Gpx3 (glutathione peroxidase 3) - Rat Genome Database

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Gene: Gpx3 (glutathione peroxidase 3) Rattus norvegicus
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Symbol: Gpx3
Name: glutathione peroxidase 3
RGD ID: 69224
Description: Enables mercury ion binding activity and selenium binding activity. Involved in several processes, including response to corticosterone; response to molecule of fungal origin; and response to selenium ion. Located in extracellular space. Biomarker of several diseases, including artery disease (multiple); obesity; polycystic ovary syndrome; sciatic neuropathy; and spermatic cord torsion. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Orthologous to human GPX3 (glutathione peroxidase 3); PARTICIPATES IN arachidonic acid metabolic pathway; glutathione metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: REVIEWED
Previously known as: GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P; plasma glutathione peroxidase; plasma glutathione peroxidase precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21039,028,624 - 39,036,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,028,570 - 39,037,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,717,089 - 43,725,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,207,165 - 43,215,235 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,710,877 - 38,718,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,247,436 - 40,255,423 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,247,436 - 40,255,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,019,704 - 40,027,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,311,094 - 40,319,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,324,744 - 40,333,004 (+)NCBI
Celera1038,366,821 - 38,374,734 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
acute myocardial infarction  (ISO)
adenocarcinoma  (ISO)
aortic valve disease  (ISO)
atherosclerosis  (IEP)
Barrett's adenocarcinoma  (ISO)
Barrett's esophagus  (ISO)
Binge Drinking  (IEP)
brain ischemia  (ISO)
Carbon Tetrachloride Poisoning  (IEP)
Cardiac Fibrosis  (IEP)
Cardiomegaly  (IEP)
cardiovascular system disease  (ISO)
Carotid Atherosclerosis  (ISO)
cerebral infarction  (ISO)
cerebral venous thrombosis  (ISO)
cerebrovascular disease  (ISO)
colon cancer  (ISO)
colorectal adenoma  (ISO)
colorectal carcinoma  (ISO)
congenital heart disease  (ISO)
coronary artery disease  (ISO)
depressive disorder  (IEP)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP,ISO)
disease of cellular proliferation  (ISO)
endometrial adenocarcinoma  (IEP)
endometriosis  (ISO)
esophageal cancer  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
familial adenomatous polyposis 1  (ISO)
Fanconi syndrome  (ISO)
gallbladder carcinoma  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (IEP,ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (IEP)
Insulin Resistance  (IEP,ISO)
intracranial sinus thrombosis  (ISO)
Kidney Reperfusion Injury  (IEP)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IEP)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphoplasmacytic lymphoma  (ISO)
male infertility  (IEP)
meningioma  (ISO)
Mercury Poisoning  (IDA)
Metabolic Syndrome  (ISO)
mild pre-eclampsia  (ISO)
multiple myeloma  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
nephrotic syndrome  (IEP,ISO)
nephrotoxicity  (IEP)
neurodegenerative disease  (ISO)
obesity  (IEP,ISO)
Perinatal Asphyxia  (ISO)
polycystic ovary syndrome  (IEP)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries  (IEP)
rectum cancer  (ISO)
sciatic neuropathy  (IEP)
severe pre-eclampsia  (ISO)
spermatic cord torsion  (IEP)
Spinal Cord Injuries  (IEP)
stomach cancer  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular Calcification  (IEP)
vitamin B12 deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
acetamide  (EXP)
acrylonitrile  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chlorobenzene  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cumene  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
ethanol  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 7647  (EXP,ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
isoeugenol  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
lycopene  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
metam  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP,ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetylsphingosine  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (EXP,ISO)
nitrogen dioxide  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
selenium(2+)  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetradecane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic identification of novel differentiation plasma protein markers in hypobaric hypoxia-induced rat model. Ahmad Y, etal., PLoS One. 2014 May 19;9(5):e98027. doi: 10.1371/journal.pone.0098027. eCollection 2014.
2. Screening of the GPX3 gene identifies the "T" allele of the SNP -861A/T as a risk for ischemic stroke in young Asian Indians. Akhter MS, etal., J Stroke Cerebrovasc Dis. 2014 Sep;23(8):2060-2068. doi: 10.1016/j.jstrokecerebrovasdis.2014.03.010. Epub 2014 Aug 8.
3. Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells. An BC, etal., Mol Cells. 2016 Aug 31;39(8):631-8. doi: 10.14348/molcells.2016.0164. Epub 2016 Aug 3.
4. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Assayed ME, Immunopharmacol Immunotoxicol. 2010 Jun;32(2):284-96. doi: 10.3109/08923970903307552.
5. Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion. Ayvaz S, etal., J Pediatr Urol. 2014 Jun;10(3):550-8. doi: 10.1016/j.jpurol.2013.11.019. Epub 2013 Dec 27.
6. Glutathione peroxidase 3 serum levels and GPX3 gene polymorphisms in subjects with metabolic syndrome. Baez-Duarte BG, etal., Arch Med Res. 2014 Jul;45(5):375-82. doi: 10.1016/j.arcmed.2014.05.001. Epub 2014 May 10.
7. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Barrett CW, etal., Cancer Res. 2013 Feb 1;73(3):1245-55. doi: 10.1158/0008-5472.CAN-12-3150. Epub 2012 Dec 5.
8. Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity. Basile DP, etal., Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1494-502. doi: 10.1152/ajprenal.00691.2011. Epub 2012 Mar 21.
9. Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese Zucker rats. Belobrajdic DP, etal., Nutr Metab (Lond). 2011 May 3;8:27. doi: 10.1186/1743-7075-8-27.
10. Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's. Buijsse B, etal., PLoS One. 2012;7(6):e38901. doi: 10.1371/journal.pone.0038901. Epub 2012 Jun 15.
11. Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue. Cao S, etal., Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):198-204. doi: 10.1016/j.clinre.2014.09.003. Epub 2014 Oct 13.
12. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes. Chen QM, etal., Mol Pharmacol. 2005 Jun;67(6):1861-73. Epub 2005 Mar 8.
13. Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss. Chien CY, etal., Kaohsiung J Med Sci. 2017 Jul;33(7):359-364. doi: 10.1016/j.kjms.2017.04.003. Epub 2017 May 9.
14. Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. Chung SS, etal., Mol Cell Biol. 2009 Jan;29(1):20-30. Epub 2008 Oct 20.
15. Association of combined genetic variations in SOD3, GPX3, PON1, and GSTT1 with hypertension and severity of coronary artery disease. Decharatchakul N, etal., Heart Vessels. 2020 Jul;35(7):918-929. doi: 10.1007/s00380-020-01564-6. Epub 2020 Feb 8.
16. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
17. Acute hypoglycemia induces retinal cell death in mouse. Emery M, etal., PLoS One. 2011;6(6):e21586. doi: 10.1371/journal.pone.0021586. Epub 2011 Jun 27.
18. Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype. Fèvre-Montange M, etal., Int J Oncol. 2009 Dec;35(6):1395-407. doi: 10.3892/ijo_00000457.
19. Baseline glutathione peroxidase activity affects prognosis after acute coronary syndromes. García-Pinilla JM, etal., Tex Heart Inst J. 2008;35(3):262-7.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis. Gong Y, etal., Life Sci. 2018 Apr 1;198:94-98. doi: 10.1016/j.lfs.2018.02.035. Epub 2018 Feb 26.
22. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
23. Gelatinases A and B and Antioxidant Enzyme Activity in the Early Phase of Acute Myocardial Infarction. Gopcevic K, etal., Folia Biol (Praha). 2017;63(1):20-26.
24. Impaired glomerular and tubular antioxidative defense mechanisms in nephrotic syndrome. Granqvist A, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F898-904. doi: 10.1152/ajprenal.00124.2010. Epub 2010 Aug 4.
25. Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves. Greene CL, etal., Genes (Basel). 2020 Jul 14;11(7):789. doi: 10.3390/genes11070789.
26. No association of the plasma glutathione peroxidase (GPx-3) gene with cerebral venous thrombosis in the German population. Grond-Ginsbach C, etal., Stroke. 2009 Feb;40(2):e24; author reply e25. doi: 10.1161/STROKEAHA.108.540062. Epub 2008 Dec 18.
27. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China. Hao Y, etal., Chin Med J (Engl). 2011 Jul;124(14):2113-6.
28. Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer. Haug U, etal., Genes Chromosomes Cancer. 2012 Jun;51(6):598-605. doi: 10.1002/gcc.21946. Epub 2012 Feb 27.
29. NO2-induced acute and chronic lung injury cause imbalance of glutathione metabolism in type II pneumocytes. Hochscheid R, etal., Med Sci Monit. 2005 Aug;11(8):BR273-9. Epub 2005 Jul 25.
30. Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Holley A, etal., J Investig Med. 2017 Jun;65(5):919-925. doi: 10.1136/jim-2016-000361. Epub 2017 Mar 15.
31. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
32. Increased gene expression of glutathione peroxidase-3 in diabetic mouse heart. Iwata K, etal., Biol Pharm Bull. 2006 May;29(5):1042-5.
33. Increased glutathione utilization augments tumor cell proliferation in Waldenstrom Macroglobulinemia. Jalali S, etal., Redox Biol. 2020 Sep;36:101657. doi: 10.1016/j.redox.2020.101657. Epub 2020 Aug 1.
34. Clinical Prognosis for SAH Consistent with Redox Imbalance and Lipid Peroxidation. Jarocka-Karpowicz I, etal., Molecules. 2020 Apr 21;25(8):1921. doi: 10.3390/molecules25081921.
35. Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway. Ji Y, etal., Front Pharmacol. 2021 Apr 15;12:643456. doi: 10.3389/fphar.2021.643456. eCollection 2021.
36. Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia. Jin X, etal., Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1207-1214. doi: 10.1016/j.bbapap.2017.07.003. Epub 2017 Jul 10.
37. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
38. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
39. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Kaneko H, etal., Atherosclerosis. 2011 Aug;217(2):350-7. doi: 10.1016/j.atherosclerosis.2011.03.042. Epub 2011 Apr 8.
40. Gene expression profiling predicts a three-gene expression signature of endometrial adenocarcinoma in a rat model. Karlsson S, etal., Cancer Cell Int. 2009 May 8;9:12.
41. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
42. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Kenet G, etal., Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):2017-23. doi: 10.1161/01.atv.19.8.2017.
43. Glutathione Peroxidase 3 as a Biomarker of Recurrence after Lung Cancer Surgery. Kho BG, etal., J Clin Med. 2020 Nov 24;9(12). pii: jcm9123801. doi: 10.3390/jcm9123801.
44. Proteome analysis of serum from type 2 diabetics with nephropathy. Kim HJ, etal., J Proteome Res. 2007 Feb;6(2):735-43.
45. Oxidative stress in perinatal asphyxia. Kumar A, etal., Pediatr Neurol. 2008 Mar;38(3):181-5. doi: 10.1016/j.pediatrneurol.2007.10.008.
46. Biomarker Discovery by Mass Spectrometry in Cerebrospinal Fluid and Plasma after Global Hypoxia-Ischemia in Newborn Piglets. Kyng KJ, etal., Neonatology. 2018;114(4):307-314. doi: 10.1159/000490393. Epub 2018 Jul 19.
47. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. Lee DE, etal., JCSM Rapid Commun. 2021 Jan-Jun;4(1):3-15. doi: 10.1002/rco2.18. Epub 2020 Aug 7.
48. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Lee OJ, etal., Neoplasia. 2005 Sep;7(9):854-61. doi: 10.1593/neo.05328.
49. Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. Lee SH, etal., Am J Chin Med. 2008;36(1):107-14.
50. Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. Lee YS, etal., Mol Endocrinol. 2008 Sep;22(9):2176-89. Epub 2008 Jun 18.
51. A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects. Li M, etal., Ann Hum Genet. 2016 Jan;80(1):20-31. doi: 10.1111/ahg.12139. Epub 2015 Nov 27.
52. Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats. Li W, etal., Atherosclerosis. 2011 Apr;215(2):323-30. doi: 10.1016/j.atherosclerosis.2010.12.037. Epub 2011 Jan 19.
53. Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis. Li X, etal., PLoS One. 2014 Jul 22;9(7):e103162. doi: 10.1371/journal.pone.0103162. eCollection 2014.
54. Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery. Li XY, etal., J Thorac Cardiovasc Surg. 2021 Sep;162(3):851-863.e3. doi: 10.1016/j.jtcvs.2020.01.079. Epub 2020 Feb 19.
55. Gastrodin improves cognitive dysfunction and decreases oxidative stress in vascular dementia rats induced by chronic ischemia. Li Y and Zhang Z, Int J Clin Exp Pathol. 2015 Nov 1;8(11):14099-109. eCollection 2015.
56. Characterization of mercury-binding proteins in rat blood plasma. Li Y, etal., Chem Commun (Camb). 2018 Jul 3;54(54):7439-7442. doi: 10.1039/c8cc02144a.
57. Association between glutathione peroxidase-3 activity and carotid atherosclerosis in patients with type 2 diabetes mellitus. Ling P, etal., Brain Behav. 2020 Oct;10(10):e01773. doi: 10.1002/brb3.1773. Epub 2020 Aug 29.
58. Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. Lubieniecka JM, etal., PLoS One. 2011 Apr 29;6(4):e19247. doi: 10.1371/journal.pone.0019247.
59. Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2. Maciel-Dominguez A, etal., Mol Nutr Food Res. 2013 Dec;57(12):2195-205. doi: 10.1002/mnfr.201300168. Epub 2013 Aug 12.
60. Effects of Heracleum persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats. Majidi Z, etal., Iran J Med Sci. 2020 May;45(3):199-206. doi: 10.30476/ijms.2019.45805.
61. Circulating Lipopolysaccharides and Impaired Antioxidant Status in Patients With Atrial Fibrillation. Data From the ATHERO-AF Study. Menichelli D, etal., Front Cardiovasc Med. 2021 Nov 17;8:779503. doi: 10.3389/fcvm.2021.779503. eCollection 2021.
62. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
63. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Mistry HD, etal., Hypertension. 2008 Nov;52(5):881-8. doi: 10.1161/HYPERTENSIONAHA.108.116103. Epub 2008 Oct 13.
64. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Mistry HD, etal., Placenta. 2010 May;31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
65. Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients. Mitranun W, etal., Scand J Med Sci Sports. 2014 Apr;24(2):e69-76. doi: 10.1111/sms.12112. Epub 2013 Sep 17.
66. The nephroprotection exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy. Molina-Jijón E, etal., Biofactors. 2016 Nov 12;42(6):686-702. doi: 10.1002/biof.1313. Epub 2016 Jul 13.
67. Deferoxamine pretreatment prevents Cr(VI)-induced nephrotoxicity and oxidant stress: role of Cr(VI) chelation. Molina-Jijón E, etal., Toxicology. 2012 Jan 27;291(1-3):93-101. doi: 10.1016/j.tox.2011.11.003. Epub 2011 Nov 15.
68. Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats. Muhamad Adyab NS, etal., BMC Complement Altern Med. 2019 Dec 2;19(1):344. doi: 10.1186/s12906-019-2764-5.
69. Selective antioxidant enzymes during ischemia/reperfusion in myocardial infarction. Muzáková V, etal., Physiol Res. 2000;49(3):315-22.
70. Oxidative stress and adhesion molecules in children with type 1 diabetes mellitus: a possible link. Mylona-Karayanni C, etal., Pediatr Diabetes. 2006 Feb;7(1):51-9.
71. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
72. Sulforaphane attenuates gentamicin-induced nephrotoxicity: role of mitochondrial protection. Negrette-Guzmán M, etal., Evid Based Complement Alternat Med. 2013;2013:135314. doi: 10.1155/2013/135314. Epub 2013 Apr 4.
73. The fungal nephrotoxin orellanine simultaneously increases oxidative stress and down-regulates cellular defenses. Nilsson UA, etal., Free Radic Biol Med. 2008 Apr 15;44(8):1562-9. Epub 2008 Jan 31.
74. Plasma glutathione peroxidase in pediatric stroke families. Nowak-Göttl U, etal., J Thromb Haemost. 2011 Jan;9(1):33-8. doi: 10.1111/j.1538-7836.2010.04103.x.
75. Diagnostic value of serum glutathione peroxidase 3 levels in patients with lung cancer. Oh IJ, etal., Thorac Cancer. 2014 Sep;5(5):425-30. doi: 10.1111/1759-7714.12113. Epub 2014 Aug 25.
76. Binge drinking during adolescence disrupts Se homeostasis and its main hepatic selenoprotein expression. Ojeda ML, etal., Alcohol Clin Exp Res. 2015 May;39(5):818-26. doi: 10.1111/acer.12707. Epub 2015 Apr 10.
77. Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation. Pastori D, etal., J Am Heart Assoc. 2016 Sep 8;5(9):e003682. doi: 10.1161/JAHA.116.003682.
78. GPX3 and GSTT1 as biomarkers related to oxidative stress during renal ischemia reperfusion injuries and their relationship with immune infiltration. Pei J, etal., Front Immunol. 2023 Mar 22;14:1136146. doi: 10.3389/fimmu.2023.1136146. eCollection 2023.
79. Does bromocriptine play a role in decreasing oxidative stress for early weaned programmed obesity? Peixoto-Silva N, etal., Life Sci. 2014 Jan 24;95(1):14-21. doi: 10.1016/j.lfs.2013.12.013. Epub 2013 Dec 17.
80. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Peng DF, etal., Gut. 2009 Jan;58(1):5-15. doi: 10.1136/gut.2007.146290. Epub 2008 Jul 29.
81. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. Peng DF, etal., PLoS One. 2012;7(10):e46214. doi: 10.1371/journal.pone.0046214. Epub 2012 Oct 10.
82. Vitamin E protection of obesity-enhanced vascular calcification in uremic rats. Peralta-Ramírez A, etal., Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F422-9. doi: 10.1152/ajprenal.00355.2013. Epub 2013 Dec 26.
83. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
84. Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma. Qi X, etal., Oncotarget. 2014 Nov 30;5(22):11103-20. doi: 10.18632/oncotarget.2549.
85. The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation. Qi X, etal., Theranostics. 2016 Aug 8;6(11):1934-46. doi: 10.7150/thno.16023. eCollection 2016.
86. Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence. Qi X, etal., Theranostics. 2018 Jan 1;8(1):212-222. doi: 10.7150/thno.21656. eCollection 2018.
87. Homocysteine and thiol metabolites in vitamin B12 deficiency. Ranganath LR, etal., Clin Sci (Lond). 2001 Jan;100(1):111-6.
88. GOA pipeline RGD automated data pipeline
89. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
90. Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis. Rosenling T, etal., J Proteome Res. 2012 Apr 6;11(4):2048-60. Epub 2012 Feb 23.
91. Depot-specific overexpression of proinflammatory, redox, endothelial cell, and angiogenic genes in epicardial fat adjacent to severe stable coronary atherosclerosis. Sacks HS, etal., Metab Syndr Relat Disord. 2011 Dec;9(6):433-9. doi: 10.1089/met.2011.0024. Epub 2011 Jun 16.
92. The effect of leaf hydroalcoholic extract of Ephedra pachyclada infertility in male rats treated with cyclophosphamide: An experimental study. Saleh S, etal., Int J Reprod Biomed. 2023 May 8;21(4):285-294. doi: 10.18502/ijrm.v21i4.13268. eCollection 2023 May.
93. A DNA methylation-based test for esophageal cancer detection. Salta S, etal., Biomark Res. 2020 Nov 25;8(1):68. doi: 10.1186/s40364-020-00248-7.
94. Diabetes mellitus increases reactive oxygen species production in the thyroid of male rats. Santos MC, etal., Endocrinology. 2013 Mar;154(3):1361-72. doi: 10.1210/en.2012-1930. Epub 2013 Feb 13.
95. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
96. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Shankar K, etal., Endocrinology. 2011 Nov;152(11):4158-70. Epub 2011 Aug 23.
97. Analysis of proteins expressed in rat plasma exposed to dioxin using 2-dimensional gel electrophoresis. Son WK, etal., Proteomics. 2003 Dec;3(12):2393-401.
98. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
99. Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis. Sun Q, etal., Nutrients. 2020 Jun 25;12(6):1894. doi: 10.3390/nu12061894.
100. Dietary selenium requirements based on tissue selenium concentration and glutathione peroxidase activities in old female rats. Sunde RA and Thompson KM, J Trace Elem Med Biol. 2009;23(2):132-7. Epub 2009 Mar 14.
101. Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats. Sunde RA, etal., J Nutr. 2005 Sep;135(9):2144-50.
102. Incorporation of selenium into selenoprotein P and extracellular glutathione peroxidase: HPLC-ICPMS data with enriched selenite. Suzuki KT, etal., Analyst. 1999 Dec;124(12):1749-53.
103. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. Takata Y, etal., PLoS One. 2012;7(6):e38612. doi: 10.1371/journal.pone.0038612. Epub 2012 Jun 8.
104. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
105. Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Thomas MC, etal., Kidney Int. 2003 Jun;63(6):2152-61.
106. Pregnancy-induced hypertension is associated with changes in maternal and umbilical blood antioxidants. Uotila J, etal., Gynecol Obstet Invest. 1993;36(3):153-7. doi: 10.1159/000292616.
107. Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Uotila JT, etal., Br J Obstet Gynaecol. 1993 Mar;100(3):270-6. doi: 10.1111/j.1471-0528.1993.tb15242.x.
108. Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats. Uslusoy F, etal., J Pharm Pharmacol. 2019 Jan;71(1):83-92. doi: 10.1111/jphp.12741. Epub 2017 May 16.
109. Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity. Usuki F and Fujimura M, Arch Toxicol. 2016 Apr;90(4):917-26. doi: 10.1007/s00204-015-1528-3. Epub 2015 May 16.
110. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Voetsch B, etal., Stroke. 2007 Jan;38(1):41-9. doi: 10.1161/01.STR.0000252027.53766.2b. Epub 2006 Nov 22.
111. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Voetsch B, etal., Stroke. 2008 Feb;39(2):303-7. doi: 10.1161/STROKEAHA.107.490094. Epub 2007 Dec 20.
112. Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer. Wang JY, etal., Clin Chim Acta. 2010 Oct 9;411(19-20):1432-6. doi: 10.1016/j.cca.2010.05.026. Epub 2010 May 27.
113. Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of abdominal aortic aneurysm. Wang L, etal., Mol Med Rep. 2014 Feb;9(2):435-42. doi: 10.3892/mmr.2013.1846. Epub 2013 Dec 6.
114. The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity. Weinreb O, etal., Chem Biol Interact. 2008 Sep 25;175(1-3):318-26. Epub 2008 Jun 12.
115. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
116. Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3. Wu X, etal., FASEB J. 2023 Feb;37(2):e22738. doi: 10.1096/fj.202201400R.
117. Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer. Yang ZL, etal., Dis Markers. 2013;35(3):163-72. doi: 10.1155/2013/187043. Epub 2013 Aug 25.
118. Tissue specific expression of the plasma glutathione peroxidase gene in rat kidney. Yoshimura S, etal., J Biochem (Tokyo) 1991 Jun;109(6):918-23.
119. Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
120. Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer. Zhang H, etal., Cell Physiol Biochem. 2018;48(6):2247-2257. doi: 10.1159/000492642. Epub 2018 Aug 16.
121. Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy. Zhang M, etal., Med Sci Monit. 2020 Jun 27;26:e924372. doi: 10.12659/MSM.924372.
122. The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial. Zhao Z, etal., J Pineal Res. 2018 Nov;65(4):e12521. doi: 10.1111/jpi.12521. Epub 2018 Sep 30.
123. GPX3 hypermethylation in gastric cancer and its prognostic value in patients aged over 60. Zhou C, etal., Future Oncol. 2019 Apr;15(11):1279-1289. doi: 10.2217/fon-2018-0674. Epub 2019 Mar 29.
124. Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome. Zhou Y, etal., Oxid Med Cell Longev. 2022 May 26;2022:5558599. doi: 10.1155/2022/5558599. eCollection 2022.
125. GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma. Zhu X, etal., Am J Transl Res. 2018 Jun 15;10(6):1908-1920. eCollection 2018.
Additional References at PubMed
PMID:1897960   PMID:2491950   PMID:3619451   PMID:3693360   PMID:8889548   PMID:10617683   PMID:19199708   PMID:19219623   PMID:23376485   PMID:23533145   PMID:24006456   PMID:37633909  
PMID:37761814  


Genomics

Comparative Map Data
Gpx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21039,028,624 - 39,036,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,028,570 - 39,037,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,717,089 - 43,725,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,207,165 - 43,215,235 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,710,877 - 38,718,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,247,436 - 40,255,423 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,247,436 - 40,255,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,019,704 - 40,027,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,311,094 - 40,319,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,324,744 - 40,333,004 (+)NCBI
Celera1038,366,821 - 38,374,734 (+)NCBICelera
Cytogenetic Map10q22NCBI
GPX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,020,591 - 151,028,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,020,591 - 151,028,988 (+)EnsemblGRCh38hg38GRCh38
GRCh375150,400,152 - 150,408,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,380,192 - 150,388,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 345150,380,111 - 150,388,741NCBI
Celera5146,481,339 - 146,489,894 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,545,808 - 145,554,363 (+)NCBIHuRef
CHM1_15149,832,791 - 149,841,346 (+)NCBICHM1_1
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBIT2T-CHM13v2.0
Gpx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,793,680 - 54,801,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,793,279 - 54,801,203 (+)EnsemblGRCm39 Ensembl
GRCm381154,902,854 - 54,910,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,902,453 - 54,910,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,716,355 - 54,723,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,746,373 - 54,753,800 (+)NCBIMGSCv36mm8
Celera1159,492,255 - 59,499,807 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Gpx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,622,741 - 2,629,032 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,622,162 - 2,629,088 (-)NCBIChiLan1.0ChiLan1.0
GPX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15144,391,889 - 144,400,394 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,447,939 - 146,456,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,450,426 - 152,458,994 (+)NCBIpanpan1.1PanPan1.1panPan2
GPX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,200,671 - 58,209,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,200,672 - 58,209,010 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,952,390 - 57,960,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,638,793 - 58,647,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,638,795 - 58,647,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,456,392 - 58,464,733 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,555,078 - 58,563,407 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,058,428 - 59,066,768 (-)NCBIUU_Cfam_GSD_1.0
Gpx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,903,260 - 116,911,461 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,906,113 - 3,913,498 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,904,787 - 3,914,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,980,475 - 71,989,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,980,467 - 71,989,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21678,282,309 - 78,290,916 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,576,950 - 53,585,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,129,632 - 24,138,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,957,999 - 40,962,993 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,957,895 - 40,963,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpx3
85 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat

Markers in Region
AA997285  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,037,061 - 39,037,152 (+)MAPPERmRatBN7.2
Rnor_6.01040,255,790 - 40,255,880NCBIRnor6.0
Rnor_5.01040,028,058 - 40,028,148UniSTSRnor5.0
RGSC_v3.41040,319,749 - 40,319,839UniSTSRGSC3.4
Celera1038,375,101 - 38,375,191UniSTS
RH 3.4 Map10412.9UniSTS
Cytogenetic Map10q22UniSTS
RH129879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,036,484 - 39,036,693 (+)MAPPERmRatBN7.2
Rnor_6.01040,255,213 - 40,255,421NCBIRnor6.0
Rnor_5.01040,027,481 - 40,027,689UniSTSRnor5.0
RGSC_v3.41040,319,172 - 40,319,380UniSTSRGSC3.4
Celera1038,374,524 - 38,374,732UniSTS
RH 3.4 Map10412.9UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 23 2
Medium 3 43 28 12 19 12 8 11 56 12 31 9 8
Low 29 29 29 18 10
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI029092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK477403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK480346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV079715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM066296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM066354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM067533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000079830   ⟹   ENSRNOP00000073271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,028,570 - 39,037,035 (+)Ensembl
Rnor_6.0 Ensembl1040,247,436 - 40,255,422 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,035,566 - 39,036,695 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,032,569 - 39,036,705 (+)Ensembl
RefSeq Acc Id: NM_022525   ⟹   NP_071970
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21039,028,624 - 39,036,695 (+)NCBI
Rnor_6.01040,247,436 - 40,255,423 (+)NCBI
Rnor_5.01040,019,704 - 40,027,691 (+)NCBI
RGSC_v3.41040,311,094 - 40,319,382 (+)RGD
Celera1038,366,821 - 38,374,734 (+)RGD
Sequence:
RefSeq Acc Id: NP_071970   ⟸   NM_022525
- Peptide Label: precursor
- UniProtKB: Q6P6H2 (UniProtKB/Swiss-Prot),   P23764 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073271   ⟸   ENSRNOT00000079830

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697192
Promoter ID:EPDNEW_R7717
Type:multiple initiation site
Name:Gpx3_1
Description:glutathione peroxidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01040,247,464 - 40,247,524EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69224 AgrOrtholog
BioCyc Gene G2FUF-25097 BioCyc
BioCyc Pathway DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
  PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image DETOX1-PWY-1 BioCyc
  PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000052564 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079830 ENTREZGENE
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921653 IMAGE-MGC_LOAD
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:64317 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72828 IMAGE-MGC_LOAD
NCBI Gene 64317 ENTREZGENE
PANTHER GLUTATHIONE PEROXIDASE 3 UniProtKB/Swiss-Prot
  PTHR11592 UniProtKB/Swiss-Prot
Pfam GSHPx UniProtKB/Swiss-Prot
PhenoGen Gpx3 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052564 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
TIGR TC204190
UniProt A6HEJ3_RAT UniProtKB/TrEMBL
  A6HEJ6_RAT UniProtKB/TrEMBL
  GPX3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P6H2 ENTREZGENE
UniProt Secondary Q6P6H2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Gpx3  glutathione peroxidase 3      Symbol and Name updated 629477 APPROVED
2003-03-14 Gpx3  glutathione peroxidase 3  Gpxp  plasma glutathione peroxidase precursor  Data merged from RGD:621613 628472 PROVISIONAL
2002-08-07 Gpxp  plasma glutathione peroxidase precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gpx3  glutathione peroxidase 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is high in kidney and low in lung 68789