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Gene: Tlr2 (toll-like receptor 2) Rattus norvegicus
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Symbol: Tlr2
Name: toll-like receptor 2
Description: Exhibits lipopeptide binding activity. Involved in several processes, including microglial cell activation; neurogenesis; and response to molecule of bacterial origin. Localizes to the cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of brain disease; kidney failure; lung disease; pancreatitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); dermatitis (multiple); eye disease (multiple); rhinitis (multiple); and tuberculosis (multiple). Orthologous to human TLR2 (toll like receptor 2); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; Entamoebiasis pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: toll-like receptor 2 variant 1; toll-like receptor 2 variant 2
Orthologs:
Homo sapiens (human) : TLR2 (toll like receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Tlr2 (toll-like receptor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr2 (toll like receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR2 (toll like receptor 2)
Canis lupus familiaris (dog) : TLR2 (toll like receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr2 (toll like receptor 2)
Sus scrofa (pig) : TLR2 (toll like receptor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tlr2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735138
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.