Arhgef7 (Rho guanine nucleotide exchange factor 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Arhgef7 (Rho guanine nucleotide exchange factor 7) Rattus norvegicus
Analyze
Symbol: Arhgef7
Name: Rho guanine nucleotide exchange factor 7
RGD ID: 620624
Description: Enables protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin cytoskeleton organization; astrocyte cell migration; and small GTPase mediated signal transduction. Located in several cellular components, including focal adhesion; growth cone; and postsynaptic density. Part of protein-containing complex. Is active in GABA-ergic synapse. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7); PARTICIPATES IN adenosine signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-Pix; P85spr; PAK-interacting exchange factor beta; Pak3bp; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor (GEF7)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21677,671,021 - 77,782,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1682,951,484 - 83,030,424 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01686,404,129 - 86,483,069 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01681,646,838 - 81,725,963 (-)NCBIRnor_WKY
Rnor_6.01683,006,732 - 83,117,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,479,277 - 82,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,521,224 - 82,603,338 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11682,517,165 - 82,563,059 (-)NCBI
Celera1675,472,865 - 75,551,301 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Fiuza M, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12. doi: 10.1073/pnas.1312211110. Epub 2013 Dec 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2. Hoelz A, etal., J Mol Biol. 2006 Apr 28;358(2):509-22. Epub 2006 Feb 28.
5. N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Hua KT, etal., Cancer Cell. 2011 Feb 15;19(2):218-31. doi: 10.1016/j.ccr.2010.11.010. Epub 2011 Feb 3.
6. Cbl promotes clustering of endocytic adaptor proteins. Jozic D, etal., Nat Struct Mol Biol. 2005 Nov;12(11):972-9.
7. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
8. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
9. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Manser E, etal., Mol Cell 1998 Jan;1(2):183-92.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Osmani N, etal., Curr Biol. 2006 Dec 19;16(24):2395-405. Epub 2006 Nov 2.
13. Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker. Paris S, etal., Int J Biochem Cell Biol. 2002 Jul;34(7):826-37.
14. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. Park E, etal., J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7.
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. Shin EY, etal., J Biol Chem 2002 Nov 15;277(46):44417-30.
20. GIT1 and ßPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Smith KR, etal., Cell Rep. 2014 Oct 9;9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. Epub 2014 Oct 2.
21. ß-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses. Sun Y and Bamji SX, J Neurosci. 2011 Nov 23;31(47):17123-33. doi: 10.1523/JNEUROSCI.2359-11.2011.
Additional References at PubMed
PMID:8889548   PMID:10896954   PMID:11864573   PMID:12477932   PMID:12695502   PMID:16795052   PMID:16954223   PMID:17310244   PMID:18325335   PMID:18385518   PMID:19041750   PMID:19136011  
PMID:19322025   PMID:20117114   PMID:20338996   PMID:21048939   PMID:21088884   PMID:21423176   PMID:21828338   PMID:24029230   PMID:24752242   PMID:25009260   PMID:25500533   PMID:29191942  
PMID:30053369   PMID:34006608   PMID:34154701  


Genomics

Comparative Map Data
Arhgef7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21677,671,021 - 77,782,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1682,951,484 - 83,030,424 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01686,404,129 - 86,483,069 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01681,646,838 - 81,725,963 (-)NCBIRnor_WKY
Rnor_6.01683,006,732 - 83,117,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,479,277 - 82,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,521,224 - 82,603,338 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11682,517,165 - 82,563,059 (-)NCBI
Celera1675,472,865 - 75,551,301 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
ARHGEF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813111,114,619 - 111,305,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13111,114,559 - 111,305,737 (+)EnsemblGRCh38hg38GRCh38
GRCh3713111,766,966 - 111,958,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613110,565,783 - 110,756,079 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413110,565,782 - 110,745,543NCBI
Celera1392,614,729 - 92,805,032 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1392,335,232 - 92,556,608 (+)NCBIHuRef
CHM1_113111,735,565 - 111,925,520 (+)NCBICHM1_1
T2T-CHM13v2.013110,344,517 - 110,535,326 (+)NCBIT2T-CHM13v2.0
Arhgef7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,778,053 - 11,885,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl811,777,721 - 11,885,219 (+)EnsemblGRCm39 Ensembl
GRCm38811,728,001 - 11,835,219 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl811,727,721 - 11,835,219 (+)EnsemblGRCm38mm10GRCm38
MGSCv37811,728,105 - 11,835,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36811,758,319 - 11,835,191 (+)NCBIMGSCv36mm8
Celera811,933,357 - 12,010,286 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Arhgef7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554041,748,665 - 1,814,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554041,749,051 - 1,835,455 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113111,427,905 - 111,545,413 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13111,427,905 - 111,545,413 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01392,246,107 - 92,436,173 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARHGEF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12259,207,278 - 59,305,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2259,206,868 - 59,303,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2258,888,587 - 59,015,004 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02259,801,684 - 59,928,168 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2259,801,654 - 59,928,162 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12259,303,236 - 59,429,725 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02259,295,788 - 59,422,676 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02259,330,969 - 59,457,416 (+)NCBIUU_Cfam_GSD_1.0
Arhgef7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945194,095,753 - 194,167,935 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364721,784,195 - 1,874,774 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364721,784,215 - 1,857,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1177,427,368 - 77,530,993 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11177,427,352 - 77,531,001 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,902,021 - 85,006,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1389,287,663 - 89,467,846 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl389,287,863 - 89,468,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604646,054,615 - 46,237,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247931,880,382 - 1,995,610 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247931,880,681 - 1,995,604 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef7
318 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:925
Count of miRNA genes:290
Interacting mature miRNAs:364
Transcripts:ENSRNOT00000017947, ENSRNOT00000043449
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
D16Rat126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,701,318 - 77,701,521 (+)MAPPERmRatBN7.2
Rnor_6.01683,037,016 - 83,037,218NCBIRnor6.0
Rnor_5.01682,509,634 - 82,509,836UniSTSRnor5.0
RGSC_v3.41682,553,695 - 82,553,897UniSTSRGSC3.4
FHH x ACI Map1645.9899RGD
FHH x ACI Map1645.9899UniSTS
Cytogenetic Map16q12.5UniSTS
RH136837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,671,176 - 77,671,318 (+)MAPPERmRatBN7.2
Rnor_6.01683,006,888 - 83,007,029NCBIRnor6.0
Rnor_5.01682,479,433 - 82,479,574UniSTSRnor5.0
RGSC_v3.41682,521,380 - 82,521,521UniSTSRGSC3.4
Celera1675,473,021 - 75,473,162UniSTS
RH 3.4 Map16746.2UniSTS
Cytogenetic Map16q12.5UniSTS
RH143440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,693,890 - 77,694,140 (+)MAPPERmRatBN7.2
Rnor_6.01683,029,590 - 83,029,839NCBIRnor6.0
Rnor_5.01682,502,208 - 82,502,457UniSTSRnor5.0
RGSC_v3.41682,546,269 - 82,546,518UniSTSRGSC3.4
Celera1675,495,980 - 75,496,229UniSTS
RH 3.4 Map16752.8UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 37 33 9 33 2 5 74 31 39 11 2
Low 7 20 8 10 8 6 6 4 2 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF044673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY034823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY996221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM390964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB792685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017947   ⟹   ENSRNOP00000017947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)Ensembl
Rnor_6.0 Ensembl1683,006,734 - 83,084,975 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043449   ⟹   ENSRNOP00000043761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,671,023 - 77,782,695 (-)Ensembl
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100639   ⟹   ENSRNOP00000095285
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119685   ⟹   ENSRNOP00000084089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,671,023 - 77,782,695 (-)Ensembl
RefSeq Acc Id: NM_001113521   ⟹   NP_001106993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,021 - 77,749,942 (-)NCBI
Rnor_6.01683,006,732 - 83,084,975 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,472,865 - 75,551,301 (-)RGD
Sequence:
RefSeq Acc Id: NM_001113522   ⟹   NP_001106994
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,021 - 77,749,942 (-)NCBI
Rnor_6.01683,006,732 - 83,084,975 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,472,865 - 75,551,301 (-)RGD
Sequence:
RefSeq Acc Id: NM_053740   ⟹   NP_446192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,681,110 - 77,723,813 (-)NCBI
Rnor_6.01683,016,821 - 83,058,844 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,482,954 - 75,525,170 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771376   ⟹   XP_008769598
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,732,469 (-)NCBI
Rnor_6.01683,006,736 - 83,076,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771379   ⟹   XP_008769601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,585 (-)NCBI
Rnor_6.01683,006,736 - 83,117,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771380   ⟹   XP_008769602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,585 (-)NCBI
Rnor_6.01683,006,736 - 83,117,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094098   ⟹   XP_038950026
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,386 (-)NCBI
RefSeq Acc Id: XM_039094099   ⟹   XP_038950027
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,782,593 (-)NCBI
RefSeq Acc Id: XM_039094100   ⟹   XP_038950028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,671,025 - 77,749,646 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446192   ⟸   NM_053740
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001106993   ⟸   NM_001113521
- Peptide Label: isoform a
- UniProtKB: A0A0G2QC21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106994   ⟸   NM_001113522
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: XP_008769602   ⟸   XM_008771380
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008769601   ⟸   XM_008771379
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769598   ⟸   XM_008771376
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000043761   ⟸   ENSRNOT00000043449
RefSeq Acc Id: ENSRNOP00000017947   ⟸   ENSRNOT00000017947
RefSeq Acc Id: XP_038950027   ⟸   XM_039094099
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950026   ⟸   XM_039094098
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950028   ⟸   XM_039094100
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000095285   ⟸   ENSRNOT00000100639
RefSeq Acc Id: ENSRNOP00000084089   ⟸   ENSRNOT00000119685
Protein Domains
Calponin-homology (CH)   DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55043-F1-model_v2 AlphaFold O55043 1-646 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700241
Promoter ID:EPDNEW_R10765
Type:initiation region
Name:Arhgef7_1
Description:Rho guanine nucleotide exchange factor 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,084,945 - 83,085,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620624 AgrOrtholog
BioCyc Gene G2FUF-10664 BioCyc
Ensembl Genes ENSRNOG00000012934 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017947 ENTREZGENE
  ENSRNOP00000017947.5 UniProtKB/TrEMBL
  ENSRNOP00000043761.6 UniProtKB/TrEMBL
  ENSRNOP00000084089.1 UniProtKB/TrEMBL
  ENSRNOP00000095285 ENTREZGENE
  ENSRNOP00000095285.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017947 ENTREZGENE
  ENSRNOT00000017947.5 UniProtKB/TrEMBL
  ENSRNOT00000043449.7 UniProtKB/TrEMBL
  ENSRNOT00000100639 ENTREZGENE
  ENSRNOT00000100639.1 UniProtKB/TrEMBL
  ENSRNOT00000119685.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8364481 IMAGE-MGC_LOAD
InterPro BetaPIX_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GEF_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_Cool_Pix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114559 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156613 IMAGE-MGC_LOAD
NCBI Gene 114559 ENTREZGENE
Pfam betaPIX_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef7 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2QC21 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWI0_RAT UniProtKB/TrEMBL
  A0A8I6AP31_RAT UniProtKB/TrEMBL
  A0A8L2Q927_RAT UniProtKB/TrEMBL
  A3KMH4_RAT UniProtKB/TrEMBL
  ARHG7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q52NK0_RAT UniProtKB/TrEMBL
  Q923I5_RAT UniProtKB/TrEMBL
UniProt Secondary F1LNB0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef7  Rho guanine nucleotide exchange factor 7  Arhgef7  Rho guanine nucleotide exchange factor (GEF) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-25 Arhgef7  Rho guanine nucleotide exchange factor (GEF) 7   Arhgef7  Rho guanine nucleotide exchange factor (GEF7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Arhgef7  Rho guanine nucleotide exchange factor (GEF7)  Arhgef7  Rho guanine nucleotide exchange factor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Arhgef7  Rho guanine nucleotide exchange factor 7  Pak3bp  PAK-interacting exchange factor beta  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pak3bp  PAK-interacting exchange factor beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of PIX (PAK-interacting exchange factor)/Cool (cloned out of library) protein family 633693
gene_regulation phosphorylated via the Ras/ERK cascade 633693