Acaa2 (acetyl-CoA acyltransferase 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Acaa2 (acetyl-CoA acyltransferase 2) Rattus norvegicus
Analyze
Symbol: Acaa2
Name: acetyl-CoA acyltransferase 2
RGD ID: 620482
Description: Enables acetyl-CoA C-acyltransferase activity and fatty acyl-CoA hydrolase activity. Involved in acetyl-CoA metabolic process and fatty acid beta-oxidation. Located in mitochondrial matrix. Orthologous to human ACAA2 (acetyl-CoA acyltransferase 2); PARTICIPATES IN fatty acid beta degradation pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-ketoacyl-CoA thiolase, mitochondrial; acetyl-CoA acetyltransferase; acetyl-CoA acyltransferase; acetyl-Coenzyme A acyltransferase 2; acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase); acyl-CoA hydrolase, mitochondrial; beta-ketothiolase; mitochondrial 3-oxoacyl-CoA thiolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,620,310 - 70,648,417 (+)NCBIGRCr8
mRatBN7.21868,345,136 - 68,373,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,345,012 - 68,373,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1870,453,198 - 70,481,430 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,122,661 - 71,150,827 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,979,238 - 69,007,466 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,733,872 - 70,762,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,733,872 - 70,762,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,873,084 - 69,901,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,587,259 - 71,632,610 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,660,459 - 71,705,811 (+)NCBI
Celera1866,521,595 - 66,549,734 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-benzoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
ciglitazone  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
flavone  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
leflunomide  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
obeticholic acid  (ISO)
oleic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA thiolase with no transient presequence: structural relationship with peroxisomal isozyme. Arakawa H, etal., EMBO J 1987 May;6(5):1361-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Complete beta-oxidation of valproate: cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase. Silva MF, etal., Biochem J. 2002 Mar 15;362(Pt 3):755-60.
11. Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase. Yamashita H, etal., Biochim Biophys Acta. 2006 Jan;1761(1):17-23. Epub 2006 Jan 30.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:18371312   PMID:18614015   PMID:22658674   PMID:23376485   PMID:24625528   PMID:25478839   PMID:29867124   PMID:30053369  


Genomics

Comparative Map Data
Acaa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,620,310 - 70,648,417 (+)NCBIGRCr8
mRatBN7.21868,345,136 - 68,373,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,345,012 - 68,373,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1870,453,198 - 70,481,430 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,122,661 - 71,150,827 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,979,238 - 69,007,466 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,733,872 - 70,762,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,733,872 - 70,762,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,873,084 - 69,901,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,587,259 - 71,632,610 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,660,459 - 71,705,811 (+)NCBI
Celera1866,521,595 - 66,549,734 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
ACAA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381849,782,164 - 49,813,533 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1849,782,164 - 49,813,953 (-)EnsemblGRCh38hg38GRCh38
GRCh371847,308,534 - 47,339,903 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361845,563,873 - 45,593,900 (-)NCBINCBI36Build 36hg18NCBI36
Build 341845,563,872 - 45,593,900NCBI
Celera1844,166,539 - 44,196,918 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1844,164,298 - 44,194,528 (-)NCBIHuRef
CHM1_11847,305,498 - 47,335,866 (-)NCBICHM1_1
T2T-CHM13v2.01849,981,292 - 50,015,307 (-)NCBIT2T-CHM13v2.0
Acaa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391874,912,283 - 74,939,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1874,912,268 - 74,939,279 (+)EnsemblGRCm39 Ensembl
GRCm381874,779,212 - 74,806,207 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1874,779,197 - 74,806,208 (+)EnsemblGRCm38mm10GRCm38
MGSCv371874,938,866 - 74,965,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361874,904,577 - 74,931,572 (+)NCBIMGSCv36mm8
Celera1876,003,491 - 76,030,308 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.76NCBI
Acaa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540234,857,317 - 34,885,169 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,857,317 - 34,885,169 (-)NCBIChiLan1.0ChiLan1.0
ACAA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21767,310,784 - 67,341,328 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11853,003,387 - 53,033,936 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01843,164,504 - 43,195,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11846,512,374 - 46,542,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1846,512,374 - 46,542,737 (-)Ensemblpanpan1.1panPan2
ACAA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1779,028,636 - 79,057,720 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha778,425,399 - 78,464,609 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,086,363 - 79,125,478 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,086,417 - 79,125,474 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1778,802,328 - 78,841,679 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0778,830,801 - 78,869,895 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,116,676 - 79,155,898 (+)NCBIUU_Cfam_GSD_1.0
Acaa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494438,003,267 - 38,029,972 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649713,242,644 - 13,269,532 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649713,242,644 - 13,269,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl199,284,140 - 99,311,321 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1199,284,467 - 99,310,759 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,842,950 - 108,869,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11831,152,067 - 31,181,020 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1831,152,074 - 31,181,706 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660505,299,842 - 5,328,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acaa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477813,307,094 - 13,336,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477813,307,236 - 13,336,347 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acaa2
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:37
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000067018
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat

Markers in Region
D18Mco7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81870,637,110 - 70,637,266 (+)Marker Load Pipeline
mRatBN7.21868,361,937 - 68,362,093 (+)MAPPERmRatBN7.2
Rnor_6.01870,751,072 - 70,751,227NCBIRnor6.0
Rnor_5.01869,890,284 - 69,890,439UniSTSRnor5.0
RGSC_v3.41871,603,978 - 71,604,134RGDRGSC3.4
RGSC_v3.41871,603,979 - 71,604,134UniSTSRGSC3.4
RGSC_v3.11871,677,179 - 71,677,335RGD
Celera1866,538,396 - 66,538,551UniSTS
Cytogenetic Map18q12.3UniSTS
RH129363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,373,051 - 68,373,240 (+)MAPPERmRatBN7.2
Rnor_6.01870,762,201 - 70,762,389NCBIRnor6.0
Rnor_5.01869,901,642 - 69,901,830UniSTSRnor5.0
RGSC_v3.41871,632,416 - 71,632,604UniSTSRGSC3.4
RGSC_v3.41871,616,004 - 71,616,192UniSTSRGSC3.4
Celera1866,549,540 - 66,549,728UniSTS
RH 3.4 Map18691.0UniSTS
Cytogenetic Map18q12.3UniSTS
RH129395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,373,087 - 68,373,246 (+)MAPPERmRatBN7.2
Rnor_6.01870,762,237 - 70,762,395NCBIRnor6.0
Rnor_5.01869,901,678 - 69,901,836UniSTSRnor5.0
RGSC_v3.41871,632,452 - 71,632,610UniSTSRGSC3.4
RGSC_v3.41871,616,040 - 71,616,198UniSTSRGSC3.4
Celera1866,549,576 - 66,549,734UniSTS
RH 3.4 Map18688.0UniSTS
Cytogenetic Map18q12.3UniSTS
RH129515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,372,955 - 68,373,164 (+)MAPPERmRatBN7.2
Rnor_6.01870,762,105 - 70,762,313NCBIRnor6.0
Rnor_5.01869,901,546 - 69,901,754UniSTSRnor5.0
RGSC_v3.41871,632,320 - 71,632,528UniSTSRGSC3.4
RGSC_v3.41871,615,908 - 71,616,116UniSTSRGSC3.4
Celera1866,549,444 - 66,549,652UniSTS
RH 3.4 Map18689.2UniSTS
Cytogenetic Map18q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000067018   ⟹   ENSRNOP00000060140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,345,012 - 68,373,249 (+)Ensembl
Rnor_6.0 Ensembl1870,733,872 - 70,762,395 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085601   ⟹   ENSRNOP00000073665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,350,357 - 68,373,249 (+)Ensembl
Rnor_6.0 Ensembl1870,739,492 - 70,762,134 (+)Ensembl
RefSeq Acc Id: NM_130433   ⟹   NP_569117
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,620,310 - 70,648,417 (+)NCBI
mRatBN7.21868,345,136 - 68,373,246 (+)NCBI
Rnor_6.01870,733,872 - 70,762,395 (+)NCBI
Rnor_5.01869,873,084 - 69,901,836 (+)NCBI
RGSC_v3.41871,587,259 - 71,632,610 (+)RGD
Celera1866,521,595 - 66,549,734 (+)RGD
Sequence:
RefSeq Acc Id: NP_569117   ⟸   NM_130433
- UniProtKB: P13437 (UniProtKB/Swiss-Prot),   G3V9U2 (UniProtKB/TrEMBL),   A6KRG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060140   ⟸   ENSRNOT00000067018
Ensembl Acc Id: ENSRNOP00000073665   ⟸   ENSRNOT00000085601
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13437-F1-model_v2 AlphaFold P13437 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700867
Promoter ID:EPDNEW_R11390
Type:multiple initiation site
Name:Acaa2_1
Description:acetyl-CoA acyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01870,733,995 - 70,734,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620482 AgrOrtholog
BioCyc Gene G2FUF-7008 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-7948 [4-oxopentanoate degradation] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY-8182 [valproate beta-oxidation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-7948 BioCyc
  PWY-8181 BioCyc
  PWY-8182 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000013766 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000067018 ENTREZGENE
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:170465 UniProtKB/Swiss-Prot
NCBI Gene 170465 ENTREZGENE
PANTHER 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PhenoGen Acaa2 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot
  THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013766 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A0G2K642_RAT UniProtKB/TrEMBL
  A6KRG0_RAT UniProtKB/TrEMBL
  A6KRG2_RAT UniProtKB/TrEMBL
  A6KRG3 ENTREZGENE, UniProtKB/TrEMBL
  A6KRG4_RAT UniProtKB/TrEMBL
  A6KRG5_RAT UniProtKB/TrEMBL
  A6KRG6_RAT UniProtKB/TrEMBL
  A6KRG7_RAT UniProtKB/TrEMBL
  A6KRG8_RAT UniProtKB/TrEMBL
  A6KRG9_RAT UniProtKB/TrEMBL
  A6KRH0_RAT UniProtKB/TrEMBL
  G3V9U2 ENTREZGENE, UniProtKB/TrEMBL
  P13437 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acaa2  acetyl-CoA acyltransferase 2  Acaa2  acetyl-Coenzyme A acyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Acaa2  acetyl-Coenzyme A acyltransferase 2  Acaa2  acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Acaa2  acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Acaa2  acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has 37% identity with peroxisomal 3-oxoacyl-CoA thiolase 632025
gene_protein 397 amino acids 632025