Dus3l (dihydrouridine synthase 3-like) - Rat Genome Database

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Gene: Dus3l (dihydrouridine synthase 3-like) Rattus norvegicus
Analyze
Symbol: Dus3l
Name: dihydrouridine synthase 3-like
RGD ID: 1563228
Description: Predicted to enable mRNA dihydrouridine synthase activity and tRNA dihydrouridine synthase activity. Predicted to be involved in regulation of translation and tRNA dihydrouridine synthesis. Orthologous to human DUS3L (dihydrouridine synthase 3 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dihydrouridine synthase 3-like (S. cerevisiae); MGC124806; mRNA-dihydrouridine synthase DUS3L; similar to putative zinc finger protein; tRNA-dihydrouridine synthase 3-like; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,680,619 - 1,685,784 (+)NCBIGRCr8
mRatBN7.291,593,491 - 1,598,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,594,123 - 1,598,655 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,028,265 - 2,032,806 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,377,380 - 7,381,917 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,333,460 - 6,338,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,289,440 - 10,294,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,289,446 - 10,293,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,286,520 - 9,291,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,918,090 - 6,922,626 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:22681889  


Genomics

Comparative Map Data
Dus3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,680,619 - 1,685,784 (+)NCBIGRCr8
mRatBN7.291,593,491 - 1,598,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,594,123 - 1,598,655 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,028,265 - 2,032,806 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,377,380 - 7,381,917 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,333,460 - 6,338,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,289,440 - 10,294,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,289,446 - 10,293,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,286,520 - 9,291,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,918,090 - 6,922,626 (-)NCBICelera
Cytogenetic Map9q11NCBI
DUS3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,785,140 - 5,791,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,784,832 - 5,791,225 (-)EnsemblGRCh38hg38GRCh38
GRCh37195,785,151 - 5,791,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,736,151 - 5,742,192 (-)NCBINCBI36Build 36hg18NCBI36
Celera195,723,144 - 5,730,021 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,546,085 - 5,552,589 (-)NCBIHuRef
CHM1_1195,785,079 - 5,791,308 (-)NCBICHM1_1
T2T-CHM13v2.0195,771,937 - 5,778,591 (-)NCBIT2T-CHM13v2.0
Dus3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,069,224 - 57,077,093 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,071,757 - 57,077,093 (+)EnsemblGRCm39 Ensembl
GRCm381756,764,751 - 56,770,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,764,757 - 56,770,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,904,174 - 56,909,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,449,902 - 56,454,965 (+)NCBIMGSCv36mm8
Celera1761,108,892 - 61,114,234 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.5NCBI
Dus3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,653,257 - 3,660,331 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,653,613 - 3,660,331 (+)NCBIChiLan1.0ChiLan1.0
DUS3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,179,205 - 10,186,888 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,403,225 - 9,413,083 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl195,731,457 - 5,737,775 (-)Ensemblpanpan1.1panPan2
DUS3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,250,369 - 54,255,981 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,250,871 - 54,255,995 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,977,808 - 53,983,421 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,902,723 - 54,908,336 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,903,204 - 54,908,350 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,969,030 - 53,974,635 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,449,603 - 54,455,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,646,813 - 54,652,426 (+)NCBIUU_Cfam_GSD_1.0
Dus3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,497,957 - 214,502,948 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,331,904 - 3,337,277 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,331,563 - 3,337,276 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUS3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,197,669 - 73,204,977 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,197,614 - 73,202,676 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,719,549 - 73,724,598 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUS3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,430,558 - 5,437,638 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,430,580 - 5,437,452 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,627,456 - 2,630,452 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dus3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,431,167 - 4,437,365 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,431,172 - 4,437,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dus3l
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000072703
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000072703   ⟹   ENSRNOP00000066698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,594,123 - 1,598,655 (+)Ensembl
Rnor_6.0 Ensembl910,289,446 - 10,293,980 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115667   ⟹   ENSRNOP00000095494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,594,626 - 1,598,655 (+)Ensembl
RefSeq Acc Id: NM_001034923   ⟹   NP_001030095
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,681,248 - 1,685,784 (+)NCBI
mRatBN7.291,594,123 - 1,598,659 (+)NCBI
Rnor_6.0910,289,444 - 10,293,980 (-)NCBI
Rnor_5.099,286,520 - 9,291,291 (-)NCBI
Celera96,918,090 - 6,922,626 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244314   ⟹   XP_006244376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,680,619 - 1,685,784 (+)NCBI
mRatBN7.291,593,491 - 1,598,663 (+)NCBI
Rnor_6.0910,289,440 - 10,294,213 (-)NCBI
Rnor_5.099,286,520 - 9,291,291 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001030095   ⟸   NM_001034923
- UniProtKB: Q3KRC5 (UniProtKB/Swiss-Prot),   A6KQU6 (UniProtKB/TrEMBL),   M0RAY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244376   ⟸   XM_006244314
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ALK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066698   ⟸   ENSRNOT00000072703
Ensembl Acc Id: ENSRNOP00000095494   ⟸   ENSRNOT00000115667
Protein Domains
C3H1-type   DUS-like FMN-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3KRC5-F1-model_v2 AlphaFold Q3KRC5 1-640 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696451
Promoter ID:EPDNEW_R6976
Type:initiation region
Name:Dus3l_1
Description:dihydrouridine synthase 3-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,294,005 - 10,294,065EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563228 AgrOrtholog
BioCyc Gene G2FUF-28513 BioCyc
Ensembl Genes ENSRNOG00000050381 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055016163 UniProtKB/Swiss-Prot
  ENSRNOG00060018048 UniProtKB/Swiss-Prot
  ENSRNOG00065013974 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072703.2 UniProtKB/TrEMBL
  ENSRNOT00000115667.1 UniProtKB/TrEMBL
  ENSRNOT00055027426 UniProtKB/Swiss-Prot
  ENSRNOT00060030981 UniProtKB/Swiss-Prot
  ENSRNOT00065023076 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc finger, CCCH-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932299 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUS-like_FMN-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_hU_synthase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301122 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124806 IMAGE-MGC_LOAD
NCBI Gene 301122 ENTREZGENE
PANTHER TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE UniProtKB/Swiss-Prot
  TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE UniProtKB/Swiss-Prot
  TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE UniProtKB/TrEMBL
  TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE UniProtKB/TrEMBL
Pfam Dus UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dus3l PhenoGen
PROSITE UPF0034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050381 RatGTEx
  ENSRNOG00055016163 RatGTEx
  ENSRNOG00060018048 RatGTEx
  ENSRNOG00065013974 RatGTEx
Superfamily-SCOP FMN-linked oxidoreductases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ALK0 ENTREZGENE, UniProtKB/TrEMBL
  A6KQU6 ENTREZGENE, UniProtKB/TrEMBL
  A6KQU7_RAT UniProtKB/TrEMBL
  A6KQU8_RAT UniProtKB/TrEMBL
  A6KQU9_RAT UniProtKB/TrEMBL
  DUS3L_RAT UniProtKB/Swiss-Prot
  M0RAY0 ENTREZGENE, UniProtKB/TrEMBL
  Q3KRC5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Dus3l  dihydrouridine synthase 3-like  Dus3l  dihydrouridine synthase 3-like (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dus3l  dihydrouridine synthase 3-like (S. cerevisiae)  MGC124806  similar to putative zinc finger protein  Symbol and Name updated 1299863 APPROVED
2006-02-09 MGC124806  similar to putative zinc finger protein      Symbol and Name status set to provisional 70820 PROVISIONAL