Adnp (activity-dependent neuroprotector homeobox) - Rat Genome Database
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Gene: Adnp (activity-dependent neuroprotector homeobox) Rattus norvegicus
Analyze
Symbol: Adnp
Name: activity-dependent neuroprotector homeobox
RGD ID: 71030
Description: Exhibits beta-tubulin binding activity; copper ion binding activity; and peptide binding activity. Involved in several processes, including estrous cycle; positive regulation of nervous system development; and regulation of protein modification process. Localizes to several cellular components, including axon; dendrite; and neuronal cell body. Used to study brain infarction and ischemia. Human ortholog(s) of this gene implicated in Helsmoortel-Van Der Aa Syndrome. Orthologous to human ADNP (activity dependent neuroprotector homeobox); INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 2,2',4,4'-Tetrabromodiphenyl ether; 7-NITROINDAZOLE.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activity-dependent neuroprotective protein; activity-dependent neuroprotector homeobox protein; NAP peptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,886,921 - 156,921,500 (-)NCBI
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03164,937,188 - 164,964,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03171,077,543 - 171,087,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,345,280 - 159,355,067 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13159,253,471 - 159,255,943 (-)NCBI
Celera3155,464,855 - 155,474,635 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. Ashur-Fabian O, etal., Neurosci Lett 2001 Jul 20;307(3):167-70.
2. Ashur-Fabian O, etal., Peptides. 2003 Sep;24(9):1413-23.
3. Bassan M, etal., J Neurochem. 1999 Mar;72(3):1283-93.
4. Beni-Adani L, etal., J Pharmacol Exp Ther. 2001 Jan;296(1):57-63.
5. Cattano D, etal., Neurosci Lett. 2008 Aug 8;440(3):217-21. Epub 2008 May 28.
6. Chen S and Charness ME, Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19962-7. Epub 2008 Dec 1.
7. Chen SY, etal., Dev Neurosci. 2005 Jan-Feb;27(1):13-9.
8. Cosgrave AS, etal., J Mol Neurosci. 2009 Jan 7.
9. Dangoor D, etal., Peptides. 2005 Dec;26(12):2579-84. Epub 2005 Jul 14.
10. Divinski I, etal., J Neurochem. 2006 Aug;98(3):973-84.
11. Furman S, etal., Neuron Glia Biol. 2004 Aug;1(3):193-199.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Gennet N, etal., Histol Histopathol. 2008 Mar;23(3):309-17.
14. Gozes I, etal., J Mol Neurosci. 2002 Aug-Oct;19(1-2):167-70.
15. Gozes I, etal., J Mol Neurosci. 2004;24(1):67-72.
16. Gozes I, etal., J Pharmacol Exp Ther 2000 Jun;293(3):1091-8.
17. Jehle T, etal., Graefes Arch Clin Exp Ophthalmol. 2008 Sep;246(9):1255-63. Epub 2008 Apr 15.
18. Kumral A, etal., Brain Res. 2006 Oct 18;1115(1):169-78. Epub 2006 Aug 30.
19. Leker RR, etal., Stroke 2002 Apr;33(4):1085-92.
20. Matsuoka Y, etal., J Pharmacol Exp Ther. 2008 Apr;325(1):146-53. Epub 2008 Jan 16.
21. NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Offen D, etal., Brain Res 2000 Jan 31;854(1-2):257-62.
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Smith-Swintosky VL, etal., J Mol Neurosci. 2005;25(3):225-38.
27. Steingart RA, etal., J Mol Neurosci 2000 Dec;15(3):137-45.
28. Visochek L, etal., J Neurosci. 2005 Aug 10;25(32):7420-8.
29. Vulih-Shultzman I, etal., J Pharmacol Exp Ther. 2007 Nov;323(2):438-49. Epub 2007 Aug 24.
30. Wilkemeyer MF, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8543-8. Epub 2003 Jun 13.
31. Zamostiano R, etal., J Biol Chem 2001 Jan 5;276(1):708-14.
32. Zhang TA, etal., Neuroscience. 2005;134(2):583-93.
33. Zusev M and Gozes I, Regul Pept. 2004 Dec 15;123(1-3):33-41.
Additional References at PubMed
PMID:8889548   PMID:17222401   PMID:17952636   PMID:22454142   PMID:23272107   PMID:25178163   PMID:27003787  


Genomics

Comparative Map Data
Adnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,886,921 - 156,921,500 (-)NCBI
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03164,937,188 - 164,964,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03171,077,543 - 171,087,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,345,280 - 159,355,067 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13159,253,471 - 159,255,943 (-)NCBI
Celera3155,464,855 - 155,474,635 (-)NCBICelera
Cytogenetic Map3q42NCBI
ADNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2050,888,916 - 50,931,437 (-)EnsemblGRCh38hg38GRCh38
GRCh382050,888,918 - 50,931,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372049,505,455 - 49,547,974 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372049,505,585 - 49,547,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,940,290 - 48,980,934 (-)NCBINCBI36hg18NCBI36
Build 342048,940,289 - 48,980,934NCBI
Celera2046,211,143 - 46,251,787 (-)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2046,255,283 - 46,295,816 (-)NCBIHuRef
CHM1_12049,410,848 - 49,452,793 (-)NCBICHM1_1
Adnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,022,885 - 168,049,032 (-)NCBIGRCm39mm39
GRCm382168,180,965 - 168,207,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,180,986 - 168,207,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv372168,006,465 - 168,032,562 (-)NCBIGRCm37mm9NCBIm37
MGSCv362168,006,465 - 168,032,562 (-)NCBImm8
Celera2174,124,697 - 174,151,114 (-)NCBICelera
Cytogenetic Map2H3NCBI
Adnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,492,257 - 7,531,862 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,498,223 - 7,530,828 (+)NCBIChiLan1.0ChiLan1.0
ADNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12048,361,036 - 48,400,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,361,043 - 48,400,387 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02047,233,696 - 47,276,075 (-)NCBIMhudiblu_PPA_v0panPan3
ADNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2437,213,942 - 37,243,702 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12437,211,776 - 37,245,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365143,855,113 - 3,883,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,317,669 - 52,350,757 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,316,388 - 52,350,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,757,490 - 58,790,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103244305
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,037,446 - 13,080,287 (+)NCBI
ChlSab1.1 Ensembl213,039,866 - 13,081,161 (+)Ensembl
Adnp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247904,822,467 - 4,854,852 (+)NCBI

Position Markers
RH134339  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03164,937,228 - 164,937,416NCBIRnor6.0
Rnor_5.03171,077,583 - 171,077,771UniSTSRnor5.0
RGSC_v3.43159,345,320 - 159,345,508UniSTSRGSC3.4
Celera3155,464,895 - 155,465,083UniSTS
RH 3.4 Map31480.7UniSTS
Cytogenetic Map3q42UniSTS
Adnp  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03164,941,293 - 164,941,679NCBIRnor6.0
Rnor_5.03171,081,648 - 171,082,034UniSTSRnor5.0
RGSC_v3.43159,349,385 - 159,349,771UniSTSRGSC3.4
Celera3155,468,960 - 155,469,346UniSTS
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3148348517171467264Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153381237174632112Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3153381237174632112Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3153381237174632112Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3153381237174632112Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3153381237174632112Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3153381237174632112Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3153381237174632112Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153412455165355668Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)3153412455170534769Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3156381661176418101Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:174
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000014595
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 6 8 74 35 41 11 6
Low 2 2 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014595   ⟹   ENSRNOP00000014595
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)Ensembl
RefSeq Acc Id: NM_001347532   ⟹   NP_001334461
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,891,381 - 156,917,312 (-)NCBI
RefSeq Acc Id: NM_022681   ⟹   NP_073172
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03164,937,188 - 164,964,819 (-)NCBI
Rnor_5.03171,077,543 - 171,087,330 (-)NCBI
RGSC_v3.43159,345,280 - 159,355,067 (-)RGD
Celera3155,464,855 - 155,474,635 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105806   ⟹   XP_038961734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,889,885 - 156,921,051 (-)NCBI
RefSeq Acc Id: XM_039105808   ⟹   XP_038961736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,889,885 - 156,921,051 (-)NCBI
RefSeq Acc Id: XM_039105809   ⟹   XP_038961737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,886,921 - 156,921,500 (-)NCBI
RefSeq Acc Id: XM_039105810   ⟹   XP_038961738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,889,885 - 156,921,051 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_073172   ⟸   NM_022681
- Sequence:
RefSeq Acc Id: ENSRNOP00000014595   ⟸   ENSRNOT00000014595
RefSeq Acc Id: XP_038961737   ⟸   XM_039105809
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961738   ⟸   XM_039105810
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961736   ⟸   XM_039105808
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961734   ⟸   XM_039105806
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001334461   ⟸   NM_001347532
- UniProtKB: Q9JKL8 (UniProtKB/Swiss-Prot)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71030 AgrOrtholog
Ensembl Genes ENSRNOG00000010975 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014595 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014595 UniProtKB/Swiss-Prot
InterPro ADNP/ADNP2 UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:64622 UniProtKB/Swiss-Prot
NCBI Gene 64622 ENTREZGENE
PANTHER PTHR15740 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Adnp PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt ADNP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V7G3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adnp  activity-dependent neuroprotector homeobox  Adnp  activity-dependent neuroprotective protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Adnp  activity-dependent neuroprotective protein      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains the orthologous human protein contains nine zinc finger regions and a homeobox domain suggesting it could function as a trancription factor; protein is upregulated in malignant cells and has been shown to contribute to the maintenance of cell viability 1358231
gene_function the conserved, active peptide fragment NAPVSIPQ (NAP peptide) from Adnp prevents cytotoxicity in tetrodotoxin-treated cultured cortical neurons 1358224
gene_function the NAP peptide of Adnp reduces motor disability and infarct volumes, two measurements of cerebral injury, in a model of stroke in SHR rats, apparently by reducing the number of cells undergoing apoptosis; neuroprotection is still apparent for at least 30 days after administration of the peptide 1358226
gene_function daily intranasal administration of the NAP peptide improved short-term spatial memory in rats treated with the cholinotoxin ethylcholine aziridium, presumably by protecting agains loss of choline acetyl transferase activity; pretreatment with NAP significantly improved performance 1358227
gene_function the NAP peptide causes an increase in cGMP production in cultured cerebral cortical cells at concentrations previously associated with neuroprotection; NAP also increases NO production in these cells, apparently by a different mechanism than required for the cGMP effect 1358228
gene_function the NAP peptide protects cultured neurons against dopamine toxicity, suggesting that its neuroprotective activities could be mediated through an increase in cellular resistance to oxidative stress 1358229
gene_function NAP peptide given in the presence of hydrogen peroxide increases cell survival rate in the rat PC12 cell line compared to exposure to hydrogen peroxide alone 1358230