Cox7c (cytochrome c oxidase subunit 7C) - Rat Genome Database

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Gene: Cox7c (cytochrome c oxidase subunit 7C) Rattus norvegicus
Analyze
Symbol: Cox7c
Name: cytochrome c oxidase subunit 7C
RGD ID: 2300145
Description: Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Orthologous to human COX7C (cytochrome c oxidase subunit 7C); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cox7c1; Cytochrome c oxidase polypeptide VIIc; Cytochrome c oxidase polypeptide VIIIA; cytochrome c oxidase subunit 7C, mitochondrial; cytochrome c oxidase, subunit VIIc; MGC188847
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8218,577,145 - 18,579,170 (-)NCBIGRCr8
mRatBN7.2216,841,771 - 16,843,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl216,840,837 - 16,843,760 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx223,907,988 - 23,910,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0222,008,260 - 22,010,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0216,708,658 - 16,710,683 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0214,699,878 - 14,701,903 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl214,699,882 - 14,701,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0214,553,402 - 14,555,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4215,254,040 - 15,256,065 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera213,075,378 - 13,077,403 (-)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
hydralazine  (ISO)
isobutanol  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
methylparaben  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
pinosylvin  (ISO)
pirinixic acid  (ISO)
probenecid  (ISO)
pyrogallol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tetrachloromethane  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reduced Mitochondrial Activity is Early and Steady in the Entorhinal Cortex but it is Mainly Unmodified in the Frontal Cortex in Alzheimer's Disease. Armand-Ugon M, etal., Curr Alzheimer Res. 2017;14(12):1327-1334. doi: 10.2174/1567205014666170505095921.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7601105   PMID:8889548   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:18614015   PMID:20833797   PMID:30030519   PMID:31536960  


Genomics

Comparative Map Data
Cox7c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8218,577,145 - 18,579,170 (-)NCBIGRCr8
mRatBN7.2216,841,771 - 16,843,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl216,840,837 - 16,843,760 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx223,907,988 - 23,910,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0222,008,260 - 22,010,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0216,708,658 - 16,710,683 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0214,699,878 - 14,701,903 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl214,699,882 - 14,701,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0214,553,402 - 14,555,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4215,254,040 - 15,256,065 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera213,075,378 - 13,077,403 (-)NCBICelera
Cytogenetic Map2q11NCBI
COX7C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38586,617,941 - 86,620,962 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl586,617,928 - 86,620,962 (+)EnsemblGRCh38hg38GRCh38
GRCh37585,913,758 - 85,916,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36585,949,540 - 85,952,339 (+)NCBINCBI36Build 36hg18NCBI36
Build 34585,949,539 - 85,952,337NCBI
Celera581,805,741 - 81,808,540 (+)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef581,115,920 - 81,118,719 (+)NCBIHuRef
CHM1_1585,346,717 - 85,349,516 (+)NCBICHM1_1
T2T-CHM13v2.0587,100,950 - 87,103,971 (+)NCBIT2T-CHM13v2.0
Cox7c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391386,192,917 - 86,194,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1386,192,935 - 86,195,023 (-)EnsemblGRCm39 Ensembl
GRCm381386,044,798 - 86,046,795 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1386,044,816 - 86,046,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371386,184,403 - 86,186,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361386,518,203 - 86,520,174 (-)NCBIMGSCv36mm8
Celera1388,283,958 - 88,285,955 (-)NCBICelera
Cytogenetic Map13C3NCBI
LOC102008533
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541824,413,883 - 24,416,530 (-)NCBIChiLan1.0ChiLan1.0
LOC100979972
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2428,783,927 - 28,786,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1526,937,550 - 26,940,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0528,763,336 - 28,766,369 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1528,898,380 - 28,901,243 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl528,898,380 - 28,901,243 (-)Ensemblpanpan1.1panPan2
LOC102155410
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,841,405 - 20,841,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,869,724 - 11,870,148 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03012,016,436 - 12,016,861 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13011,937,902 - 11,938,326 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03012,043,715 - 12,044,137 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03012,163,728 - 12,164,154 (-)NCBIUU_Cfam_GSD_1.0
LOC101961000
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213177,286,007 - 177,288,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364695,337,333 - 5,342,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364695,337,331 - 5,339,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX7C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl294,345,447 - 94,352,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1294,345,436 - 94,347,709 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2296,864,369 - 96,866,649 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231597
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,261,111 - 11,261,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605613,053,352 - 13,053,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101713193
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247436,223,835 - 6,229,258 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247436,224,040 - 6,226,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox7c
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000051895
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5
Medium 3 38 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000051895   ⟹   ENSRNOP00000049222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl216,840,837 - 16,843,760 (-)Ensembl
Rnor_6.0 Ensembl214,699,882 - 14,701,903 (-)Ensembl
RefSeq Acc Id: NM_001134705   ⟹   NP_001128177
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8218,577,145 - 18,579,170 (-)NCBI
mRatBN7.2216,841,771 - 16,843,796 (-)NCBI
Rnor_6.0214,699,878 - 14,701,903 (-)NCBI
Rnor_5.0214,553,402 - 14,555,427 (-)NCBI
RGSC_v3.4215,254,040 - 15,256,065 (-)RGD
Celera213,075,378 - 13,077,403 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128177 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66894 (Get FASTA)   NCBI Sequence Viewer  
  EDM09981 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049222
  ENSRNOP00000049222.2
  ENSRNOP00055004963
  ENSRNOP00060000211
  ENSRNOP00065005762
GenBank Protein P80432 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001128177   ⟸   NM_001134705
- UniProtKB: B2RYT3 (UniProtKB/Swiss-Prot),   P80432 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000049222   ⟸   ENSRNOT00000051895

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80432-F1-model_v2 AlphaFold P80432 1-63 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691050
Promoter ID:EPDNEW_R1575
Type:multiple initiation site
Name:Cox7c_1
Description:cytochrome c oxidase subunit 7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0214,701,861 - 14,701,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2300145 AgrOrtholog
BioCyc Gene G2FUF-54920 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000030237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055004061 UniProtKB/Swiss-Prot
  ENSRNOG00060000738 UniProtKB/Swiss-Prot
  ENSRNOG00065005545 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051895 ENTREZGENE
  ENSRNOT00000051895.3 UniProtKB/Swiss-Prot
  ENSRNOT00055006481 UniProtKB/Swiss-Prot
  ENSRNOT00060000864 UniProtKB/Swiss-Prot
  ENSRNOT00065008226 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.49.10 UniProtKB/Swiss-Prot
InterPro COX7C/Cox8 UniProtKB/Swiss-Prot
  COX7C/Cox8_sf UniProtKB/Swiss-Prot
KEGG Report rno:100188937 UniProtKB/Swiss-Prot
NCBI Gene 100188937 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR13313 UniProtKB/Swiss-Prot
Pfam COX7C UniProtKB/Swiss-Prot
PhenoGen Cox7c PhenoGen
RatGTEx ENSRNOG00000030237 RatGTEx
  ENSRNOG00055004061 RatGTEx
  ENSRNOG00060000738 RatGTEx
  ENSRNOG00065005545 RatGTEx
Superfamily-SCOP SSF81427 UniProtKB/Swiss-Prot
UniProt B2RYT3 ENTREZGENE
  COX7C_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RYT3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox7c  cytochrome c oxidase subunit 7C  Cox7c  cytochrome c oxidase, subunit VIIc  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-06 Cox7c  cytochrome c oxidase, subunit VIIc      Symbol and Name status set to provisional 70820 PROVISIONAL