Trpc6 (transient receptor potential cation channel, subfamily C, member 6) - Rat Genome Database

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Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6) Rattus norvegicus
Symbol: Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
RGD ID: 619788
Description: Enables several functions, including ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of dendrite morphogenesis; and positive regulation of peptidyl-threonine phosphorylation. Predicted to be located in cytoplasm; membrane; and slit diaphragm. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Used to study focal segmental glomerulosclerosis; kidney disease; and transient cerebral ischemia. Biomarker of proteinuria and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6); PARTICIPATES IN endothelin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 1-Oleoyl-2-acetyl-sn-glycerol; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: short transient receptor potential channel 6; transient receptor protein 6; Trrp6
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Trpc6em3Mcwi   Trpc6em4Mcwi   Trpc6em1Mcwi  
Genetic Models: SS-Trpc6em1Mcwi SS-Trpc6em4Mcwi SS-Trpc6em3Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8814,044,216 - 14,148,808 (+)NCBIGRCr8
mRatBN7.285,759,387 - 5,864,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,758,935 - 5,828,092 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx89,686,632 - 9,791,048 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,984,275 - 8,088,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.086,019,710 - 6,124,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,811,543 - 6,917,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,811,543 - 6,917,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,799,564 - 6,904,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,472,515 - 5,577,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.185,472,514 - 5,577,536 (+)NCBI
Celera87,300,179 - 7,404,007 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-conocarpan  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetylcholine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amiloride  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
caesium atom  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbachol  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloroprene  (ISO)
clotrimazole  (EXP)
Cuprizon  (EXP)
daunorubicin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
docebenone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
fasudil  (ISO)
flavonoids  (EXP)
flufenamic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gadolinium atom  (ISO)
GDP-beta-S  (ISO)
geldanamycin  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
hydrogen peroxide  (ISO)
hyperforin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
KT 5823  (EXP,ISO)
lanthanum atom  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium atom  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP)
rubidium atom  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
salvianolic acid B  (EXP)
SB 431542  (ISO)
sildenafil citrate  (ISO)
SKF-96365 hydrochloride  (EXP,ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
strontium atom  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. Alessandri-Haber N, etal., J Neurosci. 2009 May 13;29(19):6217-28. doi: 10.1523/JNEUROSCI.0893-09.2009.
2. Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats. Du W, etal., J Clin Invest. 2010 Oct;120(10):3480-92. doi: 10.1172/JCI43165. Epub 2010 Sep 1.
3. Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta: implications for age-related vasospastic disorders. Erac Y, etal., Age (Dordr). 2010 Jun;32(2):223-30. doi: 10.1007/s11357-009-9126-z. Epub 2010 Jan 13.
4. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. Fortin DA, etal., J Neurosci. 2012 Jun 13;32(24):8127-37. doi: 10.1523/JNEUROSCI.6034-11.2012.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
7. Canonical transient receptor potential 6 (TRPC6), a redox-regulated cation channel. Graham S, etal., J Biol Chem. 2010 Jul 23;285(30):23466-76. doi: 10.1074/jbc.M109.093500. Epub 2010 May 25.
8. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. He Z, etal., J Neurosci. 2012 Jul 4;32(27):9383-95. doi: 10.1523/JNEUROSCI.6363-11.2012.
9. TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. Jung S, etal., Am J Physiol Cell Physiol 2002 Feb;282(2):C347-59.
10. TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity. Li H, etal., J Neurochem. 2012 Dec;123(6):1010-8. doi: 10.1111/jnc.12045. Epub 2012 Nov 1.
11. Neuroprotective Effect of Resveratrol on Ischemia/Reperfusion Injury in Rats Through TRPC6/CREB Pathways. Lin Y, etal., J Mol Neurosci. 2013 Jul;50(3):504-13. doi: 10.1007/s12031-013-9977-8. Epub 2013 Feb 23.
12. Recombinant human erythropoietin pretreatment alleviates renal glomerular injury induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation. Liu X, etal., J Thorac Cardiovasc Surg. 2013 Mar 24. pii: S0022-5223(13)00274-2. doi: 10.1016/j.jtcvs.2013.02.076.
13. Tissue expression of TRPC3 and TRPC6 in hypertensive Munich Wistar Fromter rats showing proteinuria. Liu Y, etal., Am J Nephrol. 2010;31(1):36-44. doi: 10.1159/000254060. Epub 2009 Oct 30.
14. Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Lu W, etal., Am J Physiol Cell Physiol. 2010 Jan;298(1):C114-23. doi: 10.1152/ajpcell.00629.2008. Epub 2009 Nov 4.
15. Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats. Luan J, etal., J Pharmacol Sci. 2012;119(2):167-76. Epub 2012 May 22.
16. Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients. Marshall-Gradisnik S, etal., J Int Med Res. 2016 Dec;44(6):1381-1394. doi: 10.1177/0300060516671622. Epub 2016 Nov 11.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome. Mir S, etal., Nephrol Dial Transplant. 2012 Jan;27(1):205-9. doi: 10.1093/ndt/gfr202. Epub 2011 Apr 21.
19. Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats. Mita M, etal., Clin Exp Pharmacol Physiol. 2010 Jul;37(7):670-8. doi: 10.1111/j.1440-1681.2010.05373.x. Epub 2010 Mar 12.
20. Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria. Nakuluri K, etal., Sci Rep. 2019 Nov 29;9(1):17897. doi: 10.1038/s41598-019-52872-5.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Nijenhuis T, etal., Am J Pathol. 2011 Oct;179(4):1719-32. doi: 10.1016/j.ajpath.2011.06.033. Epub 2011 Aug 11.
23. TRPC6 gene variants in Czech adult patients with focal segmental glomerulosclerosis and minimal change disease. Obeidova L, etal., Folia Biol (Praha). 2012;58(4):173-6.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Reiser J, etal., Nat Genet. 2005 Jul;37(7):739-44. Epub 2005 May 27.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. Shin HY, etal., PLoS One. 2010 May 7;5(5):e10359. doi: 10.1371/journal.pone.0010359.
31. Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease. Sonneveld R, etal., Am J Pathol. 2013 Apr;182(4):1196-204. doi: 10.1016/j.ajpath.2012.12.011. Epub 2013 Feb 4.
32. Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Spires D, etal., Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1091-F1097. doi: 10.1152/ajprenal.00155.2018. Epub 2018 Jun 20.
33. TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. Wang X, etal., Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5751-8. Epub 2010 Jun 16.
34. Transient receptor potential channels regulate myogenic tone of resistance arteries. Welsh DG, etal., Circ Res 2002 Feb 22;90(3):248-50.
35. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Winn MP, etal., Science. 2005 Jun 17;308(5729):1801-4. Epub 2005 May 5.
36. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Xie J, etal., Nat Commun. 2012;3:1238. doi: 10.1038/ncomms2240.
37. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Yu Y, etal., Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13861-6. Epub 2004 Sep 9.
38. Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization. Zhang L and Saffen D, J Biol Chem 2001 Apr 20;276(16):13331-9.
Additional References at PubMed
PMID:8646775   PMID:9368034   PMID:10998353   PMID:14505576   PMID:15194687   PMID:15199065   PMID:15623527   PMID:15672411   PMID:16204251   PMID:17082763   PMID:17112478   PMID:17141310  
PMID:17533154   PMID:17684020   PMID:17699554   PMID:17699555   PMID:17723267   PMID:17977908   PMID:18559891   PMID:18835357   PMID:19246091   PMID:19386284   PMID:19443836   PMID:19936226  
PMID:19961855   PMID:20177073   PMID:20179889   PMID:20307499   PMID:20426773   PMID:20622104   PMID:21487005   PMID:21525431   PMID:21799177   PMID:22129453   PMID:22865594   PMID:22926417  
PMID:23149561   PMID:23171048   PMID:23193081   PMID:23224895   PMID:23291369   PMID:23494294   PMID:23526217   PMID:23526219   PMID:23764398   PMID:24037962   PMID:24336649   PMID:24553432  
PMID:24731445   PMID:25041367   PMID:25203114   PMID:25292315   PMID:25365342   PMID:25467798   PMID:25649357   PMID:25740156   PMID:25939574   PMID:26155749   PMID:26193076   PMID:26248296  
PMID:26327362   PMID:26718737   PMID:26823720   PMID:27147559   PMID:28039055   PMID:28263796   PMID:28300348   PMID:28331185   PMID:28495616   PMID:28596571   PMID:28627661   PMID:28646178  
PMID:28902407   PMID:28983729   PMID:29785489   PMID:30476735   PMID:30664212   PMID:31236585   PMID:31310676   PMID:31683954   PMID:31778750   PMID:32844288   PMID:33667520   PMID:33918778  
PMID:33924991   PMID:34995919   PMID:35427673   PMID:35489424   PMID:35805070   PMID:36115513   PMID:36285371   PMID:36289215   PMID:36642172   PMID:37002575   PMID:37093422   PMID:37178933  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8814,044,216 - 14,148,808 (+)NCBIGRCr8
mRatBN7.285,759,387 - 5,864,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,758,935 - 5,828,092 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx89,686,632 - 9,791,048 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,984,275 - 8,088,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.086,019,710 - 6,124,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,811,543 - 6,917,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,811,543 - 6,917,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,799,564 - 6,904,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,472,515 - 5,577,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.185,472,514 - 5,577,536 (+)NCBI
Celera87,300,179 - 7,404,007 (+)NCBICelera
Cytogenetic Map8q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811101,451,564 - 101,584,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11101,451,564 - 101,872,562 (-)EnsemblGRCh38hg38GRCh38
GRCh3711101,322,295 - 101,454,738 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611100,827,584 - 100,959,869 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411100,827,582 - 100,959,869NCBI
Celera1198,491,501 - 98,623,915 (-)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1197,256,362 - 97,388,472 (-)NCBIHuRef
CHM1_111101,205,451 - 101,337,498 (-)NCBICHM1_1
T2T-CHM13v2.011101,461,274 - 101,593,486 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3998,543,868 - 8,680,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl98,544,143 - 8,680,742 (+)EnsemblGRCm39 Ensembl
GRCm3898,543,867 - 8,680,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,544,142 - 8,680,741 (+)EnsemblGRCm38mm10GRCm38
MGSCv3798,544,142 - 8,680,741 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3698,544,711 - 8,642,583 (+)NCBIMGSCv36mm8
Celera95,924,518 - 6,060,945 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554124,906,650 - 4,950,525 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554124,905,039 - 5,019,678 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v29102,259,076 - 102,404,403 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111103,343,535 - 103,492,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01196,414,498 - 96,551,670 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11199,918,382 - 100,051,110 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1199,919,410 - 100,050,685 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1529,897,378 - 30,007,885 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,897,210 - 30,007,723 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,849,049 - 29,959,895 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,962,647 - 30,073,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,962,428 - 30,072,938 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1530,016,217 - 30,126,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,864,510 - 29,975,743 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0530,042,168 - 30,153,079 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494785,253,510 - 85,362,868 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365516,174,122 - 6,282,925 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365516,173,588 - 6,282,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl932,332,771 - 32,439,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,332,768 - 32,439,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,257,623 - 36,364,097 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1192,828,546 - 92,970,224 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,829,253 - 92,885,086 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604332,920,602 - 33,049,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248781,321,497 - 1,468,865 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248781,321,022 - 1,469,964 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Trpc6
870 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:95
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000008905, ENSRNOT00000042553
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.086,904,442 - 6,905,652NCBIRnor6.0
Rnor_5.086,891,531 - 6,892,741UniSTSRnor5.0
RGSC_v3.485,564,444 - 5,565,654UniSTSRGSC3.4
Celera87,390,915 - 7,392,125UniSTS
Cytogenetic Map8q11UniSTS

Genetic Models
This gene Trpc6 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 6 6 6
Low 3 39 36 22 17 22 7 7 68 35 30 5 7
Below cutoff 4 16 14 2 14 1 4 3 1


RefSeq Acc Id: ENSRNOT00000008905   ⟹   ENSRNOP00000008905
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,758,935 - 5,828,092 (+)Ensembl
Rnor_6.0 Ensembl86,811,543 - 6,917,535 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000042553   ⟹   ENSRNOP00000043514
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl86,811,617 - 6,907,623 (+)Ensembl
RefSeq Acc Id: NM_053559   ⟹   NP_446011
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8814,044,216 - 14,148,808 (+)NCBI
mRatBN7.285,759,387 - 5,864,000 (+)NCBI
Rnor_6.086,811,543 - 6,917,534 (+)NCBI
Rnor_5.086,799,564 - 6,904,623 (+)NCBI
RGSC_v3.485,472,515 - 5,577,537 (+)RGD
Celera87,300,179 - 7,404,007 (+)NCBI
RefSeq Acc Id: NP_446011   ⟸   NM_053559
- UniProtKB: Q99N78 (UniProtKB/TrEMBL),   Q99N77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008905   ⟸   ENSRNOT00000008905
RefSeq Acc Id: ENSRNOP00000043514   ⟸   ENSRNOT00000042553
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99N78-F1-model_v2 AlphaFold Q99N78 1-930 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619788 AgrOrtholog
BioCyc Gene G2FUF-31755 BioCyc
Ensembl Genes ENSRNOG00000006324 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008905.6 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  TRP_dom UniProtKB/TrEMBL
  TRPC6_channel UniProtKB/TrEMBL
  TRPC_channel UniProtKB/TrEMBL
KEGG Report rno:89823 UniProtKB/TrEMBL
  PTHR10117:SF7 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  TRP_2 UniProtKB/TrEMBL
PhenoGen Trpc6 PhenoGen
RatGTEx ENSRNOG00000006324 RatGTEx
  TRP_2 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Trpc6  transient receptor potential cation channel, subfamily C, member 6    transient receptor protein 6  Name updated 1299863 APPROVED
2004-09-10 Trpc6  transient receptor protein 6  Trrp6    Symbol and Name updated 1299863 APPROVED
2002-08-07 Trrp6  transient receptor protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by diacylglycerol 634440