 2009 Jan;150(1):445-51. Epub 2008 Sep 4.
3. Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells. Chabrolle C, etal., Reprod Biol Endocrinol. 2008 Mar 19;6:11.
4. Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. Chandra AK, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):388-96. Epub 2007 Aug 1.
5. Mutations in the type II 3 beta-hydroxysteroid dehydrogenase gene in a patient with classic salt-wasting 3 beta-hydroxysteroid dehydrogenase deficiency congenital adrenal hyperplasia. Chang YT, etal., Pediatr Res. 1993 Nov;34(5):698-700.
6. Lithium action on adrenomedullary and adrenocortical functions and serum ionic balance in different age-groups of albino rats. Chaudhuri-Sengupta S, etal., Arch Physiol Biochem. 2003 Jul;111(3):246-53.
7. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Chen YJ, etal., Endocrinology. 2008 Sep;149(9):4658-68. Epub 2008 May 29.
8. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Cherradi N, etal., J Biol Chem. 1997 Mar 21;272(12):7899-907.
9. Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias. Codner E, etal., J Clin Endocrinol Metab. 2004 Feb;89(2):957-64.
10. Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase activity in vitro. Cooke GM Biol Reprod. 1989 Sep;41(3):438-45.
11. Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase. de Launoit Y, etal., Endocrinology. 1992 Jan;130(1):553-5.
12. Expression of liver-specific member of the 3 beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity. de Launoit Y, etal., J Biol Chem. 1992 Mar 5;267(7):4513-7.
13. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
14. Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization. Dupont E, etal., Endocrinology. 1991 Nov;129(5):2687-92.
15. Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Elumalai P, etal., Reprod Toxicol. 2009 Jan;27(1):41-5. Epub 2008 Nov 24.
16. Inhibition of rat granulosa cell differentiation by overexpression of Galphaq. Escamilla-Hernandez R, etal., Endocrine. 2008 Feb;33(1):21-31. Epub 2008 Apr 10.
17. Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation. Escamilla-Hernandez R, etal., Mol Endocrinol. 2008 Aug;22(8):1842-52. Epub 2008 Jun 5.
18. Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Feng Y, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Gautam DK, etal., Apoptosis. 2006 Jan;11(1):39-46.
21. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Ge RS, etal., Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2719-24. Epub 2006 Feb 8.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Hypothyroidism prolongs corpus luteum function in the pregnant rat. Hapon MB, etal., Reproduction. 2007 Jan;133(1):197-205.
24. Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury. Hashimoto N, etal., Neurosci Lett 2003 Apr 3;340(1):45-8.
25. The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. Hu GX, etal., J Steroid Biochem Mol Biol. 2009 May;115(1-2):14-9. Epub 2009 Feb 14.
26. Influence of commercial dietary oils on lipid composition and testosterone production in interstitial cells isolated from rat testis. Hurtado de Catalfo GE, etal., Lipids. 2009 Apr;44(4):345-57. Epub 2009 Jan 8.
27. Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats. Jana K and Samanta PK, Contraception. 2006 Mar;73(3):289-300. Epub 2005 Oct 20.
28. Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats. Jana K, etal., Appl Physiol Nutr Metab. 2008 Oct;33(5):903-14.
29. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Jana K, etal., Reprod Biol Endocrinol. 2006 Feb 16;4:9.
30. Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization. Juneau C, etal., Biol Reprod. 1993 Feb;48(2):226-34.
31. Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats. Keeney DS and Mason JI, Endocrinology. 1992 Apr;130(4):2007-15.
32. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
33. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones. Kumar V, etal., Food Chem Toxicol. 2008 Dec;46(12):3563-70. Epub 2008 Aug 31.
34. Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system. Kumar V, etal., J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):208-16. Epub 2008 Jun 18.
35. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9.
36. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
37. 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase expression in rat and characterization of the testis isoform. Lorence MC, etal., Mol Cell Endocrinol. 1991 Sep;80(1-3):21-31.
38. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30.
39. Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) expression and activity in the rat ovary. Martel C, etal., Mol Cell Endocrinol. 1990 Aug 20;72(2):R7-13.
40. Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels. McVey MJ, etal., Food Chem Toxicol. 2008 Jan;46(1):259-69. Epub 2007 Sep 11.
41. Evidence that Leydig precursors localize in immature band two cells isolated on Percoll gradients. Murono EP and Washburn AL, J Steroid Biochem Mol Biol. 1990 Dec 10;37(5):675-80.
42. Enhanced stimulation of 5 alpha-reductase activity in cultured Leydig cell precursors by human chorionic gonadotropin. Murono EP, etal., J Steroid Biochem Mol Biol. 1994 Mar;48(4):377-84.
43. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Murugesan P, etal., Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16.
44. A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. Nakamura E, etal., Endocrinology. 2010 Nov;151(11):5506-18. Epub 2010 Sep 1.
45. Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary. Nampoothiri LP and Gupta S, J Biochem Mol Toxicol. 2008 Sep;22(5):337-44.
46. Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Naville D, etal., Mol Endocrinol 1991 Aug;5(8):1090-100.
47. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. Nelson VL, etal., J Clin Endocrinol Metab. 2001 Dec;86(12):5925-33.
48. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis. Parthasarathy C and Balasubramanian K, J Cell Biochem. 2008 Aug 1;104(5):1671-83.
51. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
52. Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Pinilla L, etal., Endocrinology. 2009 Jun;150(6):2889-97. Epub 2009 Feb 19.
53. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
54. Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats. Rajeswary S, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):371-80. Epub 2007 Apr 5.
55. GOA pipeline RGD automated data pipeline
56. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
58. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Rosmond R, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):629-32.
59. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Shi Z, etal., Toxicol Sci. 2007 Jul;98(1):206-15. Epub 2007 Mar 30.
60. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. Slominski AT, etal., PLoS One. 2009;4(2):e4309. Epub 2009 Feb 3.
61. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Soma KK, etal., Endocrinology. 2005 Oct;146(10):4386-90. Epub 2005 Jul 14.
62. Effect of exogenous selenium on the testicular toxicity induced by ethanol in rats. Swathy SS, etal., Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):215-24.
63. Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats. Szoltys M, etal., Acta Histochem. 2010 Nov;112(6):576-82. Epub 2009 Sep 22.
64. Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat. Szoltys M, etal., Reprod Fertil Dev. 2007;19(2):356-65.
65. Effects of maternal toluene exposure on testosterone levels in fetal rats. Tsukahara S, etal., Toxicol Lett. 2009 Mar 10;185(2):79-84. Epub 2008 Dec 6.
66. Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats. Vachhrajani KD and Chowdhury AR, Indian J Exp Biol. 1990 Aug;28(8):746-51.
67. Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study. Vaithinathan S, etal., Arch Toxicol. 2008 Nov;82(11):833-9. Epub 2008 Apr 10.
68. Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine. Victor-Costa AB, etal., Reprod Toxicol. 2010 Jun;29(3):323-31. Epub 2010 Jan 4.
69. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. Viollet B, etal., J Biol Chem 1996 Jan 19;271(3):1405-15.
70. Zhonghua nan ke xue = National journal of andrology Wu XY, etal., Zhonghua Nan Ke Xue. 2008 Apr;14(4):371-6.
71. Glucocorticoid suppresses steroidogenesis in rat progenitor leydig cells. Xiao YC, etal., J Androl. 2010 Jul-Aug;31(4):365-71. Epub 2010 Jan 14.
72. Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. Zhao HF, etal., J Biol Chem 1991 Jan 5;266(1):583-93.
73. Gonadotropin stimulation of ovarian fractalkine expression and fractalkine augmentation of progesterone biosynthesis by luteinizing granulosa cells. Zhao P, etal., Endocrinology. 2008 Jun;149(6):2782-9. Epub 2008 Feb 21.
74. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Zurvarra FM, etal., Reprod Fertil Dev. 2009;21(7):827-39.
Additional References at PubMed
PMID:2243100   PMID:8274411   PMID:12477932   PMID:15489334   PMID:18614015   PMID:21166213   PMID:21427060   PMID:22217836   PMID:23332974   PMID:34215832  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22186,169,864 - 186,175,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,825,866 - 193,831,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,621,665 - 191,627,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,458,432 - 186,464,495 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.42193,500,916 - 193,507,633 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,651,833 - 178,657,861 (-)NCBICelera
Cytogenetic Map2q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381119,507,203 - 119,515,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,507,198 - 119,515,054 (+)EnsemblGRCh38hg38GRCh38
GRCh371120,049,826 - 120,057,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,851,349 - 119,859,204 (+)NCBINCBI36Build 36hg18NCBI36
Build 341119,761,892 - 119,769,716NCBI
Celera1118,280,577 - 118,288,432 (+)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,908,314 - 117,916,173 (+)NCBIHuRef
CHM1_11120,165,347 - 120,173,201 (+)NCBICHM1_1
T2T-CHM13v2.01119,520,389 - 119,528,244 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39398,749,672 - 98,767,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,759,510 - 98,767,110 (-)EnsemblGRCm39 Ensembl
GRCm38398,842,356 - 98,859,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,852,194 - 98,859,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv37398,656,120 - 98,663,717 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36398,981,255 - 98,987,280 (-)NCBIMGSCv36mm8
Celera3100,188,018 - 100,195,618 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.89NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.14101,565,229 - 101,574,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,555,576 - 111,564,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q16-q21NCBI


Variants in Hsd3b1
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:4
Interacting mature miRNAs:4
Transcripts:ENSRNOT00000026306, ENSRNOT00000056172, ENSRNOT00000068511
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat



RefSeq Acc Id: ENSRNOT00000086835   ⟹   ENSRNOP00000075324
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)Ensembl
RefSeq Acc Id: NM_001007719   ⟹   NP_001007720
Rat AssemblyChrPosition (strand)Source
mRatBN7.22186,169,864 - 186,175,984 (-)NCBI
RGSC_v3.42193,500,916 - 193,507,633 (-)RGD
Celera2178,651,833 - 178,657,861 (-)RGD
Protein Sequences
Protein RefSeqs NP_001007720 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63474 (Get FASTA)   NCBI Sequence Viewer  
  AAH86578 (Get FASTA)   NCBI Sequence Viewer  
  ABF70960 (Get FASTA)   NCBI Sequence Viewer  
  EDL85558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053018
GenBank Protein P22071 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007720   ⟸   NM_001007719
- UniProtKB: Q19P43 (UniProtKB/Swiss-Prot),   P22071 (UniProtKB/Swiss-Prot),   A6K3E2 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075324   ⟸   ENSRNOT00000086835
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22071-F1-model_v2 AlphaFold P22071 1-373 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308676 AgrOrtholog
BioCyc Gene G2FUF-51907 BioCyc
Ensembl Genes ENSRNOG00000042884 UniProtKB/TrEMBL
  ENSRNOG00000070622 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056172 UniProtKB/TrEMBL
  ENSRNOT00000086835 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360348 UniProtKB/Swiss-Prot
Pfam 3Beta_HSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd3b1 PhenoGen
RatGTEx ENSRNOG00000042884 RatGTEx
  ENSRNOG00000070622 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 3BHS1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q19P43 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Name and Symbol changed 629549 APPROVED
2010-11-02 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-18 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b1_predicted  hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Hsd3b1_predicted  hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted)      Symbol and Name status set to approved 70820 APPROVED