Ckmt2 (creatine kinase, mitochondrial 2)

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Gene: Ckmt2 (creatine kinase, mitochondrial 2) Rattus norvegicus

Analyze

Symbol:

Ckmt2

Name:

creatine kinase, mitochondrial 2

RGD ID:

61977

Description:

Enables cardiolipin binding activity. Involved in heart development and skeletal muscle tissue development. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human CKMT2 (creatine kinase, mitochondrial 2); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH 3-guanidinopropanoic acid; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

basic-type mitochondrial creatine kinase; creatine kinase S-type, mitochondrial; creatine kinase, mitochondrial 2, sarcomeric; MGC187999; mib-CK; S-MtCK; sarcomeric mitochondrial creatine kinase; similar to creatine kinase, mitochondrial 2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CKMT2 (creatine kinase, mitochondrial 2)	HGNC	HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Ckmt2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ckmt2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CKMT2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CKMT2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ckmt2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CKMT2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CKMT2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ckmt2 (creatine kinase, mitochondrial 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ckmt2 (creatine kinase, mitochondrial 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CKMT2 (creatine kinase, mitochondrial 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ckmt2a (creatine kinase, mitochondrial 2a (sarcomeric))	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ckmt2b (creatine kinase, mitochondrial 2b (sarcomeric))	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5144	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F32B5.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	W10C8.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	argk-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Argk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F46H5.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC434.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4546	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	23,079,920 - 23,110,518 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	23,079,918 - 23,110,430 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	30,120,491 - 30,150,955 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,220,830 - 28,251,294 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	23,046,970 - 23,076,912 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	21,422,680 - 21,452,797 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	21,422,818 - 21,437,193 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	40,627,924 - 40,657,402 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	22,084,948 - 22,106,014 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	22,005,331 - 22,026,403 (-)	NCBI
Celera	2	19,182,609 - 19,209,711 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-guanidinopropanoic acid (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

acrolein (ISO)

acrylamide (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

copper(II) chloride (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

doxorubicin (EXP,ISO)

Echimidine (EXP)

fonofos (ISO)

fulvestrant (ISO)

graphite (ISO)

Heliotrine (EXP)

Indeno[1,2,3-cd]pyrene (ISO)

indometacin (ISO)

ivermectin (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel atom (ISO)

nicotine (ISO)

ozone (EXP,ISO)

paracetamol (ISO)

parathion (ISO)

pioglitazone (ISO)

pirinixic acid (EXP)

Platyphylline (EXP)

resveratrol (ISO)

senecionine (EXP)

streptozocin (EXP)

sunitinib (ISO)

T-2 toxin (EXP)

terbufos (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

tunicamycin (ISO)

vanadyl sulfate (EXP)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

heart development (IEP)

phosphocreatine biosynthetic process (IBA,IEA)

phosphorylation (IEA)

skeletal muscle tissue development (IEP)

Cellular Component

mitochondrial inner membrane (IEA)

mitochondrion (IBA)

Molecular Function

ATP binding (IEA)

cardiolipin binding (IDA)

creatine kinase activity (IBA,IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

arginine and proline metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Cardiolipin is the membrane receptor for mitochondrial creatine phosphokinase.	Muller M, etal., J Biol Chem. 1985 Mar 25;260(6):3839-43.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Developmental expression of sarcomeric and ubiquitous mitochondrial creatine kinase is tissue-specific.	Payne RM and Strauss AW, Biochim Biophys Acta. 1994 Sep 13;1219(1):33-8.
7.	Structural characterization and tissue-specific expression of the mRNAs encoding isoenzymes from two rat mitochondrial creatine kinase genes.	Payne RM, etal., Biochim Biophys Acta 1991 Jul 23;1089(3):352-61.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3338460	PMID:12477932	PMID:18614015	PMID:20833797	PMID:29867124

Genomics

Comparative Map Data

Ckmt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	23,079,920 - 23,110,518 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	23,079,918 - 23,110,430 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	30,120,491 - 30,150,955 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,220,830 - 28,251,294 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	23,046,970 - 23,076,912 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	21,422,680 - 21,452,797 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	21,422,818 - 21,437,193 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	40,627,924 - 40,657,402 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	22,084,948 - 22,106,014 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	22,005,331 - 22,026,403 (-)	NCBI
Celera	2	19,182,609 - 19,209,711 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

CKMT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	81,233,322 - 81,266,398 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	81,233,320 - 81,266,398 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	80,529,141 - 80,562,217 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	80,564,895 - 80,597,973 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	80,564,937 - 80,597,972	NCBI
Celera	5	76,433,409 - 76,466,487 (+)	NCBI		Celera
Cytogenetic Map	5	q14.1	NCBI
HuRef	5	75,738,057 - 75,771,119 (+)	NCBI		HuRef
CHM1_1	5	79,961,936 - 79,995,008 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	81,717,903 - 81,750,979 (+)	NCBI		T2T-CHM13v2.0

Ckmt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	92,001,510 - 92,025,001 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	92,001,506 - 92,025,004 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	91,853,386 - 91,876,923 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	91,853,387 - 91,876,885 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	91,992,992 - 92,016,490 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	92,327,626 - 92,351,124 (-)	NCBI		MGSCv36	mm8
Celera	13	95,480,623 - 95,504,103 (-)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI

Ckmt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	28,909,915 - 28,927,704 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	28,909,999 - 28,929,109 (-)	NCBI	ChiLan1.0	ChiLan1.0

CKMT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	32,189,641 - 32,222,132 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	34,013,387 - 34,046,522 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	34,324,529 - 34,357,963 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	34,324,529 - 34,356,919 (-)	Ensembl	panpan1.1		panPan2

CKMT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	26,011,261 - 26,042,646 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	26,011,263 - 26,026,991 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,247,362 - 27,263,081 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	25,925,683 - 25,957,453 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	25,925,685 - 25,957,366 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	25,877,524 - 25,893,259 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	25,847,135 - 25,862,863 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,126,835 - 26,142,587 (-)	NCBI		UU_Cfam_GSD_1.0

Ckmt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	182,027,158 - 182,049,174 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	575,785 - 598,612 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936469	575,836 - 598,601 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CKMT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	89,796,474 - 89,832,990 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	89,796,470 - 89,830,293 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	91,754,202 - 91,770,538 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	2	p16	NCBI

CKMT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	75,379,181 - 75,414,640 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	75,398,939 - 75,414,715 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	24,253,413 - 24,288,192 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ckmt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	1,791,423 - 1,812,970 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	1,791,040 - 1,812,970 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ckmt2
212 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	124
Count of miRNA genes:	108
Interacting mature miRNAs:	113
Transcripts:	ENSRNOT00000074008
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	37410502	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41244106	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
61368	Mcs1	Mammary carcinoma susceptibility QTL 1	4.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	23319447	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	42804738	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	9023519	54023519	Rat
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	11591100	56591100	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	11852062	49003364	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High		7						3
Medium		22	2	2		2	8	8			2	8	8
Low		14	24	8	16	8			8	6	15	3
Below cutoff	1		4	4	2	4			14	12	21

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000084002 ⟹ ENSRNOP00000069574

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	23,079,920 - 23,110,430 (-)	Ensembl
Rnor_6.0 Ensembl	2	21,422,818 - 21,437,193 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111326 ⟹ ENSRNOP00000096397

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	23,079,920 - 23,110,430 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118630 ⟹ ENSRNOP00000089864

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	23,079,918 - 23,100,113 (-)	Ensembl

RefSeq Acc Id:

NM_001127652 ⟹ NP_001121124

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	23,079,920 - 23,110,387 (-)	NCBI
Rnor_6.0	2	21,422,680 - 21,452,797 (-)	NCBI
Rnor_5.0	2	40,627,924 - 40,657,402 (-)	NCBI
RGSC_v3.4	2	22,084,948 - 22,106,014 (-)	RGD
Celera	2	19,182,609 - 19,209,711 (-)	RGD

Sequence:

show sequence

CGACAGACTCCTCCAGCTTCAAGACACTCAACCAAGAAGAAGGATGGCCAGTGCCTTCTCTAAG
TTGCTAACTGGCCGAAATGCATCTCTGCTGTTTACGACACTGGGAACCAGTGCCCTGACCACGG
GCTACCTGTTGAATAGGCAGAAGGTATCTGCTGATGCCCGGGAACAGCACAAGCTCTTTCCCCC
AAGTGCAGACTATCCTGACCTTCGAAAACATAACAACTGCATGGCCGAGTGCCTCACCCCAACC
ATCTATGCCAAACTCCGAAACAAGATGACACCCAGTGGCTATACCCTGGACCAGTGCATCCAAA
CCGGAGTGGACAACCCCGGCCACCCCTTCATTAAGACTGTGGGCATGGTGGCTGGTGACGAGGA
GTCGTATGAGGTGTTTGCTGACCTTTTTGATCCTGTCATCAAGTTAAGGCACAATGGCTATGAC
CCTAGGGTGATGAAGCATCCTACTGACCTGGATGCATCCAAGATCACTCACGGGCAGTTTGATG
AACGCTATGTGTTGTCCTCTCGGGTACGCACTGGCCGCAGCATCCGCGGGCTGAGCCTGCCTCC
TGCCTGCTCTCGGGCAGAAAGAAGGGAGGTGGAGAATGTGGCCATTACTGCCCTGGAGGGCCTC
AAAGGGGATCTGGCTGGTCGCTACTACAAGCTGTCTGAGATGACAGAGCAGGATCAACAACGGC
TCATCGATGACCACTTTCTGTTTGATAAGCCAGTGTCCCCTTTACTAACATGCGCTGGGATGGC
CCGTGACTGGCCTGATGCCAGAGGAATCTGGCATAATTATGACAAGACATTTCTCATCTGGATA
AATGAAGAAGACCACACCAGGGTGATTTCAATGGAGAAGGGAGGCAATATGAAACGCGTATTTG
AGCGATTCTGTCGTGGACTAAAGGAAGTGGAACGACTAATCCAAGAACGAGGCTGGGAGTTCAT
GTGGAATGAACGTCTAGGATACATTTTGACTTGCCCCTCGAACCTCGGAACTGGATTGCGAGCT
GGTGTCCACGTTAGGATCCCAAAGCTCAGCAAGGATCCACGCTTTTCTAAGATCTTGGAGAACC
TGCGGCTCCAGAAGCGTGGCACAGGAGGCGTGGACACTGCAGCAGTGGCCGACGTGTACGACAT
TTCCAACATAGATCGGATCGGTAGATCTGAGGTTGAGCTTGTTCAGATTGTTATTGACGGAGTC
AACTACCTGGTGGATTGTGAAAAGAAGCTGGAGAGAGGCCAGGACATCAAGGTGCCGCCTCCCC
TGCCTCAGTTTGGCAGGAAGTGAATTTAGCCTGCCAAGGTTCTGGGTGATGTGTCTGCTGGTAT
GACAGACACAGGAAGTCTCTGCTCTGAGAGTTTTTGTAGACTTGAAAACATGTAAAATTGTAGG
TACTGCTATTTTACAATAAAACTCTCCTTAATAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039103157 ⟹ XP_038959085

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	23,079,920 - 23,110,518 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001121124	(Get FASTA)	NCBI Sequence Viewer
	XP_038959085	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58763	(Get FASTA)	NCBI Sequence Viewer
	P09605	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001121124 ⟸ NM_001127652
- Peptide Label:	precursor
- UniProtKB:	B0BNC0 (UniProtKB/TrEMBL), A0A0G2JVQ1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASAFSKLLTGRNASLLFTTLGTSALTTGYLLNRQKVSADAREQHKLFPPSADYPDLRKHNNCM AECLTPTIYAKLRNKMTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIK LRHNGYDPRVMKHPTDLDASKITHGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVA ITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYD KTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSN LGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELV QIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGRK hide sequence

RefSeq Acc Id:

ENSRNOP00000069574 ⟸ ENSRNOT00000084002

RefSeq Acc Id:	XP_038959085 ⟸ XM_039103157
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000096397 ⟸ ENSRNOT00000111326

RefSeq Acc Id:

ENSRNOP00000089864 ⟸ ENSRNOT00000118630

Protein Domains

Phosphagen kinase C-terminal Phosphagen kinase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P09605-F1-model_v2	AlphaFold	P09605	1-419	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61977	AgrOrtholog
BioCyc Gene	G2FUF-54874	BioCyc
BioCyc Pathway	PWY-6158 [creatine phosphate biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000055450	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000069574	ENTREZGENE
	ENSRNOP00000069574.2	UniProtKB/TrEMBL
	ENSRNOP00000089864.1	UniProtKB/TrEMBL
	ENSRNOP00000096397.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000084002	ENTREZGENE
	ENSRNOT00000084002.2	UniProtKB/TrEMBL
	ENSRNOT00000111326.1	UniProtKB/TrEMBL
	ENSRNOT00000118630.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.135.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glutamine synthetase/guanido kinase, catalytic domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7105696	IMAGE-MGC_LOAD
InterPro	ATP-guanido_PTrfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln_synth/guanido_kin_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:688698	UniProtKB/TrEMBL
MGC_CLONE	MGC:187999	IMAGE-MGC_LOAD
NCBI Gene	688698	ENTREZGENE
PANTHER	CREATINE KINASE S-TYPE, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11547	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ATP-gua_Ptrans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-gua_PtransN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ckmt2	PhenoGen
PROSITE	PHOSPHAGEN_KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48034	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55931	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JVQ1	ENTREZGENE
	A0A8I6A864_RAT	UniProtKB/TrEMBL
	A0A8I6AQI5_RAT	UniProtKB/TrEMBL
	B0BNC0	ENTREZGENE, UniProtKB/TrEMBL
	KCRS_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A0G2JVQ1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Ckmt2	creatine kinase, mitochondrial 2	Ckmt2	creatine kinase, mitochondrial 2, sarcomeric	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC688698	similar to creatine kinase, mitochondrial 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Ckmt2	creatine kinase, mitochondrial 2, sarcomeric			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed exclusively in skeletal muscle and heart	61552

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)