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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621252
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt3
Name: metallothionein 3
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt3decreases response to substanceISOMT3 (Homo sapiens)6480464CTDMT3 protein results in decreased susceptibility to Hydrogen PeroxidePMID:12067712 PMID:12383939 PMID:19767621
Mt3multiple interactionsISOMT3 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]; RELA protein promotes the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]; staurosporine aglycone inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]PMID:19767621
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