Arhgef7 (Rho guanine nucleotide exchange factor 7) - Rat Genome Database
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Gene: Arhgef7 (Rho guanine nucleotide exchange factor 7) Rattus norvegicus
Analyze
Symbol: Arhgef7
Name: Rho guanine nucleotide exchange factor 7
RGD ID: 620624
Description: Exhibits protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin cytoskeleton organization; astrocyte cell migration; and small GTPase mediated signal transduction. Localizes to several cellular components, including GABA-ergic synapse; focal adhesion; and growth cone. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7); PARTICIPATES IN adenosine signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-Pix; P85spr; PAK-interacting exchange factor beta; Pak3bp; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor (GEF7)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21677,671,021 - 77,782,593 (-)NCBI
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01683,006,732 - 83,117,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01682,479,277 - 82,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,521,224 - 82,603,338 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11682,517,165 - 82,563,059 (-)NCBI
Celera1675,472,865 - 75,551,301 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA)
centrosome  (ISO,ISS)
cytoplasm  (IDA)
cytosol  (IEA,ISO,TAS)
focal adhesion  (IDA)
GABA-ergic synapse  (IDA,IMP)
growth cone  (IDA)
lamellipodium  (IEA,ISO,ISS)
mitotic spindle pole  (ISO,ISS)
neuron projection  (ISO)
neuronal cell body  (ISO)
plasma membrane  (IEA,ISO)
postsynapse  (IEA,ISO,ISS)
protein-containing complex  (IDA,ISO)
ruffle  (IEA)
storage vacuole  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10896954   PMID:11864573   PMID:12477932   PMID:12695502   PMID:16795052   PMID:16954223   PMID:17310244   PMID:18325335   PMID:18385518   PMID:19041750   PMID:19136011  
PMID:19322025   PMID:20117114   PMID:20338996   PMID:21048939   PMID:21088884   PMID:21423176   PMID:21828338   PMID:24029230   PMID:24752242   PMID:25009260   PMID:25500533   PMID:29191942  
PMID:30053369  


Genomics

Comparative Map Data
Arhgef7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21677,671,021 - 77,782,593 (-)NCBI
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01683,006,732 - 83,117,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01682,479,277 - 82,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,521,224 - 82,603,338 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11682,517,165 - 82,563,059 (-)NCBI
Celera1675,472,865 - 75,551,301 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
ARHGEF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl13111,114,559 - 111,305,737 (+)EnsemblGRCh38hg38GRCh38
GRCh3813111,114,619 - 111,305,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713111,766,966 - 111,958,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613110,565,783 - 110,756,079 (+)NCBINCBI36hg18NCBI36
Build 3413110,565,782 - 110,745,543NCBI
Celera1392,614,729 - 92,805,032 (+)NCBI
Cytogenetic Map13q34NCBI
HuRef1392,335,232 - 92,556,608 (+)NCBIHuRef
CHM1_113111,734,907 - 111,925,520 (+)NCBICHM1_1
Arhgef7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,778,053 - 11,885,219 (+)NCBIGRCm39mm39
GRCm39 Ensembl811,777,721 - 11,885,219 (+)Ensembl
GRCm38811,728,001 - 11,835,219 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl811,727,721 - 11,835,219 (+)EnsemblGRCm38mm10GRCm38
MGSCv37811,728,105 - 11,835,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv36811,758,319 - 11,835,191 (+)NCBImm8
Celera811,933,357 - 12,010,286 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Arhgef7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554041,748,665 - 1,814,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554041,749,051 - 1,835,455 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113111,427,905 - 111,545,413 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13111,427,905 - 111,545,413 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01392,246,107 - 92,436,173 (+)NCBIMhudiblu_PPA_v0panPan3
ARHGEF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2259,206,868 - 59,303,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12259,207,278 - 59,305,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Arhgef7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364721,784,215 - 1,857,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1177,427,368 - 77,530,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11177,427,352 - 77,531,001 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,902,021 - 85,006,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1389,287,663 - 89,467,846 (+)NCBI
ChlSab1.1 Ensembl389,287,863 - 89,468,511 (+)Ensembl
Arhgef7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247931,880,681 - 1,995,604 (-)NCBI

Position Markers
D16Rat126  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01683,037,016 - 83,037,218NCBIRnor6.0
Rnor_5.01682,509,634 - 82,509,836UniSTSRnor5.0
RGSC_v3.41682,553,695 - 82,553,897UniSTSRGSC3.4
FHH x ACI Map1645.9899RGD
FHH x ACI Map1645.9899UniSTS
Cytogenetic Map16q12.5UniSTS
RH136837  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01683,006,888 - 83,007,029NCBIRnor6.0
Rnor_5.01682,479,433 - 82,479,574UniSTSRnor5.0
RGSC_v3.41682,521,380 - 82,521,521UniSTSRGSC3.4
Celera1675,473,021 - 75,473,162UniSTS
RH 3.4 Map16746.2UniSTS
Cytogenetic Map16q12.5UniSTS
RH143440  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01683,029,590 - 83,029,839NCBIRnor6.0
Rnor_5.01682,502,208 - 82,502,457UniSTSRnor5.0
RGSC_v3.41682,546,269 - 82,546,518UniSTSRGSC3.4
Celera1675,495,980 - 75,496,229UniSTS
RH 3.4 Map16752.8UniSTS
Cytogenetic Map16q12.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:925
Count of miRNA genes:290
Interacting mature miRNAs:364
Transcripts:ENSRNOT00000017947, ENSRNOT00000043449
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 37 33 9 33 2 5 74 31 39 11 2
Low 7 20 8 10 8 6 6 4 2 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF044673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY034823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY996221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM390964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB792685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017947   ⟹   ENSRNOP00000017947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1683,006,734 - 83,084,975 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043449   ⟹   ENSRNOP00000043761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)Ensembl
RefSeq Acc Id: NM_001113521   ⟹   NP_001106993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,021 - 77,749,942 (-)NCBI
Rnor_6.01683,006,732 - 83,084,975 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,472,865 - 75,551,301 (-)RGD
Sequence:
RefSeq Acc Id: NM_001113522   ⟹   NP_001106994
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,021 - 77,749,942 (-)NCBI
Rnor_6.01683,006,732 - 83,084,975 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,472,865 - 75,551,301 (-)RGD
Sequence:
RefSeq Acc Id: NM_053740   ⟹   NP_446192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,681,110 - 77,723,813 (-)NCBI
Rnor_6.01683,016,821 - 83,058,844 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,482,954 - 75,525,170 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771376   ⟹   XP_008769598
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,732,469 (-)NCBI
Rnor_6.01683,006,736 - 83,076,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771377   ⟹   XP_008769599
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,006,736 - 83,076,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771378   ⟹   XP_008769600
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,006,736 - 83,076,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771379   ⟹   XP_008769601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,585 (-)NCBI
Rnor_6.01683,006,736 - 83,117,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771380   ⟹   XP_008769602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,585 (-)NCBI
Rnor_6.01683,006,736 - 83,117,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599975   ⟹   XP_017455464
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,006,736 - 83,047,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599976   ⟹   XP_017455465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,014,269 - 83,047,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094098   ⟹   XP_038950026
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,386 (-)NCBI
RefSeq Acc Id: XM_039094099   ⟹   XP_038950027
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,593 (-)NCBI
RefSeq Acc Id: XM_039094100   ⟹   XP_038950028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,749,646 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446192   ⟸   NM_053740
- Peptide Label: isoform c
- UniProtKB: A3KMH4 (UniProtKB/TrEMBL),   Q923I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106993   ⟸   NM_001113521
- Peptide Label: isoform a
- UniProtKB: A3KMH4 (UniProtKB/TrEMBL),   Q52NK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106994   ⟸   NM_001113522
- Peptide Label: isoform b
- UniProtKB: O55043 (UniProtKB/Swiss-Prot),   A3KMH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769602   ⟸   XM_008771380
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008769601   ⟸   XM_008771379
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769600   ⟸   XM_008771378
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008769598   ⟸   XM_008771376
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008769599   ⟸   XM_008771377
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017455464   ⟸   XM_017599975
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455465   ⟸   XM_017599976
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000043761   ⟸   ENSRNOT00000043449
RefSeq Acc Id: ENSRNOP00000017947   ⟸   ENSRNOT00000017947
RefSeq Acc Id: XP_038950027   ⟸   XM_039094099
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950026   ⟸   XM_039094098
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950028   ⟸   XM_039094100
- Peptide Label: isoform X6
Protein Domains
Calponin-homology (CH)   DH   PH   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700241
Promoter ID:EPDNEW_R10765
Type:initiation region
Name:Arhgef7_1
Description:Rho guanine nucleotide exchange factor 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,084,945 - 83,085,005EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620624 AgrOrtholog
Ensembl Genes ENSRNOG00000012934 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017947 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000043761 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017947 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000043449 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8364481 IMAGE-MGC_LOAD
InterPro BetaPIX_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GEF_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114559 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156613 IMAGE-MGC_LOAD
NCBI Gene 114559 ENTREZGENE
Pfam betaPIX_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef7 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2QC21_RAT UniProtKB/TrEMBL
  A3KMH4 ENTREZGENE, UniProtKB/TrEMBL
  ARHG7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q52NK0 ENTREZGENE, UniProtKB/TrEMBL
  Q923I5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LNB0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef7  Rho guanine nucleotide exchange factor 7  Arhgef7  Rho guanine nucleotide exchange factor (GEF) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-25 Arhgef7  Rho guanine nucleotide exchange factor (GEF) 7   Arhgef7  Rho guanine nucleotide exchange factor (GEF7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Arhgef7  Rho guanine nucleotide exchange factor (GEF7)  Arhgef7  Rho guanine nucleotide exchange factor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Arhgef7  Rho guanine nucleotide exchange factor 7  Pak3bp  PAK-interacting exchange factor beta  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pak3bp  PAK-interacting exchange factor beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of PIX (PAK-interacting exchange factor)/Cool (cloned out of library) protein family 633693
gene_regulation phosphorylated via the Ras/ERK cascade 633693