Kcnj3 (potassium inwardly-rectifying channel, subfamily J, member 3) - Rat Genome Database

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Gene: Kcnj3 (potassium inwardly-rectifying channel, subfamily J, member 3) Rattus norvegicus
Analyze
Symbol: Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
RGD ID: 2958
Description: Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in response to electrical stimulus. Located in T-tubule and external side of plasma membrane. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-activated inward rectifier potassium channel 1; GIRK-1; GIRK1; inward rectifier K(+) channel Kir3.1; KGA; KGB1; potassium channel inwarding rectifying channel subfamily J member 3; potassium channel subunit Kir3.1 type 3 delta; potassium channel, inwardly rectifying subfamily J member 3; potassium channel, inwardly rectifying subfamily J, member 3; potassium inwardly-rectifying channel subfamily J member 3; potassium voltage-gated channel subfamily J member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hrtrt17
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8360,353,990 - 60,518,110 (+)NCBIGRCr8
mRatBN7.2339,944,896 - 40,106,646 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl339,945,351 - 40,109,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx343,306,813 - 43,466,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0351,891,606 - 52,051,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0349,676,492 - 49,836,251 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0341,019,898 - 41,181,070 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl341,019,898 - 41,181,070 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0346,103,695 - 46,264,737 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4337,068,672 - 37,256,990 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,763,612 - 70,766,543 (+)NCBI
Celera338,059,571 - 38,220,833 (+)NCBICelera
RH 3.4 Map3507.0RGD
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-duloxetine hydrochloride  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amoxapine  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbachol  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (ISO)
genistein  (ISO)
glycidol  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mianserin  (ISO)
mirtazapine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
nefazodone  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
phenylmercury acetate  (ISO)
potassium atom  (EXP,ISO)
propranolol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
scopolamine  (ISO)
sertraline  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thallium  (ISO)
titanium dioxide  (EXP,ISO)
triclosan  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tropicamide  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cardiac strong inward rectifier potassium channels. Anumonwo JM and Lopatin AN, J Mol Cell Cardiol. 2010 Jan;48(1):45-54. doi: 10.1016/j.yjmcc.2009.08.013. Epub 2009 Aug 22.
2. Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Chung HJ, etal., Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):629-34. Epub 2008 Dec 31.
3. Atrial G protein-activated K+ channel: expression cloning and molecular properties. Dascal N, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10235-9.
4. Distribution of the muscarinic K+ channel proteins Kir3.1 and Kir3.4 in the ventricle, atrium, and sinoatrial node of heart. Dobrzynski H, etal., J Histochem Cytochem. 2001 Oct;49(10):1221-34.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Huang CL, etal., Nature. 1998 Feb 19;391(6669):803-6. doi: 10.1038/35882.
8. IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain. Karschin C, etal., J Neurosci 1996 Jun 1;16(11):3559-70.
9. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Kubo Y, etal., Nature 1993 Aug 26;364(6440):802-6.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase. Mullner C, etal., FEBS J. 2009 Nov;276(21):6218-26. doi: 10.1111/j.1742-4658.2009.07325.x. Epub 2009 Sep 17.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Cloning and characterization of Kir3.1 (GIRK1) C-terminal alternative splice variants. Nelson CS, etal., Brain Res Mol Brain Res 1997 Jun;46(1-2):185-96.
15. Alteration in expression of G-protein-activated inward rectifier K+-channel subunits GIRK1 and GIRK2 in the rat brain following electroconvulsive shock. Pei Q, etal., Neuroscience. 1999 May;90(2):621-7.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Identification of structural elements involved in G protein gating of the GIRK1 potassium channel. Slesinger PA, etal., Neuron. 1995 Nov;15(5):1145-56. doi: 10.1016/0896-6273(95)90102-7.
Additional References at PubMed
PMID:7704424   PMID:12297500   PMID:15716420   PMID:15775962   PMID:16797547   PMID:17012364   PMID:17296805   PMID:17884923   PMID:18097938   PMID:18178009   PMID:18698588   PMID:19558451  
PMID:20560207   PMID:21191090   PMID:21422294   PMID:21653876   PMID:21795707   PMID:23829864   PMID:24065610   PMID:24576551   PMID:25446346   PMID:26199148   PMID:26460748   PMID:28009293  
PMID:28205094   PMID:28951616  


Genomics

Comparative Map Data
Kcnj3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8360,353,990 - 60,518,110 (+)NCBIGRCr8
mRatBN7.2339,944,896 - 40,106,646 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl339,945,351 - 40,109,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx343,306,813 - 43,466,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0351,891,606 - 52,051,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0349,676,492 - 49,836,251 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0341,019,898 - 41,181,070 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl341,019,898 - 41,181,070 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0346,103,695 - 46,264,737 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4337,068,672 - 37,256,990 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,763,612 - 70,766,543 (+)NCBI
Celera338,059,571 - 38,220,833 (+)NCBICelera
RH 3.4 Map3507.0RGD
Cytogenetic Map3q21NCBI
KCNJ3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382154,698,695 - 154,858,354 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2154,697,855 - 154,858,354 (+)EnsemblGRCh38hg38GRCh38
GRCh372155,555,207 - 155,714,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362155,263,339 - 155,421,260 (+)NCBINCBI36Build 36hg18NCBI36
Build 342155,380,600 - 155,538,522NCBI
Celera2149,169,529 - 149,327,383 (+)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2147,441,981 - 147,601,674 (+)NCBIHuRef
CHM1_12155,561,395 - 155,721,100 (+)NCBICHM1_1
T2T-CHM13v2.02155,151,671 - 155,311,378 (+)NCBIT2T-CHM13v2.0
Kcnj3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39255,301,814 - 55,488,157 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl255,325,982 - 55,488,157 (+)EnsemblGRCm39 Ensembl
GRCm38255,411,798 - 55,598,145 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl255,435,970 - 55,598,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv37255,289,567 - 55,447,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36255,252,542 - 55,410,911 (+)NCBIMGSCv36mm8
Celera257,211,331 - 57,365,389 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Kcnj3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544019,716,081 - 19,833,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544019,716,081 - 19,836,957 (+)NCBIChiLan1.0ChiLan1.0
KCNJ3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21357,366,681 - 57,525,646 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B57,381,657 - 57,540,624 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B41,965,152 - 42,124,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B159,214,030 - 159,370,956 (+)NCBIpanpan1.1PanPan1.1panPan2
KCNJ3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,354,686 - 1,496,397 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,354,678 - 1,493,766 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha361,385,232 - 1,526,573 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,366,227 - 1,507,708 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,366,153 - 1,507,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,374,461 - 1,515,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,435,400 - 1,577,189 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,478,631 - 1,620,408 (+)NCBIUU_Cfam_GSD_1.0
Kcnj3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303118,314,441 - 118,454,663 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646923,165,707 - 23,302,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646923,163,057 - 23,304,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1562,264,069 - 62,413,566 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11562,263,913 - 62,415,915 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21569,329,216 - 69,481,280 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11040,096,042 - 40,258,641 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1040,096,527 - 40,255,646 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040159,286,264 - 159,444,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473211,132,024 - 11,278,026 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473211,128,474 - 11,278,528 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj3
990 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:685
Count of miRNA genes:291
Interacting mature miRNAs:391
Transcripts:ENSRNOT00000007335
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat

Markers in Region
RH142429  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2340,105,812 - 40,106,021 (+)MAPPERmRatBN7.2
Rnor_6.0341,180,237 - 41,180,445NCBIRnor6.0
Rnor_5.0346,263,904 - 46,264,112UniSTSRnor5.0
RGSC_v3.4337,256,157 - 37,256,365UniSTSRGSC3.4
Celera338,220,000 - 38,220,208UniSTS
RH 3.4 Map3507.0UniSTS
Cytogenetic Map3q31-q35UniSTS
Kcnj3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2340,106,155 - 40,106,342 (+)MAPPERmRatBN7.2
Rnor_6.0341,180,580 - 41,180,766NCBIRnor6.0
Rnor_5.0346,264,247 - 46,264,433UniSTSRnor5.0
RGSC_v3.4337,256,500 - 37,256,686UniSTSRGSC3.4
Celera338,220,343 - 38,220,529UniSTS
Cytogenetic Map3q31-q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 69 68 38 20 38 6 191 91 93 45 52 30

Sequence


Ensembl Acc Id: ENSRNOT00000007335   ⟹   ENSRNOP00000007335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl339,945,363 - 40,106,098 (+)Ensembl
Rnor_6.0 Ensembl341,019,898 - 41,181,070 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116585   ⟹   ENSRNOP00000082842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl339,945,351 - 40,109,124 (+)Ensembl
RefSeq Acc Id: NM_031610   ⟹   NP_113798
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8360,354,287 - 60,515,600 (+)NCBI
mRatBN7.2339,945,305 - 40,106,646 (+)NCBI
Rnor_6.0341,019,898 - 41,181,070 (+)NCBI
Rnor_5.0346,103,695 - 46,264,737 (+)NCBI
RGSC_v3.4337,068,672 - 37,256,990 (+)RGD
Celera338,059,571 - 38,220,833 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105731   ⟹   XP_038961659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8360,353,990 - 60,514,975 (+)NCBI
mRatBN7.2339,944,908 - 40,105,912 (+)NCBI
RefSeq Acc Id: XM_039105732   ⟹   XP_038961660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8360,353,990 - 60,514,829 (+)NCBI
mRatBN7.2339,944,910 - 40,042,681 (+)NCBI
RefSeq Acc Id: XM_039105733   ⟹   XP_038961661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8360,353,990 - 60,364,114 (+)NCBI
mRatBN7.2339,944,896 - 39,955,141 (+)NCBI
RefSeq Acc Id: XM_039105734   ⟹   XP_038961662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8360,353,990 - 60,518,110 (+)NCBI
mRatBN7.2339,944,904 - 40,106,078 (+)NCBI
RefSeq Acc Id: NP_113798   ⟸   NM_031610
- UniProtKB: P63251 (UniProtKB/Swiss-Prot),   A6JF43 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007335   ⟸   ENSRNOT00000007335
RefSeq Acc Id: XP_038961661   ⟸   XM_039105733
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961662   ⟸   XM_039105734
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q345 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961659   ⟸   XM_039105731
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961660   ⟸   XM_039105732
- Peptide Label: isoform X2
- UniProtKB: A6JF44 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082842   ⟸   ENSRNOT00000116585
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63251-F1-model_v2 AlphaFold P63251 1-501 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692081
Promoter ID:EPDNEW_R2606
Type:single initiation site
Name:Kcnj3_1
Description:potassium voltage-gated channel subfamily J member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0341,019,905 - 41,019,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2958 AgrOrtholog
BioCyc Gene G2FUF-49683 BioCyc
Ensembl Genes ENSRNOG00000005369 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000706 UniProtKB/Swiss-Prot
  ENSRNOG00060008163 UniProtKB/Swiss-Prot
  ENSRNOG00065008281 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007335.5 UniProtKB/TrEMBL
  ENSRNOT00000116585.1 UniProtKB/Swiss-Prot
  ENSRNOT00055001216 UniProtKB/Swiss-Prot
  ENSRNOT00060013520 UniProtKB/Swiss-Prot
  ENSRNOT00065013133 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir3.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50599 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 50599 ENTREZGENE
PANTHER G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNJ3 RGD
PhenoGen Kcnj3 PhenoGen
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR31CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005369 RatGTEx
  ENSRNOG00055000706 RatGTEx
  ENSRNOG00060008163 RatGTEx
  ENSRNOG00065008281 RatGTEx
Superfamily-SCOP E set domains UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q345 ENTREZGENE, UniProtKB/TrEMBL
  A6JF43 ENTREZGENE, UniProtKB/TrEMBL
  A6JF44 ENTREZGENE, UniProtKB/TrEMBL
  KCNJ3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P35562 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj3  potassium inwardly-rectifying channel, subfamily J, member 3  Kcnj3  potassium voltage-gated channel subfamily J member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj3  potassium voltage-gated channel subfamily J member 3  Kcnj3  potassium channel, inwardly rectifying subfamily J, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj3  potassium channel, inwardly rectifying subfamily J, member 3  Kcnj3  potassium inwardly-rectifying channel, subfamily J, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Kcnj3  Potassium inwardly-rectifying channel, subfamily J, member 3      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-23 Kcnj3  Potassium channel, inwarding rectifying channel, subfamily J, member 3      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in regulating the heartbeat 729292