Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6) Rattus norvegicus
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Symbol: Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Description: Exhibits several functions, including ATPase binding activity, calcium channel activity, and cytoskeletal protein binding activity; involved in several processes, including aging, cellular response to hydrogen peroxide, and generation of neurons; localizes to the plasma membrane; used to study focal segmental glomerulosclerosis, kidney disease, and transient cerebral ischemia; biomarker of type 2 diabetes mellitus; orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6); PARTICIPATES IN endothelin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: short transient receptor potential channel 6; transient receptor protein 6; Trrp6
Orthologs:
Allele / Splice: Trpc6em3Mcwi   Trpc6em4Mcwi   Trpc6em1Mcwi  
Genetic Models: SS-Trpc6em1Mcwi SS-Trpc6em4Mcwi SS-Trpc6em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.086,811,543 - 6,917,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.086,799,564 - 6,904,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,472,515 - 5,577,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.185,472,514 - 5,577,536 (+)NCBI
Celera87,300,179 - 7,404,007 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Trpc6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619788
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.