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Gene: Chat (choline O-acetyltransferase) Rattus norvegicus
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Symbol: Chat
Name: choline O-acetyltransferase
Description: Exhibits choline O-acetyltransferase activity and choline binding activity. Involved in several processes, including acetylcholine biosynthetic process; antral ovarian follicle growth; and response to ethanol. Localizes to the neuron projection. Biomarker of Alzheimer's disease and asthma. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CHOACTase; choline acetylase; choline acetyltransferase; LOC290567
Orthologs:
Homo sapiens (human) : CHAT (choline O-acetyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Chat (choline acetyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chat (choline O-acetyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : CHAT (choline O-acetyltransferase)
Canis lupus familiaris (dog) : CHAT (choline O-acetyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chat (choline O-acetyltransferase)
Sus scrofa (pig) : CHAT (choline O-acetyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0168,576,858 - 8,686,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0168,493,024 - 8,526,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01610,603,449 - 10,652,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,913,026 - 7,965,985 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1167,913,023 - 7,968,456 (-)NCBI
Celera167,483,676 - 7,543,221 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Chat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304627
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.