S100a6 (S100 calcium binding protein A6) - Rat Genome Database

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Gene: S100a6 (S100 calcium binding protein A6) Rattus norvegicus
Analyze
Symbol: S100a6
Name: S100 calcium binding protein A6
RGD ID: 620264
Description: Enables calcium ion binding activity and monoatomic ion transmembrane transporter activity. Predicted to be involved in cellular response to virus. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; nuclear envelope; and ruffle. Predicted to be active in nucleus and perinuclear region of cytoplasm. Orthologous to human S100A6 (S100 calcium binding protein A6); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium binding protein A6 (calcyclin); calcyclin; prolactin receptor-associated protein; protein S100-A6; S100 calcium binding protein A6 (calcyclin); S100 calcium-binding protein A6
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,398,189 - 178,399,763 (+)NCBIGRCr8
GRCr8 Ensembl2178,398,481 - 178,399,762 (+)EnsemblGRCr8 Ensembl
mRatBN7.22176,100,619 - 176,102,181 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2176,100,899 - 176,102,180 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,241,176 - 183,242,401 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,263,442 - 181,264,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,863,300 - 175,864,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02190,007,013 - 190,008,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2190,007,216 - 190,008,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,441,142 - 209,442,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,895,080 - 182,896,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2170,035,682 - 170,036,907 (+)NCBICelera
RGSC_v3.12182,845,185 - 182,846,411 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvedilol  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (EXP,ISO)
D-penicillamine  (EXP)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP)
furan  (EXP)
furfural  (ISO)
gadolinium atom  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
glycidol  (EXP,ISO)
glyphosate  (ISO)
graphite  (ISO)
griseofulvin  (ISO)
heparin  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
metacetamol  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (ISO)
Miglitol  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic side of plasma membrane  (IEA,ISO,ISS)
cytosol  (IEA,ISO,ISS)
membrane  (IEA)
nuclear envelope  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)
ruffle  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Calcyclin is an early vasopressin-induced gene in the renal collecting duct. Role in the long term regulation of ion transport. Courtois-Coutry N, etal., J Biol Chem 2002 Jul 12;277(28):25728-34.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2358072   PMID:2448309   PMID:8634083   PMID:10673048   PMID:10913138   PMID:11937060   PMID:12042313   PMID:12118070   PMID:12477932   PMID:12577318   PMID:12601007   PMID:12805373  
PMID:15502186   PMID:15652358   PMID:18753141   PMID:19056867   PMID:19199708   PMID:19724273   PMID:20027335   PMID:21663912   PMID:22206666   PMID:23376485   PMID:25480733   PMID:27068509  
PMID:28174168   PMID:31916625   PMID:33942537  


Genomics

Comparative Map Data
S100a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,398,189 - 178,399,763 (+)NCBIGRCr8
GRCr8 Ensembl2178,398,481 - 178,399,762 (+)EnsemblGRCr8 Ensembl
mRatBN7.22176,100,619 - 176,102,181 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2176,100,899 - 176,102,180 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,241,176 - 183,242,401 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,263,442 - 181,264,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,863,300 - 175,864,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02190,007,013 - 190,008,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2190,007,216 - 190,008,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,441,142 - 209,442,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,895,080 - 182,896,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2170,035,682 - 170,036,907 (+)NCBICelera
RGSC_v3.12182,845,185 - 182,846,411 (+)NCBI
Cytogenetic Map2q34NCBI
S100A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,534,599 - 153,535,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,534,599 - 153,536,244 (-)EnsemblGRCh38hg38GRCh38
GRCh371153,507,075 - 153,508,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,773,700 - 151,775,341 (-)NCBINCBI36Build 36hg18NCBI36
Build 341150,320,148 - 150,321,790NCBI
Celera1126,578,337 - 126,579,978 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,870,339 - 124,871,980 (-)NCBIHuRef
CHM1_11154,903,041 - 154,904,682 (-)NCBICHM1_1
T2T-CHM13v2.01152,671,855 - 152,673,247 (-)NCBIT2T-CHM13v2.0
S100a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,520,491 - 90,531,797 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,520,189 - 90,531,488 (+)EnsemblGRCm39 Ensembl
GRCm38390,612,894 - 90,614,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,612,882 - 90,624,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv37390,416,816 - 90,418,336 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,699,111 - 90,700,341 (+)NCBIMGSCv36mm8
Celera390,654,296 - 90,655,816 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.35NCBI
S100A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,297,611 - 96,299,362 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,032,847 - 96,034,544 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,889,749 - 128,891,425 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,518,834 - 132,520,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,518,834 - 132,520,499 (-)Ensemblpanpan1.1panPan2
S100A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,501,430 - 43,503,100 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,501,989 - 43,541,604 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,994,834 - 42,995,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,451,601 - 43,452,754 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1743,153,876 - 43,155,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,207,730 - 43,208,875 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,491,387 - 43,492,538 (+)NCBIUU_Cfam_GSD_1.0
S100a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,316,803 - 24,317,471 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,347,152 - 3,348,105 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,347,185 - 3,347,878 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S100A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,098,525 - 96,099,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,098,264 - 96,099,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
S100A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,267,708 - 10,269,361 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2010,267,556 - 10,269,405 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660389,659,199 - 9,660,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in S100a6
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000015612
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH128207  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82178,399,218 - 178,399,718 (+)Marker Load Pipeline
mRatBN7.22176,101,636 - 176,102,136 (+)MAPPERmRatBN7.2
Rnor_6.02190,007,968 - 190,008,467NCBIRnor6.0
Rnor_5.02209,442,061 - 209,442,560UniSTSRnor5.0
RGSC_v3.42182,895,762 - 182,896,261UniSTSRGSC3.4
Celera2170,036,364 - 170,036,863UniSTS
RH 3.4 Map21188.5UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF140232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015612   ⟹   ENSRNOP00000015612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2178,398,481 - 178,399,762 (+)Ensembl
mRatBN7.2 Ensembl2176,100,899 - 176,102,180 (+)Ensembl
Rnor_6.0 Ensembl2190,007,216 - 190,008,511 (+)Ensembl
RefSeq Acc Id: NM_053485   ⟹   NP_445937
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82178,398,537 - 178,399,762 (+)NCBI
mRatBN7.22176,100,955 - 176,102,180 (+)NCBI
Rnor_6.02190,007,286 - 190,008,511 (+)NCBI
Rnor_5.02209,441,142 - 209,442,605 (+)NCBI
RGSC_v3.42182,895,080 - 182,896,305 (+)RGD
Celera2170,035,682 - 170,036,907 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232779   ⟹   XP_006232841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82178,398,227 - 178,399,763 (+)NCBI
mRatBN7.22176,100,656 - 176,102,181 (+)NCBI
Rnor_6.02190,007,013 - 190,008,512 (+)NCBI
Rnor_5.02209,441,142 - 209,442,605 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103273   ⟹   XP_038959201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82178,398,189 - 178,399,763 (+)NCBI
mRatBN7.22176,100,619 - 176,102,181 (+)NCBI
RefSeq Acc Id: NP_445937   ⟸   NM_053485
- UniProtKB: Q9R2B7 (UniProtKB/Swiss-Prot),   P05964 (UniProtKB/Swiss-Prot),   B2GVB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232841   ⟸   XM_006232779
- Peptide Label: isoform X1
- UniProtKB: Q9R2B7 (UniProtKB/Swiss-Prot),   P05964 (UniProtKB/Swiss-Prot),   B2GVB1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015612   ⟸   ENSRNOT00000015612
RefSeq Acc Id: XP_038959201   ⟸   XM_039103273
- Peptide Label: isoform X1
- UniProtKB: P05964 (UniProtKB/Swiss-Prot),   Q9R2B7 (UniProtKB/Swiss-Prot),   B2GVB1 (UniProtKB/TrEMBL)
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05964-F1-model_v2 AlphaFold P05964 1-89 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691509
Promoter ID:EPDNEW_R2034
Type:multiple initiation site
Name:S100a6_1
Description:S100 calcium binding protein A6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02190,007,262 - 190,007,322EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620264 AgrOrtholog
BioCyc Gene G2FUF-52326 BioCyc
Ensembl Genes ENSRNOG00000011647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015612 ENTREZGENE
  ENSRNOT00000015612.6 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7931905 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  S-100A6 UniProtKB/Swiss-Prot
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot
  S100_Ca-bd_sub UniProtKB/Swiss-Prot
KEGG Report rno:85247 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188372 IMAGE-MGC_LOAD
NCBI Gene 85247 ENTREZGENE
PANTHER PROTEIN S100-A6 UniProtKB/Swiss-Prot
  S100 CALCIUM-BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam S_100 UniProtKB/Swiss-Prot
PhenoGen S100a6 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  S100_CABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011647 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
  S_100 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt B2GVB1 ENTREZGENE, UniProtKB/TrEMBL
  P05964 ENTREZGENE
  Q9R2B7 ENTREZGENE
  S10A6_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9R2B7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 S100a6  S100 calcium binding protein A6  S100a6  S100 calcium binding protein A6 (calcyclin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 S100a6  S100 calcium binding protein A6 (calcyclin)    calcium binding protein A6 (calcyclin)  Name updated 1299863 APPROVED
2002-08-07 S100a6  calcium binding protein A6 (calcyclin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the glomerulus, the collecting duct, and in the epithelium lining the papilla of the kidney 633924
gene_regulation mRNA expression is increased by arginine vasopressin 633924