Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6) Rattus norvegicus
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Symbol:
Trpc6
Name:
transient receptor potential cation channel, subfamily C, member 6
Description:
Exhibits several functions, including ATPase binding activity; calcium channel activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; generation of neurons; and positive regulation of peptidyl-threonine phosphorylation. Localizes to plasma membrane. Used to study focal segmental glomerulosclerosis; kidney disease; and transient cerebral ischemia. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6); PARTICIPATES IN endothelin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; 7,12-dimethyltetraphene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
short transient receptor potential channel 6; transient receptor protein 6; Trrp6
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TRPC6 (transient receptor potential cation channel subfamily C member 6) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Trpc6 (transient receptor potential cation channel, subfamily C, member 6) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Trpc6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TRPC6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TRPC6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Trpc6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TRPC6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
TRPC6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Trpc6 (transient receptor potential cation channel subfamily C member 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TRPC3 (transient receptor potential cation channel subfamily C member 3) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Trpc6 (transient receptor potential cation channel, subfamily C, member 6)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|OrthoFinder|OrthoInspector|TreeFam|Hieranoid)
Homo sapiens (human):
TRPC6 (transient receptor potential cation channel subfamily C member 6)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|HGNC|OMA|PANTHER|OrthoFinder|OrthoInspector|TreeFam|Hieranoid)
Drosophila melanogaster (fruit fly):
Trpgamma
Alliance
DIOPT (OMA|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
trp-2
Alliance
DIOPT (OMA|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
trp-1
Alliance
DIOPT (OMA|PANTHER|TreeFam)
Drosophila melanogaster (fruit fly):
trp
Alliance
DIOPT (OMA|Hieranoid|TreeFam)
Allele / Splice:
Trpc6em3Mcwi
Trpc6em4Mcwi
Trpc6em1Mcwi
Genetic Models:
SS-Trpc6em1Mcwi
SS-Trpc6em4Mcwi
SS-Trpc6em3Mcwi
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 8 6,811,543 - 6,917,534 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 6,811,543 - 6,917,535 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 6,799,564 - 6,904,623 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 5,472,515 - 5,577,537 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 8 5,472,514 - 5,577,536 (+) NCBI Celera 8 7,300,179 - 7,404,007 (+) NCBI Celera Cytogenetic Map 8 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar PMID:26467025 , PMID:28492532 focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar PMID:28492532 focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar PMID:25741868 , PMID:28492532 focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar PMID:19380626 focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar PMID:19936226 more ... focal segmental glomerulosclerosis ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis ClinVar PMID:25741868 , PMID:26467025 focal segmental glomerulosclerosis 1 ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal sclerosis with hyalinosis ClinVar PMID:25741868 , PMID:28492532 focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis 2 ClinVar PMID:26467025 focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis 2 ClinVar PMID:15924139 , PMID:25741868 focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by OMIM:603965 ClinVar focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis 2 ClinVar PMID:19936226 more ... focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by OMIM:603965 ClinVar PMID:10200986 , PMID:15879175 focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by OMIM:603965 ClinVar PMID:15924139 focal segmental glomerulosclerosis 2 ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Focal segmental glomerulosclerosis 2 ClinVar PMID:25741868 , PMID:26467025 nephrotic syndrome ISO RGD:1347433 8554872 ClinVar Annotator: match by term: Nephrotic syndrome ClinVar PMID:26467025 , PMID:28204945
Imported Annotations - CTD
disease of mental health ISO RGD:1347433 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21059368 Disease Susceptibility ISO RGD:1347433 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20130021 focal segmental glomerulosclerosis ISO RGD:1347433 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26892346 Hypertrophy ISO RGD:1347433 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20177073 Imported Annotations - OMIM
focal segmental glomerulosclerosis 2 ISO RGD:1347433 7240710 OMIM
(+)-catechin multiple interactions ISO RGD:1347433 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TRPC6 mRNA CTD PMID:24763279 (+)-conocarpan increases activity ISO RGD:732721 6480464 conocarpan results in increased activity of TRPC6 protein CTD PMID:31054997 (+)-conocarpan multiple interactions ISO RGD:732721 6480464 SAR7334 inhibits the reaction [conocarpan results in increased activity of TRPC6 protein] CTD PMID:31054997 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of TRPC6 mRNA CTD PMID:17351261 17beta-estradiol multiple interactions ISO RGD:1347433 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of TRPC6 mRNA CTD PMID:20660070 17beta-estradiol increases expression ISO RGD:1347433 6480464 Estradiol results in increased expression of TRPC6 mRNA CTD PMID:21795739 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732721 6480464 Tetrachlorodibenzodioxin affects the expression of TRPC6 mRNA CTD PMID:21570461 4,4'-sulfonyldiphenol increases expression ISO RGD:1347433 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of TRPC6 mRNA CTD PMID:25912373 4,4'-sulfonyldiphenol increases expression ISO RGD:732721 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of TRPC6 mRNA CTD PMID:30951980 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions ISO RGD:732721 6480464 fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions ISO RGD:1347433 6480464 fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TRPC6 mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:19480007 8-bromo-3',5'-cyclic GMP multiple interactions EXP 6480464 8-bromocyclic GMP inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] CTD PMID:20177073 8-bromo-3',5'-cyclic GMP increases phosphorylation ISO RGD:1347433 6480464 8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein CTD PMID:20177073 8-bromo-3',5'-cyclic GMP multiple interactions ISO RGD:1347433 6480464 KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein] CTD PMID:20177073 acetylcholine multiple interactions EXP 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]] more ... CTD PMID:11535132 aflatoxin B1 decreases methylation ISO RGD:1347433 6480464 Aflatoxin B1 results in decreased methylation of TRPC6 gene CTD PMID:27153756 aflatoxin B1 increases expression ISO RGD:1347433 6480464 Aflatoxin B1 results in increased expression of TRPC6 protein CTD PMID:27818125 alpha-Zearalanol increases expression ISO RGD:1347433 6480464 Zeranol results in increased expression of TRPC6 protein CTD PMID:27224899 amiloride decreases activity ISO RGD:732721 6480464 Amiloride results in decreased activity of TRPC6 protein CTD PMID:11179201 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TRPC6 mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of TRPC6 mRNA CTD PMID:30779732 barium(0) multiple interactions ISO RGD:732721 6480464 1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC6 protein affects the transport of Barium], ADRA1A protein promotes the reaction [TRPC6 protein results in increased transport of Barium] CTD PMID:11179201 , PMID:16055711 barium(0) increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Barium CTD PMID:11179201 barium(0) affects transport ISO RGD:732721 6480464 TRPC6 protein affects the transport of Barium CTD PMID:16055711 benzo[a]pyrene increases expression ISO RGD:1347433 6480464 Benzo(a)pyrene results in increased expression of TRPC6 mRNA CTD PMID:17879257 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TRPC6 mRNA CTD PMID:21839799 benzo[b]fluoranthene increases expression ISO RGD:732721 6480464 benzo(b)fluoranthene results in increased expression of TRPC6 mRNA CTD PMID:26377693 bis(2-chloroethyl) sulfide increases expression ISO RGD:732721 6480464 Mustard Gas results in increased expression of TRPC6 mRNA CTD PMID:15674844 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of TRPC6 mRNA CTD PMID:31199487 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TRPC6 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1347433 6480464 bisphenol A results in decreased expression of TRPC6 mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:732721 6480464 bisphenol A results in increased expression of TRPC6 mRNA CTD PMID:30951980 bisphenol F increases expression ISO RGD:732721 6480464 bisphenol F results in increased expression of TRPC6 mRNA CTD PMID:30951980 Butylbenzyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of TRPC6 mRNA CTD PMID:31199487 cadmium atom decreases activity ISO RGD:732721 6480464 Cadmium results in decreased activity of TRPC6 protein CTD PMID:11179201 caesium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Cesium CTD PMID:11179201 calcium atom multiple interactions ISO RGD:1347433 6480464 [Diglycerides results in increased activity of TRPC6 protein] which results in increased abundance of Calcium more ... CTD PMID:14551041 , PMID:21562303 calcium atom affects transport ISO RGD:732721 6480464 TRPC6 protein affects the transport of Calcium CTD PMID:18209485 calcium atom affects transport ISO RGD:1347433 6480464 TRPC6 protein affects the transport of Calcium CTD PMID:18209485 calcium atom increases transport EXP 6480464 TRPC6 protein results in increased transport of Calcium CTD PMID:18822394 calcium atom affects transport EXP 6480464 TRPC6 protein affects the transport of Calcium CTD PMID:15672411 calcium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Calcium CTD PMID:11179201 calcium atom increases uptake EXP 6480464 TRPC6 protein results in increased uptake of Calcium CTD PMID:11535132 calcium atom multiple interactions EXP 6480464 1 more ... CTD PMID:11535132 , PMID:15672411 calcium atom increases uptake ISO RGD:1347433 6480464 TRPC6 protein results in increased uptake of Calcium CTD PMID:21562303 calcium(0) multiple interactions ISO RGD:1347433 6480464 [Diglycerides results in increased activity of TRPC6 protein] which results in increased abundance of Calcium more ... CTD PMID:14551041 , PMID:21562303 calcium(0) affects transport ISO RGD:1347433 6480464 TRPC6 protein affects the transport of Calcium CTD PMID:18209485 calcium(0) increases transport EXP 6480464 TRPC6 protein results in increased transport of Calcium CTD PMID:18822394 calcium(0) affects transport EXP 6480464 TRPC6 protein affects the transport of Calcium CTD PMID:15672411 calcium(0) increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Calcium CTD PMID:11179201 calcium(0) affects transport ISO RGD:732721 6480464 TRPC6 protein affects the transport of Calcium CTD PMID:18209485 calcium(0) increases uptake EXP 6480464 TRPC6 protein results in increased uptake of Calcium CTD PMID:11535132 calcium(0) multiple interactions EXP 6480464 1 more ... CTD PMID:11535132 , PMID:15672411 calcium(0) increases uptake ISO RGD:1347433 6480464 TRPC6 protein results in increased uptake of Calcium CTD PMID:21562303 carbachol increases activity ISO RGD:732721 6480464 Carbachol results in increased activity of TRPC6 protein CTD PMID:17603544 carbachol multiple interactions ISO RGD:732721 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:17603544 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of TRPC6 mRNA CTD PMID:18500788 chloroprene decreases expression ISO RGD:732721 6480464 Chloroprene results in decreased expression of TRPC6 mRNA CTD PMID:23125180 dextran sulfate multiple interactions ISO RGD:732721 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TRPC6 mRNA CTD PMID:29950665 dibenziodolium multiple interactions ISO RGD:1347433 6480464 diphenyleneiodonium inhibits the reaction [INS protein results in increased expression of TRPC6 protein] CTD PMID:22031853 dibenziodolium decreases expression ISO RGD:732721 6480464 diphenyleneiodonium results in decreased expression of TRPC6 protein CTD PMID:22031853 dibutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of TRPC6 mRNA CTD PMID:31199487 diethyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of TRPC6 mRNA CTD PMID:31199487 diisobutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of TRPC6 mRNA CTD PMID:31199487 diisononyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of TRPC6 mRNA CTD PMID:31199487 dioxygen multiple interactions ISO RGD:732721 6480464 fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein], Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 dioxygen increases expression ISO RGD:1347433 6480464 Oxygen deficiency results in increased expression of TRPC6 protein CTD PMID:30831131 dioxygen multiple interactions ISO RGD:1347433 6480464 fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] more ... CTD PMID:30831131 dioxygen increases expression ISO RGD:732721 6480464 Oxygen deficiency results in increased expression of TRPC6 protein CTD PMID:30831131 dorsomorphin multiple interactions ISO RGD:1347433 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin multiple interactions EXP 6480464 salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC6 protein] CTD PMID:28495616 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of TRPC6 protein CTD PMID:28495616 entinostat increases expression ISO RGD:1347433 6480464 entinostat results in increased expression of TRPC6 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:1347433 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA CTD PMID:27188386 fasudil hydrochloride multiple interactions ISO RGD:1347433 6480464 fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 fasudil hydrochloride multiple interactions ISO RGD:732721 6480464 fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of TRPC6 mRNA CTD PMID:18035473 flufenamic acid multiple interactions ISO RGD:1347433 6480464 [Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium CTD PMID:21562303 flufenamic acid multiple interactions EXP 6480464 Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]], Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]] CTD PMID:11535132 flufenamic acid increases activity ISO RGD:1347433 6480464 Flufenamic Acid results in increased activity of TRPC6 protein CTD PMID:14551041 , PMID:21562303 furan increases expression EXP 6480464 furan results in increased expression of TRPC6 mRNA CTD PMID:27387713 gadolinium atom decreases activity ISO RGD:732721 6480464 Gadolinium results in decreased activity of TRPC6 protein CTD PMID:11179201 GDP-beta-S decreases activity ISO RGD:732721 6480464 guanosine 5'-O-(2-thiodiphosphate) results in decreased activity of TRPC6 protein CTD PMID:11179201 geldanamycin increases expression ISO RGD:1347433 6480464 geldanamycin results in increased expression of TRPC6 mRNA CTD PMID:26705709 guanosine 5'-[gamma-thio]triphosphate increases activity ISO RGD:732721 6480464 Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of TRPC6 protein CTD PMID:11179201 hydrogen peroxide increases expression ISO RGD:732721 6480464 Hydrogen Peroxide results in increased expression of TRPC6 protein CTD PMID:22031853 iron atom increases uptake ISO RGD:732721 6480464 TRPC6 protein results in increased uptake of Iron CTD PMID:14640978 iron(0) increases uptake ISO RGD:732721 6480464 TRPC6 protein results in increased uptake of Iron CTD PMID:14640978 KT 5823 multiple interactions ISO RGD:1347433 6480464 KT 5823 inhibits the reaction [4-((3 more ... CTD PMID:20177073 KT 5823 multiple interactions EXP 6480464 KT 5823 inhibits the reaction [4-((3 more ... CTD PMID:20177073 lanthanum atom decreases activity ISO RGD:732721 6480464 Lanthanum results in decreased activity of TRPC6 protein CTD PMID:11179201 lead diacetate increases expression ISO RGD:732721 6480464 lead acetate results in increased expression of TRPC6 mRNA CTD PMID:22613225 lithium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Lithium CTD PMID:11179201 lithium hydride increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Lithium CTD PMID:11179201 manganese atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Manganese CTD PMID:11179201 manganese atom increases uptake EXP 6480464 TRPC6 protein results in increased uptake of Manganese CTD PMID:11535132 manganese atom multiple interactions EXP 6480464 1 more ... CTD PMID:11535132 manganese(0) increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Manganese CTD PMID:11179201 manganese(0) increases uptake EXP 6480464 TRPC6 protein results in increased uptake of Manganese CTD PMID:11535132 manganese(0) multiple interactions EXP 6480464 1 more ... CTD PMID:11535132 ML-7 decreases activity ISO RGD:732721 6480464 ML 7 results in decreased activity of TRPC6 protein CTD PMID:17603544 nickel atom affects expression ISO RGD:1347433 6480464 Nickel affects the expression of TRPC6 mRNA CTD PMID:14575637 nickel atom multiple interactions ISO RGD:1347433 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of TRPC6 mRNA] CTD PMID:14575637 nitrofen increases expression EXP 6480464 nitrofen results in increased expression of TRPC6 mRNA, nitrofen results in increased expression of TRPC6 protein CTD PMID:28983729 ouabain increases expression EXP 6480464 Ouabain results in increased expression of TRPC6 protein CTD PMID:19897708 ouabain multiple interactions EXP 6480464 SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein] more ... CTD PMID:19897708 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TRPC6 mRNA CTD PMID:25729387 panobinostat multiple interactions ISO RGD:1347433 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1347433 6480464 panobinostat results in increased expression of TRPC6 mRNA CTD PMID:26272509 phenylephrine multiple interactions EXP 6480464 TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium] CTD PMID:15672411 pirinixic acid multiple interactions ISO RGD:1347433 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRPC6 mRNA CTD PMID:19710929 potassium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Potassium CTD PMID:11179201 progesterone multiple interactions ISO RGD:1347433 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of TRPC6 mRNA CTD PMID:20660070 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of TRPC6 mRNA CTD PMID:20726854 reactive oxygen species multiple interactions EXP 6480464 [AGT protein modified form results in increased abundance of Reactive Oxygen Species] which results in increased activity of TRPC6 protein CTD PMID:24037962 resveratrol increases activity EXP 6480464 resveratrol results in increased activity of TRPC6 protein CTD PMID:23435869 rubidium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Rubidium CTD PMID:11179201 S-nitroso-N-acetyl-D-penicillamine multiple interactions EXP 6480464 S-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] CTD PMID:20177073 salvianolic acid B multiple interactions EXP 6480464 salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC6 protein] CTD PMID:28495616 SB 431542 multiple interactions ISO RGD:1347433 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sildenafil citrate increases phosphorylation ISO RGD:732721 6480464 Sildenafil Citrate results in increased phosphorylation of TRPC6 protein CTD PMID:20177073 SKF-96365 hydrochloride decreases activity ISO RGD:732721 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased activity of TRPC6 protein CTD PMID:11179201 SKF-96365 hydrochloride multiple interactions EXP 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]], 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]] CTD PMID:11535132 sodium arsenite decreases expression ISO RGD:1347433 6480464 sodium arsenite results in decreased expression of TRPC6 mRNA CTD PMID:25493608 sodium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Sodium CTD PMID:11179201 strontium atom increases transport ISO RGD:732721 6480464 TRPC6 protein results in increased transport of Strontium CTD PMID:11179201 sulforaphane decreases expression ISO RGD:732721 6480464 sulforafan results in decreased expression of TRPC6 mRNA CTD PMID:30529165 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of TRPC6 mRNA CTD PMID:16644059 tetraphene increases expression ISO RGD:732721 6480464 benz(a)anthracene results in increased expression of TRPC6 mRNA CTD PMID:26377693 thapsigargin multiple interactions EXP 6480464 2-aminoethyl diphenylborinate inhibits the reaction [Thapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium]], Thapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium] CTD PMID:11535132 titanium dioxide increases expression ISO RGD:732721 6480464 titanium dioxide results in increased expression of TRPC6 mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:732721 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TRPC6 mRNA CTD PMID:29950665 titanium dioxide decreases expression ISO RGD:732721 6480464 titanium dioxide results in decreased expression of TRPC6 mRNA CTD PMID:29264374 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TRPC6 mRNA CTD PMID:25729387 trichostatin A multiple interactions ISO RGD:1347433 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of TRPC6 mRNA] CTD PMID:14575637 trichostatin A increases expression ISO RGD:1347433 6480464 trichostatin A results in increased expression of TRPC6 mRNA CTD PMID:26705709 U-73122 multiple interactions ISO RGD:732721 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:17603544 U-73122 decreases activity ISO RGD:732721 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:11179201 valproic acid increases expression ISO RGD:1347433 6480464 Valproic Acid results in increased expression of TRPC6 mRNA CTD PMID:24383497 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of TRPC6 mRNA CTD PMID:23869203 Y-27632 multiple interactions ISO RGD:732721 6480464 Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 Y-27632 multiple interactions ISO RGD:1347433 6480464 Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131
Gene-Chemical Interaction Annotations
