Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6) Rattus norvegicus
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Symbol: Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Description: ENCODES a protein that exhibits actin binding; actinin binding; ATPase binding; INVOLVED IN aging; cellular response to hydrogen peroxide; cellular response to hypoxia; PARTICIPATES IN endothelin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH Albuminuria; Diabetic Nephropathies; focal segmental glomerulosclerosis; FOUND IN plasma membrane; cytoplasm (ortholog); membrane (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil
AGR Description: Exhibits several functions, including ATPase binding activity, calcium channel activity, and cytoskeletal protein binding activity; involved in several processes, including aging, cellular response to hydrogen peroxide, and generation of neurons; localizes to the plasma membrane; used to study focal segmental glomerulosclerosis, kidney disease, and transient cerebral ischemia; biomarker of type 2 diabetes mellitus; orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).
Merged Description: Exhibits several functions, including ATPase binding activity, calcium channel activity, and cytoskeletal protein binding activity; involved in several processes, including aging, cellular response to hydrogen peroxide, and generation of neurons; localizes to the plasma membrane; used to study focal segmental glomerulosclerosis, kidney disease, and transient cerebral ischemia; biomarker of type 2 diabetes mellitus; orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6); PARTICIPATES IN endothelin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: short transient receptor potential channel 6; transient receptor protein 6; Trrp6
Orthologs:
Homo sapiens (human) : TRPC6 (transient receptor potential cation channel subfamily C member 6)  HGNC  Alliance
Mus musculus (house mouse) : Trpc6 (transient receptor potential cation channel, subfamily C, member 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trpc6 (transient receptor potential cation channel subfamily C member 6)
Pan paniscus (bonobo/pygmy chimpanzee) : TRPC6 (transient receptor potential cation channel subfamily C member 6)
Canis lupus familiaris (dog) : TRPC6 (transient receptor potential cation channel subfamily C member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trpc6 (transient receptor potential cation channel subfamily C member 6)
Sus scrofa (pig) : TRPC6 (transient receptor potential cation channel subfamily C member 6)
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Allele / Splice: Trpc6em3Mcwi   Trpc6em4Mcwi   Trpc6em1Mcwi  
Genetic Models: SS-Trpc6em1Mcwi SS-Trpc6em4Mcwi SS-Trpc6em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.086,811,543 - 6,917,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.086,799,564 - 6,904,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,472,515 - 5,577,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.185,472,514 - 5,577,536 (+)NCBI
Celera87,300,179 - 7,404,007 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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More on Trpc6
Alliance Gene
NCBI Gene
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JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619788
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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