Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) - Rat Genome Database

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Gene: Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) Rattus norvegicus
Analyze
Symbol: Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
RGD ID: 1308676
Description: ENCODES a protein that exhibits 3-beta-hydroxy-delta5-steroid dehydrogenase activity; dihydrotestosterone 17-beta-dehydrogenase activity; NAD binding; INVOLVED IN adrenal gland development; biphenyl metabolic process; C21-steroid hormone metabolic process; PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH hyperprolactinemia; hypertension; hypogonadism; FOUND IN intracellular membrane-bounded organelle; mitochondrial crista; endoplasmic reticulum (ortholog); INTERACTS WITH (-)-citrinin; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3 beta-hydroxysteroid dehydrogenase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3betaHSD; delta-5-3-ketosteroid isomerase; dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; LOC360348; MGC105549; steroid Delta-isomerase
RGD Orthologs
Human
Mouse
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22186,169,864 - 186,175,984 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)Ensembl
RGSC_v3.42193,500,916 - 193,507,633 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2178,651,833 - 178,657,861 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trichlorophenol  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
captan  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlormequat chloride  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
Chorionic gonadotropin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (EXP)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenarimol  (ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
glucose  (ISO)
glutathione  (EXP)
glycidol  (ISO)
glycitein  (EXP)
glycitin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
hesperidin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
icariin  (ISO)
iodoacetic acid  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lycopene  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nicotine  (EXP,ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pasireotide  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sertraline  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulfasalazine  (EXP)
sulindac sulfide  (ISO)
terbutylazine  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
trilostane  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
uranium atom  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEP)
biphenyl metabolic process  (IEP)
C21-steroid hormone metabolic process  (IBA,IDA)
cellular response to antibiotic  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to luteinizing hormone stimulus  (IEP)
cellular response to mercury ion  (IEP)
cellular response to methylmercury  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
dibenzo-p-dioxin metabolic process  (IEP)
diterpenoid metabolic process  (IEP)
female gonad development  (IEP)
granulocyte differentiation  (IEP)
hippocampus development  (IBA,IEP)
insecticide metabolic process  (IEP)
Leydig cell differentiation  (IEP)
male gonad development  (IEP)
maternal process involved in female pregnancy  (IEP)
organic acid metabolic process  (IEP)
ovulation  (IEP)
phenol-containing compound metabolic process  (IEP)
phosphatidylcholine metabolic process  (IEP)
progesterone biosynthetic process  (IDA)
response to activity  (IEP)
response to alkaloid  (IEP)
response to arsenic-containing substance  (IEP)
response to cadmium ion  (IEP)
response to calcium ion  (IEP)
response to corticosterone  (IBA,IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to fungicide  (IEP)
response to herbicide  (IEP)
response to L-ascorbic acid  (IEP)
response to lead ion  (IEP)
response to lithium ion  (IEP)
response to metal ion  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
steroid biosynthetic process  (IBA)
steroid metabolic process  (IDA)
testosterone biosynthetic process  (IEP)
toluene metabolic process  (IEP)

References

References - curated
1. Adamsson A, etal., Int J Androl. 2009 Oct;32(5):575-85. Epub 2008 Jul 9.
2. Brokken LJ, etal., Endocrinology. 2009 Jan;150(1):445-51. Epub 2008 Sep 4.
3. Chabrolle C, etal., Reprod Biol Endocrinol. 2008 Mar 19;6:11.
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5. Chang YT, etal., Pediatr Res. 1993 Nov;34(5):698-700.
6. Chaudhuri-Sengupta S, etal., Arch Physiol Biochem. 2003 Jul;111(3):246-53.
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8. Cherradi N, etal., J Biol Chem. 1997 Mar 21;272(12):7899-907.
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13. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
14. Dupont E, etal., Endocrinology. 1991 Nov;129(5):2687-92.
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16. Escamilla-Hernandez R, etal., Endocrine. 2008 Feb;33(1):21-31. Epub 2008 Apr 10.
17. Escamilla-Hernandez R, etal., Mol Endocrinol. 2008 Aug;22(8):1842-52. Epub 2008 Jun 5.
18. Feng Y, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.
19. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Gautam DK, etal., Apoptosis. 2006 Jan;11(1):39-46.
21. Ge RS, etal., Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2719-24. Epub 2006 Feb 8.
22. GOA data from the GO Consortium
23. Hapon MB, etal., Reproduction. 2007 Jan;133(1):197-205.
24. Hashimoto N, etal., Neurosci Lett 2003 Apr 3;340(1):45-8.
25. Hu GX, etal., J Steroid Biochem Mol Biol. 2009 May;115(1-2):14-9. Epub 2009 Feb 14.
26. Hurtado de Catalfo GE, etal., Lipids. 2009 Apr;44(4):345-57. Epub 2009 Jan 8.
27. Jana K and Samanta PK, Contraception. 2006 Mar;73(3):289-300. Epub 2005 Oct 20.
28. Jana K, etal., Appl Physiol Nutr Metab. 2008 Oct;33(5):903-14.
29. Jana K, etal., Reprod Biol Endocrinol. 2006 Feb 16;4:9.
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35. Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9.
36. Lorence MC, etal., Mol Cell Endocrinol. 1991 Sep;80(1-3):21-31.
37. MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30.
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41. Murono EP, etal., J Steroid Biochem Mol Biol. 1994 Mar;48(4):377-84.
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43. Nakamura E, etal., Endocrinology. 2010 Nov;151(11):5506-18. Epub 2010 Sep 1.
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48. OMIM Disease Annotation Pipeline
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52. Pipeline to import SMPDB annotations from SMPDB into RGD
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54. RGD automated data pipeline
55. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:2243100   PMID:8274411   PMID:12477932   PMID:15489334   PMID:18614015   PMID:21166213   PMID:21427060   PMID:22217836   PMID:23332974  


Genomics

Comparative Map Data
Hsd3b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22186,169,864 - 186,175,984 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)Ensembl
RGSC_v3.42193,500,916 - 193,507,633 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2178,651,833 - 178,657,861 (-)NCBICelera
Cytogenetic Map2q34NCBI
HSD3B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,507,198 - 119,515,054 (+)EnsemblGRCh38hg38GRCh38
GRCh381119,507,203 - 119,515,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,049,826 - 120,057,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,851,349 - 119,859,204 (+)NCBINCBI36hg18NCBI36
Build 341119,761,892 - 119,769,716NCBI
Celera1118,280,577 - 118,288,432 (+)NCBI
Cytogenetic Map1p12NCBI
HuRef1117,908,314 - 117,916,173 (+)NCBIHuRef
CHM1_11120,165,347 - 120,173,201 (+)NCBICHM1_1
Hsd3b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,749,672 - 98,767,110 (-)NCBIGRCm39mm39
GRCm39 Ensembl398,759,510 - 98,767,110 (-)Ensembl
GRCm38398,842,356 - 98,859,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,852,194 - 98,859,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv37398,656,120 - 98,663,717 (-)NCBIGRCm37mm9NCBIm37
MGSCv36398,981,255 - 98,987,280 (-)NCBImm8
Celera3100,188,018 - 100,195,618 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.89NCBI
HSD3B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14101,565,229 - 101,574,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,555,576 - 111,564,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q16-q21NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:4
Interacting mature miRNAs:4
Transcripts:ENSRNOT00000026306, ENSRNOT00000056172, ENSRNOT00000068511
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086835   ⟹   ENSRNOP00000075324
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)Ensembl
RefSeq Acc Id: NM_001007719   ⟹   NP_001007720
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22186,169,864 - 186,175,984 (-)NCBI
RGSC_v3.42193,500,916 - 193,507,633 (-)RGD
Celera2178,651,833 - 178,657,861 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007720 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63474 (Get FASTA)   NCBI Sequence Viewer  
  AAH86578 (Get FASTA)   NCBI Sequence Viewer  
  ABF70960 (Get FASTA)   NCBI Sequence Viewer  
  EDL85558 (Get FASTA)   NCBI Sequence Viewer  
  P22071 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001007720   ⟸   NM_001007719
- UniProtKB: P22071 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075324   ⟸   ENSRNOT00000086835

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000070622 Ensembl
IMAGE_CLONE IMAGE:7306702 IMAGE-MGC_LOAD
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:360348 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105549 IMAGE-MGC_LOAD
NCBI Gene 360348 ENTREZGENE
Pfam 3Beta_HSD UniProtKB/Swiss-Prot
PhenoGen Hsd3b1 PhenoGen
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt 3BHS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q19P43 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Name and Symbol changed 629549 APPROVED
2010-11-02 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-18 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b1_predicted  hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Hsd3b1_predicted  hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted)      Symbol and Name status set to approved 70820 APPROVED