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Gene: Btg2 (BTG anti-proliferation factor 2) Rattus norvegicus
Symbol: Btg2
Name: BTG anti-proliferation factor 2
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; and response to electrical stimulus. Predicted to localize to cytoplasm and nucleus. Biomarker of brain ischemia. Orthologous to human BTG2 (BTG anti-proliferation factor 2); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
Also known as: Agl; An; an-1; B-cell translocation gene 2; B-cell translocation gene 2 anti-proliferative; B-cell translocation gene 2, anti-proliferative; BTG family, member 2; cell surface alloantigen; Early induced gene B-cell translocation gene 2; NGF-inducible anti-proliferative protein PC3; NGF-inducible anti-proliferative putative secreted protein; PC3; Tis21
Homo sapiens (human) : BTG2 (BTG anti-proliferation factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Btg2 (BTG anti-proliferation factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btg2 (BTG anti-proliferation factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BTG2 (BTG anti-proliferation factor 2)
Canis lupus familiaris (dog) : BTG2 (BTG anti-proliferation factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btg2 (BTG anti-proliferation factor 2)
Sus scrofa (pig) : BTG2 (BTG anti-proliferation factor 2)
Chlorocebus sabaeus (African green monkey) : BTG2 (BTG anti-proliferation factor 2)
Heterocephalus glaber (naked mole-rat) : Btg2 (BTG anti-proliferation factor 2)
more info ...
Allele / Splice: Btg2em11Mcwi   Btg2em13Mcwi   Btg2em7Mcwi   Btg2em21Mcwi   Btg2em24Mcwi  
Genetic Models: SS.BN-(D13Rat25-rs106935835)-Btg2em11Mcwi SS.BN-(D13Rat25-rs106935835)-Btg2em13Mcwi SS.BN-(D13Rat25-rs198199323)-Btg2em24Mcwi SS.BN-(D13Rat25-rs198199323)-Btg2em21Mcwi SS.BN-(D13Rat25-rs106935835)-Btg2em7Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01350,913,185 - 50,916,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,913,180 - 50,916,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,966,299 - 55,970,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,026,986 - 47,030,745 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11347,041,028 - 47,044,788 (-)NCBI
Celera1345,860,186 - 45,864,450 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Btg2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2225
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.