RGD Reference Report - Tolerance of aged rat brains to mild hyperoxia: possible involvement of higher GIF content. - Rat Genome Database

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Tolerance of aged rat brains to mild hyperoxia: possible involvement of higher GIF content.

Authors: Gomi, F  Nakano, S  Uchida, Y 
Citation: Gomi F, etal., Brain Res. 2005 Feb 1;1033(1):113-6.
RGD ID: 9686051
Pubmed: PMID:15680347   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2004.11.028   (Journal Full-text)

We investigate the aging effects of the hyperoxia-mediated induction of two antioxidants and three antioxidant enzymes in the rat brain. All of these genes responded to hyperoxia in young but not aged brains. Despite the partial inactivation of CuZn SOD and glutathione peroxidase by hyperoxia in aged rat brains, lipid peroxidation did not increase. The higher growth inhibitory factor (GIF) content in aged rat brains may be utilized as an antioxidant during hyperoxia.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MT3HumanHyperoxia  ISOMt3 (Rattus norvegicus) RGD 
Mt3RatHyperoxia  IEP  RGD 
Mt3MouseHyperoxia  ISOMt3 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mt3  (metallothionein 3)

Genes (Mus musculus)
Mt3  (metallothionein 3)

Genes (Homo sapiens)
MT3  (metallothionein 3)


Additional Information