Mt3 (metallothionein 3) - Rat Genome Database

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Gene: Mt3 (metallothionein 3) Rattus norvegicus
Symbol: Mt3
Name: metallothionein 3
RGD ID: 621252
Description: Enables copper ion binding activity and zinc ion binding activity. Involved in negative regulation of hydrogen peroxide catabolic process. Located in several cellular components, including astrocyte end-foot; mitochondrial outer membrane; and synaptic vesicle. Used to study motor neuron disease. Biomarker of borna disease; cerebrovascular disease (multiple); hypothyroidism; median neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
Previously known as: GIF; growth inhibitory factor; metallothionein III; metallothionein-3; metallothionein-III; Mt-3; MT-III
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81910,854,676 - 10,856,080 (-)NCBIGRCr8
mRatBN7.21910,848,754 - 10,850,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,848,755 - 10,850,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,816,785 - 10,818,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,583,639 - 11,585,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,870,637 - 10,872,043 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,324,708 - 11,326,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,324,698 - 11,326,139 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,300,014 - 11,301,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,284,554 - 11,286,402 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,289,380 - 11,291,228 (-)NCBI
Celera1910,734,686 - 10,736,090 (-)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-dihydro-8-oxoguanine  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (EXP,ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dithionitrobenzoic acid  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
fonofos  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
iron(III) nitrilotriacetate  (ISO)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP,ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (ISO)
mercury(0)  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naringin  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nitrogen dioxide  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pinostrobin  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium dichromate  (EXP)
purine-6-thiol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tamibarotene  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
triclosan  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vitamin E  (EXP)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular detoxification  (ISO,ISS)
cellular response to cadmium ion  (IBA)
cellular response to copper ion  (IBA)
cellular response to hypoxia  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (ISO,ISS)
cellular response to zinc ion  (IBA)
detoxification of cadmium ion  (ISO)
detoxification of copper ion  (IBA)
energy reserve metabolic process  (ISO,ISS)
intracellular monoatomic cation homeostasis  (ISO)
intracellular zinc ion homeostasis  (IBA,ISO,ISS)
leptin-mediated signaling pathway  (ISO,ISS)
negative regulation of apoptotic process  (ISO)
negative regulation of axon extension  (ISO,ISS)
negative regulation of cell growth  (ISO,ISS,NAS)
negative regulation of dendrite morphogenesis  (NAS)
negative regulation of hydrogen peroxide catabolic process  (IDA)
negative regulation of neurogenesis  (ISO,NAS)
negative regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IBA,ISO,ISS)
positive regulation of gene expression  (ISO,ISS)
positive regulation of oxygen metabolic process  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO,ISS)
protein stabilization  (ISO,ISS)
regulation of response to food  (ISO,ISS)
removal of superoxide radicals  (ISO,ISS)
response to hypoxia  (ISO,ISS)
response to oxidative stress  (ISO)
sequestering of metal ion  (ISO,ISS)
zinc ion transport  (ISO,ISS)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Expression of growth inhibitory factor (metallothionein-III) mRNA and protein following excitotoxic immature brain injury. Acarin L, etal., J Neuropathol Exp Neurol. 1999 Apr;58(4):389-97.
2. Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes. Amoureux MC, etal., Biochem Biophys Res Commun 1995 Sep 14;214(2):639-45.
3. Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice. Byun HR, etal., Neurobiol Dis. 2011 Oct;44(1):125-32. Epub 2011 Jun 25.
4. Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains. Carrasco J, etal., J Neurotrauma. 1999 Nov;16(11):1115-29.
5. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. Choi KH, etal., BMC Psychiatry. 2008 Nov 7;8:87.
6. Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting. Chung RS, etal., Exp Neurol 2002 Nov;178(1):1-12.
7. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Erickson JC, etal., Brain Res. 1994 Jun 27;649(1-2):297-304.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Tolerance of aged rat brains to mild hyperoxia: possible involvement of higher GIF content. Gomi F, etal., Brain Res. 2005 Feb 1;1033(1):113-6.
11. Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. Honda A, etal., J Toxicol Sci. 2010 Apr;35(2):209-15.
12. Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds--an immunocytochemical study using confocal laser scan microscope. Hozumi I, etal., Brain Res. 1996 Nov 25;741(1-2):197-204.
13. Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain. Hozumi I, etal., Neurosci Lett. 2006 Mar 13;395(3):220-3. Epub 2005 Nov 28.
14. Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats. Inuzuka T, etal., Brain Res. 1996 Feb 12;709(1):151-31.
15. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. Ishigaki S, etal., FEBS Lett. 2002 Nov 6;531(2):354-8.
16. Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Koumura A, etal., Brain Res. 2009 Oct 6;1292:148-54. Epub 2009 Jul 25.
17. Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. Koumura A, etal., Neurosci Lett. 2009 Dec 18;467(1):11-4. Epub 2009 Sep 30.
18. Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, etal., J Neurochem. 2009 Sep;110(5):1674-84. Epub 2009 Jul 8.
19. Expression of antioxidant molecules after peripheral nerve injury and regeneration. Lanza C, etal., J Neurosci Res. 2012 Apr;90(4):842-8. doi: 10.1002/jnr.22778. Epub 2012 Jan 18.
20. Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease. Martin BL, etal., Mol Cell Biochem. 2006 Feb;283(1-2):129-37.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Age-related changes in expression of metallothionein-III in rat brain. Miyazaki I, etal., Neurosci Res. 2002 Aug;43(4):323-33.
23. Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration? Mocchegiani E, etal., Brain Res Bull 2004 Mar 15;63(2):133-42.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus. Ni H, etal., Toxicol Lett. 2013 Feb 27;217(2):162-9. doi: 10.1016/j.toxlet.2012.12.010. Epub 2012 Dec 21.
26. Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy. Pountney DL, etal., Neurotox Res. 2011 Jan;19(1):115-22. Epub 2009 Dec 29.
27. Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins. Puttaparthi K, etal., J Neurosci. 2002 Oct 15;22(20):8790-6.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Growth inhibitory factor prevents degeneration of injured adult rat motoneurons. Sakamoto T, etal., Neuroreport. 2003 Dec 2;14(17):2147-51.
31. The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2. Somji S, etal., Toxicol Sci. 2006 Apr;90(2):369-76. Epub 2005 Dec 30.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis. Tokuda E, etal., Toxicology. 2007 Jan 5;229(1-2):33-41. Epub 2006 Sep 29.
34. Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. Tougu V, etal., J Neurochem. 2009 Sep;110(6):1784-95. Epub 2009 Jul 8.
35. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. Tsuji S, etal., EMBO J. 1992 Dec;11(13):4843-50.
36. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Tsuruma K, etal., Invest Ophthalmol Vis Sci. 2012 Nov 29;53(12):7896-903. doi: 10.1167/iovs.12-10165.
37. Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. Uchida Y, etal., J Biol Chem 2002 Aug 30;277(35):32353-9.
38. Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration. Watabe K, etal., Neuropathology. 2005 Dec;25(4):371-80.
39. Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection. Williams BL, etal., Brain Pathol. 2006 Jan;16(1):1-14.
40. Subcellular localization of growth inhibitory factor in rat brain: light and electron microscopic immunohistochemical studies. Yamada M, etal., Brain Res. 1996 Oct 7;735(2):257-64.
41. Identification of cell-specific messenger ribonucleic acids in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization. Yamashita M, etal., Endocrinology 2002 Nov;143(11):4464-76.
42. Ischemia induces metallothionein III expression in neurons of rat brain. Yanagitani S, etal., Life Sci. 1999;64(8):707-15.
43. Regulation of metallothionein-3 mRNA by thyroid hormone in developing rat brain and primary cultures of rat astrocytes and neurons. Yeiser EC, etal., Brain Res Dev Brain Res. 1999 Jun 2;115(2):195-200.
Additional References at PubMed
PMID:7931547   PMID:8412560   PMID:10355541   PMID:10366715   PMID:12130647   PMID:12383939   PMID:12692462   PMID:12763630   PMID:14998173   PMID:15129022   PMID:15489334   PMID:16336778  
PMID:16601975   PMID:16945328   PMID:17712581   PMID:18157556   PMID:18206644   PMID:18295594   PMID:18479819   PMID:18554677   PMID:19536566   PMID:20544854   PMID:21320589   PMID:21359432  
PMID:21818286   PMID:22367221   PMID:25778834   PMID:27939232  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81910,854,676 - 10,856,080 (-)NCBIGRCr8
mRatBN7.21910,848,754 - 10,850,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,848,755 - 10,850,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,816,785 - 10,818,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,583,639 - 11,585,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,870,637 - 10,872,043 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,324,708 - 11,326,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,324,698 - 11,326,139 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,300,014 - 11,301,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,284,554 - 11,286,402 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,289,380 - 11,291,228 (-)NCBI
Celera1910,734,686 - 10,736,090 (-)NCBICelera
Cytogenetic Map19p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381656,589,528 - 56,591,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,589,074 - 56,591,088 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,623,440 - 56,624,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,180,768 - 55,182,501 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,180,767 - 55,182,500NCBI
Celera1641,120,754 - 41,122,487 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,492,901 - 42,494,634 (+)NCBIHuRef
CHM1_11658,029,740 - 58,031,473 (+)NCBICHM1_1
T2T-CHM13v2.01662,384,459 - 62,386,016 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39894,879,235 - 94,880,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,879,235 - 94,880,774 (+)EnsemblGRCm39 Ensembl
GRCm38894,152,607 - 94,154,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,152,607 - 94,154,146 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,676,507 - 96,678,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,041,873 - 97,043,260 (+)NCBIMGSCv36mm8
Celera898,484,267 - 98,485,940 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.29NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21866,071,291 - 66,073,006 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,990,250 - 71,991,887 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,875,919 - 36,877,558 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,007,922 - 56,009,828 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,007,922 - 56,028,093 (+)NCBIpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1259,624,845 - 59,630,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,258,480 - 56,264,041 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,169,540 - 60,175,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,169,544 - 60,171,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,000,204 - 57,005,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,008,894 - 58,014,626 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,902,010 - 58,907,559 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934950,722,559 - 50,724,569 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,864,675 - 8,866,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,864,512 - 8,866,516 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl618,634,261 - 18,636,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,634,735 - 18,636,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,377,693 - 26,380,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1542,502,306 - 42,504,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604733,859,328 - 33,861,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Mt3
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:66
Interacting mature miRNAs:72
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 1 6 2 2 69 32 2
Low 2 37 20 4 14 4 6 9 4 28 7 8 6
Below cutoff 17 17 3 17 7 2 3


RefSeq Acc Id: ENSRNOT00000025669   ⟹   ENSRNOP00000025669
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,848,755 - 10,850,158 (-)Ensembl
Rnor_6.0 Ensembl1911,324,698 - 11,326,139 (-)Ensembl
RefSeq Acc Id: NM_053968   ⟹   NP_446420
Rat AssemblyChrPosition (strand)Source
GRCr81910,854,676 - 10,856,080 (-)NCBI
mRatBN7.21910,848,754 - 10,850,158 (-)NCBI
Rnor_6.01911,324,708 - 11,326,112 (-)NCBI
Rnor_5.01911,300,014 - 11,301,422 (-)NCBI
RGSC_v3.41911,284,554 - 11,286,402 (-)RGD
Celera1910,734,686 - 10,736,090 (-)RGD
Protein Sequences
Protein RefSeqs NP_446420 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB28366 (Get FASTA)   NCBI Sequence Viewer  
  AAH58453 (Get FASTA)   NCBI Sequence Viewer  
  CAA61762 (Get FASTA)   NCBI Sequence Viewer  
  EDL87352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025669
GenBank Protein P37361 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446420   ⟸   NM_053968
- UniProtKB: P37361 (UniProtKB/Swiss-Prot),   A6JY74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025669   ⟸   ENSRNOT00000025669

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37361-F1-model_v2 AlphaFold P37361 1-66 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700951
Promoter ID:EPDNEW_R11475
Type:single initiation site
Description:metallothionein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,326,112 - 11,326,172EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621252 AgrOrtholog
BioCyc Gene G2FUF-6475 BioCyc
Ensembl Genes ENSRNOG00000018958 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025669 ENTREZGENE
  ENSRNOT00000025669.6 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23299 UniProtKB/Swiss-Prot
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt3 PhenoGen
RatGTEx ENSRNOG00000018958 RatGTEx
Superfamily-SCOP Metallothionein UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  MT3_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mt3  metallothionein 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mt3  metallothionein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease drastically reduced in Alzheimers disease brains 628363
gene_expression preferentially found in vasopressin (VP)-expressing magnocellular neurons (MCNs) 628363
gene_process inhibits the formation and growth of both axons and dendrites 727475
gene_process may inhibit growth of rat C6 glial cells 729282
gene_process may play a role in regulation of copper and zinc in the nervous system, in tissue repair after adult brain injury and in preventing neuronal sprouting 628363
gene_product brain-specific member of the metallothionein protein family 628363